ライフサイエンスコーパス: PH domain

1 tes with PtdIns(4)P for association with the PH domain.

2 Instead it is negatively controlled by the PH domain.

3 inositol 4,5-bisphosphate (PIP2) through the PH domain.

4 e autoinhibitory elements in addition to the PH domain.

5 nge of its interaction partner from Ras to a PH domain.

6 h nuclear localization-dependent on the Vav3 PH domain.

7 ization is an important function of the Vav3 PH domain.

8 h homology to Ras superfamily proteins and a PH domain.

9 a better substrate than the one without the PH domain.

10 ecific PIP3 recognition mode for the kindlin PH domain.

11 pendent of PI3K, PDK1, and mTORC2 as well as PH domain.

12 nd appear to be modulated by the first RNase PH domain.

13 tient had a missense mutation (E208Q) in the PH domain.

14 two SH3 domains and a C-terminal RhoGEF (DH)-PH domain.

15 ith PI(3,4)P2 on the plasma membrane via its PH domain.

16 s of the full-length protein compared to its PH domain.

17 dient was dependent on its PI(3,4)P2-binding PH domain.

18 exhibited strong binding affinities to GAB1 PH domain.

19 ily as the most likely origin of the kindlin PH domain.

20 d by overexpression of five of the RhoGEF DH-PH domains.

21 K1, without affecting several PIP2-selective PH domains.

22 mbrane insertion of its pleckstrin homology (PH) domain.

23 r473 independent of the pleckstrin homology (PH) domain.

24 targeting site-2 of the pleckstrin homology (PH) domain.

25 termination within the pleckstrin homology (PH) domain.

26 lighting the multifunctional nature of ATXR5 PHD domain.

27 one-binding affinity by interacting with the PHD domain.

28 Dbl-homology (DH), and pleckstrin-homology (PH) domains.

29 h their Dbl homology/pleckstrin homology (DH.PH) domains.

30 nding motifs, SET methyltransferase, HMG and PHD domains.

31 , ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) in the Golgi, which facilitates vesi

32 ociating (RA) domain, a pleckstrin-homology (PH) domain, a family-specific BPS (between PH and SH2) r

33 Dok7 comprises a pleckstrin-homology (PH) domain, a phosphotyrosine-binding (PTB) domain, and

34 thesis that binding of activated RhoA to the PH domains acts as a positive feedback mechanism.

35 e by site-directed mutagenesis increases the PH domain affinity for Ins(3,4,5)P(3) as measured by sur

36 Overexpression of these PH domains alone can block RhoA-dependent signaling in c

37 fines a new subclass of pleckstrin homology (PH) domains along with a new family of proteins carrying

38 We showed previously that the RA and PH domains, along with the BPS region and SH2 domain, ar

39 GAC PH domain also binds to phosphatidic acid, a lipid media

40 ptor with neurofibromin Pleckstrin Homology (PH) domain also inhibits receptor constitutive activity,

41 BAR (Bin-amphiphysin-Rvs) domain linked to a PH domain and a C-terminal phosphotyrosine-binding domai

42 A resolution crystal structure of the FAPP1 PH domain and detail the molecular mechanisms of the Ptd

43 localization to the plasma membrane via the PH domain and implicate this mechanism in the inhibition

44 her form a positively charged surface on the PH domain and interact with the negatively charged headg

45 or protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1) signaling endosom

46 some 10 (PTEN) overexpression down-regulated PH domain and leucine-rich repeat phosphatase (PHLPP) an

47 in the degradation of two splice variants of PH domain and Leucine-rich repeat Protein Phosphatase 1

48 ion via inhibition of the translation of the PH domain and leucine-rich repeat protein phosphatases 1

49 rface plasmon resonance analysis of the PDK1 PH domain and selected mutants shows that the PH domain

50 terically regulated by PIP(2) binding to the PH domain and that activity depends on the interdomain l

51 Thus, the PH domain and the interdomain linker of Brag2 may be tar

52 Y415 is located downstream of a PH domain and upstream of the catalytic HKD-1 domain of

53 ort high-resolution structures of the DH and PH domains and characterize conformations of the DH-PH u

54 termined the crystal structure of the RA and PH domains and found that, despite an intervening linker

55 structure consists of a Pleckstrin Homology (PH) domain and a Phosphotyrosine Binding (PTB) domain.

56 we have focused on its pleckstrin homology (PH) domain and find that deletion of this domain elimina

57 M2A consisting of a CXXC type zinc finger, a PHD domain and a newly identified Heterochromatin Protei

58 ytic site within the second duplicated RNase PH domain, and appear to be modulated by the first RNase

59 daptor Protein, Phosphotyrosine Interaction, PH domain, and leucine zipper containing 1 (APPL1) that

60 Brag2 contains a pleckstrin homology (PH) domain, and its nucleotide exchange activity is stim

61 hotyrosine interaction, pleckstrin homology (PH) domain, and leucine zipper-containing protein)) are

62 domain, Fbxl10 consists of a CxxC domain, a PHD domain, and an Fbox domain.

63 vitro assays, the AKT mutant containing the PH domain appeared to be a better substrate than the one

64 ; both myristoylated-Akt and Akt lacking the PH domain are phosphorylated at Ser-473.

65 Specific residues within the PH domain are responsible for both membrane binding and

66 d autoinhibition by elements proximal to the PH domain are well-characterized.

67 PH domains are often involved in membrane localization o

68 Pleckstrin homology (PH) domains are lipid-binding modules present in periphe

69 we report that acidic residues in the BAZ2B PHD domain are essential for H3 binding and that BAZ2B P

70 f the phospholipid-binding pocket of the ITK PH domain, are conserved in the PH domains of all Tec ki

71 identify a hydrophobic face of the PLC-beta PH domain as the Gbetagamma binding interface.

72 fic small-molecule targeting PIP3 binding by PH domains as potential anticancer agents that can simul

73 Cdc42/Rac interactive binding region in the PH domain, as well as the PX domain, and it involves, fo

74 d the other without the pleckstrin homology (PH) domain, as substrates for mTORC2 to dissect the role

75 tor MS1 (MALE STERILITY 1), which contains a PHD domain associated with chromatin re-organization.

76 lin 3-IPRR, has a four-residue insert in the PH domain at a critical site that influences phosphoinos

77 ated the search and bind process in the GRP1 PH domain at the molecular scale.

78 revealed that the START domain binds to the PH domain at the same site for PtdIns(4)P-binding, sugge

79 PHF8 is recruited to promoters by its PHD domain based on interaction with H3K4me2/3 and contr

80 ity of DMIB for PIP(2)/PIP(3) similar to the PH domain-based specificity of other class I myosins.

81 onstrate that PITs inhibit PIP3/ARNO or GRP1 PH domain binding and membrane localization, resulting i

82 C(50) ranges from 13.4 to 31 muM in PIP3/Akt PH domain binding assay).

83 PH domain binding leads to local clustering of PIP molec

84 y activity that directly interferes with the PH domain binding to PIP3 and facilitates Akt ubiquitina

85 kt phosphatase, through pleckstrin homology (PH) domain binding.

86 Although lipid overlay assays suggested the PH domain binds inositol monophosphates, surface plasmon

87 nine nucleotide exchange factor, whereas the PH domain binds to various phosphatidylinositol-phosphat

88 tylation while a double pleckstrin-homology (PH) domain binds the K56-containing region of H3.

89 as association (RA) and pleckstrin homology (PH) domains, both of which were required for lymphocyte

90 The PH domain bound phosphoinositol 4,5-bisphosphate (PI(4,5

91 etermined the NMR structure of the kindlin-2 PH domain bound to the head group of PIP3, inositol 1,3,

92 iled molecular characterization of tandem RA-PH domains bound to a small GTPase and provides insights

93 e of Pak1/2, we found that ArhGAP15, via its PH domain, bound to these kinases.

94 Lipid binding is mediated by the PH domain, but is further enhanced by a central helical

95 Hence, the PH domain, but not the DH domain, plays an important rol

96 CNM mutations in the PH domain C-terminal alpha-helix appear to cause conform

97 We show that the isolated PH domain can compete with full-length PLC-beta3 for bin

98 PH domains can be grouped by the relative strength of th

99 Furthermore, PH domains carrying mutations identified in NF1 patients

100 isms for phosphoinositide recognition by the PH domain, catalysis of nucleotide exchange by the Sec7

101 arbours a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain.

102 domains of all Tec kinases, but not in other PH-domain containing proteins, suggesting an important f

103 Mutations in human FYVE, RhoGEF, and PH domain-containing 1 (FGD1) cause faciogenital dysplas

104 Ventricular zone expressed PH domain-containing 1 (VEPH1) is the mammalian ortholog

105 helial specific gene named FYVE, RhoGEF, and PH domain-containing 5 (FGD5) that plays a crucial role

106 The PH domain-containing family member, Osh3, localizes to P

107 hreonine kinase Akt/protein kinase B and the PH domain-containing protein PhdA, were previously chara

108 Furthermore, we identify a tandem PH domain-containing protein, Opy1, as a novel Mss4-inte

109 lso suggest that additional conserved tandem PH domain-containing proteins may play important roles i

110 dI were identified as previously undescribed PH domain-containing proteins.

111 we identify an acylated pleckstrin-homology (PH) domain-containing protein (APH) on the microneme sur

112 t that mutations in the pleckstrin homology (PH) domain-containing protein AtPH1 rescue the iron-defi

113 ophila melted encodes a pleckstrin homology (PH) domain-containing protein that enables normal tissue

114 conserved armadillo and pleckstrin homology (PH) domain-containing protein, termed glideosome-associa

115 ule, acts by recruiting pleckstrin-homology (PH) domain-containing proteins to cell membranes.

116 coideum, including five pleckstrin homology (PH) domain-containing proteins.

117 nd consequently recruit pleckstrin homology (PH) domain-containing signaling proteins.

118 chromodomain-containing Eaf3 subunit and the PHD domain-containing Rco1 subunit to recognize nucleoso

119 taneous binding of multiple PIP molecules by PH domains contributes to high-affinity membrane interac

120 of a serine-rich motif immediately after the PH domain decreases both PtdIns(4)P binding and ceramide

121 ed at the C-terminal region encompassing the PH domain, decreases SMAD2 retention at TbetaRI and enha

122 In contrast, PKD1-DeltaPH (a PH domain deletion mutant) is recovered as a constitutiv

123 protected from drug induced cell death in a PH-domain dependent manner.

124 A known PH domain-dependent allosteric inhibitor, which stabiliz

125 However, the molecular mechanisms underlying PH domain-dependent membrane fission remain obscure.

126 oactivates AR in a Vav3 pleckstrin homology (PH) domain-dependent but GEF-independent manner.

127 P3 search process, before and after the GRP1 PH domain docks with the PIP3 lipid.

128 techniques, we demonstrate that the isolated PH domain does not act to bend membranes but instead sen

129 Third, we show that ATXR5 PHD domain employs a narrow binding pocket to selectivel

130 protein marks by PCGEM1-recruited pygopus 2 PHD domain enhances selective looping of androgen-recept

131 The PHD domain exerts a dual function in binding H3K4me3 and

132 ns in the number of PIPs associated with the PH domain exhibit 1/f noise.

133 inhibits receptor constitutive activity, and PH domain expression rescues 5-HT6 receptor-operated cAM

134 The structure reveals a canonical PH domain fold, yet with a distinct IP4 binding pocket t

135 The FAPP1 PH domain folds into a seven-stranded beta-barrel capped

136 a confirming the importance of the kindlin-1 PH domain for integrin activation and its x-ray crystal

137 allel dimerization, properly positioning the PH domains for simultaneous membrane interaction.

138 ous studies have reported specificity of the PHD domain for the unmodified N terminus of histone H3 a

139 The structure reveals that the Grb14 RA and PH domains form an integrated structural unit capable of

140 hosphorylation of PTEN to release the P-REX2 PH domain from its neighboring diffuse B-cell lymphoma h

141 by mechanisms that depend on removal of the PH domain from the kinase domain.

142 he Warts kinase of the Hippo pathway and the PH-domain growth regulator Melted regulates the choice b

143 We show that the kindlin 3 PH domain has binding affinity for phosphoinositide PI(3

144 so suggest that Akt inhibitors targeting the PH domain have no effect on the tumors in which hyperact

145 In cells, deletion of the PH domain impairs leading edge localization.

146 ed that the linker between the sec7d and the PH domain in Brag2 may directly contact Arf.

147 Therefore, intrinsic movement of the PH domain in PLC-beta modulates Gbetagamma access to its

148 amed "CRIB-1" and "CRIB-2" in and around the PH domain in PLD2.

149 the two membrane binding states of the GRP1 PH domain in the PIP3 search process, before and after t

150 ture at 2.4-A resolution of the Grb14 RA and PH domains in complex with GTP-loaded H-Ras (G12V).

151 of the (H3-H4)(2) tetramer while two double PH domains in the Rtt106 dimer interact with each of the

152 our understanding of membrane recognition by PH domains in vivo.

153 actions between both the peckstrin homology (PH) domain in Lpd and phosphatidylinositol (3,4)-bisphos

154 quires interaction of a pleckstrin homology (PH) domain in Ste5 with phosphatidylinositol 4,5-bisphos

155 These ArfGEFs carry a pleckstrin homology (PH) domain in tandem with their catalytic Sec7 domain, w

156 bit interactions of a number of PIP3-binding PH domains, including those of Akt and PDK1, without aff

157 PHLPP1, as its binding affinities for other PH domains, including those of ILK and PDK1, were an ord

158 resents the discovery of first-in-class GAB1 PH domain inhibitors with potential for targeted breast

159 The BAR domain adjacent to the PH domain instead interacts with the BAR domains of neig

160 ecular dynamics (MD) simulations of the GRP1 PH domain interacting with phosphatidylinositol (3,4,5)-

161 nists (PITs) that block pleckstrin homology (PH) domain interaction, including activation of Akt, and

162 olecule antagonists (PITenins, PITs) of PIP3-PH domain interactions (IC(50) ranges from 13.4 to 31 mu

163 We investigated the molecular basis of FAPP1-PH domain interactions with PI4P bilayers in liposome se

164 toinhibitory elements in grooves at the Arf6/PH domain interface.

165 NA-binding ARID domain and a histone-binding PHD domain into the Jumonji domain, which separates the

166 us, the correct functioning of the kindlin 3 PH domain is central to the role that kindlin 3 performs

167 Second, constructs of Akt in which the PH domain is constitutively disengaged from the kinase d

168 The specific PIP3 lipid docking of GRP1 PH domain is essential to protein cellular function and

169 The initial encounter of the Dok7 PH domain is followed by formation of additional interac

170 buted, but it remains to be seen whether the PH domain is involved in either process independent of d

171 he phosphate binding pocket in the kindlin-1 PH domain is more occluded than in kindlins-2 and -3 due

172 st the physiological ligand of the kindlin-1 PH domain is most likely not an inositol phosphate but a

173 on membranes and that, similar to BRAGs, its PH domain is not autoinhibitory and strongly potentiates

174 However, in the context of ORP4L, the PH domain is required for normal organization of the vim

175 omology (PH) domain, we demonstrate that the PH domain is the minimal Gbetagamma binding region in PL

176 al studies suggest that the key role of this PH domain is to mediate the Ste5-Ste11 interaction.

177 cance of the FYF amino acid motif in the ITK-PH domain is unknown.

178 P3) binding function of pleckstrin homology (PH) domain is essential for the activation of oncogenic

179 The pleckstrin homology (PH) domain is one of the most widespread, binding specif

180 Intramolecular pleckstrin homology (PH) domain-kinase domain (KD) interactions are important

181 n by the rapid loss of Golgi localization of PH domains known to bind PtdIns4P after Sac1 recruitment

182 teraction by competitive binding of the Akt2-PH domain led to reduced cell viability and invasion.

183 We show that the phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP

184 In this study, we demonstrated that PH domain leucine-rich repeat protein phosphatase (PHLPP

185 PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1) is

186 membrane co-localization of Akt and PHLPP1 (PH domain leucine-rich repeat protein phosphatase isofor

187 The PH domain leucine-rich repeat protein phosphatase, PHLPP

188 PH domain leucine-rich-repeats protein phosphatase (PHLP

189 Akt phosphatase PHLPP1 (pleckstrin homology (PH) domain leucine-rich repeat protein phosphatase) to A

190 ve the C1 domain (but not the autoinhibitory PH domain) limit maximal PKD1 activity toward physiologi

191 Pleckstrin homology (PH) domains mediate protein-membrane interactions by bin

192 ensory function, disruption of the predicted PH domain-mediated interactions with Gbetagamma and phos

193 esults indicate a functional role for P-REX2 PH-domain-mediated inhibition of PTEN in regulating insu

194 ey shed light upon a mechanism as to how the PH domain mediates membrane engagement of kindlin-2 to p

195 utational analysis supports the bifunctional PH domain mediation of DH-RhoA interactions and explains

196 ate, GTP-insensitive "electrostatic mode" of PH domain-membrane interactions that retains dynamin on

197 Blocking PH domain motion in PLC-beta by cross-linking it to the

198 tructures and an open conformation where the PH domain moves away from the EF hands.

199 PH domains must locate specific PIPs in the presence of

200 PH-domain mutants alter subcellular localization and res

201 phenylquinolin-2(1H)-one interacted with the PH domain of Akt, apparently inducing a conformation tha

202 SC79 specifically binds to the PH domain of Akt.

203 s (perifosine and triciribine) targeting the PH domain of Akt.

204 between an internal domain of AEG-1 and the PH domain of Akt2, a major driver in GBM.

205 The effect of PIP(2) required the PH domain of Brag2 and the N terminus of Arf and was lar

206 The unique tandem C2-PH domain of CAPS may serve as a PI(4,5)P2-triggered swi

207 pid transfer protein CERT that relied on the PH domain of CERT.

208 Our simulations indicate that the PH domain of Dok7 associates with membranes containing p

209 als that fit into a surface groove of the DH-PH domain of LARG, a G-protein-regulated Rho GEF involve

210 The PH domain of ORP4L also binds phosphatidylinositol 4-pho

211 d domain) with a subsequent insertion of the PH domain of separate origin.

212 not interact with Ras, but instead binds the PH domain of the Ste5 scaffold.

213 The GLD and PH domains of AGAP1 bound the motor domain of Kif2A.

214 AGAP1, and a protein composed of the GLD and PH domains of AGAP1 increased ATPase activity of Kif2A.

215 Like 3, 20 preferentially recognized the PH domains of Akt and PHLPP1, as its binding affinities

216 t of the ITK PH domain, are conserved in the PH domains of all Tec kinases, but not in other PH-domai

217 ed pool of PI4P as well as the expression of PH domains of Golgi proteins that specifically recognize

218 Y16 binds to the junction site of the DH-PH domains of LARG with a approximately 80 nM K(d) and s

219 Thus, the RA-PH domains of RIAM function as a proximity detector for

220 m4p interacted with the pleckstrin homology (PH) domain of Cdc24p, which functions in an autoinhibito

221 over, we identified the pleckstrin homology (PH) domain of G protein-coupled receptor kinase 2 (Gprk2

222 y, we aim to target the pleckstrin homology (PH) domain of GAB1 for cancer treatment.

223 The pleckstrin homology (PH) domain of Lbc is located at the C-terminal end of th

224 The pleckstrin homology (PH) domain of P-REX2 inhibits PTEN by interacting with t

225 the exogenous isolated pleckstrin-homology (PH) domain of p63RhoGEF (residues 331-580) into permeabi

226 ,4-bisphosphate, to the pleckstrin homology (PH) domain of PDK1 is known to be essential for its inte

227 RhoA also binds to the pleckstrin homology (PH) domain of PDZRhoGEF.

228 ng proteins such as the pleckstrin homology (PH) domain of phospholipase Cdelta1.

229 The N-terminal pleckstrin homology (PH) domain of PLCbeta2 mediates both the response to Gbe

230 The pleckstrin homology (PH) domain of the general receptor of phosphoinositides

231 osphate (PIP(3)) to the Pleckstrin Homology (PH) domain of the Tec family protein tyrosine kinase, In

232 e Dbl-homology (DH) and Pleckstrin-homology (PH) domains of Bcr-Abl p210, which constitute the only s

233 tive recruitment of the pleckstrin homology (PH) domains of FAPP proteins to the trans-Golgi network.

234 we have found that the pleckstrin homology (PH) domains of PLCbeta2 and PLCbeta3 are the regions tha

235 e Dbl homology (DH) and Pleckstrin homology (PH) domains of SOS (the DH-PH unit) block allosteric Ras

236 h the Dbl homology (DH)/pleckstrin homology (PH) domains of SOS, bringing GDP-Ras to the proximity of

237 aging of InsP7 leads to translocation of the PH-domain of Akt, an important signalling-node kinase in

238 By purifying the JmjC and the PHD domain of Fbxl10 and using different approaches we w

239 ranslational and rotational diffusion of the PH domain on the lipid membrane surface exhibit transien

240 lization and anomalous dynamics of the DAPP1 PH domain on the surface of a PIP-containing lipid bilay

241 ce energy transfer approaches to distinguish PH-domain orientation from proximity at the membrane sur

242 and a variant without a pleckstrin homology (PH) domain (ORP4S) bind 25-hydroxycholesterol and extrac

243 d the reappearance of the PI(4,5)P2-specific PH domain PH-phospholipase C delta-EGFP at the PM after

244 or protein containing a pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain, and le

245 or protein containing a pleckstrin-homology (PH) domain, phosphotyrosine-binding (PTB) domain, and le

246 simultaneous engagement of the membrane by a PH domain PIP(2)-binding interaction and electrostatic i

247 domain (MTD) families, such as C1-, C2- and PH domains, play a key role in signal transduction and m

248 In vivo, ARAP3 PH domain point mutant bone marrow chimeras exhibit redu

249 ARAP3 PH domain point mutant neutrophils are characterized by

250 utrophils from an ARAP3 pleckstrin homology (PH) domain point mutation knock-in mouse (R302, 303A), i

251 A PH-domain probe revealed that the regulatory lipid phosp

252 (Arfgap with Coil coil, Ankyrin repeat, and PH domain protein 1) contains a BAR domain.

253 This work identifies a PH domain protein as a regulator of plant metal transpor

254 ArfGAP with coiled-coil, ankyrin repeat, and PH domains protein 1) is an ARF6 GAP that also acts as a

255 s a bistable feedback loop between Melted, a PH-domain protein, and Warts, a kinase in the Hippo grow

256 of rbf and rhinoceros (rno), which encodes a PHD domain protein, leads to a synergistic delay in phot

257 Analysis of wild type and mutant PH domain proteins in addition to recombinant versions o

258 porter localization, providing evidence that PH domain proteins may be effectors of PI3P for protein

259 ery, but involving PI3-kinase and downstream PH domain proteins, CRAC and PhdA.

260 possessing independent GEF activity and the PH domain providing a broad seat for RhoA-GTP docking ra

261 ptor Protein containing pleckstrin homology [PH] domain, PTB domain and Leucine zipper motif 1) APPL1

262 demonstrate that deletion or mutation of the PHD domain reduces the catalytic efficiency (kcat/Km of

263 e-bound dynamin spirals, indicating that the PH domain regulates membrane fission through the control

264 Respectively, N- and C-terminal to the PH domain Sec3N presents an additional alpha-helix and t

265 H domain and selected mutants shows that the PH domain specifically binds phosphatidylserine using a

266 layers identify the determinants of PLCbeta2-PH domain specificity for Gbetagamma and lipid membranes

267 Structural comparison with other PH domains suggests that the phosphate binding pocket in

268 This PH domain surface is not solvent-exposed in crystal stru

269 CERT's N-terminal pleckstrin homology (PH) domain targets it to the Golgi by binding to phospha

270 to the multivalent membrane anchoring by the PH domain that may augment affinity and selectivity of F

271 and contains a putative pleckstrin-homology (PH) domain that has been shown to play a role in phospho

272 in contains an inserted pleckstrin homology (PH) domain that recognizes membrane phosphoinositides, i

273 Unlike previously characterized CD and PHD domains that bind to their targets with micromolar a

274 ding site and unique peripheral sites of the PH domain, the Arf GTPase and, unexpectedly, the Sec7 do

275 Together with the tethering PH domain, three membrane-associating elements synergist

276 dle is coupled to the structurally dependent PH domain through a helical linker, which reduces its ac

277 etween non-PIP anionic lipids attracting the PH domain to the bilayer surface in a favourable orienta

278 We have quantified the binding of the PH domain to the model bilayers by calculating a density

279 through binding of its pleckstrin homology (PH) domain to phosphatidylinositol 4-phosphate (PtdIns(4

280 estabilization is reversed by binding of the PHD domain to a histone H3 peptide trimethylated on lysi

281 hieved by the binding of the PCL1 N-terminal PHD domain to the C-terminal domain of p53 through two u

282 orientational electrostatic steering of the PH domain towards the PI(3,4,5)P(3)-containing anionic b

283 ng of all ORP4 variants (including a partial PH domain truncation termed ORP4M) in HEK293 and HeLa ce

284 molecular dynamics studies showed that GAB1 PH domain underwent large conformational changes upon li

285 Membrane penetration by the FAPP1-PH domain was mediated by an exposed, conserved hydropho

286 olecule at the canonical binding site of the PH domain, we observe additional PIP molecules in contac

287 P(2) with a green fluorescent protein-tagged PH domain, we show that PLCzeta effects minimal loss of

288 or 594-labeled PLC-beta pleckstrin homology (PH) domain, we demonstrate that the PH domain is the min

289 oinositide (PI) binding pleckstrin homology (PH) domain, we focused on genetic interactions between a

290 nt distributions of cationic residues on the PH domain, were observed, involving PIP interactions at

291 PPIs with the expression of nuclear-targeted PH domains, which inhibits recruitment of Ataxia telangi

292 Association of the Dok7 PH domain with PIP lipids is therefore seen as a key ste

293 and long-term correlated interaction of the PH domain with the membrane may contribute to an enhance

294 dscapes for the interactions of 12 different PH domains with membranes containing PIP2 or PIP3, allow

295 the complexities of the interactions of the PH domains with PIP molecules in membranes.

296 ular interaction of the pleckstrin homology (PH) domain with the von Willebrand type A (VWA) domain b

297 mology (PH) domain within Rgc2 and a partial PH domain within Fps1.

298 ain is interrupted by a pleckstrin homology (PH) domain within its F2 subdomain.

299 n involves a tripartite pleckstrin homology (PH) domain within Rgc2 and a partial PH domain within Fp

300 tural and dynamical insights into how DH and PH domains work together in solution to support regulate