1 olipid hydroperoxide glutathione peroxidase (
PhGPx).
2 sperm, including glutathione peroxidase GPx4/
PHGPx.
3 etion of two conserved SECIS elements in the
PhGPx 3' UTR (AUGA in the 5' stem or AAAAC in the termin
4 not to the UAA mutant, upon insertion of the
PhGPx 3' UTR.
5 nds specifically to the sense strands of the
PhGPx and GPx 3' UTRs.
6 lowed translational readthrough, whereas the
PhGPx and GPx antisense 3' UTRs did not.
7 is likely attributable to the expression of
PHGPx cDNA rather than the PHGPx gene.
8 tructure model generated for the H. vulgaris
PHGPx displayed the thioredoxin fold.
9 olipid hydroperoxide glutathione peroxidase (
PHGPX;
E.C. 1.1.1.1.9).
10 The N-terminal section of this
PHGPX encodes a recognisable chloroplast transit peptide
11 lipid hydroperoxide glutathione peroxidases (
PHGPx)
from several organisms.
12 We conclude that 1) the sequence of the
PHGPx gene is adequate to support the NMD of product mRN
13 These results indicated that the
PHGPx gene is affected by the cellular stress response a
14 H35 hepatocytes transiently transfected with
PHGPx gene variants under selenium-supplemented or selen
15 the expression of PHGPx cDNA rather than the
PHGPx gene.
16 The pea
PHGPX has highly conserved homologues in Arabidopsis, ci
17 Se-replete L1210 or K562 cells, implicating
PHGPX in these reactions.
18 Apparent first-order rate constants for GSH/
PHGPX-
induced peroxide loss (or diol accumulation) in Tr
19 isolated pea chloroplasts confirmed that the
PHGPX is a chloroplast-located enzyme.
20 olipid hydroperoxide glutathione peroxidase (
PHGPX)
is a selenoenzyme that can catalyze the direct re
21 ure of previous reports to detect the NMD of
PHGPx mRNA in cultured cells is likely attributable to t
22 Hence the expression of
PHGPx mRNA in hydra may have potential use as molecular
23 mented or selenium-deficient conditions that
PHGPx mRNA is, in fact, a substrate for NMD when the sel
24 We also demonstrate that the endogenous
PHGPx mRNA of untransfected H35 cells is subject to NMD.
25 idative stress responded by regulating their
PHGPx mRNA transcription.
26 patocytes that precludes or masks the NMD of
PHGPx mRNA.
27 olipid hydroperoxide glutathione peroxidase (
PHGPx)
mRNA, another selenocysteine-encoding mRNA, fails
28 This non-selenocysteine
PHGPx named NPGPx is a cytoplasmic protein with molecula
29 The activity of purified testicular
PHGPX on several photochemically-generated cholesterol h
30 olipid hydroperoxide glutathione peroxidase (
PHGPX or GPX4), respectively.
31 , like human phospholipid hydroperoxide GPX (
PHGPX),
possibly encodes mitochondrial and cytosolic iso
32 Efficient import in vitro of the pre-
PHGPX protein into the stroma of isolated pea chloroplas
33 relatively inefficient metabolism by the GSH/
PHGPX system might be the reason.
34 olipid hydroperoxide glutathione peroxidase (
PHGPx),
which incorporates cysteine instead of selenocys