ライフサイエンスコーパス: PI

1 PI patients showed higher BOLD activation to SS in the p

2 PI showed hyper-responses to SS in the precentral cortex

3 PI(3,4,5)P3 can be dephosphorylated by 3- or 5-phosphata

4 PI(3,5)P2 is generated from PI3P by the conserved lipid

5 PI(4,5)P2 activation of exocytosis did not depend on the

6 PI-CF subjects had lower acute insulin, C-peptide, and g

7 0:1/18:3), DG(24:1/22:6/0:0), PS(18:2/18:0), PI(16:0/16:0), PS(18:0/18:1), PS(14:1/14:0), dihydroxyac

8 cultures of ileal and colonic mucosa from 10 PI-IBS, diarrhea predominant subtype (D) patients, and 1

9 as it interacts with membranes containing 2% PI(3)P and 98% phosphatidylcholine.

10 The incidence rate resulted in 30.91 PI-CC per 1000 person-years (95% CI 25.14, 38).

11 %), 0.60% (95% PI: 0.08%, 1.11%), 0.24% (95% PI: 0.02%, 0.46%), and 0.29% (95% PI: 0.07%, 0.50%) high

12 ior interval (PI): 0.13%, 0.35%], 0.27% (95% PI: 0.10%, 0.44%), 0.60% (95% PI: 0.08%, 1.11%), 0.24% (

13 0.24% (95% PI: 0.02%, 0.46%), and 0.29% (95% PI: 0.07%, 0.50%) higher daily mortality from all nonacc

14 r respiratory hospitalizations, a 2.57% (95% PI: 0.87%, 4.30%) increase per 10-mug/m(3) increase in P

15 %], 0.27% (95% PI: 0.10%, 0.44%), 0.60% (95% PI: 0.08%, 1.11%), 0.24% (95% PI: 0.02%, 0.46%), and 0.2

16 interval (PI): -0.71%, 1.41%] and 0.98% (95% PI: 0.73%, 1.23%) increases in hospitalization risk per

17 ons showed FA decreases greater than the 99% PI for zero change.

18 Here we show that PTEN also functions as a PI(3,4)P2 3-phosphatase, both in vitro and in vivo.

19 ressor is thought to function primarily as a PI(3,4,5)P3 3-phosphatase, limiting activation of this p

20 ne CC report and the probability of having a PI-CC.

21 KDU731, a PI (4) kinase inhibitor, blocks Cryptosporidium infectio

22 However, binding of a PI(3,4,5)P3-embedded membrane nanodisc to Akt(PHD) with

23 g and/or gp41 in 61 individuals with VF on a PI/r (n = 40) or NNRTI (n = 20) containing regimen.

24 ents treated in our health system received a PI-CC during the first ten consecutive years after a nor

25 even in a climate held to 2 degrees C above PI, Karachi (Pakistan) and Kolkata (India) could expect

26 In addition, PIs induced beta-amyloid production, indicative of incre

27 ina seed lecithin is a promising alternative PI-rich emulsifier for various food applications.

28 quires both the rhg1-a and Rhg4 alleles, and PI 88788-type soybean, whose resistance requires only th

29 cterium prausnitzii were depleted in EFV and PI compared to HIV SN and negatively correlated with int

30 to endosomal membranes mediated by GIPC and PI(4,5)P2 are crucial for filopodia formation.

31 C), a recently described class of NAADP- and PI(3,5)P2-sensitive Ca(2+)-permeable cation channels in

32 ollowed by 2 expansion cohorts (PI-naive and PI-exposed patients) at the maximum tolerated dose (MTD)

33 Our data show that (i) PI(3)P and PI(4)P are dispensable for the disassembly and activatio

34 sm by which the coincidence of PI(4,5)P2 and PI(3)P in a curved vesicle triggers actin polymerization

35 's phosphoinositide substrates PI(4,5)P2 and PI(3,4,5)P3 accumulated at the transition zone (TZ) in H

36 ethod permitting separation of PI(3,4)P2 and PI(4,5)P2, a technical issue hindering the phosphoinosit

37 in addition to the blastodisc, while PE and PI species are mostly absent in the yolk.

38 ecific interaction between PLC delta1-PH and PI(4,5)P2, encoded within the conformational properties

39 nding has been observed between Akt(PHD) and PI(3,4,5)P3-free nanodiscs, demonstrating that PI(3,4,5)

40 YO6 to regulate the localization of PIP3 and PI(3)P phosphoinositides and Akt activation.

41 In contrast, the Rec2 and PI domains tolerate mutation better than other regions.

42 erging evidence suggests that both IMiDs and PIs can have cardiovascular (CV) sequelae, which include

43 TIs (L100I, Y181C, K103N, V108I, Y188L), and PIs (V82L).

44 Apoptosis was confirmed (annexin-PI, SubG1/cell-cycle, apoptotic genes, caspase-3 and pol

45 as obesity, edema, and tenderness., Arterial PI can be used as a complimentary technique for the dete

46 Lesions classified as PI-RADS category 3 at DW MR imaging and as positive at D

47 an PIs were 7.5 in both groups; mean average PIs assessed at 10, 20, and 30 min postadministration we

48 phatidylinositol (PI) by targeting bacterial PI-specific phospholipase C to the PIS domain impairs re

49 areas under the curve were compared between PI-RADS versions 1 and 2.

50 The relationship between PI values of the popliteal artery and the number of thro

51 ed software SignalP v4.1, TargetP v1.01, Big-PI predictor, TMHMM v2.0 and ProtComp v9.0 were utilized

52 BIO PIs considered a range of computational needs important

53 However, BIO PIs said the most pressing unmet needs are training in d

54 ces Directorate principal investigators (BIO PIs), nearly 90% indicated they are currently or will so

55 ) and phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), suggesting that the macropinosome is the loc

56 ates phosphatidylinositide 4,5 bisphosphate (PI(4,5)P2).

57 PPI phosphatidylinositol (3,5)-bisphosphate (PI(3,5)P2) is essential in multiple organ systems.

58 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a negatively charged phospholipid that pla

59 with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), the main lipid marker of the plasma membrane

60 main in a phosphoinositide 4,5-bisphosphate (PI(4,5)P2)-dependent manner, ciliary delivery by intrafl

61 te PM phosphatidylinositol 4,5-bisphosphate (PI[4,5]P2) levels, important for localization of STIM1 a

62 ctors phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and ubiquitin for its activation in vitro We

63 s the phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] precursor phosphatidylinositol between bilaye

64 ially phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], regulate the activities of many actin-bindin

65 ds to phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2].

66 gical failure (VF) while receiving a boosted PI (PI/r)-containing regimen.

67 TIRAP PBM bound PIs through basic and nonpolar residues with high affini

68 Shu1 cleavability by PI-PLC and its predicted hydropathy profile strongly sug

69 translocation is thermodynamically driven by PI(4,5)P2-induced membrane insertion of FGF2 oligomers.

70 Ionization energy exhibited by PI, equivalent to 10.8 eV, resulted in significant reten

71 e when compared with DW imaging in the TZ by PI-RADS version 2 criteria.

72 f phosphoinositide-specific phospholipase C (PI-PLC) is one of the earliest responses triggered by th

73 h phosphoinositide-specific phospholipase C (PI-PLC).

74 pathies, neurological disorders, and cancer, PI-converting enzymes represent potential targets for dr

75 ility of having a potentially inadequate CC (PI-CC, e.g. a CC that was performed earlier that recomme

76 n phase was followed by 2 expansion cohorts (PI-naive and PI-exposed patients) at the maximum tolerat

77 In a buffer solution, E. coli PI-7 displayed a longer lag phase prior to decay and a l

78 Subpopulations of E. coli PI-7 expressed genes related to dormancy and persister c

79 Virulence functions unique to E. coli PI-7 were also upregulated.

80 The first is E. coli PI-7, a virulent and antibiotic-resistant strain that wa

81 ctive mechanisms were upregulated in E. coli PI-7.

82 lence and antibiotic resistance than E. coli PI-7.

83 ers cell growth and proteostasis and confers PI sensitivity.

84 the mechanisms that spatiotemporally control PI conversion in endocytosis and endolysosomal membrane

85 NF1), NF-kappaB signaling (PRKCB, CSNK1A1), PI-3-kinase signaling (PIK3R1, VAV1), RHOA/cytoskeleton

86 Strikingly, lipid recognition by the default PI(4,5)P2 lipid sensor, phospholipase C delta 1 pleckstr

87 As defective PI conversion underlies human genetic diseases, includin

88 a unique cohort of individuals who developed PI-IBS following exposure to contaminated drinking water

89 The DH44 PI-Hugin SEZ circuit controls circadian locomotor activi

90 If gag and/or gp41 encode PI-resistance mutations, they may not be confined to con

91 Conclusion Existing PI-RADS V2 decision rules exhibited reasonable performan

92 The impact of existing PI-RADS V2 decision rules, as well as a series of explor

93 male, pointing to a potential role of female PIs in influencing the gender balance.

94 ith pancreatic-insufficient cystic fibrosis (PI-CF) are at increased risk for developing diabetes.

95 Finally, PI(4,5)P2 uncaging triggered the rapid fusion of a subse

96 hemolysis, cell viability, and AnnexinV-FITC/PI staining assays.

97 ncer detection of 15.7%, 16.0%, and 9.2% for PI-RADS category 2, 3, and 4 lesions, respectively.

98 s were detected in areas under the curve for PI-RADS version 2 versus 1.

99 The probability of cancer detection for PI-RADS category 2, 3, 4, and 5 lesions was 15.7%, 33.1%

100 These results point to a role for PI(3,4)P2 in the phenotype caused by loss-of-function mu

101 muli (NS) were compared between 14 drug-free PI patients and 18 good sleepers (GS) using functional m

102 Viruses released from PI cells induced higher cell-to-cell fusion than the par

103 ion IMiD pomalidomide, the second-generation PIs carfilzomib and ixazomib, the DACI panobinostat, and

104 Our data show that (i) PI(3)P and PI(4)P are dispensable for the disassembly an

105 ctor attachment protein receptors, that (ii) PI(3)P is required only after the tethering step, and th

106 nly after the tethering step, and that (iii) PI(4)P is required during and after tethering.

107 eighted, and diffusion-weighted (DW) imaging PI-RADS scores was calculated in the peripheral zone (PZ

108 Peri-implant PI, BOP, and PD >/=4 mm were recorded, and mesial and di

109 ne third of the minimum clinically important PI difference of two points.

110 rtments contain other functionally important PIs.

111 s no statistically significant difference in PI, BOP, PD >/=4 mm, and total CBL among smokers with IL

112 s during glucose potentiation were higher in PI-CF, suggesting impaired proinsulin processing.

113 d by light, allowing sub-second increases in PI(4,5)P2 levels.

114 higher while IL-10 mRNA levels were lower in PI-IBS D than in HC in both ileum and colon.

115 dulating the inflammatory/immune-response in PI-IBS in an ex-vivo organ culture model.

116 ficantly reduced expression of the SbCAD2 in PI 595743 throughout its growth stages.

117 pathways that regulate NKG2D ligands include PI-3 kinase activation, histone acetylation, and the int

118 PTEN deletion increased PI(3,4)P2 levels in a mouse model of prostate cancer, an

119 Outcome measures were plaque index (PI), gingival index (GI), bleeding on probing (BOP), PD,

120 They included plaque index (PI), modified sulcus bleeding index (mSBI), probing dept

121 sulcus bleeding index (mSBI), plaque index (PI), probing depth (PD), and clinical attachment level (

122 mplant soft tissue parameters (plaque index [PI], bleeding on probing [BOP], and probing depth [PD] >

123 ical data (probing depth [PD], plaque index [PI], gingival index [GI], bleeding on probing [BOP], and

124 lesions in vitro at 27 days post-infection (PI), providing new evidence of the role of the parasite

125 main family 4 (RASSF4) positively influences PI(4,5)P2 synthesis through ARF6-dependent regulation of

126 OCRL) deficiencies are reduced by inhibiting PI(3)P production, suggesting PI(3)P kinase inhibitors a

127 fumarate (TDF) without a protease inhibitor (PI) (0.18 [interquartile range {IQR}, 0.08-0.30]; n = 37

128 models to show that HIV protease inhibitor (PI) class ARVs induced neuronal damage and ER stress, le

129 GRL-09510, a novel HIV-1 protease inhibitor (PI) containing a newly-generated P2-crown-tetrahydrofura

130 rferon (IFN; 2003-2010), protease inhibitor (PI; 2011-2013), and direct-acting antiviral (DAA; 2014-2

131 y efficacy of the oral proteasome inhibitor (PI) ixazomib in patients with relapsed/refractory immuno

132 V) or ritonavir-boosted Protease Inhibitors (PI) with the same backbone of Nucleoside Reverse Transcr

133 cleoside RTIs (NNRTIs), protease inhibitors (PIs), and integrase inhibitors (IIs) did not affect HK2,

134 ory drugs (IMiDs) and proteasome inhibitors (PIs) has greatly improved the overall survival of patien

135 atory agents (IMiDs), proteasome inhibitors (PIs), histone deacetylase inhibitors (DACIs), and monocl

136 Psychophysiological insomnia (PI) includes arousal to sleep-related stimuli (SS), whic

137 Average pain intensity (PI) assessed on a 0 to 10 numerical rating scale at 10,

138 ressing neurons in the pars intercerebralis (PI) through hugin+ SEZ neurons to the ventral nerve cord

139 ban counties: 0.35% [95% posterior interval (PI): -0.71%, 1.41%] and 0.98% (95% PI: 0.73%, 1.23%) inc

140 sociated with 0.24% [95% posterior interval (PI): 0.13%, 0.35%], 0.27% (95% PI: 0.10%, 0.44%), 0.60%

141 We used the 99% prediction interval (PI) for zero change from historical control reproducibil

142 /TUB N terminus, and subsequent release into PI(4,5)P2-deficient ciliary membrane.

143 e faculty member and principal investigator (PI) as both unattainable and undesirable.

144 ic-science faculty [principal investigators (PIs)] younger than 46.

145 deoxyuridine (BrdU) assay, propidium iodide (PI) staining and growth curves, and blocks cell migratio

146 h phorbol 12-myristate 13-acetate/ionomycin (PI) or lipopolysaccharide (LPS), and stained for Tregs (

147 uggest that the Cryptosporidium lipid kinase PI(4)K (phosphatidylinositol-4-OH kinase) is a target fo

148 ytosol, and loss of PTEN and INPP4B, a known PI(3,4)P2 4-phosphatase, leads to synergistic accumulati

149 gnin reduction in the sorghum germplasm line PI 595743.

150 rk demonstrated that the endolysosomal lipid PI(3,5)P2 activates V-ATPases containing the vacuolar a-

151 red with the control group (P <0.001): lower PI and GI, less BOP, less increase in GCF volume, and lo

152 PTEN is a major PI(3,4)P2 phosphatase in Mcf10a cytosol, and loss of PTE

153 Classical ways of manipulating PI(4,5)P2 levels are slower than its metabolism, making

154 Significant reduction in mean PI, GI, PD, and BOP were found after treatment in all gr

155 s with 1 and/or 2 thrombosed veins, the mean PI was 6.03+/-0.54 on the side of cDVT and 5.68+/-0.39 o

156 Baseline mean PIs were 7.5 in both groups; mean average PIs assessed a

157 Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P3.

158 ty of cancer detection than did DCE-negative PI-RADS category 3 lesions (67.8% vs 40.0%, P = .02).

159 F moiety sheds lights in the design of novel PIs.

160 Lesions were GS >/=7 in 0%-4.1% of PI-RADS categories 1 and 2, 11.4%-27.1% of PI-RADS categ

161 f PI-RADS categories 1 and 2, 11.4%-27.1% of PI-RADS category 3, 44.4%-49.3% of PI-RADS category 4, a

162 -27.1% of PI-RADS category 3, 44.4%-49.3% of PI-RADS category 4, and 72.1%-73.7% of PI-RADS category

163 3% of PI-RADS category 4, and 72.1%-73.7% of PI-RADS category 5 lesions.

164 hatase, leads to synergistic accumulation of PI(3,4)P2, which correlated with increased invadopodia i

165 man aortic VSMC apoptosis (via activation of PI-3 kinase/Akt signalling) and proliferation.

166 that neuronal signaling within the bowel of PI-IBS patients is sensitized 2 years after the initial

167 date a mechanism by which the coincidence of PI(4,5)P2 and PI(3)P in a curved vesicle triggers actin

168 icle endocytosis to the dephosphorylation of PI(4,5)P2, a reaction needed for the shedding of endocyt

169 s in living cells, we show that depletion of PI(4,5)P2 completely prevents Gag PM targeting and assem

170 er, ezrin can limit the lateral diffusion of PI(4,5)P2 along the lipid bilayer.

171 approaches to optimize the effectiveness of PI-based ART in high-tuberculosis-burden settings are ne

172 aking it difficult to distinguish effects of PI(4,5)P2 from those of its metabolites.

173 (3)P is produced by the INPP4A hydrolysis of PI(3,4)P2, and this is necessary for actin-driven endocy

174 nanodisc, indicating proper incorporation of PI(3,4,5)P3 on the nanodisc surface.

175 inase domain that lead to elevated levels of PI(3,5)P2 and impair the interaction between the kinase

176 First, capabilities and limitations of PI were tested using an authentic mixture of compounds o

177 that allows rapidly tunable manipulation of PI(4,5)P2 levels in living cells, we show that depletion

178 Electrokinetic potential measurements of PI(4,5)P2 containing liposomes reveal that Ca(2+) as wel

179 esponse in an ex-vivo organ culture model of PI-IBS D.

180 fecting lipid chain or headgroup moieties of PI(3,4,5)P3.

181 Multiple copy number of PI 88788-type GmSNAP18, GmAAT, and GmWI12 in one genomic

182 Second, considering the potential of PI for hydrocarbons, base oils, complex mixtures of satu

183 moves on actin filaments in the presence of PI(3,4,5)P3, an activator of myosin-X.

184 Defects in the dynamic regulation of PI(3,5)P2 are linked to human diseases.

185 between bilayers, allowing replenishment of PI(4,5)P2 hydrolyzed during signaling.

186 These results reveal an important role of PI(4,5)P2 for HIV-1 morphogenesis beyond Gag recruitment

187 leasable vesicles, revealing a rapid role of PI(4,5)P2 in fusion triggering.

188 Mean scores of PI (P <0.05) and PD >/=4 mm (P <0.05) were statistically

189 ovel HPLC-MS method permitting separation of PI(3,4)P2 and PI(4,5)P2, a technical issue hindering the

190 traced viral evolution under the pressure of PIs using Gag-protease single genome sequencing and coev

191 e that directly linking the benzene rings of PIs with a single C-C bond is a viable method for genera

192 Here, we review the roles of PIs in different compartments of the endolysosomal syste

193 These findings implicate a subset of PIs as potential mediators of neurodegeneration in HIV-a

194 eatment failure if there is increased use of PIs-based therapy.

195 unger PIs (below 46) and increased for older PIs (above 55).

196 ades-long trend of more money going to older PIs.

197 CBT-I may exert its treatment effects on PI by reducing hyper-responses to SS in the precentral c

198 from age 4.5 to 6 years (P(U,LPS) < 0.001; P(PI) = 0.051; P(FOXP3) < 0.001).

199 In addition, PD, PI, BOP, MR, and SUP varied significantly according to P

200 ids (PIPs) phosphatidylinositol 3-phosphate (PI(3)P) and phosphatidylinositol 4-phosphate (PI(4)P) as

201 containing phosphatidylinositol-3-phosphate (PI[3]P).

202 I(3)P) and phosphatidylinositol 4-phosphate (PI(4)P) as regulators of PLF.

203 e equilibrium between phosphatidylinositide (PI) species within the cell and increases basal autophag

204 embranes containing the phosphatidylinositol PI(4)P, thus possibly explaining the primary residency o

205 thanolamines (PE), and phosphatidylinositol (PI), in newly fertilized individual zebrafish embryos.

206 the predominant Golgi phosphatidylinositol (PI) species, directly interacts with the cytosolic amino

207 C and EDLC was rich in phosphatidylinositol (PI), and contents were 37.8 and 25.2wt%, respectively.

208 Depletion of phosphatidylinositol (PI) by targeting bacterial PI-specific phospholipase C t

209 phatidylglycerol (PG), phosphatidylinositol (PI), and sulfatides (ST).

210 ol in spines depends on the phosphoinositide PI(3,4,5)P3 and involves the actin monomer-binding prote

211 al program dependent on the phosphoinositide PI(3,4,5)P3 is sufficient to trigger all steps of myelin

212 f TIRAP is mediated by its phosphoinositide (PI)-binding motif (PBM).

213 By phosphorylating the phosphoinositide- (PI) binding domain of Daple, Akt abolishes Daple's abili

214 Phosphoinositides (PIs) are phospholipids that perform crucial cell functio

215 unction involved binding to the phospholipid PI(3)P and promoting actin nucleation at nascent autopha

216 eloped a membrane-permeant, photoactivatable PI(4,5)P2, which is loaded into cells in an inactive for

217 In this study, photoionization (PI) was evaluated as the ion source for GCxGC-TOF-MS mea

218 l failure (VF) while receiving a boosted PI (PI/r)-containing regimen.

219 At clathrin-coated pits, PI(3)P is produced by the INPP4A hydrolysis of PI(3,4)P2

220 ions through ARF6-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological

221 Subsequent restoration of PM PI(4,5)P2 reinduced assembly site formation even in the

222 ucted on nanoholes array textured polyimide (PI) substrates.

223 ng to below 2 degrees C above preindustrial (PI) to prevent dangerous climate change.

224 y 3- or 5-phosphatases, the latter producing PI(3,4)P2.

225 hods Two radiologists independently provided PI-RADS V2 scores for the dominant lesion on 343 prostat

226 ion of a series of X-shaped pyromellitimide (PI) oligomers (Xn-R, n = 2-4, R = Hex or Ph) linked toge

227 tations definitively responsible for reduced PI susceptibility have been identified in individuals wi

228 the helical structure of TIRAP PBM, reducing PI interactions and cell membrane targeting.

229 However, few mechanisms that regulate PI(3,5)P2 have been identified.

230 which we term protein interaction by SAMDI (PI-SAMDI), has the advantages that it is applicable to l

231 dy drop in the number of young basic-science PIs and could reduce future US discoveries in fundamenta

232 PI success ratio (fraction of basic-science PIs who are R01 grantees) dropped for younger PIs (below

233 ntify gag and gp41 mutations under selective PI pressure, we sequenced gag and/or gp41 in 61 individu

234 search Award (MIRA) program to reward senior PIs with research time in exchange for less funding, thi

235 ed electron is largely localized on a single PI unit.

236 INPP5E's phosphoinositide substrates PI(4,5)P2 and PI(3,4,5)P3 accumulated at the transition

237 by inhibiting PI(3)P production, suggesting PI(3)P kinase inhibitors as a therapeutic strategy in Lo

238 in post-infectious irritable bowel syndrome (PI-IBS) is convincing.

239 prostate imaging reporting and data system (PI-RADS) (version 2).

240 Prostate Imaging Reporting and Data System (PI-RADS) version 2 (V2) decision rules, as well as of pr

241 Prostate Imaging Reporting and Data System (PI-RADS) version 2 score to better understand false-nega

242 Prostate Imaging Reporting and Data System (PI-RADS) version 2; only thereafter, the remaining full

243 {IQR}, 0.08-0.30]; n = 372), LDV/SOF and TDF/PI (0.17 [IQR, 0.04-0.30]; n = 100), and LDV/SOF without

244 The Arabidopsis (Arabidopsis thaliana) PI-PLC gene family is composed of nine members.

245 PHD) with a 10(3)-fold tighter affinity than PI(3,4,5)P3 is able to completely displace CaM.

246 ming a different role in SCN resistance than PI 88788-type GmSNAP18.

247 aromyces cerevisiae Here we demonstrate that PI(4)P, the predominant Golgi phosphatidylinositol (PI)

248 its activation in vitro We demonstrated that PI(4,5)P2 also induces the oligomerization of ExoU and t

249 (3,4,5)P3-free nanodiscs, demonstrating that PI(3,4,5)P3 is required for membrane binding, CaM displa

250 Moreover, our data indicate that PI(4)P is needed to anchor Arl8 (Arf-like GTPase 8) and

251 Our results indicate that PI(4,5)P2 induces the oligomerization of ExoU, which may

252 We show that PI(3,4,5)P3 binding to Akt(PHD) displaces the C-terminal

253 mouse adrenal chromaffin cells, we show that PI(4,5)P2 uncaging potentiates exocytosis and identify s

254 ,5)P2-binding CAPS-proteins, suggesting that PI(4,5)P2 uncaging may bypass CAPS-function.

255 aining the primary residency of Naa60 at the PI(4)P-rich Golgi.

256 V and NASH populations increased in both the PI and DAA eras (P < 0.001 for all) whereas HCC WL in HB

257 developed in gag and in gp41-CD in both the PI- and NNRTI-treated groups.

258 stance is mechanistically different from the PI 88788-type of resistance that only requires rhg1 We a

259 Listing for DC in HBV also decreased in the PI (-17%; P = 0.002) and DAA eras (-24%; P < 0.001).

260 y, WL for DC in NASH increased by 41% in the PI era (P < 0.001) and 81% in the DAA era (P < 0.001).

261 or DC in HCV patients decreased by 5% in the PI era (P = 0.004) and 32% in the DAA era (P < 0.001) co

262 rs Xn-Hex, reveal that the reductions of the PI units occur at multiple distinct potentials, highligh

263 The second version of the PI-RADS guidelines enabled standardized imaging, evaluat

264 tivation of exocytosis did not depend on the PI(4,5)P2-binding CAPS-proteins, suggesting that PI(4,5)

265 During this time, the PI success ratio (fraction of basic-science PIs who are

266 tion of hydrophobic residues adjacent to the PI(3)P binding site, in addition to electrostatic intera

267 Nonetheless, since 2015 - when the PI-RADS v.2 was published, numerous questions regarding

268 ly orthogonal conformations adopted by their PI units.

269 es the oligomerization of ExoU and that this PI(4,5)P2-mediated oligomerization does not require ubiq

270 ancer diagnosis when stratified according to PI-RADS versions 1 and 2.

271 ng the development of resistance of HIV-1 to PIs.

272 CRF02_AG population with little exposure to PIs ( 3%), mutations in the Gag P2/NC CS could increase

273 ecedented intrinsic sensitivity of AL PCs to PIs, even higher than that of MM PCs, associated with di

274 with the development of HIV-1 resistance to PIs, we traced viral evolution under the pressure of PIs

275 or phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) and phosphatidylinositol 3,4-bisphosphate (

276 of phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) and play important roles in regulating the

277 nd phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3).

278 Unexpectedly, PI(4,5)P2 depletion also caused loss of pre-assembled Ga

279 ase assay, Hoechst 33342 staining, annexin V/PI staining, and JC-1 staining.

280 (HOPS) to (phago)lysosome membranes, whereas PI(3)P is required for membrane association of HOPS only

281 To test whether PI sensitivity stems from AL LC production, we engineere

282 ucose tolerance, adolescents and adults with PI-CF have impairments in functional islet mass and asso

283 ate cancer, and it inversely correlated with PI(3,4)P2 levels across several EGF-stimulated prostate

284 Lesions were detected with PI-RADS version 2 and were compared with whole-mount pro

285 tion that prevents C2E from interacting with PI(4,5)P2-rich membranes, as previously suggested by stu

286 of Stv1NT is essential for interaction with PI(4)P in vitro and in vivo, and interaction with PI(4)P

287 P in vitro and in vivo, and interaction with PI(4)P is required for efficient localization of Stv1-co

288 addition to electrostatic interactions with PI(3)P.

289 ial and mutually exclusive interactions with PI(4,5)P2 and heparan sulfates on opposing sides of the

290 TPase a2 isoform specifically interacts with PI(4)P in vitro, consistent with its Golgi localization

291 Men with PI-RADS categories 1-2 remained in urologic follow-up fo

292 Men with PI-RADS categories 3-5 underwent MR-guided targeted biop

293 onal signaling in the bowel of patients with PI-IBS.

294 enerated from tissue biopsy of patients with PI-IBS.

295 -subunit isoforms interact specifically with PI lipids in their organelles of residence.

296 MR targets with PI-RADS version 2 category 2, 3, 4, and 5 scores had a p

297 protein sequences in 4 patients treated with PIs over a 9-year period.

298 The donor substrate, which is modified with "PI islands" to become selectively adhesive for the S4s,

299 tage investigator (ESI) policy to fund young PIs at higher rates.

300 Is who are R01 grantees) dropped for younger PIs (below 46) and increased for older PIs (above 55).