ライフサイエンスコーパス: PKA

1 PKA activation also promotes survival of murine neutroph

2 PKA activation potentiated MF glutamatergic responses of

3 PKA phosphorylates TCF4 directly and a PKA phosphorylati

4 PKA stimulates cellular gene expression by phosphorylati

5 PKA was performed using a 2-tissue, 3-compartment irreve

6 IL-22 and IL-17, Bax and Bcl-2, PKA/PKG and the brain derived neurotropic factor (BDNF)

7 uantitative phosphoproteomics identified 229 PKA phosphorylation sites.

8 A PKA-specific activator, 6-Bnz-cAMP, increased PKA activi

9 ibronectin on OPC maturation by activating a PKA-dependent signaling pathway.

10 , both in vitro and in vivo, by activating a PKA-dependent signaling pathway.

11 PKA phosphorylates TCF4 directly and a PKA phosphorylation site in TCF4 is necessary for its tr

12 and serum deprivation, ABA stimulates, in a PKA- and cADPR-dependent fashion, the mitogen-activated

13 ose-stimulated insulin secretion (GSIS) in a PKA-dependent manner and prevented saturated fatty acid-

14 neuronal networks appear to be affected in a PKA-dependent manner, whereas behaviorally important hip

15 uronal networks appeared to be affected in a PKA-dependent manner, whereas hippocampal-PFC projection

16 and concomitant upregulation of NR4A2/3 in a PKA-dependent manner.

17 uolar membranes revealed that ML1 mediates a PKA-activated conductance on TV membranes that is requir

18 The additional of a PKA inhibitor (KT5720) significantly ameliorated these e

19 fic to AKAP150, as viral overexpression of a PKA-binding deficient mutant of AKAP150 also impairs coc

20 Furthermore, we found that a PKA inhibitor impaired ES cell proliferation, tumor grow

21 in the presence of insulin, treatment with a PKA-selective agonist mimicked the ability of glucagon t

22 nhibit Nrg1III by limiting protein kinase A (PKA) activation, which is required to initiate myelinati

23 Protein kinase A (PKA) activation, which mediates CD dispersion in xanthop

24 a SvJ129 background, cAMP/protein kinase A (PKA) and AMP-activated protein kinase (AMPK) signaling p

25 res the activation of both protein kinase A (PKA) and the GTPase Ras, and is induced upon the activat

26 e monophosphate (cAMP) and protein kinase A (PKA) are important mediators and regulators of apoptosis

27 A protein kinase A (PKA) biosensor allowed us to resolve minute PKA activity

28 ein kinase II (CaMKII) and protein kinase A (PKA) both in vitro and in heterologous cells.

29 ociated with a decrease of protein kinase A (PKA) catalytic subunit alpha (Calpha) expression both at

30 he activation of localized protein kinase A (PKA) holoenzymes.

31 Protein kinase A (PKA) integrates inputs from G-protein-coupled neuromodul

32 In eukaryotes, protein kinase A (PKA) is a master regulator of cell proliferation and sur

33 Ser133 phosphorylation by protein kinase A (PKA) is a well-characterized CREB activation mechanism.

34 gulatory domain of CFTR by protein kinase A (PKA) is required for its channel activity.

35 Protein Kinase A (PKA) modulates Hh signaling activity through phosphoryla

36 ced activation of the cAMP/protein kinase A (PKA) pathway by melanocortin 2 receptor (MC2R), leading

37 positive modulators of the protein kinase A (PKA) pathway, inhibited by the CB1R antagonist rimonaban

38 Protein kinase A (PKA) phosphorylation of GRK2 at Ser-685 targets it to th

39 regulated kinase (ERK) and protein kinase A (PKA) play important roles in LTP and spine structural pl

40 Protein kinase A (PKA) plays critical roles in neuronal function that are

41 DEs actively targeting the protein kinase A (PKA) R-subunit through formation of a PDE-PKAR-cyclic ad

42 ssociated with a late cAMP/protein kinase A (PKA) response at the Golgi/TGN.

43 s support a major role for protein kinase A (PKA) signaling in shaping the FLC gene expression landsc

44 of the beta-adrenergic and protein kinase A (PKA) signaling pathway.

45 iple signals that activate protein kinase A (PKA) signaling, which positively regulates neutrophil su

46 luble adenylyl cyclase and protein kinase A (PKA) signaling.

47 ine acting via D1 receptor/protein kinase A (PKA) signaling.

48 nder conditions of maximal protein kinase A (PKA) stimulation.

49 n yeast, glucose activates protein kinase A (PKA) to accelerate aging by inhibiting transcription fac

50 PRKAR1beta), activation of protein kinase A (PKA), and phosphorylation of alpha4-integrin on serine 9

51 of protein kinase G (PKG), protein kinase A (PKA), phosphodiesterase 3B (PDE3B), and a membrane-perme

52 I PDZ motif with SAP97 and protein kinase A (PKA)-anchoring protein (AKAP) 5, which anchor the recept

53 effects were mediated by a protein kinase A (PKA)-dependent enhancement of presynaptic GABA release.

54 sma membrane and increased protein kinase A (PKA)-dependent protein phosphorylation in purified medul

55 -1R activation promoting a protein kinase A (PKA)-dependent signaling cascade leading to phosphorylat

56 aled that GD1a activated a protein kinase A (PKA)-dependent signaling pathway and increased phosphory

57 aling molecule, and report protein kinase A (PKA)-independent CFTR activation by calmodulin.

58 ts were caused by impaired protein kinase A (PKA)-mediated phosphorylation because exogenous PKA rest

59 ers the relief of Ig20 and protein kinase A (PKA)-mediated phosphorylation of Ser-2152, thereby dynam

60 ncipally by activating the protein kinase A (PKA)-targeted transcription factors.

61 1) in the lipid droplet by protein kinase A (PKA).

62 gely through activation of protein kinase A (PKA).

63 tion of MeCP2 at Ser421 by Protein Kinase A (PKA).

64 tion of its main effector, protein kinase A (PKA).

65 n of I942 towards EPAC2 or protein kinase A (PKA).

66 , ferrochelatase (FECH) by protein kinase A (PKA).

67 prevented by inhibitors of protein kinase A (PKA).

68 Broadly, our results implicate aberrant PKA signaling in the pathogenesis of hematologic disease

69 ediated through the activation of common (AC/PKA) and distinct (PLC/PKC, intra-/extra-cellular calciu

70 of cAMP required to half-maximally activate PKA, which measures in the 100-300 nM range.

71 muscarinic acetylcholine receptors activate PKA.

72 eta-Adrenergic stimulation rapidly activated PKA, which led to the phosphorylation of ATGL and HSL an

73 -adrenergic signaling cascade that activates PKA.

74 echniques revealed that catalytically active PKA holoenzymes remained intact within the cytoplasm.

75 is, and DRG neuronal hyperexcitability after PKA activation.

76 In this study, pharmacokinetic analysis (PKA) of (18)F-FMISO dynamic PET extended to 3 h after in

77 ngs indicate that the parameters of anchored PKA holoenzyme action are much more restricted than orig

78 ush-pull between direct TRPV1 activation and PKA-dependent regulation of channel inactivation, with p

79 e competition between calmodulin binding and PKA phosphorylation and the differential effects of this

80 well the serine/threonine kinases CaMKII and PKA.

81 othesis that C. sakazakii increases cAMP and PKA activation in experimental NEC resulting in increase

82 ased reporters for the detection of cAMP and PKA activity in intact cells and we establish that the s

83 ated the effects of C. sakazakii on cAMP and PKA in vitro and in vivo.

84 y, these observations indicate that cAMP and PKA phosphorylation are associated with increased apopto

85 Similarly, increased intestinal cAMP and PKA phosphorylation were demonstrated in a rat pup model

86 naling from PGE2 receptors, through cAMP and PKA, to histamine-evoked Ca(2+) signals.

87 ubstrates and a cross-talk between CDPK1 and PKA, and show the role of CDPK1 in parasite invasion.

88 ved sensors, we succeeded in imaging ERK and PKA activation in single dendritic spines during structu

89 inct CREB regulatory mechanisms by HIPK2 and PKA.

90 drial PDE2A2 regulates local cAMP levels and PKA-dependent phosphorylation of Drp1.

91 between the control of ARPP-16 by MAST3 and PKA that creates a mechanism whereby cAMP mediates PP2A

92 ng in cultured cells and in vitro by PKC and PKA.

93 Under hyperglycemia, cAMP production and PKA activity were markedly increased as a result of gluc

94 These results reveal a crosstalk between PKA and PKG pathways to govern egress in T. gondii.

95 processes downstream of PKA, we deleted both PKA catalytic subunits using CRISPR-Cas9, followed by a

96 line, which displayed marked defects in both PKA activation and isoproterenol-induced ATGL translocat

97 Upregulation of both PKA and ROCK has been reported in Ophn1(-/y) mice, but i

98 ed the phosphorylation of p38 MAP kinase but PKA-CQR did not.

99 -mediated DOR desensitization is directed by PKA via AKAP scaffolding.

100 e binding of 14-3-3zeta to MAP2c enhanced by PKA-mediated phosphorylation is likely to influence micr

101 Phosphorylation by PKA also acts to prevent inhibition of PP2A by ARPP-16 p

102 We find that phosphorylation by PKA or MAST3 mutually suppresses the ability of the othe

103 spond to the same signal (phosphorylation by PKA) but have different downstream effects, indicating a

104 oupled receptors modulate phosphorylation by PKA, a classical Galphas/Galphai effector.

105 murf1 is critical for its phosphorylation by PKA.

106 signaling to ERKs and Rap1 is potentiated by PKA.

107 nisms revealed that activation of PPP1R1A by PKA phosphorylation at Thr35, and subsequent PP1 binding

108 horylation, and this effect was prevented by PKA inhibitors, suggesting the involvement of PKA in ROL

109 rsed by IGF-1 treatment and recapitulated by PKA and mTOR inhibition.

110 n that ARPP-16 is phosphorylated at Ser88 by PKA.

111 ith ionomycin and is likely also targeted by PKA.

112 ERKs is transient and rapidly terminated by PKA phosphorylation of the Raf isoforms C-Raf and B-Raf.

113 folding protein for Protein Kinases A and C (PKA and PKC, respectively), AKAP facilitates phosphoryla

114 BDNF)/TrkB and presynaptic cyclic AMP (cAMP)/PKA signaling.

115 e more compartmentalized regulation of cAMP, PKA, and EPAC, they have limited ability to link this re

116 dent mechanism and the latter through a cAMP-PKA dependent mechanism.

117 enosine monophosphate-protein kinase A (cAMP-PKA)-dependent signaling pathway.

118 l-d-aspartate receptors and weakened by cAMP-PKA-potassium channel signaling in dendritic spines.

119 Critical role of the cAMP-PKA pathway in hyperglycemia-induced epigenetic activati

120 tively, these data demonstrate that the cAMP-PKA pathway plays a key role in epigenetic regulation of

121 ctivation of ICAM-4 is regulated by the cAMP-PKA pathway.

122 o study the effect of modulation of the cAMP-PKA-dependent pathway on ICAM-4 receptor activation.

123 a-adrenergic receptor and activates the cAMP-PKA-dependent pathway, caused a significant increase in

124 cAMP/PKA signalling is compartmentalised with tight spatial a

125 ough ADORA2A and ADORA2B receptors in a cAMP/PKA pathway-dependent mechanism to induce V-ATPase-depen

126 HD, and that measurements of sleep and cAMP/PKA could be prodromal indicators of disease, and serve

127 -sensing pathways such as the TORC1 and cAMP/PKA pathways.

128 induces local Gs-protein activation and cAMP/PKA signaling at a critical position near the nucleus, w

129 also involved activation of Galphas and cAMP/PKA, and inhibition of increase in exchange protein dire

130 nt to participation of the cGMP/PKG and cAMP/PKA/Epac (exchange protein directly activated by cAMP) d

131 Compartmentalized cAMP/PKA signalling is now recognized as important for physio

132 study, we interrogate the complexity in cAMP/PKA-MAPK/ERK1&2 crosstalk by using multi-parameter biose

133 tically, the absence of Cav-1 increased cAMP/PKA signaling in EC, as indicated by elevated phosphoryl

134 aptic activity via mechanisms involving cAMP/PKA-dependent CREB activation.

135 rties, regulation and function of local cAMP/PKA signals is lacking.

136 ts, suggesting the presence of multiple cAMP/PKA signalling domains within the organelle.

137 Here, we describe a novel cAMP/PKA signalling domain localised at mitochondrial membran

138 ATF4 expression and that activation of cAMP/PKA and PI3K/Akt/mTORC1 mediates the effect of glucagon

139 induced ADP is blocked by inhibitors of cAMP/PKA signaling, insensitive to pertussis toxin or beta-ar

140 rization was dependent on inhibition of cAMP/PKA signaling, whereas reversal of Gbetagamma-stimulated

141 phoproteomes of the functional pools of cAMP/PKA/EPAC that are regulated by specific cAMP-PDEs (the P

142 his PGI2 increase appeared to stimulate cAMP/PKA pathways, contributing to the enhanced lipolysis in

143 tivation elicits the ADP by stimulating cAMP/PKA signaling.

144 Several components of the cAMP/PKA cascade are located to different mitochondrial sub-c

145 ribution to the dynamic features of the cAMP/PKA signaling network.

146 st differentiation and function through cAMP/PKA and Wnt/beta-catenin pathways.

147 l of Gbetagamma-stimulated adhesion was cAMP/PKA independent.

148 calcineurin, and increases resting cellular PKA phosphorylation.

149 rule out a role for all conserved consensus PKA phosphorylation sites in alpha1C in beta-adrenergic

150 cocaine-seeking behavior by amplifying D1DR/PKA-dependent AMPA transmission in the nucleus accumbens

151 ion is also compromised since cAMP-dependent PKA activity is enhanced, increasing the probability of

152 nteric glial cells through hormone-dependent PKA signaling.

153 ated to identify a causal network describing PKA signaling that explains vasopressin-mediated regulat

154 The ERK2 site is downstream of a direct PKA site in the Rap1GAP, Sipa1l1, that indirectly inhibi

155 In addition, a direct PKA site that inhibits the MAP kinase kinase kinase Map3

156 ulated of these being NR4A2 and NR4A3 Direct PKA activation by the site-selective PKA agonist pair N6

157 Three cAMP sensors, Epac2, PKA, and neuritogenic cAMP sensor-Rapgef2, mediate disti

158 We provide evidence that excessive PKA activation amplifies promyelinating signals downstre

159 )-mediated phosphorylation because exogenous PKA restored all parameters to control levels.

160 9 proteins were discovered as substrates for PKA, but the function of PKA phosphorylation is unknown.

161 findings suggest the existence of a glucose-PKA pathway that inactivates conserved zinc finger stres

162 or --> Gs --> adenylate cyclase --> cAMP --> PKA --> cAMP response element-binding protein pathway me

163 Thus, these results highlight PKA as a biochemical integrator of three major types of

164 tein Smoothened (Smo) in Drosophila, but how PKA activity is regulated remains elusive.

165 Our study reveals how PKA isoform specificity is defined by precise localizati

166 expression of the water-channel gene Aqp2 in PKA knockout cells.

167 Global changes in PKA phosphorylation patterns are not altered in AC9(-/-)

168 age, which was associated with increases in PKA and Calpha expression.

169 eased activity of one or more MAP kinases in PKA knockout cells.

170 ociated with activation of ERK2 were seen in PKA knockout cells.

171 ated in vitro by multiple kinases, including PKA and PKC, and pharmacological activation of these kin

172 ntestinal cells through mechanisms including PKA activation.

173 KA-specific activator, 6-Bnz-cAMP, increased PKA activity (6.8 +/- 2.0 mean fold versus vehicle; P =

174 e signalling via erythrocyte ADORA2B induces PKA phosphorylation, ubiquitination and proteasomal degr

175 locking receptor internalization, inhibiting PKA II/interfering with its Golgi/TGN localization, sile

176 biochemical evidence that mRNA-cap inhibits PKA kinase activity to promote Hh signaling.

177 lates PKA activity, whereas Galphai inhibits PKA activity.

178 e, but only later in life, and this involves PKA, its catalytic subunit Calpha, and the Wnt/beta-cate

179 IL-1Ra upregulation elicited by LPS alone is PKA-independent, whereas the rolipram-enhanced response

180 knockdown of cAMP-dependent protein kinase (PKA) activity in prestalk cells reduced stalk gene induc

181 tion by cyclic AMP-dependent protein kinase (PKA) underlies key cellular processes, including sympath

182 phorylated by cAMP-dependent protein kinase (PKA), even in highly homologous regions.

183 increases in cAMP-dependent protein kinase (PKA), or the activity of exchange protein activated by c

184 inhibition of cAMP-dependent protein kinase (PKA).

185 ection and from AKAP-knock-out mice had less PKA activity, GRK2 Ser-685 phosphorylation, and GRK2 pla

186 Changes in cAMP/cGMP levels, PKA/PKG and BDNF expression were also prevented by BAY.

187 ted CREB at Ser271 but not Ser133; likewise, PKA phosphorylated CREB at Ser133 but not Ser271, sugges

188 A-kinase anchoring proteins (AKAPs) localize PKA to AMPARs leading to enhanced phosphorylation of Glu

189 The lack of EH-myomesin, combined with low PKA-mediated phosphorylation of myofilament proteins and

190 families, including ATM, CDKs, GSK-3, MAPKs, PKA, PKB, PKC, and SRC.

191 ages of two donors to simultaneously measure PKA and ERK1&2 kinase activities in the same cellular lo

192 utants indicated that impaired AKAP-mediated PKA scaffolding significantly reduces DOR-GRK2 associati

193 tivation of intracellular second messengers, PKA and PKCepsilon, indicating that HMWH-induced antihyp

194 ortant component of the inflammatory milieu, PKA internalizes Slack channels from the DRG membrane, r

195 (PKA) biosensor allowed us to resolve minute PKA activity microdomains on the plasma membranes of liv

196 tes Hh signaling activity through modulating PKA activity.

197 -activated cross-linking approach to monitor PKA subunit interactions with temporal precision in livi

198 Moreover, PKA phosphorylates MAST3 at multiple sites resulting in

199 Moreover, PKA-Smurf1-PIPKIgamma signal transduction takes a signif

200 hrough a process involving the activation of PKA and GluA1-containing AMPA receptors (AMPARs).

201 ociation failed to augment the activation of PKA and lipolytic response to ACTH.

202 Activation of PKA in striatal slices leads to phosphorylation of Ser88

203 opin-releasing hormone through activation of PKA.

204 in B receptor (CCKBR)-mediated activation of PKA.

205 ergence of pathways indicating activation of PKA.

206 and treatment with endogenous activators of PKA, including adenosine and prostaglandin E2, results i

207 allenge is to understand how the activity of PKA catalytic subunits is directed in cells.

208 The activity of PKA is subject to elaborate control and exhibits complex

209 ng an undiscovered mode for amplification of PKA activity by cAMP-mediated sequestration of the R-sub

210 We also examined the architecture of PKA complexes containing RII subunits using cross-linkin

211 Association of PKA regulatory type II (RII) subunits with A-kinase-anch

212 To probe the quantitative attributes of PKA dynamics in the yeast Saccharomyces cerevisiae, we d

213 We show that blockade of PKA binding to AKAPs in the nucleus accumbens shell of S

214 techniques to determine the consequences of PKA-mediated phosphorylation.

215 ement of the apparent activation constant of PKA or shielding of PKA from bulk cytosolic cAMP via loc

216 o identify signaling processes downstream of PKA, we deleted both PKA catalytic subunits using CRISPR

217 nstead, we have identified other features of PKA signaling for reducing catalytic subunit diffusion a

218 d as substrates for PKA, but the function of PKA phosphorylation is unknown.

219 ased apoptosis in NEC and that inhibition of PKA activation protects against apoptosis and experiment

220 Pharmacological inhibition of PKA activity reduced protection supporting the hypothesi

221 Second, subthreshold inhibition of PKA or PKC phosphorylation did not prevent TAAR1 suppres

222 Inhibition of PKA, PI3K, Akt, and mammalian target of rapamycin comple

223 KA inhibitors, suggesting the involvement of PKA in ROL-induced AnxA1 expression.

224 These results presented a novel mechanism of PKA and IkappaB pathway, which may be targeted for treat

225 uced LD breakdown and the phosphorylation of PKA substrates, including HSL.

226 akii, and cAMP levels and phosphorylation of PKA were measured.

227 The simultaneous recording of PKA and ERK1&2 kinase activities reveals concomitant EGF

228 , using two independent optical reporters of PKA activity in acute mouse hippocampus slices, we show

229 Here, we investigated the role of PKA-dependent phosphorylation on the activity of the act

230 lls and we establish that the sensitivity of PKA to cAMP is almost twenty times lower when measured i

231 t activation constant of PKA or shielding of PKA from bulk cytosolic cAMP via localization of the enz

232 which influenced the downstream signaling of PKA pathway, including altered the expression of MKP-1.

233 ch encodes the R1alpha regulatory subunit of PKA.

234 vels of catalytic and regulatory subunits of PKA were increased by glucocorticoids in wild-type mice.

235 l actin-binding domain (ABD), is a target of PKA.

236 One of the targets of PKA is Rap1 itself, directly phosphorylating Rap1a on se

237 ivates tip-expressed ACA, which then acts on PKA to induce stalk genes.

238 isplatin-induced DNA damage was dependent on PKA-mediated phosphorylation of ATR on S435 which promot

239 Inhibition of adenylyl cyclase or PKA activity blocked p65 and CREB phosphorylation, CBP r

240 Phosphorylation of Kelch-like 3 by PKC or PKA downstream of AngII or vasopressin signaling, respec

241 an important kinase and phosphatase pathway, PKA/PPP1R1A/PP1, in ES pathogenesis.

242 Analysis of phospho-PKA levels showed lower cytoplasmic levels in STHdh (Q11

243 on, as well as an increase in phosphorylated PKA.

244 type II and a number of other phosphorylated PKA substrates.

245 eonine, which is predicted to be a potential PKA phosphorylation site by at least one prediction tool

246 oes not require any combination of potential PKA phosphorylation sites conserved in human, guinea pig

247 I) subunits were found to be the predominant PKA subunit.

248 pancreatic islets, fasting conditions reduce PKA and mTOR activity and induce Sox2 and Ngn3 expressio

249 fasting or glucose restriction (GR) regulate PKA and AMP-activated protein kinase (AMPK) to protect a

250 ted ERK1&2 kinase activity while reinforcing PKA activation.

251 in de novo through a mechanism that required PKA.

252 uggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding.

253 ms expressed in macrophages, and it requires PKA but not Epac activity.

254 These findings suggest that AKAP scaffolds PKA to increase plasma membrane targeting and phosphoryl

255 at the plasma membrane in neurons, scaffolds PKA to target proteins to mediate downstream signal.

256 Direct PKA activation by the site-selective PKA agonist pair N6/8-AHA (8-AHA-cAMP and N6-MB-cAMP) an

257 ell proliferation and survival such as SGK1, PKA, PKC, or ERK1/2.

258 Although ACTH was known to stimulate PKA-dependent lipolysis, the functional involvement of M

259 Galphas signaling stimulates PKA activity, whereas Galphai inhibits PKA activity.

260 Our report also demonstrated that PKA-calpha can directly bind to IkappaBalpha upon S. aur

261 of CFTR current activation, we propose that PKA phosphorylation of the R domain is enabled by its in

262 neutrophil gene array studies, we show that PKA activation upregulates a significant number of apopt

263 tro pharmacological experiments suggest that PKA dysregulation in the mPFC underlies cognitive dysfun

264 to refute the recently proposed theory that PKA catalytic subunits remain tethered to regulatory sub

265 achieve real-time regulation of cAMP and the PKA pathway.

266 ifferential phosphorylation of STEP61 at the PKA sites, Ser-160 and Ser-221 regulates the affinity of

267 ereas the effect of GD1a was mimicked by the PKA activator dibutyryl-cAMP.

268 graded phosphorylation of SMO, mainly by the PKA and CKI kinases.

269 fibronectin aggregates was abolished by the PKA inhibitor H89, whereas the effect of GD1a was mimick

270 , to study the properties of feedback in the PKA signaling network and dissect the nonintuitive dynam

271 working, in part, through activation of the PKA network.

272 phosphosites that enhance the effects of the PKA/CKI kinases on SMO accumulation, its localization at

273 ntial therapeutic value of inhibition of the PKA/PPP1R1A/PP1 pathway in the treatment of primary and

274 This effect depended on the PKA and Tor1 pathways, downstream of stress-response kin

275 Either ADORA2A or ADORA2B antagonists or the PKA inhibitor mPKI blocked these effects.

276 Thus, we propose that the PKA-Smurf1-PIPKIgamma pathway has an important role in p

277 ptors increases HSC survival in part via the PKA-mediated induction of the cAMP response element-bind

278 EB activation mechanism in parallel with the PKA-phospho-Ser133 CREB axis.

279 Most of these PKA targets are thus far unannotated in public databases

280 Here, we show that this PKA-induced retrograde trafficking of Slack channels als

281 llular Ca(2+) increase ([Ca(2+)] i ) through PKA activation and subsequent cADPR generation.

282 IL-27 does not appear to be mediated through PKA, exchange protein activated by cAMP, PI3K, or MAPKs.

283 The model predicts that, through PKA activation, vasopressin stimulates AQP2 exocytosis b

284 The model also predicts that, through PKA activation, vasopressin stimulates Aqp2 transcriptio

285 , the P2204L mutant is readily accessible to PKA, promoting ligand-independent phosphorylation on Ser

286 This cognitive deficit is consecutive to PKA deregulation in the mPFC that prevents Ophn1 KO mice

287 tions," wherein cAMP is locally delivered to PKA at supersaturating concentrations to cause uncouplin

288 of a downstream transcriptional response to PKA activation in the neutrophil, and that they positive

289 y was to define transcriptional responses to PKA activation and to delineate the roles of these facto

290 whether Galphaq-coupled receptors signal to PKA in their native context.

291 We reveal that after damage, PINK1 triggers PKA displacement from A-kinase anchoring protein 1.

292 Unrestrained PKA activity is pathological, and an enduring challenge

293 m spiny neurons but that dopamine acting via PKA inactivates ARPP-16 leading to selective potentiatio

294 paBalpha activation induced by S. aureus via PKA-MKP-1 pathway.

295 ERK phosphorylation on Thr(202)/Tyr(204) was PKA-dependent, but MEK(Ser(217)/Ser(221)) phosphorylatio

296 Consequently, unlike in WT filamin, where PKA-mediated Ser-2152 phosphorylation is ligand-dependen

297 ed stalk gene induction by c-di-GMP, whereas PKA activation bypassed the c-di-GMP requirement for sta

298 GSKIP interacts with PKA and also directly interacts with GSK3beta.

299 The GABAergic LTP is mimicked with PKA or PKC activation.

300 pho-RhoA was localised in actin nodules with PKA type II and a number of other phosphorylated PKA sub