ライフサイエンスコーパス: PLP

1 PLP acts as an anti-activator of PdxR and is the only ef

2 PLP and the substrate glycine bind in the active site of

3 PLP concentrations were inversely associated with glucos

4 PLP synthase (PLPS) is a remarkable single-enzyme biosyn

5 PLP synthesis occurs in the synthase active site by a co

6 PLP was used as direct biomarker for vitamin B-6 status,

7 PLP, a highly reactive aldehyde, poses a problem for cel

8 PLP, pyridoxal, pyridoxic acid (PA), 3-hydroxykynurenine

9 PLP-150Q mice show progressive neurological symptoms and

10 PLP-dependent enzymes optimize specific chemical reactio

11 PLP-derived RNA was detected in the cytoplasm of the Hep

12 PLP-EGFP was highly expressed as cells delaminated from

13 PLP-SYN and age-matched wild-type mice were treated for

14 PLPs did not synthesize GFP, but in coculture with HepG2

15 PLPs generated under shear flow displayed improved funct

16 PLPs were synthesized by combining highly deformable mic

17 c partners (GRASP) analyses suggest that 5HT-PLP neurons form contacts with 5HT1A receptor-expressing

18 ich can be released by activation of the 5HT-PLP neurons.

19 and binding-induced cleavage of the Lys(629)-PLP covalent bond, dynamic motion of the cobalamin-bindi

20 oxidative C-S bond formation reaction and a PLP-mediated C-S lyase (EgtE) reaction results in a net

21 homolog (bacterial), PROSC, which encodes a PLP-binding protein of hitherto unknown function.

22 e S-modified analogs as substrates through a PLP-dependent beta-elimination reaction, establishing l-

23 say is based on fast imine metathesis with a PLP aryl imine probe to capture the target compound for

24 la enterica, a stable 2-aminoacrylate (2-AA)/PLP adduct forms on the biosynthetic alanine racemase, A

25 aled an array of different preferences among PLPs.

26 TBSs, retinyl esters, some carotenoids, and PLP differed by village site.

27 Our data reveal that Cnn and PLP directly interact at two defined sites to coordinate

28 dynamic interface between the cobalamin and PLP-binding domains.

29 ctrochemical and fluorescence detection, and PLP is analyzed by HPLC with fluorescence detection.

30 transferase-like activity involving GABA and PLP is not essential to its primary function as a transc

31 sferase activity in the presence of GABA and PLP, and the presence of an active site configuration th

32 in formation of the second intermediate and PLP.

33 ical performance for the detection of Py and PLP by a square wave stripping voltammetric technique (S

34 erein, two different MIP formats (for Py and PLP) were synthesized on the surface of vinyl silane mod

35 crog L(-1) and 0.043 microg L(-1) for Py and PLP, respectively, at signal to noise ratio of 3.

36 synthesize specific MIP cavities for Py and PLP.

37 the WDR1 KD phenotype of megakaryocytes and PLPs.

38 ptide species, a multiple sclerosis antigen (PLP) and an ICAM-1 ligand (LABL) known to block immune c

39 Vitamin B-6 deficiency was defined as PLP <20 nmol/L, and insufficiency as PLP 20-30 nmol/L.

40 Purified PdxS functionally displayed as PLP synthase, whereas PdxT exhibited glutaminase activit

41 ined as PLP <20 nmol/L, and insufficiency as PLP 20-30 nmol/L.

42 ures of the Eb/O-PLP-AFPA complex and Asp-AT-PLP-AFPA complex revealed that GabR is incapable of faci

43 methasone was co-delivered with autoantigen (PLP) in vivo to create effective ASIT for the treatment

44 re that the external aldimine formed between PLP and GABA is apparently responsible for triggering th

45 We evaluated the vitamin B-6 biomarkers PLP, pyridoxal, and pyridoxic acid (PA) and the pyridoxi

46 While plants can biosynthesize PLP de novo, they also have salvage pathways that serve

47 , and its ability to repress is increased by PLP.

48 that the expression of pdxS was repressed by PLP and activated by a transcription factor, PdxR.

49 We found that in wild-type cerebellum, PLP associates with alphav integrin and the calcium-impe

50 compared vitamin B-6 intake and circulating PLP concentrations of RTRs with those of healthy control

51 intracellular availability of the cofactor (PLP) and, therefore, present as potential markers of fun

52 y (IQR: 4.8-6.1 y) and 297 healthy controls, PLP, plasma 3-hydroxykynurenine (3-HK), and xanthurenic

53 dies is the first insight into a coronavirus PLP's interface with ISG15 via SARS-CoV PLpro in complex

54 the distinct specificities among coronavirus PLPs observed and addresses a critical gap of how PLPs c

55 isease virus leader protease and coronavirus PLPs, which act as deubiquitinating and deISGylating (in

56 e to the recognition of ISG15 by coronavirus PLPs at a structural and biochemical level are poorly un

57 We crossed PLP-EGFP reporter mice into a Plp1-null background to in

58 inhibition reduced fibrinogen binding of d12 PLPs.

59 lem for cells, which is how to supply enough PLP for apoenzymes while maintaining free PLP concentrat

60 wever, cultured fibroblasts showed excessive PLP accumulation.

61 The padlock probe-lateral flow (PLP-LF) test is the first of its kind and can ideally be

62 Plasma folate, PLP, and vitamin B-12 concentrations were categorized di

63 ird compared with the first quartile and for PLP sufficiency compared with deficiency [OR: 0.60 (95%

64 substrate specificity loop of chronophin for PLP coordination.

65 lated relative and absolute risks of CRC for PLP and the ratios 3-hydroxykynurenine:XA (HK:XA), an in

66 reacts with the second intermediate to form PLP.

67 The results here identified a fourth PLP enzyme as a target of enamine stress in Salmonella.

68 gh PLP for apoenzymes while maintaining free PLP concentrations low enough to avoid unwanted reaction

69 racing, we identify a population of GAP43(+) PLP(+) precursors in embryonic nerve roots as the cells

70 We next generated PLPs containing green fluorescent protein (GFP)-tagged a

71 oxal] differed from that of CSF (pyridoxal > PLP > PA > pyridoxamine).

72 mperature neutron structure of a homodimeric PLP-dependent enzyme, aspartate aminotransferase, which

73 observed and addresses a critical gap of how PLPs can interact with ISG15s from a wide variety of spe

74 VX-765 prevented motor deficits in PLP-SYN mice compared with placebo controls.

75 ly, plasma levels of metabolites involved in PLP-dependent reactions, such as the kynurenine pathway,

76 LM-PLP infection preferentially induced PLP-specific CD8 T-cell responses.

77 Caspase-3 inhibition reduced shear-induced PLP/PPT and MkMP formation.

78 that ectopic Centrobin expression influenced PLP levels on the basal centrosome, suggesting it may no

79 phosphorylation disrupts Pfn1 binding to its PLP-containing ligands with little effect on actin bindi

80 tate NMR experiments on isotopically labeled PLP aldimines formed by lyophilization with poly-L-lysin

81 f 5-ethynyluridine (EU) and added EU-labeled PLPs to HepG2 cells.

82 it of the AMPA receptor, but in mice lacking PLP, alphav integrin did not associate with GluR2.

83 cule bonded tightly to Lecsl to form a Lecsl-PLP complex.

84 LM-PLP infection preferentially induced PLP-specific CD8 T-

85 rotein peptide (PLP) amino acids 178-191 (LM-PLP).

86 he induction of PLP-specific CD8 T-cells, LM-PLP infection did not result in disease.

87 In fact, LM-PLP infection resulted in significant amelioration of PL

88 Importantly, infection with LM-PLP ameliorated established disease.

89 onlinear, with the strongest relation at low PLP.

90 areas under the curve for discriminating low PLP (less than the fifth percentile; 18.6 nmol/L) were 0

91 tment cerebrospinal fluid samples showed low PLP concentrations and evidence of reduced activity of P

92 e of multi-branched 'pre-myelinating' MBP+ / PLP+ oligodendrocytes that interact with axons but fail

93 g worse functional vitamin B-6 status.Median PLP, 3-HK, and XA concentrations were 41 nmol/L (IQR: 29

94 We then established transgenic mice (PLP-150Q) that selectively express mutant huntingtin in

95 d a catalytic site characteristic of minimal PLP catalytic domains.

96 As development progressed, most PLP-EGFP-expressing cells gave rise to oligodendrocyte p

97 Expression of a mutant PLP linked to impaired trafficking resulted in the detec

98 n the distributions of wild-type and mutated PLPs.

99 ased the migration rate of wild-type but not PLP null OPCs.

100 omparison between the structures of the Eb/O-PLP-AFPA complex and Asp-AT-PLP-AFPA complex revealed th

101 urotransmitter stimulation in the absence of PLP and GluR2 or when alphav integrin levels were reduce

102 In the absence of PLP, normal numbers of OPCs were generated and their dis

103 an effectual mechanism for the activation of PLP, as is N-protonation, and that enzymes that are inca

104 trations and evidence of reduced activity of PLP-dependent enzymes.

105 tion: in this protocol, only the analysis of PLP requires mixing with trichloroacetic acid to release

106 th Esmond E. Snell established one aspect of PLP enzyme mechanism.

107 site from solvent and hinders the binding of PLP and glycine in the active site.

108 r variation in circulating concentrations of PLP influences long-term outcome.We compared vitamin B-6

109 A deficiency of PLP can present, therefore, as seizures and other sympto

110 Deficiency of PLP in the brain can be caused by inborn errors affectin

111 this data indicated that the co-delivery of PLP and dexamethasone with a water-in-oil emulsion is ef

112 red trafficking resulted in the detection of PLP tetramers that persist in the endoplasmic reticulum,

113 structural waters, is located at the edge of PLP opposite the reactive Schiff base.

114 The expression of PLP-EGFP in the spinal cord was quite dynamic during dev

115 tigation since the initial identification of PLP's role as a coenzyme in this extensive class of enzy

116 B6 vitamer metabolism or by inactivation of PLP, which can occur when compounds accumulate as a resu

117 Despite the induction of PLP-specific CD8 T-cells, LM-PLP infection did not resul

118 We show that the interaction of PLP with calmodulin (CaM) at two highly conserved CaM-bi

119 reated with a single injection (10 mg/kg) of PLP-LCL or empty LCL as a control.

120 or PL supplementation, but higher levels of PLP and PM phosphate (PMP), the two active forms of the

121 -positive neurons in the substantia nigra of PLP-SYN mice.

122 Protonation of the pyridine nitrogen of PLP and the coupled proton transfer from the phenolic ox

123 rotonation state of the pyridine nitrogen of PLP, which affects the rates of catalysis.

124 /J mice with AZD1480 delays disease onset of PLP-induced relapsing-remitting disease, reduces relapse

125 In the presence of PLP and GABA, GabR activates the gabTD operon, which all

126 The presence of PLP-EGFP expression in OPCs raises the question of its r

127 molecular probe to examine the reactivity of PLP in both GabR and a homologous aspartate aminotransfe

128 d in intracellular homeostatic regulation of PLP, supplying this cofactor to apoenzymes while minimiz

129 through the imine into the pyridine ring of PLP.

130 indicates a previously unrecognized role of PLP binding in Pfn1 antitumor effects.

131 1-null background to investigate the role of PLP in early OPC development.

132 tions by modulating the electronic states of PLP through distinct active site environments.

133 tions by modulating the electronic states of PLP through weak interactions in the active site.

134 tion by reducing its load in the striatum of PLP-SYN mice.

135 PACT domain controls the proper targeting of PLP to the centrosome.

136 mechanism underlying impaired trafficking of PLP.

137 Therefore, the activity of PLPs from SARS-CoV, MERS-CoV, and mouse hepatitis virus

138 to the unique deformability and affinity of PLPs for fibrin fibres, as evidenced by dissipative part

139 l shear dramatically increased generation of PLPs/PPTs and MkMPs by up to 10.8 and 47-fold, respectiv

140 such as Mycobacterium tuberculosis depend on PLP, and deficiencies in humans have also been associate

141 he protonation states of ionizable groups on PLP and the reacting substrates and underscore the essen

142 ind that a deprotonated pyridine nitrogen on PLP precludes formation of a true quinonoid species and

143 These pathogen-like particles, or PLPs, can come from a variety of sources, ranging from f

144 Platelets or PLPs were internalized within 1 hour by HepG2 cells and

145 ion of the efficacy of this trigger in other PLP-enzyme active sites.

146 We evaluated the ratios PA:PL, PA:PLP, and PA:(PL + PLP) as possible markers of vitamin B-

147 er of functional vitamin B-6 status, and PA:(PLP + pyridoxal) (PAr), a marker of inflammation and oxi

148 that platelets and platelet-like particles (PLPs) derived from the megakaryoblastic cell line MEG-01

149 ved a population of platelet-like particles (PLPs) in the infusate, which include platelets released

150 Platelet-like particles (PLPs) produced by WDR1 KD cells were fewer in number but

151 of fully synthetic platelet-like particles (PLPs) that augment clotting in vitro under physiological

152 on and formation of platelet-like particles (PLPs), pro/preplatelets (PPTs), and Mk microparticles (M

153 n expression of d12 platelet-like particles (PLPs), whereas p38 inhibition reduced fibrinogen binding

154 s (LM) encoding proteolipid protein peptide (PLP) amino acids 178-191 (LM-PLP).

155 ctivates a number of pyridoxal 5'-phosephate(PLP)-dependent enzymes, some of which have been linked t

156 ting concentrations of pyridoxal-5-phospate (PLP) in renal transplant recipients (RTRs).

157 In the case of the pyridoxal 5'-phosphate (PLP) and cobalamin-dependent enzymes lysine 5,6-aminomut

158 on interactions with pyridoxal-5'-phosphate (PLP) and GABA, and thereby promotes the biosynthesis of

159 n to dephosphorylate pyridoxal 5'-phosphate (PLP) and serine/threonine-phosphorylated proteins.

160 balamin (AdoCbl) and pyridoxal-5'-phosphate (PLP) and the substrate into proximity for the radical-me

161 ma concentrations of pyridoxal 5'-phosphate (PLP) are common in renal transplant recipients (RTRs) an

162 we characterized the pyridoxal 5'-phosphate (PLP) biosynthesis pathway in Streptococcus pneumoniae.

163 retinyl esters, and pyridoxal-5'-phosphate (PLP) by using high-pressure liquid chromatography, retin

164 ntified by measuring pyridoxal 5'-phosphate (PLP) concentrations in a DBS before and after a 30 min i

165 athway that produces pyridoxal 5'-phosphate (PLP) from glutamine, ribose 5-phosphate, and glyceraldeh

166 Circulating pyridoxal-5'-phosphate (PLP) has been linked to lung cancer risk.

167 e vitamin B-6 marker pyridoxal 5'-phosphate (PLP) have been associated with reduced colorectal cancer

168 Pyridoxal 5'-phosphate (PLP) is a fundamental, multifunctional enzyme cofactor u

169 ate aminotransferase.Pyridoxal 5'-phosphate (PLP) is a ubiquitous co factor for diverse enzymes, amon

170 Pyridoxal-5'-phosphate (PLP) is introduced to a biomimetic indicator displacemen

171 d among these plasma pyridoxal 5'-phosphate (PLP) is most commonly used.

172 Pyridoxal 5'-phosphate (PLP) is the active vitamer of vitamin B6 and acts as an

173 tion of the cofactor pyridoxal 5'-phosphate (PLP) of OAT by an unamplified modification of the commer

174 pyridoxine (Py) and pyridoxal-5'-phosphate (PLP) using the same MIP format.

175 tatus marker, plasma pyridoxal 5'-phosphate (PLP), decreases during inflammation; therefore, causal r

176 Pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, functions as a cofa

177 de novo synthesis of pyridoxal 5'-phosphate (PLP), the major active form of vitamin B6 .

178 Plasma concentrations of PL 5'-phosphate (PLP), which is the active coenzyme form of vitamin B-6,

179 ficiency of cellular pyridoxal 5'-phosphate (PLP), which is the coenzyme form of vitamin B-6, may imp

180 nd a long C-terminal pyridoxal 5'-phosphate (PLP)-binding putative aminotransferase domain.

181 ivates at least some pyridoxal 5'-phosphate (PLP)-containing enzymes in Salmonella enterica.

182 nhibition of BioA, a pyridoxal 5'-phosphate (PLP)-dependent aminotransferase.

183 me biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent and reversible reaction between glycine a

184 ms, results from the pyridoxal 5'-phosphate (PLP)-dependent enzymatic condensation of glycine with su

185 is catalyzed by the pyridoxal-5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT)

186 nsferase (SHMT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes a hydroxymethyl gro

187 erase (GABA-AT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degrades GABA, the principal

188 , a highly conserved pyridoxal 5'-phosphate (PLP)-dependent enzyme, present in different isoforms in

189 drives catalysis in pyridoxal-5'-phosphate (PLP)-dependent enzymes has been the subject of intense i

190 o acids performed by pyridoxal-5'-phosphate (PLP)-dependent enzymes.

191 ion of serine by the pyridoxal 5'-phosphate (PLP)-dependent serine/threonine dehydratases, IlvA and T

192 tic intermediates of pyridoxal 5'-phosphate (PLP)-dependent serine/threonine dehydratases.

193 The pyridoxal 5'-phosphate (PLP)-dependent transaminase BioA catalyzes the second st

194 hich is the cofactor pyridoxal 5'-phosphate (PLP).

195 ludes 2 vitamin B-6 [pyridoxal 5'-phosphate (PLP)]-dependent enzymes.

196 Enzymes dependent on pyridoxal 5'-phosphate (PLP, the active form of vitamin B6) perform a myriad of

197 tween plasma folate, pyridoxal 5'-phosphate (PLP; the biologically active form of vitamin B-6), and v

198 The pyridoxal-5-phosphate (PLP) molecule bonded tightly to Lecsl to form a Lecsl-PL

199 mes (LCL) containing prednisolone phosphate (PLP-LCL) in a mouse model of arthritis.

200 composition of plasma [pyridoxal phosphate (PLP) > pyridoxic acid (PA) > pyridoxal] differed from th

201 flect on my research on pyridoxal phosphate (PLP) enzymes over fifty-five years and on how I combined

202 pterins and vitamin B6 (pyridoxal phosphate (PLP))) in human cerebrospinal fluid (CSF) can be used as

203 eline serum riboflavin, pyridoxal phosphate (PLP), folate, vitamin B12, and flavin mononucleotide (FM

204 tics analysis reveals a pyridoxal phosphate (PLP)-dependent domain, we termed cysteine lyase (SH) dom

205 ited diseases involving pyridoxal phosphate (PLP)-dependent enzymes, including primary hyperoxaluria

206 e in M. jannaschii is a pyridoxal phosphate (PLP)-dependent l-aspartate decarboxylase encoded by MJ00

207 ation and production of pyridoxal phosphate (PLP).

208 uated the ratios PA:PL, PA:PLP, and PA:(PL + PLP) as possible markers of vitamin B-6 catabolism.

209 receiver operating characteristics, PA:(PL + PLP) discriminated high inflammatory concentrations with

210 PA:(PL + PLP) had the highest ICC of all vitamin B-6 metabolites

211 The ratio PA:(PL + PLP) may provide novel insights into pathologic processe

212 > 90% of the explained variation in PA:(PL + PLP).

213 Plasma PLP (AMI patients only) and PA predicted all-cause morta

214 Plasma PLP and vitamin B-12 concentrations were not associated

215 baseline vitamin B-6 was measured as plasma PLP by high-performance liquid chromatography (HPLC).

216 Vitamin B-6 deficiency as measured by plasma PLP is associated with a clear increase in CRC risk.

217 gest reductions for subjects with low plasma PLP at baseline.

218 nowledge, it is not known whether low plasma PLP concentrations have functional (i.e., intracellular)

219 In these groups, the median plasma PLP concentrations were 29 nmol/L (17-50 nmol/L) and 41

220 tality.We assessed the association of plasma PLP with functional vitamin B-6 status and explored the

221 erformed on 10 OC users (20-40 y old; plasma PLP concentrations <30 nmol/L) before and after 28 d of

222 lementation increased the mean +/- SD plasma PLP concentration from 25.8 +/- 3.6 to 143 +/- 58 nmol/L

223 inverse marker of vitamin B-6 status.Plasma PLP concentrations were associated with a reduced CRC ri

224 A ratio was inversely associated with plasma PLP (beta = -0.21, P < 0.001).

225 y, we found that, at very early time points, PLP-EGFP was expressed in Sox2+ undifferentiated precurs

226 estigated using pulsed-laser polymerization (PLP) and high-resolution mass spectrometry.

227 here a previously unknown class of potential PLP enzyme inactivators; namely, a family of quaternary,

228 irst H5N1 target hybrids with padlock probe (PLP) and then PLP is circularized upon the action of T4

229 sphorylation site within the poly-l-proline (PLP) binding pocket.

230 ity to torovirus (ToV) papain-like protease (PLP) (ToV-PLP).

231 ron (IFN) antagonists, papain-like protease (PLP) and N protein.

232 uctural studies of the papain-like protease (PLP) domains of coronaviruses (CoVs) revealed an adjacen

233 omains, including two papain-like proteases (PLPs) and a highly conserved ADP-ribose-1''-phosphatase

234 ncode multifunctional papain-like proteases (PLPs) that have the ability to process the viral polypro

235 ecedented role for Pericentrin-like protein (PLP), which localizes to the tips of extended Cnn flares

236 we use Drosophila pericentrin-like-protein (PLP) to understand how the PACT domain is regulated.

237 proteins include myelin proteolipid protein (PLP) and axon-enriched proteins involved in mitochondria

238 ell compartments of the proteolipid protein (PLP) expressed in COS-7 cells.

239 the function of myelin proteolipid protein (PLP), one of the major proteins in compact myelin.

240 yelin-specific protein, proteolipid protein (PLP), was unaltered.

241 301 gene predisposes to proteolipid protein (PLP)-induced experimental autoimmune encephalomyelitis (

242 ely, Tsc1 deletion from proteolipid protein (PLP)-positive oligodendrocytes slowed remyelination.

243 The transfer of proteolipid protein (PLP)-stimulated lymph node cells to 4MU-fed mice resulte

244 urprisingly, the myelin proteolipid protein (PLP).

245 domain proteins, myelin proteolipid protein (PLP, 30 kDa) and DM-20 (26 kDa), from various regions of

246 d as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during in

247 cid (PA) and the pyridoxic acid:(pyridoxal + PLP) ratio (PAr), a proposed marker of vitamin B-6 catab

248 gesting it may normally function to regulate PLP.

249 eraction with single point mutations renders PLP inefficient in localizing to centrioles in cultured

250 dentified a symmetrical pair of serotonergic PLP neurons that are necessary for the proper escalation

251 iency, which was confirmed by very low serum PLP concentrations.

252 protection in proteolipid protein alpha-syn (PLP-SYN) mice, a transgenic mouse model of MSA.

253 D cells were fewer in number but larger than PLPs produced from unmodified MEG-01 cells, and had sign

254 Together, these studies demonstrate that PLP is critical for OPC responses to glutamate signaling

255 We show that PLP is enriched on the inactive interphase centrosome, w

256 abnormal in Plp1-null mice, suggesting that PLP plays a role either in the structural integrity of O

257 itro and in silico analyses demonstrate that PLPs actively collapse fibrin networks, an emergent beha

258 The PLP-dependent transaminase (BioA) of Mycobacterium tuber

259 between the cobalamin-binding domain and the PLP-binding TIM barrel domain.

260 Disrupting the PLP-CaM interaction with single point mutations renders

261 On the other hand, the PLP was a mixture of nonplatelet cellular fragments and

262 ion induces electronic delocalization in the PLP, which correlates with the enhancement in catalytic

263 In one monomer, the PLP remained as an internal aldimine with a deprotonated

264 ism concluding with covalent labeling of the PLP cofactor.

265 The solid-state NMR chemical shifts of the PLP pyridine ring nitrogen and additional sites, coupled

266 is coupled to the pyridinyl nitrogen of the PLP, influencing the electrophilicity of the cofactor.

267 es focused primarily on the formation of the PLP-alphav integrin-AMPA receptor complex in vivo and wh

268 he rate-limiting step of inactivation of the PLP-dependent enzyme BioA by dihydro-(1,4)-pyridone 1.

269 logue in the beta-subunit active site of the PLP-requiring enzyme tryptophan synthase.

270 chemical shift measurements of sites on the PLP coenzyme allow a detailed model of coenzyme protonat

271 ion of functional sperm does not rely on the PLP-CaM interaction, whereas production of functional me

272 at modulating the Ubl domain adjacent to the PLP reduces protease stability and viral pathogenesis, r

273 et hybrids with padlock probe (PLP) and then PLP is circularized upon the action of T4 ligase enzyme.

274 Thus, PLP activation is controlled by the proximity of the pyr

275 ine, 2,5-DAPn, 2,4-DAB, and 2,3-DAPr bind to PLP as an external aldimine and elicit the AdoCbl Co-C b

276 a1*0302 (DQ8) Tg mice were also resistant to PLP(91-110)-induced EAE, but production of proinflammato

277 Using reverse genetics, we generated a ToV-PLP knockout recombinant virus.

278 ntly, we demonstrated that the exogenous ToV-PLP gene that was inserted into the EVG genome encodes a

279 gain fitness through the acquisition of ToV-PLP from a recombination event.IMPORTANCE Enteroviruses

280 ovirus (ToV) papain-like protease (PLP) (ToV-PLP).

281 Importantly, the recombinant ToV-PLP protein derived from this novel enterovirus also sho

282 These results suggest that ToV-PLP functions as an innate immune antagonist; enteroviru

283 Compared to the wild-type virus, the ToV-PLP knockout mutant virus showed impaired growth and ind

284 ytic activity of monomeric chronophin toward PLP is strongly impaired.

285 Using PLP-EGFP mice to investigate Plp1 promoter activity, we

286 in maintenance, because their ablation using PLP-CreERT resulted in hindlimb paralysis with immobilit

287 f key immune cells, recent studies utilizing PLPs as vaccine delivery platforms have shown great prom

288 a, SER, and MTs in rodent optic nerves where PLP is replaced by the peripheral nerve myelin protein,

289 ased intracellular Ca(2+) signaling, whereas PLP null OPCs did not reduce GluR2 at the cell surface o

290 a suggest that PdxR-like proteins, for which PLP plays just a signalling role, form a separate functi

291 While PLP can be synthesized by a de novo pathway in bacteria

292 n via formation of an external aldimine with PLP.

293 Treatment of CIA with PLP-LCL significantly suppressed joint swelling.

294 n of PN phosphate (PNP), which competes with PLP for apoenzyme binding leading to the formation of an

295 markedly stronger negative correlations with PLP than did HK alone (Spearman's rho = -0.36, -0.29, an

296 B. subtilis: a 2.7-A structure of GabR with PLP bound and the 2.55-A apo structure of GabR without P

297 Immunization with PLP(91-110) peptide caused atypical EAE in DRB1*0301.DQ8

298 d to assess associations of kynurenines with PLP.

299 s and other symptoms that are treatable with PLP and/or pyridoxine.

300 and the 2.55-A apo structure of GabR without PLP.