ライフサイエンスコーパス: PLT

1 PLT and WBC counts were both inversely related to MD adh

2 PLT was greater than 150,000 in 15% of patients at the d

3 PLT-to-S. aureus exposure ratios of > or = 10:1 yielded

4 PLT/uPA-T recognizes human alphaIIbbeta3 on both quiesce

5 PLTs were obtained every 3 months, and HVPG measurements

6 Sixteen SOC (53.3%) received FFP, 10 (33.3%) PLT, and 4 (13.3%) both FFP and PLT.

7 20 known MPV associations, we identified 32 PLT and 18 MPV associations not previously observed in t

8 1 < 50 pg/mL, n = 9; IL-6 < 10 pg/mL, n = 5 [PLT 203,000 +/- 7,500/microL].

9 hor and T540 HGB (r2 = .95), HCT (r2 = .95), PLT (r2 = .94), and WBC (r2 = .95) results (n = 408); si

10 S. aureus response mechanism involving (i) a PLT-to-S. aureus ratio sufficient for activation; (ii) t

11 Cucumber basic protein (CBP) is a PLT which has a relatively short Cu(II)-S(Met89) axial b

12 different, and what they can teach us about PLT formation.

13 tion of P2X(1)/P2Y(12) receptors on adjacent PLTs; and (iv) the recursive amplification of PMP and PK

14 mbers of the AINTEGUMENTA-LIKE/PLETHORA (AIL/PLT) transcription factor family, including AINTEGUMENTA

15 Arabidopsis thaliana that encode related AIL/PLT transcription factors: AINTEGUMENTA (ANT), AINTEGUME

16 Therefore, all PLT genes can activate the formative cell divisions that

17 16 +/- 0.001 log fL; P < 1.08 x 10(-24)) and PLT (per-G effect -4.55 +/- 0.80 10(9)/L; P < 7.19 x 10(

18 5), HCT (-0.21+/-1.5), WBC (0.79+/-1.3), and PLT values (-9.2+/-16.6) as well as STKS HGB (-0.08+/-0.

19 s levels of TPO and IL-11, but not IL-6, and PLT counts in the MAT/BMT patients (TPO: r = -0.57, P <

20 ), HCT (-0.69+/-2.3), WBC (-0.62+/-5.8), and PLT values (-10.2+/-21.4).

21 ter STKS HGB (r2 = .92), HCT (r2 = .91), and PLT (r2 = .94) results (n = 141).

22 6.7%; P = 0.009 vs. SOC), and 3 both FFP and PLT (not significant).

23 , 10 (33.3%) PLT, and 4 (13.3%) both FFP and PLT.

24 s identified here between miR396 and GRF and PLT transcription factors are necessary to establish the

25 icant correlation was found between HVPG and PLT at the baseline, year 1, and year 5 (P < 0.0001).

26 d survival between groups LR and LLT, LR and PLT, and PLT and SLT.

27 indicating that MDF acts upstream of PIN and PLT gene expression.

28 l between groups LR and LLT, LR and PLT, and PLT and SLT.

29 oligodeoxynucleotide (ODN) sequestration and PLT clumping upon addition of bacterial/viral ODNs.

30 ists of increasingly narrow specificity, and PLT adhesion receptors (CD41, CD42b, and CD62P).

31 stigate the relationship between varices and PLT at the time of endoscopy, (2) investigate whether ch

32 ness of the peripheral microtubule coil, and PLTs are capable of enlarging in culture to generate bar

33 lization of 125I-rmTPO by megakaryocytes and PLTs in the spleens and marrows of ITP mice was also dem

34 expansion of stem/progenitors and of MKs and PLTs via dysregulated TPO turnover.

35 irradiation (irradiated) or rabbit antimouse PLT serum (RAMPS) for 1 day (1 d RAMPS) and 5 days (5 d

36 Reintroduction of any PLT clade member in the mutant primordia completely rest

37 A receiver operating curve did not show any PLT with high sensitivity or specificity for the presenc

38 nules, vacuoles and dense tubular system) as PLTs from peripheral blood determined by electron micros

39 n, we found that the PTT treatment augmented PLT-AuNRs targeting to the tumor sites and in turn, impr

40 oth auxin/PLETHORA (PLT)-dependent and auxin/PLT-independent redox signaling pathways.

41 In these patients, baseline PLT >/= 100,000/muL and lack of rapid early platelet dec

42 Because PLT number and size are inversely proportional, this rai

43 r PLT count, whereas the association between PLT count and the MD was not affected by adjustment for

44 ting the association between the MD and both PLT and WBC counts.

45 negative feedback loop based on circulating PLT counts, but also may, in part, be regulated by a var

46 gest that the absolute number of circulating PLTs may not always be the sole regulator of endogenous

47 go repeated abscissions to yield circulating PLTs.

48 intention-to-treat (ITT) analysis comparing PLT and SLT strategies.

49 deletion in PLTs and MKs did not compromise PLT formation but caused thrombocytosis, and resulted in

50 ker CD62P; c) platelet-leukocyte conjugates (PLT/LEU) and leukocyte activation marker CD11b; and d) i

51 Conversely, PLT activates MIR396 in the stem cells to repress the GR

52 A combination of platelet impedance count (PLT-I) and NEUT-Y at day 3 post-injury exhibited good di

53 e thrombocytopenic duration (platelet count (PLT) < 20,000 per microliter)to o.25, 0, 0.5 d, respecti

54 tine hemostasis tests except platelet count (PLT) and in all TEG parameters, on the first day of infe

55 fically with measurements of platelet count (PLT) and mean platelet volume (MPV).

56 an corpuscular volume (MCV), platelet count (PLT) and white blood cell (WBC) count.

57 an platelet volume (MPV) and platelet count (PLT) are highly heritable and tightly regulated traits.

58 reement regarding a specific platelet count (PLT) that can reliably predict GEV.

59 ssion analysis revealed that platelet count (PLT), age, AST, and INR were significantly associated wi

60 Hemoglobin (HGB), platelet count (PLT), red blood cell count, and white blood cell count (

61 1% < MAF < 5%) variants with platelet count (PLT), red blood cell indices (MCH and MCV) and HDL chole

62 tive thrombocytopenia (nadir platelet count [PLT] < 20,000/mm3), as well as the whole group of patien

63 rombocytopenia purpura (ITP), with decreased PLT survival, but intact bone marrow megakaryocytopoiesi

64 d internalization/turnover by Jak2-deficient PLTs.

65 ms that regulate PLT formation and determine PLT size offers the promise of improved therapies for cl

66 000 per microliter), and elicited an earlier PLT recovery.

67 nd MDS disappeared when further adjusted for PLT count, whereas the association between PLT count and

68 The differentiation medium was collected for PLT production analysis by flow cytometry, transmission

69 erminal megakaryopoiesis is not required for PLT production, and that Jak2 loss in PLTs and MKs resul

70 nalysis of Exomechip association results for PLT and MPV in 157,293 and 57,617 individuals, respectiv

71 on and cancer targeting characteristics from PLTs and good photothermal property from AuNRs.

72 nd that the generated MKs release functional PLTs.

73 , control vs. differentiation); 3) Generated PLTs were functional as evidenced by the up-regulation o

74 r patients, ITT survival was better in group PLT compared with group LR.

75 ase-free survival (DFS) were better in group PLT versus group LR (OS 73%/63% vs. 58%/35%, P = 0.0007;

76 out (7.1%), 340 finally underwent PLT (group PLT).

77 e and long-term outcomes compared with group PLT (starting from time of LT) (OS 54%/54% vs. 73%/63%,

78 t, to its uptake and degradation by the high PLT turnover and increased mass of megakaryocytes.

79 ad both reduced odds of being in the highest PLT-count group (MDS: odds ratio = 0.50; 95% confidence

80 of TLR9 organization and signaling in human PLTs.

81 surface adhesion receptors failed to impede PLT anti-S. aureus responses.

82 VPG correlates somewhat with PLT, changes in PLT cannot be used as a surrogate for HVPG changes.

83 GEV, and (3) investigate whether changes in PLT correlate with the hepatic venous pressure gradient

84 ndoscopy, (2) investigate whether changes in PLT from the baseline over time can predict the developm

85 vors and nonsurvivors on day 1 were found in PLT/LEU (p = .001), CD11b (p = 0.02), and EMP/MONO (p =

86 signal-related kinase (ERK), is involved in PLT activation.

87 s TLR9 to a new intracellular compartment in PLTs and (b) describes a novel mechanism of TLR9 organiz

88 Pf4-Cre-mediated Jak2 deletion in PLTs and MKs did not compromise PLT formation but caused

89 VAMP 8, which regulates its distribution in PLTs on contact activation (spreading).

90 r treatment is not due to JAK2 inhibition in PLTs and MKs, but rather due to JAK2 inhibition in stem/

91 ed for PLT production, and that Jak2 loss in PLTs and MKs results in non-autonomous expansion of stem

92 dary to both marrow hypoplasia and increased PLT destruction.

93 e, nor the inhibition of anti-HPA-1a-induced PLT phagocytosis, were affected by N-glycan modification

94 Gold nanorods (AuNRs) were first loaded into PLTs by electroporation and the resulting AuNR-loaded PL

95 Isolated PLTs were incubated with ISP479C or ISP479R (PLT/S. aure

96 PLTs were incubated with ISP479C or ISP479R (PLT/S. aureus ratio range, 1:1 to 10,000:1) in the prese

97 In addition to confirming 47 known PLT and 20 known MPV associations, we identified 32 PLT

98 4) was developed: age ([yr] x AST [U/L]) / ((PLT [10(9)/L]) x (ALT [U/L])(1/2)).

99 Labeled PLTs were also found within splenic macrophages.

100 nd may be related to "young PLTs" and "large PLTs" of both inherited and acquired macrothrombocytopen

101 crothrombocytopenias to establish how "large PLTs" observed in both conditions are similar, how they

102 lectroporation and the resulting AuNR-loaded PLTs (PLT-AuNRs) inherited long blood circulation and ca

103 ntially life saving for individuals with low PLT numbers; however, previous work revealed that PLT tr

104 may have outcomes comparable to primary LT (PLT).

105 A rise in the mean PLT after the 2nd postoperative week reflects proper gra

106 nsplant period (first 2 weeks), but the mean PLT exceeded preoperative levels during the 3rd and 4th

107 Additionally, the mean PLT volumes of RAMPS mice were significantly higher than

108 ent strategy to prevent anti-HPA-1a-mediated PLT destruction in FNAIT.

109 g a multifrequency linear array 7.2-18.0-MHz PLT-1204BX transducer focused at the level of the flexor

110 s was the bound 125I-rmTPO (cpm) per million PLT (P <.05).

111 tential new stem cell source for in vitro MK/PLT production.

112 levels remained undetectable (< 150 pg/mL, [PLT 30,500 +/- 5,500/microL], n = 15).

113 P < .05, n = 19; IL-6: 25.8 +/- 8.4 pg/mL, [PLT 32,800 +/- 5,057/microL], P > .05, n = 4] v normal d

114 < .001, n = 12; IL-11: 227.9 +/- 35 pg/mL, [PLT 32,900 +/- 57,000/microL], P < .05, n = 19; IL-6: 25

115 apy (BMT/MAT) (TPO: 1,455.5 +/- 87.3 pg/mL, [PLT 39,600 +/- 7,800/microL], P < .001, n = 12; IL-11: 2

116 nificantly increased (328.0 +/- 92.6 pg/mL, [PLT: 20,900 +/- 3,000/microL], P < .05, n = 25).

117 -HPA-1a antibodies in vivo in a mouse model (PLT clearance after 5 hours; 18% vs 62%, in the presence

118 Importantly, in two murine injury models, PLT/uPA-T did not lyse preexisting clots, even when admi

119 These results suggest a multifactorial PLT anti-S. aureus response mechanism involving (i) a PL

120 Both the nadir PLT and the percentage of the platelet fall were indepen

121 l, we demonstrate that the administration of PLT-AuNRs and localizing laser irradiation could effecti

122 he unique self-reinforcing characteristic of PLT-PTT in cancer therapy.

123 A combination of PLT-I and NEUT-Y show potential for the early diagnosis

124 improved therapies for clinical disorders of PLT production and an important source of PLTs for infus

125 :1) in the presence or absence of a panel of PLT inhibitors, including P2X and P2Y receptor antagonis

126 Pretreatment of PLT-Ecto with anti-TGF-beta1 neutralizing Ab restored su

127 endent manner, suggesting that recipients of PLT transfusions may experience reduced NK cell function

128 sent a failure in the intermediate stages of PLT production?

129 oss-sectional or longitudinal evaluations of PLTs are inadequate noninvasive markers for GEV.

130 (Oct4 and Sox2) expression; 2) The level of PLTs in the differentiation medium was 16 +/- 1 number/m

131 Preincubation of PLTs with type IV collagen specifically increased TLR9 a

132 of PLT production and an important source of PLTs for infusion.

133 Identifying genetic effects on PLT and MPV can provide mechanistic insights into platel

134 if the reaction time (r) was >40 min and/or PLT if maximum amplitude (MA) was <30 mm.

135 All SOC patients received FFP and/or PLT per hospital guidelines.

136 eleasing PLT microbicidal proteins (PMPs) or PLT kinocidins (PKs).

137 the MDF-dependent pathway in regulating PIN/PLT- and WUS/CLV-mediated meristem activity.

138 t3p, fungal laccases and some plantacyanins (PLTs).

139 (GA), but not the soleus (SOL) or plantaris (PLT) muscles, of D14 mice.

140 Platelet (PLT) and white blood cell (WBC) counts are 2 markers of

141 Platelet (PLT) production represents the final stage of megakaryoc

142 Platelet (PLT) transfusions are potentially life saving for indivi

143 ic cytokine levels and circulating platelet (PLT) counts, we measured the levels of thrombo-poietin (

144 oietin (TPO) levels and peripheral platelet (PLT) counts in patients with thrombocytopenia secondary

145 We previously showed that platelet (PLT) alpha granule-delivered urokinase plasminogen activ

146 rophils (ANC to < 500/microL) and platelets (PLT < 20,000/microL) were significantly enhanced in the

147 fresh frozen plasma (FFP) and/or platelets (PLT).

148 Platelets (PLTs) act in antimicrobial host defense by releasing PLT

149 n (HPA)-1a, which opsonizes fetal platelets (PLTs).

150 bsequent production of functional platelets (PLTs).

151 ed the impact of Jak2 deletion in platelets (PLTs) and megakaryocytes (MKs) on blood counts, stem/pro

152 Human and murine platelets (PLTs) variably express toll-like receptors (TLRs), which

153 /L, hemoglobin [Hgb] > 12.0 g/dL, platelets [PLT] > 100 x 10(9)/L), as well as resolution of splenome

154 RAM maintenance through both auxin/PLETHORA (PLT)-dependent and auxin/PLT-independent redox signaling

155 eedling roots also exhibit reduced PLETHORA (PLT), SCARECROW and SHORTROOT gene expression, a loss of

156 The GRFs repress PLETHORA (PLT) genes, regulating their spatial expression gradient

157 Recent work has identified the PLETHORA (PLT) genes as master regulators of basal/root fate, wher

158 Here, we show that three PLETHORA (PLT) genes, PLT3, PLT5, and PLT7, regulate de novo shoot

159 characterize the effects of three PLETHORA (PLT) transcription factors, PLT3, PLT5, and PLT7, during

160 poration and the resulting AuNR-loaded PLTs (PLT-AuNRs) inherited long blood circulation and cancer t

161 Four of these factors, preoperative PLT, intra-operative platelet transfusions, re-transplan

162 For preoperative PLT, platelet transfusions during the operation, re-tran

163 t period is correlated with low preoperative PLT, massive platelet transfusions, and re-transplantati

164 The preoperative PLT, intra-operative platelet transfusion requirements,

165 NGM-SZ21 prevented PLT destruction induced by maternal anti-HPA-1a antibodi

166 ript is specifically up-regulated during pro-PLT production and is distributed to a novel electron-de

167 d FFP alone (P < 0.0001 vs. SOC), 2 received PLT (6.7%; P = 0.009 vs. SOC), and 3 both FFP and PLT (n

168 Recently, PLT-Ecto were shown to reduce proinflammatory cytokine r

169 of the cytoskeletal mechanisms that regulate PLT formation and determine PLT size offers the promise

170 following thrombin stimulation; 4) Released PLTs showed similar ultra-structure characteristics (alp

171 t in antimicrobial host defense by releasing PLT microbicidal proteins (PMPs) or PLT kinocidins (PKs)

172 induced in the mutant primordia, rendering "PLT-null" LRP.

173 Additional analysis revealed PLT, age, AST, and ALT as an alternative model.

174 rbell-proPLTs that divide to yield 2 smaller PLT products.

175 chromatography indicated that staphylocidal PLT releasates contained PMPs and PKs.

176 During storage, PLT intended for transfusion continuously shed ectosomes

177 Subsequent PLT destruction is mediated via the Fc part of the alloa

178 ualize our current understanding of terminal PLT production against the backdrop of human macrothromb

179 rs predict mortality on day 1, we found that PLT/LEU had the best predictive value among the markers

180 umbers; however, previous work revealed that PLT transfusions are associated with increased infection

181 In sum, our study showed that PLT-Ecto could inhibit NK cell effector function in a TG

182 At ratios below 10:1, the PLT antistaphylococcal efficacy relative to the intrinsi

183 how an antagonistic relationship between the PLT and HD-ZIP III genes in specifying the root and shoo

184 d with training, and remained blunted in the PLT and SOL even after 28 days of detraining, at a time

185 The nadir of the drop in the PLT most commonly occurred on posttransplant day 4.

186 ups, with increases at D1, D7 and D14 in the PLT, SOL and GA muscles, respectively.

187 a specific P2Y(12) antagonist) mitigated the PLT staphylocidal response against both strains, correla

188 0.5 d, respectively, and the severity of the PLT nadir (28,000, 43,000, and 30,000 per microliter, re

189 The PLTs were compared between subjects who did and did not

190 elet-facilitated photothermal tumor therapy (PLT-PTT) strategy, in which PLTs act as carriers for tar

191 plification of PMP and PK release from these PLTs.

192 Thus, PLT/uPA-T represents the prototype of a platelet-targete

193 cells and full PBMCs from healthy donors to PLT-Ecto.

194 26 dropped-out (7.1%), 340 finally underwent PLT (group PLT).

195 n-activatable, low-molecular-weight pro-uPA (PLT/uPA-T).

196 ese effects could antagonized, in part, when PLT-Ecto were preincubated with anti-TGF-beta1 Ab.

197 Whether PLT-Ecto modify NK cells remains unclear.

198 l tumor therapy (PLT-PTT) strategy, in which PLTs act as carriers for targeted delivery of phototherm

199 portal hypertension (HVPG < 10 mm Hg) whose PLT remained greater than 100,000 had a 2-fold reduction

200 Patients with mild portal hypertension whose PLT remains greater than 100,000 have significantly less

201 to identify genetic variants associated with PLT and MPV.

202 Several variants associated with PLT/MPV (PEAR1, MRVI1, PTGES3) were also associated with

203 and long-term outcomes were comparable with PLT.

204 ociation of variants at the COPZ1 locus with PLT as well as replication of four previously reported l

205 CHC, and a variant at the ARHGEF3 locus with PLT, as well as replication of four previously reported

206 Although HVPG correlates somewhat with PLT, changes in PLT cannot be used as a surrogate for HV

207 inverse correlation of circulating TPO with PLT counts during steady-state immune thrombocytopenic m

208 partially accounted for the association with PLTs.

209 barbell-proPLTs and may be related to "young PLTs" and "large PLTs" of both inherited and acquired ma