ライフサイエンスコーパス: PMI

1 PMI 5011 also attenuated the FFA-induced upregulation of

2 PMI 5011 attenuates the reduction in insulin signaling i

3 PMI 5011 had no effect on ceramide formation or accumula

4 (PMI 5011) improves insulin action, yet the precise mecha

5 PMI competes with p53 for MDM2 and MDMX binding at an af

6 PMI is a common complication after noncardiac surgery an

7 PMI is an inhibitor of the protein-protein interaction (

8 PMI is associated with increased in-hospital mortality i

9 PMI may have significantly contributed to reducing the b

10 PMI may normally be used to catabolize excess mannose ra

11 PMI occurred after 397 of 2546 surgeries (16%; 95% confi

12 PMI program implementation was associated with a signifi

13 PMI was defined as an absolute high-sensitivity cardiac

14 PMI was defined as creatine kinase-MB isoenzyme level >

15 PMI was defined as initiation of VT during pace-mapping

16 tion coverage of malaria interventions in 19 PMI-recipient and 13 non-recipient countries between 199

17 ree enthalpies DeltaG(298)(Z vs. E) are 2.6 (PMI), 2.3 (PYI), and 6.0 (PUI) kcal/mol and for the free

18 tivation DeltaG(298)(Z --> E) they are 21.6 (PMI), 21.1 (PYI) and 19.7 (PUI) kcal/mol.

19 A PMI-derived metabolic signature consisting of aconitic a

20 he active site of PaPGI/PMI argues against a PMI mechanism involving a trans-enediol intermediate.

21 -based STI/HIV intervention (HORIZONS) and a PMI consisting of brief telephone contacts every 8 weeks

22 The non-risk-adjusted PMI was 0.115 (SD = 0.023) for all centers and 0.113 (SD

23 percentage points (95% CI 0.79-12.47) after PMI implementation.

24 y changed in the peripheral vein blood after PMI in a derivation cohort (n=15; P<5.70E-5).

25 proteins that increased within 1 hour after PMI, 23 were also elevated in patients with spontaneous

26 rization laboratory at our institution after PMI from 2003 to 2012, who had noncardiac surgery within

27 tained before and at various intervals after PMI, with patients undergoing elective diagnostic corona

28 s were detected as early as 10 minutes after PMI in an initial derivation group and were validated in

29 tained before and at 10 and 60 minutes after PMI, and protein changes were assessed by repeated-measu

30 e discussion of the halogen-bonded aggregate PMI x ClCH(3) exemplifies that the asymmetry in N-invers

31 e the identical electronic properties of all PMI amphiphiles.

32 repeatable in a mouse model system, allowing PMI to be estimated within approximately 3 days over 48

33 A factorial analysis of gender, age, and PMI with respect to copy number also showed no statistic

34 AmCYAN1 and PMI protein accumulation levels were maintained.

35 showed no evidence of decreasing AmCYAN1 and PMI protein levels across generations and no transgene s

36 ication to 1.00 for postoperative death, and PMI was derived.

37 on Brain Bank, with data on age, gender, and PMI) were analyzed for HSV-1 DNA copies (HSV-1 DNA polym

38 mics with epidemiological, intervention, and PMI-financing data to estimate the contribution PMI has

39 h a panel of p53-derived peptide ligands and PMI, a p53-mimicking but more potent peptide antagonist

40 e-mapping, electrograms that exhibit MES and PMI may be specific for sites critical to reentry.

41 ieved by coupled assays in which the PMM and PMI primary products are in vitro subjected to another e

42 ifferent kinds of reactions, whereas TIM and PMI have different structures but catalyze similar react

43 have improved freedom from recurrent VT, and PMI of VT predicts successful sites of termination durin

44 Molecular ions corresponding to apo-PMI monomer were obtained by dialyzing the holoenzyme ag

45 ovel chemical tool (hereafter referred to as PMI), which drives mitochondria into autophagy without c

46 the vast majority of PMIs are asymptomatic, PMI usually is missed in the absence of systematic scree

47 isability Adjusted Life Year (DALY) averted, PMI-funded interventions are highly cost-effective.

48 Bacteriochlorin analogue BC-PMI has more extended spectral coverage (350-750 nm) and

49 containing eight perylenes in benzonitrile, PMI decays approximately 80% by energy transfer (forming

50 the first to assess the association between PMI and all-cause child mortality in SSA with the use of

51 cused on the electronic interactions between PMI chromophores.

52 The performance of both PMI and PDI derivatives in organic devices may be limite

53 Here, five covalently bound PMI dimers with varying degrees of electronic interactio

54 ed intramolecular H-bonding network in bound PMI that contributed to its conformational stability, th

55 Each dollar of per-capita PMI expenditures in a country, a measure of PMI intensit

56 Per-capita PMI spending was also associated with a modest increase

57 let yield (<5%) is observed for the cofacial PMI dimers.

58 ene driven by a CMP promoter and the E. coli PMI gene driven by either a CMP or Ubi promoter, were us

59 ved HORIZONS and a time- and dose-consistent PMI focused on general health.

60 -financing data to estimate the contribution PMI has made to malaria control via funding for long-las

61 .7%) differed from that in healthy controls (PMI=9.2+/-3.8%; P<0.01) but not from that in umbilical c

62 ant to proteolysis, both (D)PMI-alpha and (D)PMI-gamma failed to actively traverse the cell membrane

63 pite being resistant to proteolysis, both (D)PMI-alpha and (D)PMI-gamma failed to actively traverse t

64 in-targeting cyclic-RGD peptide, however, (D)PMI-alpha exerted potent p53-dependent growth inhibitory

65 The prototypic d-peptide inhibitor (D)PMI-alpha binds ((25-109))MDM2 at an affinity of 220 nM

66 for ((25-109))MDM2 has been improved over (D)PMI-alpha by 3 orders of magnitude (K(d) = 220 pM).

67 ibitor of the p53-MDM2 interaction termed (D)PMI-alpha (TNWYANLEKLLR) that competes with p53 for MDM2

68 mal d-peptide antagonists of MDM2, termed (D)PMI-alpha, beta, gamma.

69 tive d-peptide antagonist of MDM2, termed (D)PMI-delta, of which the binding affinity for ((25-109))M

70 in a distinct D-peptide inhibitor termed (D)PMI-gamma (DWWPLAFEALLR) that binds MDM2 at an affinity

71 X-ray crystallographic studies validate (D)PMI-delta as an exceedingly potent inhibitor of the p53-

72 Thirteen patients (30%) demonstrated PMI, and termination of VT was seen in 95% (18/19) of si

73 atients with CKD before undergoing dialysis (PMI=36.1+/-11.7%) differed from that in healthy controls

74 Robust perylene-3,4-dicarboximide (PMI) pi-aggregates provide important light-harvesting an

75 rophobic residues Phe, Trp, and Leu dominate PMI or (17-28)p53 binding to MDM2 and MDMX.

76 ne, the photoexcited perylene-monoimide dye (PMI) decays rapidly ( approximately 3.5 ps) and predomin

77 n path of the isomerization (Z)-PMI <==> (E)-PMI revealed a remarkable stabilization due to asymmetry

78 es may provide a novel method for estimating PMI that avoids many of these limitations.

79 eveloped into a forensic tool for estimating PMI.

80 iscovery rate; 52 patients (12%) experienced PMI.

81 In addition, the tarragon extract PMI-5011 activated Klf4 and orexigenic neuropeptides and

82 ngs compared to the wild type (WT) following PMI.

83 To elucidate the molecular determinants for PMI activity and specificity, we performed a systematic

84 tor haplotype improved prediction models for PMI based on traditional risk factors alone (C-statistic

85 polymorphisms improved prediction models for PMI based on traditional risk factors alone (C-statistic

86 SOSP) - E(ITS) is less than 0.5 kcal/mol for PMI and PUI, but it is as high as DeltaE(def) approximat

87 ately 20% by electron transfer (also forming PMI- Zn+) and approximately 80% by the normal routes ope

88 approximately 20% by hole transfer (forming PMI- Zn+); Zn subsequently decays approximately 20% by e

89 ntaneous Ca2+ sparks in fibers isolated from PMI EDL muscles were also significantly altered.

90 In addition, RyR1 from PMI skeletal muscles were PKA-hyperphosphorylated and de

91 edge-functionalized GNRs, revealing that GNR-PMI formed an intriguing rectangular network.

92 mplex ( approximately 96 kDa) at 18 and 30 h PMI, and was SDS sensitive.

93 At 30 h PMI, each of the parasites, IE cytosol and IE ghost cont

94 parum parasite extracts only from 24 to 36 h PMI, and multiple proteins appeared to be required for t

95 first haploid division at pollen mitosis I (PMI) but fail at distinct stages of the generative cell

96 tions were studied of pyrimidin-4(3H)-imine (PMI), pyridin-2(1H)-imine (PYI), and 1H-purine-6(9H)-imi

97 ntribute to the reduced exercise capacity in PMI, out of proportion to the degree of cardiac dysfunct

98 ced amplitude and a prolonged time course in PMI.

99 Monocyte and neutrophil levels were lower in PMI than in NMI monkeys.

100 estimated that the under-5 mortality rate in PMI countries was reduced from 28.9 to 24.3 per 1,000 pe

101 ia burden should a proposed 44% reduction in PMI funding occur.

102 If a 44% reduction in PMI funding were to occur, we predict that this loss of

103 and prolonged, and anemia was more severe in PMI than in NMI monkeys.

104 lymphocyte levels were higher in NMI than in PMI monkeys.

105 se proteins were validated in an independent PMI cohort (n=15; P<2.30E-4); >85% were directionally co

106 that according to the Pain Management Index (PMI), 43.4% of patients with cancer were undertreated.

107 The Postoperative Morbidity Index (PMI) is a quantitative measure of the average burden of

108 tiation of VT, termed pace-mapped induction (PMI).

109 a shape-based principal moments of inertia (PMI) analysis.

110 therapeutic, planned myocardial infarction (PMI) for treatment of hypertrophic cardiomyopathy.

111 cardium and in a post-myocardial infarction (PMI) HF model evaluated in wild-type (wt-PMI) and Nod1(-

112 risk of postoperative myocardial infarction (PMI) in patients undergoing coronary artery bypass graft

113 esis of postoperative myocardial infarction (PMI), a multifactorial disorder with significant inter-p

114 PCI) in perioperative myocardial infarction (PMI), even though PMI is a major cause of mortality in p

115 onal model of planned myocardial infarction (PMI), patients undergoing septal ablation for hypertroph

116 uman model of planned myocardial infarction (PMI).

117 ignaling in a rat postmyocardial infarction (PMI) model of myocardial overload.

118 2 in an exclusively polymicrobial infection (PMI) model.

119 .1; P=.03), placental membrane inflammation (PMI; OR, 2.7; P=.02), and deciduitis (OR, 2.3; P=.03) an

120 her degree of probable maternal inheritance (PMI) of functional disorders than controls (12% vs. 1%,

121 derived from a high-affinity MDM2 inhibitor PMI.

122 nited States President's Malaria Initiative (PMI) since 2006, no studies have carefully assessed how

123 such as the President's Malaria Initiative (PMI), are vital to maintain progress and pursue further

124 Perioperative myocardial injury (PMI) seems to be a contributor to mortality after noncar

125 Instead, PMI activity may be the result of additional space in th

126 r detecting protein-metabolite interactions (PMIs) to identify lipids that bind to Nur77.

127 donation source, longer postmortem interval (PMI), and higher body mass index (BMI) were associated w

128 dely used to assess the postmortem interval (PMI), but errors can range from days to months.

129 ect to age, gender, and postmortem interval (PMI).

130 ime of death), and long postmortem interval (PMI).

131 he areas of estimating postmortem intervals (PMIs), locating clandestine graves, and obtaining soil a

132 IE) surface at 30 h post-merozoite invasion (PMI), concomitant with extensive oligomerization.

133 atment of perioperative myocardial ischemia (PMI) because of early graft failure or incomplete revasc

134 cted as the percentage of migrated isoforms (PMI), Epo glycosylation in patients with CKD before unde

135 three key enzymes: phosphomannose isomerase (PMI), phosphomannomutase (PMM) and GDP-mannose pyrophosp

136 f a metalloenzyme, phosphomannose isomerase (PMI), which catalyzes the interconversion of mannose 6-p

137 nomutase (PMM) and phosphomannose isomerase (PMI), which when deficient cause congenital disorders of

138 eductase (AR), and phosphomannose isomerase (PMI).

139 om glucose through phosphomannose isomerase (PMI).

140 If funding is maintained, PMI-funded interventions are estimated to avert a furthe

141 The resulting cyclotide MCo-PMI was able to bind with low nanomolar affinity to both

142 tion (mean age, 37.7 +/- 9.4 years; and mean PMI, 5.3 +/- 1.4 hours).

143 d with enhanced inflammation in the KO mice, PMI-induced mortality was also significantly higher in K

144 sed on photosensitizing perylene monomimide (PMI) chromophore amphiphiles were found to show variatio

145 The co-crystal structure of N8A-PMI-(25-109)MDM2 was determined at 1.95 A, affirming tha

146 n association was confirmed between negative PMI score, economic level, and nonspecific setting for c

147 and experimental studies reporting negative PMI scores for adults with cancer and pain published fro

148 Nod1(-/-)-PMI mice showed significantly fewer ventricular arrhythm

149 Compared with wt-PMI, hearts from Nod1(-/-)-PMI mice had better cardiac function and attenuated stru

150 ne receptors, which was blunted in Nod1(-/-)-PMI cardiomyocytes.

151 Ameliorated cardiac function in Nod1(-/-)-PMI mice was associated with prevention of Ca(2+) dynami

152 er isoproterenol administration in Nod1(-/-)-PMI mice.

153 -type (wt-PMI) and Nod1(-/-) mice (Nod1(-/-)-PMI).

154 se of metabolomics in the discovery of novel PMIs.

155 stematic Ala scanning mutational analysis of PMI and (17-28)p53.

156 0 domain requirements for the degradation of PMI and Sp100 suggests that a common mechanism is involv

157 The effect of PMI 5011 on ceramide accumulation and ceramide-induced i

158 demonstrate that SFN reverses the effects of PMI in co-treated cells by reducing the accumulation of

159 All patients showing evidence of PMI (n=399; 5.3% of total) underwent emergent coronary a

160 validated in a second, independent group of PMI patients.

161 modelling approach to estimate the impact of PMI investments to date in reducing malaria burden and t

162 We have not modelled indirect impacts of PMI funding (such as health systems strengthening) in th

163 However, the incidence of PMI in whites (n=843) expressing the combined MBL2 5' LY

164 re associated with an increased incidence of PMI.

165 uate the association between introduction of PMI and child mortality rates in sub-Saharan Africa (SSA

166 Introduction of PMI was associated with increased coverage of malaria pr

167 PMI expenditures in a country, a measure of PMI intensity, was also associated with a reduction in c

168 aplotype is a novel independent predictor of PMI and may aid in preoperative risk stratification of w

169 or haplotype was an independent predictor of PMI in whites after primary coronary artery bypass graft

170 s were found to be independent predictors of PMI (adjusted P<0.05; false discovery rate <10%).

171 tor haplotypes are independent predictors of PMI in whites undergoing primary coronary artery bypass

172 Importantly, the C-terminal residue Pro of PMI induced formation of a hydrophobic cleft in MDMX pre

173 etic contributions of individual residues of PMI and (17-28)p53 to MDM2 and MDMX association.

174 inflammatory pathways contribute to risk of PMI after cardiac surgery.

175 g-term mortality after PCI in the setting of PMI.

176 tion constant for the isomeric substrates of PMI was measured to be 88.8 microM.

177 ensive steric clashes with the C-terminus of PMI or p53 peptide and induces a significant lateral shi

178 mphocyte count 23 times greater than that of PMI monkeys.

179 Because the vast majority of PMIs are asymptomatic, PMI usually is missed in the abse

180 imer trap states in organic devices based on PMI derivatives.

181 , 0.2; P=.03), funisitis (RR, 0.4; P=.1), or PMI (RR undefined; P=.03).

182 (PMM2) and phosphomannose isomerase (MPI or PMI), respectively.

183 der and copy number, age and copy number, or PMI and copy number for each pair of variables.

184 The generalizability of our PMI findings was evaluated in a spontaneous myocardial i

185 P-PMI has an S1 lifetime (tauS) of 4.7 ns in toluene and 1

186 The porphyrin-perylene dyad P-PMI displays the most even spectral coverage from 400 to

187 e crenarchaeon Pyrobaculum aerophilum (PaPGI/PMI) has been determined in complex with glucose 6-phosp

188 isomerase from Pyrobaculum aerophilum (PaPGI/PMI) has been determined in native form at 1.16-A resolu

189 Thus, the PMI reaction in PaPGI/PMI probably uses a cis-enediol mechanism of catalysis,

190 able second base in the active site of PaPGI/PMI argues against a PMI mechanism involving a trans-ene

191 he glutamate base catalyst, shows that PaPGI/PMI uses the same catalytic mechanisms for both ring ope

192 09)Mdm2 and the nano-molar inhibitor peptide PMI.

193 but not from that in umbilical cord plasma (PMI=53.9+/-10.6%; P>0.05), which contains mainly liver-d

194 re evaluated in 8 malaria-naive primigravid (PMI) and 8 age-matched nulligravid (NMI) infected monkey

195 place of a glycine in PGI) may also promote PMI activity by positioning the C1-O1 region of M6P.

196 ure affect H2 generation, two representative PMI systems are investigated theoretically using a modif

197 apes to the exclusion of others using simple PMI plots.

198 il sacrifice, on one of four diets: standard PMI Picolab Rodent Diet 20, a milk-free modification of

199 potent duodecimal peptide inhibitor, termed PMI (TSFAEYWNLLSP), of the p53-MDM2 and -MDMX interactio

200 so found that an extract of tarragon, termed PMI-5011, activated hypothalamic Klf4 and Agrp.

201 most potent inhibitor (TSFAEYWNLLSP), termed PMI, bound to MDM2 and MDMX at low nanomolar affinities-

202 We estimate that PMI has prevented 185 million (95% CrI: 138 million, 230

203 Our model estimates that PMI has played a significant role in reducing malaria ca

204 Our findings reveal that PMI activity is essential for the survival of C. neoform

205 Here we show that PMI promotes mitochondrial respiration, leading to a sup

206 These data show that PMI skeletal muscles exhibit altered local Ca2+ signalin

207 The MAN1 gene, encoding for the PMI enzyme, was isolated and sequenced from C. neoforman

208 harge transfer is not observed in any of the PMI dimers, and only a small triplet yield (<5%) is obse

209 lish the age could give an indication of the PMI.

210 the active site of the enzyme shows that the PMI activity of this enzyme may be due to the additional

211 Thus, the PMI reaction in PaPGI/PMI probably uses a cis-enediol me

212 ticles published from 1994 to 2013 using the PMI to assess the adequacy of analgesic therapy suggests

213 6 and 24-26 proceeded more rapidly with the PMI ligands 9-11, whereas 4-exo cyclizations 28 and 5-en

214 Additional displacement of the PMIs by a biphenyl spacer along the long axis prevents e

215 ive myocardial infarction (PMI), even though PMI is a major cause of mortality in patients undergoing

216 Reductions in funding to PMI could lead to large increases in the number of malar

217 ceived a different (supplemental) treatment (PMI) to enhance effects of the primary treatment.

218 Importantly, the N8A mutation turned PMI into the most potent dual-specific antagonist of MDM

219 for a slip-stacked geometry in which the two PMI molecules are displaced along their long axes by one

220 the rest (86-93%) is catabolized to 3H2O via PMI.

221 In vivo, PMI-5011 increased Agrp promoter activity in luciferase-

222 to determine whether the mechanism by which PMI 5011 improves insulin signaling is through regulatio

223 Associations with PMI were determined by regression analysis.

224 s of MDMX and of pTyr99 MDMX in complex with PMI as well as modeling studies reveal that the phosphat

225 ynthetic MDM2 and MDMX, both in complex with PMI, at 1.6 A resolution.

226 , mortality was compared among patients with PMI not fulfilling additional criteria (ischemic symptom

227 mortality was comparable among patients with PMI not fulfilling any other of the additional criteria

228 Mortality seems comparable in patients with PMI not fulfilling any other of the additional criteria

229 heral plasma from controls and patients with PMI or spontaneous MI by quantitative multiple reaction

230 ce interval [CI], 5.7-12.0) in patients with PMI versus 1.5% (95% CI, 0.9-2.0) in patients without PM

231 In patients with PMI, in-hospital mortality was 9.4% and 3.5% in patients

232 5%) was significantly better than those with PMI and abnormal angiograms (74.9 +/- 2.9%; P<0.001 log-

233 s 7.3% and 2.9% in patients with and without PMI (P<0.001).

234 Five-year survival in patients without PMI (85.7 +/- 0.5%) was significantly better than those

235 s 1.5% (95% CI, 0.9-2.0) in patients without PMI (P<0.001).

236 Increased diastolic Ca(2+) release in wt-PMI cardiomyocytes was related to hyperphosphorylation o

237 NOD1 also prevented Ca(2+) mishandling in wt-PMI mice.

238 on (PMI) HF model evaluated in wild-type (wt-PMI) and Nod1(-/-) mice (Nod1(-/-)-PMI).

239 Compared with wt-PMI, hearts from Nod1(-/-)-PMI mice had better cardiac f

240 re N-inversion path of the isomerization (Z)-PMI <==> (E)-PMI revealed a remarkable stabilization due