ライフサイエンスコーパス: PNA

1 PNA has a much lower helical twist than RNA and the resu

2 PNA is a promising molecule for antisense therapy of tri

3 PNA may be a better choice in situations where mesenchym

4 PNA probes are an attractive alternative to DNA and RNA

5 PNA retains its overall conformation while locally there

6 PNA-binding proteins may also participate in the pattern

7 PNAs are used as exceedingly selective chemical tools th

8 o an antiparallel RNA/PNA complex and from a PNA/PNA complex to two DNA/PNA complexes (i.e., double-d

9 nyl], were synthesized and incorporated to a PNA strand, and their applicability for the monitoring o

10 RNA polymerase alpha subunit (rpoA) using a PNA that was covalently conjugated to five different CPP

11 t is positively charged, pinacyanol acetate (PNA), for the determination of orthogonal sets of RDCs i

12 Poly(A) DNA, RNA and peptide nucleic acid (PNA) all form these assemblies.

13 l C(gamma)-substituted peptide nucleic acid (PNA) analogues have been synthesized in the form of gamm

14 eplacement of dsDNA by peptide nucleic acid (PNA) and the in situ growth of electroactive polymers th

15 in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics.

16 Peptide nucleic acid (PNA) building blocks, bearing a fluorine sensor at C-5 o

17 ere we demonstrate how peptide nucleic acid (PNA) can be used to control the assembly of cytochrome c

18 ed with charge neutral peptide nucleic acid (PNA) capture probes (CPs) is first hybridized to a targe

19 nd "reporter and miRNA-peptide nucleic acid (PNA) hybrid", which yields two significantly different o

20 ockdown, we employed a peptide-nucleic acid (PNA) hybridization assay.

21 plasmid sample using a peptide nucleic acid (PNA) oligomer as the probe is described.

22 Peptide nucleic acid (PNA) oligomerization of the 5,6-benzopC monomer was carr

23 g blocking primers and peptide-nucleic acid (PNA) oligonucleotide blockers.

24 omplementing (CCCTAA)3 peptide nucleic acid (PNA) probe coupled with cardiac-specific antibody staini

25 functionalized with a peptide nucleic acid (PNA) probe specific for a gene tract of the genetically

26 Peptide nucleic acid (PNA) probes targeting APP, combined with super-resolutio

27 Briefly, thiolated peptide nucleic acid (PNA) probes were firstly immobilized onto gold electrode

28 Peptide nucleic acid (PNA) probes were used to capture RNA targets, and a micr

29 the polymer by using a peptide nucleic acid (PNA) targeting compound.

30 ased on combination of peptide nucleic acid (PNA) technology, rolling circle amplification (RCA) and

31 o acid complexes using peptide nucleic acid (PNA) to assemble peptides inside a 3D DNA nanocage.

32 y, mercapto-terminated peptide nucleic acid (PNA) was firstly immobilized onto gold electrode and use

33 eptide conjugated to a peptide nucleic acid (PNA) was shown to silence luciferase in colon adenocarci

34 The modification of peptide nucleic acid (PNA) with unnatural nucleobases enables the formation of

35 d to a short strand of peptide nucleic acid (PNA), synthetic polymers that use the same bases as DNA

36 ilding block for a new peptide nucleic acid (PNA), which exhibits excellent DNA binding affinity with

37 exible, self-assembled peptide nucleic acid (PNA).DNA complexes uncovered a well-defined and, surpris

38 ible new approach for using 3D nucleic acid (PNA-DNA) nanostructures to control the assembly of funct

39 imprinted polymers and Peptide nucleic acid (PNAs) were developed as an attractive receptor with appl

40 e neutral backbone of peptide nucleic acids (PNA), our method is based on the design of low electroph

41 ch applications using peptide nucleic acids (PNA), we herein report the chemical synthesis of fluorin

42 study, we describe a peptide nucleic acids (PNA)-based approach to block the ability of HOTAIR to in

43 grafted with multiple peptide nucleic acids (PNAs) are crosslinked upon addition of the linker DNA.

44 Peptide nucleic acids (PNAs) are engineered uncharged oligonucleotide analogues

45 f chemically modified peptide nucleic acids (PNAs) as probes for qualitative and quantitative detecti

46 Peptide nucleic acids (PNAs) have also been extensively investigated as a surro

47 Peptide nucleic acids (PNAs) present a novel method to target intracellular pat

48 that triplex-forming peptide nucleic acids (PNAs) substituted at the gamma position plus stimulation

49 markable stability of peptide nucleic acids (PNAs) towards enzymatic degradation makes this class of

50 ing oligonucleotides, peptide nucleic acids (PNAs), minor groove binding polyamides, and--more recent

51 plore the assembly of peptide nucleic acids (PNAs), which are short DNA mimics that have an amide bac

52 of mRNA for peripheral lymph node addressin (PNAd) backbone proteins as well as enhanced expression o

53 ukocytes and with peripheral node addressin (PNAd) on high endothelial venules.

54 stability compared to that of unmodified aeg PNA, perhaps due to electronic effects.

55 PNAs as compared to 2-aminoethylglycyl (aeg)-PNA is better with complementary DNA (PNA:DNA) than with

56 how that the CT rate constant through an aeg-PNA bridging unit is twice the CT rate constant through

57 f 10 base pair long homoduplexes of DNA, aeg-PNA, gamma-PNA, and a heteroduplex of DNA/aeg-PNA with i

58 NA, gamma-PNA, and a heteroduplex of DNA/aeg-PNA with identical nucleobase sequence were measured.

59 ductance value, 0.06G0, was measured for aeg-PNA duplexes with a base stack linker.

60 bilized compared to duplexes of standard aeg-PNA.

61 (RCA), peanut (Arachis hypogaea) agglutinin (PNA), Maackia amurensis lectin II (MALII), and Ulex euro

62 and found that UEA-I and Peanut agglutinin (PNA) have a specific affinity for acinar cells in the mo

63 igen for binding sites on peanut agglutinin (PNA) that is immobilized on magnetic beads.

64 ffect of beta-Lact toward peanut agglutinin (PNA), a lectin strongly binding multivalent lactosides b

65 Because platelet-neutrophil aggregates (PNAs) can dysregulate inflammatory responses and contrib

66 sitive cells, we show that clusters of AID(+)PNA(+)GL7(+) Ag-specific GC B cells form within the B ce

67 majority of the pairwise network alignment (PNA) algorithms do not have MNA counterparts.

68 Peanut allergy (PNA) has been reported to be transferred to tolerant rec

69 perior to alpha(R/S)-am PNAs and alpha(R)-am PNA better than the alpha(S) isomer.

70 and stereo-preferred manner with gamma(S)-am PNA superior to alpha(R/S)-am PNAs and alpha(R)-am PNA b

71 th gamma(S)-am PNA superior to alpha(R/S)-am PNAs and alpha(R)-am PNA better than the alpha(S) isomer

72 The am-PNAs are demonstrated to effectively traverse the cell m

73 with the springtime Pacific/North American (PNA) index.

74 The Pacific North American (PNA) teleconnection has a strong influence on North Amer

75 eratures through the Pacific-North American (PNA) teleconnection pattern.

76 ng the doping of N-phenylnaphthalen-2-amine (PNA) or its derivatives into a crystalline 4,4'-dibromob

77 h guanidino PNAs being better than the amino PNAs in both cell lines.

78 and the guanidino PNAs are superior to amino PNAs.

79 g characterized by protein network analysis (PNA).

80 anced thermodynamic stability of PNA:DNA and PNA:RNA duplexes compared with DNA:DNA and DNA:RNA duple

81 Thus, UEA-I and PNA appear to be excellent lectins for pancreatic acinar

82 age pathway induced abrogation of MAL-II and PNA epitopes in Jurkat cells.

83 f persistent synaptic plasticity, PA-LTF and PNA-LTF, expressed at the same synapse become labile whe

84 ion, suggesting the influence of the PDO and PNA teleconnections.

85 Prometryn and PNA concentrations were significantly higher at the P-si

86 induced in mice following prenatal androgen (PNA) exposure.

87 ecules, a peptide nucleic acid-antennapedia (PNA-Antp), and a TFO (AG30), as well as two lines of tra

88 Furthermore, treatment with MECA-79 anti-PNAd mAb in vivo effectively blocks lymphocyte homing to

89 opropylglycine (apg) backbone (gamma-CF2-apg PNA) have been synthesized and evaluated for biophysical

90 igher compared to that of nonfluorinated apg PNA, with NIH 3T3 cells showing better permeability comp

91 ular uptake of the fluorinated gamma-CF2-apg PNAs in NIH 3T3 and HeLa cells was 2-3-fold higher compa

92 tituted methylene (azm)/butylene (azb) azido PNAs show that these analogues enhance the stability of

93 Using iodoacetate as the warhead, 8-base PNA strands, biotin, and streptavidin-coated magnetic be

94 Bifacial PNA binding was thus used to allosterically switch-on pr

95 (aminoethoxy)phenyl]pyrrolocytosine (BoPhpC)-PNA, we explored the subcellular localization of PNA ant

96 Due to the strand replacement of dsDNA by PNA, dsDNA can be directly detected without sequence-pre

97 e and the somites that is normally formed by PNA-binding proteins that block entry to medial pathways

98 Despite the replacement of MAdCAM-1 by PNAd in HEV endothelia, lymphocytes could efficiently ho

99 al as a mimic of nucleosides, carbohydrates, PNA, amino acids, and steroid analogs.

100 useful to design new biofunctional cationic PNA analogues that not only bind RNA better but also sho

101 embrane in 3T3 and MCF-7 cells, and cationic PNAs were found to be accumulated in the vicinity of the

102 (DeltaTm) of duplexes from modified cationic PNAs as compared to 2-aminoethylglycyl (aeg)-PNA is bett

103 The differential binding avidity of cationic PNAs was assessed by the displacement of DNA duplex inte

104 The cationic PNAs were found to be specific toward their complementar

105 is trend is reversed, and negatively charged PNA shows higher affinity for DNA and RNA than does posi

106 to DNA and RNA than does negatively charged PNA.

107 low salt concentrations, positively charged PNA binds more strongly to DNA and RNA than does negativ

108 for DNA and RNA than does positively charged PNA.

109 he target NAs hybridize to the complementary PNA-beads, the beads acquire negative charge and become

110 ncluding ionic strength, AgNP concentration, PNA concentration, and DNA strand mismatches.

111 w that anti-miR activity of a Cys-containing PNA is achieved by cell uptake through both clathrin-dep

112 escales and may help researchers de-convolve PNA pattern variation from other factors reflected in pa

113 shed transfection activity, and the free CPP-PNA was recovered after reduction of the azobenzene bond

114 monomers and biophysical studies of derived PNA oligomers containing fluorine in in the acetyl side

115 alogues enhance the stability of the derived PNA:DNA duplexes.

116 es a foundation for improving and developing PNAs conjugated to CPPs to better target intracellular p

117 The X-ray crystal structure of the GC di-PNA showed the occurrence of both stacking interactions

118 All 16 combinations of the very short di-PNA building blocks were synthesized and assayed for the

119 Only three guanine-containing di-PNAs-CG, GC and GG-could form ordered assemblies, as obs

120 bserved by electron microscopy, and these di-PNAs efficiently assembled into discrete architectures w

121 (aeg)-PNA is better with complementary DNA (PNA:DNA) than with complementary RNA (PNA:RNA).

122 As in DNA, PNA strands with complementary base sequences hybridize.

123 verage rationally designed nucleic acid (DNA-PNA) nanoscaffolds to guide polypeptide engineering.

124 le-stranded overhang, and studied A-form DNA-PNA duplexes to provide additional support for the propo

125 Biophysical characterization of the DNA-PNA-peptide complex was performed using gel electrophore

126 ata were used to generate a model of the DNA-PNA-protein complexes that show the negatively charged a

127 conjugates and (ii) rigid self-assembled DNA.PNA complexes.

128 ring of interconversions from a parallel DNA/PNA complex to an antiparallel RNA/PNA complex and from

129 omplex and from a PNA/PNA complex to two DNA/PNA complexes (i.e., double-duplex invasion).

130 spondences between networks (obtained during PNA or MNA) are not lost as new networks are added.

131 (eam)- and gamma(S)-ethyleneguanidino (egd)-PNA with two carbon spacers from the backbone.

132 ilability through endosomal escape, enabling PNA to inhibit miR-122 in vivo.

133 These general approaches to engineer PNA probes may be used to detect other RNA target sequen

134 ort the development of chemically engineered PNAs for the quantitative detection of HIV RNA at clinic

135 plication for determining MNAs from existing PNAs that addresses all the aforementioned challenges.

136 rm of nonassociative long-term facilitation (PNA-LTF) of the sensorimotor synapses in Aplysia califor

137 In conditions that favor PNA duplex formation, the warhead strand (carrying the t

138 al displacement of the target DNA and the Fc-PNA from the template DNA.

139 pens up a stem-loop template DNA with the Fc-PNA hybridized to its extruded 5' end and allows a DNA p

140 We also report the first PNA-PNA duplex containing mismatches.

141 FITC-PNA-Antp accumulates in nuclei of keratinocytes, and, af

142 The fluorescent PNA oligomers synthesized by their click reaction with p

143 report the chemical synthesis of fluorinated PNA monomers and biophysical studies of derived PNA olig

144 LC show higher hydrophobicity of fluorinated PNA oligomers, dependent on the number and site of the f

145 The backbone fluorinated PNAs, which are first in this class, when combined with

146 terminus, it is evident that the fluorinated PNAs have potential to emerge as a new class of PNA anal

147 Fluorous PNA analogues possessing fluorine as inherent part of am

148 ficantly enhanced for prometryn, but not for PNA and TBT, confirming site-specific effects on local p

149 ct of ionic strength on duplex stability for PNA having a charged backbone.

150 complementary double-strand plasmid to form PNA/ds-Pl triplex structure is the principle of target p

151 The triplex-forming PNAs are unique and potent compounds that hold promise a

152 re/E1 region, which binds to ds-Pl and forms PNA/ds-Pl structure.

153 Furthermore, PNA-inhibition of bacterial protein synthesis was select

154 modifications may have potential for future PNA-based antisense agents.

155 s twice the CT rate constant through a gamma-PNA bridging unit.

156 plementary gamma-peptide nucleic acid (gamma-PNA) probes conjugated to polystyrene beads have been re

157 air long homoduplexes of DNA, aeg-PNA, gamma-PNA, and a heteroduplex of DNA/aeg-PNA with identical nu

158 The live cell imaging of amino/guanidino PNAs demonstrated their ability to penetrate the cell me

159 ity than PNA:DNA duplexes, and the guanidino PNAs are superior to amino PNAs.

160 of cationic functional group, with guanidino PNAs being better than the amino PNAs in both cell lines

161 The uptake of fluorinated homooligomeric PNAs by HeLa cells was as facile as that of nonfluorinat

162 leic acid fluorescent in situ hybridization (PNA-FISH) and confocal microscopy.

163 eic acid-fluorescence in situ hybridization (PNA-FISH) probes, P-Ca726 (targeting a novel region of t

164 molecules were introduced to the hybridized PNA/DNA heteroduplexes by employing phosphate-zirconium-

165 the free phosphate groups of the hybridized PNA/DNA heteroduplexes merely through one-step conjugati

166 ated by EDC and imidazole, of the hybridized PNA/DNA heteroduplexes, and then they were exploited as

167 lectins, including WGA, Con A, UEA-I, GS-II, PNA and SBA, were monitored in real time and without lab

168 and the Pi electrons of the peptide bonds in PNA.

169 w insight into the role of electrostatics in PNA binding, and demonstrates that introduction of negat

170 rs apposing GnRH neurons was even greater in PNA mice (56%).

171 ve GABAergic but not glutamatergic inputs in PNA mice.

172 lf-aggregation, which is a common problem in PNA due to its hydrophobic nature.

173 colocalization with progesterone receptor in PNA animals compared with controls.

174 investigate the role of charge repulsion in PNA binding by synthesizing PNA strands having negativel

175 a role for S. aureus alpha-hemolysin-induced PNA formation in alveolar capillary destruction in hemor

176 s mechanism; rather, alpha-hemolysin-induced PNA formation was solely platelet P-selectin dependent.

177 Inherently, PNA:RNA duplexes have higher stability than PNA:DNA dupl

178 We were also able to use our iodoacetyl-PNA:PNA-biotin probe for retrieval and identification of

179 The Yeast Traffic Light PNA FISH kit (YTL) correctly identified Candida spp. in

180 Perfectly-matched PNA-RNA hybrids remained intact and were detected using

181 self-assembly of cysteine conjugated 20-mer PNA oligomer probe, complementary to the HCV core/E1 reg

182 an a 6-mer and proceeded fastest for a 5-mer PNA probe.

183 Herein, we demonstrate that a 9-mer PNA forms a sequence-specific PNA-RNA triplex with a dis

184 (pH approximately 6) tumor microenvironment, PNAs were conjugated to pH-low insertion peptide (pHLIP)

185 n the design of low electrophoretic mobility PNA probes, which do not focus under isotachophoresis (I

186 ation (PDO) and Pacific North American mode (PNA).

187 ticorrelated isotopic response to the modern PNA.

188 antitative properties of chemically modified PNA for nucleic acid detection and provides a platform f

189 The modified PNAs are shown to stabilize duplexes with complementary

190 Moreover, PNA-purified acinar cells were less contaminated with me

191 ellular requirements for transferring murine PNA.

192 An applied electric field guides these NA-PNA-beads toward the pipet tip, which they obstruct, lea

193 butyltin (TBT) and N-phenyl-2-naphthylamine (PNA) were quantified in short-term toxicity tests and ex

194 t midcontinental climate reflecting negative PNA-like conditions occurred during the Medieval Climate

195 ells was as facile as that of nonfluorinated PNA.

196 Herein, novel PNA-based fluorogenic biosensors have been designed and

197 icant practical and diagnostic advantages of PNA probes over their DNA counterparts for FISH and indi

198 e advantage of both the inherent benefits of PNA and the multitude of charge-based delivery technolog

199 s have potential to emerge as a new class of PNA analogues for applications in functional inhibition

200 The combination of PNA, RCA, and DNAzymes allows for sequence-specific and

201 leads to the formation of a high density of PNA/DNA heteroduplexes on the electrode surface for the

202 novel role for B cells in the development of PNA and provide evidence that long-lived anti-peanut IgE

203 is anticipated to enable the development of PNA therapeutics that take advantage of both the inheren

204 natural nucleobases enables the formation of PNA-RNA triplexes.

205 we report on DNA-templated cross-linking of PNA probes as a way to preserve genetic information for

206 we explored the subcellular localization of PNA anti-miRs and our data suggest that anti-miR targeti

207 Holocene, provide evidence for modulation of PNA over multiple timescales and may help researchers de

208 These findings suggest the persistence of PNA-like climate variability throughout the mid- and lat

209 We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide n

210 The enhanced thermodynamic stability of PNA:DNA and PNA:RNA duplexes compared with DNA:DNA and D

211 antibody does not result in the transfer of PNA in NA recipients, demonstrating that anti-CD20 antib

212 al requirements for the adoptive transfer of PNA.

213 Induction of PNAd in mutant PPs requires lymphotoxin beta receptor ac

214 findings are valuable for further design of PNAs and other oligonucleotides as potent anti-miR agent

215 oxins from MRSA could stimulate formation of PNAs in human whole blood.

216 The remarkable stability of PNAs toward enzymatic degradation makes this class of mo

217 sensitive label-free DNA biosensor based on PNA probes immobilized on a gold electrode was used to d

218 In conjunction with our previous work on PNAs fluorinated in backbone and at N-terminus, it is ev

219 vides a platform for studying and optimizing PNA probes prior to incorporation into new technological

220 L-selectin N138G after it engages PSGL-1 or PNAd.

221 lated to the Pacific North American pattern (PNA) using a 2100-year-long multi-proxy lake-sediment re

222 lation (AO), Pacific-North American Pattern (PNA), North Pacific Index (NPI), El Nino-Southern Oscill

223 This first report on pHLIP-PNA lncRNA targeting solid tumors in vivo suggests a nov

224 esistant ovarian tumor xenografts with pHLIP-PNA constructs suppressed HOTAIR activity, reduced tumor

225 addition, we present the preparation of poly-PNA nanoparticles from amphiphilic block copolymers and

226 tion of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metath

227 fy mean states of more negative and positive PNA-like climate during the mid- and late Holocene, resp

228 250-1350 CE corresponded with drier positive PNA-like conditions, culminating in the staggered abando

229 n accelerating tendency towards the positive PNA state since the mid-1850s, but much less is known ab

230 lacement is introduced as a method to purify PNA-protein conjugates.

231 mensional plasmonic nanostructure array (Q3D-PNA) SERS substrate to detect fructose.

232 mensional plasmonic nanostructure array (Q3D-PNA) to enable an exceptionally sensitive and reproducib

233 he crystal structures of fluorinated racemic PNA monomers reveal interesting base pairing of enantiom

234 s in a 200-nm mucin segment to be 4 for RCA, PNA, and UEA, and 1.8 for MALII.

235 6, and 26 aJ was determined on pPGM for RCA, PNA, and UEA.

236 Here we reconstruct PNA-like climate variability during the mid- and late Ho

237 uced into a surface PNA probe and a reporter PNA probe to achieve quantitative detection for HIV RNA

238 For the reporter PNA probe, 25 biotin groups were attached to promote str

239 We found that the resulting PNA-aminoglucosamine conjugate is stable under acidic co

240 uplex and the PNA-RNA heteroduplexes reveals PNA's intrinsic structural properties, shedding light on

241 y DNA (PNA:DNA) than with complementary RNA (PNA:RNA).

242 present the first crystal structures of RNA-PNA duplexes.

243 allel DNA/PNA complex to an antiparallel RNA/PNA complex and from a PNA/PNA complex to two DNA/PNA co

244 With SMAL, PNAs can be combined rapidly to obtain an MNA.

245 from hyposialylated glycans, used WGA, SNA, PNA, Jacalin, HPA, and VVA, indicating glomerular hyposi

246 r the EIS assay, we used a bla(NDM)-specific PNA probe that was designed by applying a new approach t

247 e that a 9-mer PNA forms a sequence-specific PNA-RNA triplex with a dissociation constant of less tha

248 A fluorescent sense strand PNA probe binding to RNAi duplex guide strands was coupl

249 Strong PNA formation was stimulated by toxins from stationary p

250 ere systematically introduced into a surface PNA probe and a reporter PNA probe to achieve quantitati

251 For the surface PNA probe, four cyclopentane groups were incorporated to

252 rge repulsion in PNA binding by synthesizing PNA strands having negatively or positively charged side

253 850s, but much less is known about long-term PNA variability.

254 hybridize with even greater efficiency than PNA conjugated to a short peptide.

255 PNA:RNA duplexes have higher stability than PNA:DNA duplexes, and the guanidino PNAs are superior to

256 Serial blood sampling confirmed that PNA elicits increased LH pulse frequency and impaired pr

257 id hormone receptor expression revealed that PNA mice had 59% fewer progesterone receptor-expressing

258 The PNA method enables pharmacokinetic analysis of RNAi trig

259 The PNA oligomers containing fluorinated bases form hybrids

260 The PNA-FISH Yeast Traffic Light assay was performed on 54 c

261 The PNA-peptides were found to bind to the preassembled DNA

262 The PNA-proteins were assembled within 2 min at room tempera

263 by using immunofluorescent staining and the PNA-Fish assay, respectively.

264 A comparison of the PNA homoduplex and the PNA-RNA heteroduplexes reveals PNA's intrinsic structura

265 The self-assembly is mediated by the PNA-DNA complexation, which results in the formation of

266 As in DNA, the PNA duplex dissociates at moderately elevated temperatur

267 luorescence and yellowish-green RTP from the PNA-doped DBBP crystals was also confirmed by Commission

268 a change in therapy in 29% of cases had the PNA-FISH result been available to the clinician.

269 PPy, a conducting polymer, to immobilize the PNA probes.

270 the hydrophilic tetrahydrofuran ring in the PNA structure reduces nonspecific interactions and self-

271 rged side chains to be incorporated into the PNA backbone without reducing duplex stability with DNA

272 e excellent hybridization selectivity of the PNA CPs.

273 A comparison of the PNA homoduplex and the PNA-RNA heteroduplexes reveals PN

274 field that broadens the energy levels of the PNA nucleobases.

275 h the hybridization quality and yield of the PNA probes were higher than those of the DNA probes.

276 In FCM-based comparisons of the PNA probes, P-Ca726 was found to be highly specific, sho

277 traperitoneal or intradermal delivery of the PNA-Antp conjugate.

278 ytes, and, after intradermal delivery of the PNA-Antp, chromosomally modified, keratin 5-positive bas

279 After assembly of the PNA-DNA construct a padlock probe is circularized on the

280 developed a model for the arrangement of the PNA-peptides inside the DNA nanocage.

281 Type I hydrogel is formed via the PNA/DNA double-helix hybridization.

282 nique (19)F resonance shifts in NMR when the PNA was targeted to a complementary antiparallel DNA, an

283 These PNA blockers will facilitate taxonomic profiling of the

284 The performance of these PNA probes was compared quantitatively against that of D

285 Thiolated PNA molecules are firstly self-assembled onto gold elect

286 When conjugated to PNA and incorporated into the DNA nanocage, the cytochro

287 e chains is not significantly detrimental to PNA binding affinity at physiological ionic strength.

288 al crest cells and pigment localized only to PNA-free areas.

289 intrinsic fluorescence, thiazole orange (TO)-PNA and [bis-o-(aminoethoxy)phenyl]pyrrolocytosine (BoPh

290 is induced as the driving force to transport PNA-beads harboring target miRs to the tip of the pore (

291 Two PNA probe lengths were investigated and the longer probe

292 gonucleotide triple-helix that comprises two PNA sequences and one DNA.

293 With the aid of two PNA analogues having intrinsic fluorescence, thiazole or

294 Of the two, PNA blockers were the only efficient blocking strategy,

295 vity was facilitated by the use of uncharged PNA probes and large 16S rRNA target and investigations

296 lectrostatic repulsion between the uncharged PNA backbone and negatively charged DNA or RNA backbone.

297 curacy for anthrax DNA can be achieved using PNA probes with suitable chemical components designed in

298 binding to the target HIV RNA compared with PNA without the cyclopentanes.

299 aspect of HEVs, thus replacing MAdCAM-1 with PNAd.

300 ng ovarian and breast cancer cell lines with PNAs decreased invasion and increased chemotherapy sensi