ライフサイエンスコーパス: PP1

1 PP1 activity is necessary for the induction of long-term

2 PP1 also associates with NCX1; however, the molecular ba

3 PP1 binds multiple motifs of DNA-PKcs, regulates DNA-PKc

4 PP1 did not change infarct size, electrocardiographic pa

5 PP1 first reactivates PP2A-B55; this enables PP2A-B55 in

6 PP1 has been found to be essential in Plasmodium falcipa

7 PP1 inhibition involves metal center oxidation rather th

8 PP1 interaction motifs within the Rif1 N-terminal domain

9 PP1 nuclear targeting subunit (PNUTS) is a PP1 targeting

10 PP1 pharmacological inhibitors would thus not be able to

11 PP1 plays critical roles in many essential physiological

12 PP1 raised Cx43 expression by 69% in the scar border (p

13 PP1 recruitment sets one or more critical thresholds for

14 PP1 recruitment to Cut12 sets a threshold for Polo's fee

15 PP1 recruitment to human, mitotic PP2A-B56 holoenzymes a

16 PP1 treatment restored active c-Src to sham levels at th

17 PP1-mediated dephosphorylation of Mps1 occurs at kinetoc

18 PP1-treated mice had restored conduction velocity at the

19 PP1/PP2A phosphatases counteracted this gradient and pro

20 regulators governing protein phosphatase 1 (PP1) activity have crucial functions because their delet

21 interactions between protein phosphatase 1 (PP1) and its regulator CPI-17, resulted in a reversible

22 sal in budding yeast, protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) activities have e

23 domain important for protein phosphatase 1 (PP1) binding.

24 o show that host cell protein phosphatase 1 (PP1) controls VP30 dephosphorylation because expression

25 The serine-threonine protein phosphatase 1 (PP1) deactivates this pathway whereas prolonging eIF2alp

26 The serine/threonine protein phosphatase 1 (PP1) dephosphorylates hundreds of key biological targets

27 2 harbors a bipartite protein phosphatase 1 (PP1) docking domain.

28 proach, a recombinant protein phosphatase 1 (PP1) has been conjugated to MPs via coordination chemist

29 induced activation of protein phosphatase 1 (PP1) in CRMP2 regulation.

30 nd in Drosophila that Protein Phosphatase 1 (PP1) inactivates Mps1 by dephosphorylating its T-loop.

31 tment of GCs with the protein phosphatase 1 (PP1) inhibitor tautomycin increased phosphorylation of Y

32 (PPP1R1A) is a potent protein phosphatase 1 (PP1) inhibitor; however, its role in tumor development i

33 e protein phosphatase protein phosphatase 1 (PP1) is known to play an important role in learning and

34 In particular, protein phosphatase 1 (PP1) is recruited to a DSB-mimicking substrate in Xenopu

35 genetic inhibition of protein phosphatase 1 (PP1) prevented HTTex1 aggregation in both human cells an

36 ly phosphorylates the protein phosphatase 1 (PP1) regulatory subunit myosin phosphatase targeting sub

37 omprising a catalytic protein phosphatase 1 (PP1) subunit in complex with a PPP1R15-type regulatory s

38 Repo-Man is a protein phosphatase 1 (PP1) targeting subunit that regulates mitotic progressio

39 eriphery and recruits protein phosphatase 1 (PP1) to chromatin at anaphase onset, in a similar manner

40 ting serine/threonine protein phosphatase 1 (PP1) to dephosphorylate eIF2alpha.

41 domain (CTD) recruits protein phosphatase 1 (PP1) to kinetochores to promote timely anaphase onset [1

42 Ska complex recruits protein phosphatase 1 (PP1) to kinetochores.

43 IGF-1R by activating protein phosphatase 1 (PP1) to promote dephosphorylation of inhibitory Ser/Thr

44 romote the binding of protein phosphatase 1 (PP1) to the p21(CIP1) promoter, leading to reduced H3S10

45 at functional CK2 and protein phosphatase 1 (PP1) were selectively tethered to the KCNQ2 subunit.

46 ed the interaction of protein phosphatase 1 (PP1) with the SR protein splicing factor (SRSF1) to unde

47 dylinositol 3-kinase, protein phosphatase 1 (PP1), and dynamin GTPase.

48 tor, whereas purified protein phosphatase 1 (PP1), dephosphorylated Thr-450 in vitro.

49 t Gwl associates with protein phosphatase 1 (PP1), particularly PP1gamma, which mediates the dephosph

50 d) and the associated protein phosphatase 1 (PP1), requiring NMDARcd movement, and persistently reduc

51 ized Phactr family of protein phosphatase 1 (PP1)-and actin-binding proteins.

52 function by directing Protein Phosphatase 1 (PP1)-mediated dephosphorylation of the MCM complex.

53 s dephosphorylated by protein phosphatase 1 (PP1).

54 regulatory subunit of protein phosphatase 1 (PP1).

55 ctivated inhibitor of protein phosphatase 1 (PP1).

56 ting serine/threonine protein phosphatase 1 (PP1).

57 mitosis by modulating protein phosphatase 1 (PP1).

58 ive for a single PPP, protein phosphatase 1 (PP1/PPP1C).

59 Protein phosphatase-1 (PP1) activity is important for many calcium-dependent ne

60 mechanism mediated by protein phosphatase-1 (PP1) and dual specificity phosphatase-1 (DUSP1).

61 Protein phosphatase-1 (PP1) controls many processes in eukaryotic cells.

62 Serine/threonine protein phosphatase type-1 (PP1), a major phosphatase in the heart, consists of a ca

63 1NA-PP1 failed to effectively dock within WT PKCdelta.

64 yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1NA-PP1) and 1-(tert-butyl)-3-(2-methylbenzyl)-1H-pyrazolo[3

65 onor and for its selective inhibition by 1NA-PP1 and 2MB-PP1.

66 The adenine rings of 1NA-PP1 and 2MB-PP1 matched the adenine ring of ATP when doc

67 ase 1/2), p38MAPK, protein phosphatase 1/2A (PP1/2A), and reactive oxygen species (ROS) were not invo

68 ld be blocked by a protein phosphatase 1/2A (PP1/PP2A) inhibitor and was partly blocked by a NMDA rec

69 yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2MB-PP1) but not by other 4-amino-5-(4-methylphenyl)-7-(t-bu

70 The adenine rings of 1NA-PP1 and 2MB-PP1 matched the adenine ring of ATP when docked in AS PK

71 its selective inhibition by 1NA-PP1 and 2MB-PP1.

72 ation when bound by the adenosine analog 2NM-PP1 in vitro and in vivo.

73 erapeutics that selectively target the Ki-67:PP1 and RepoMan:PP1 holoenzymes.

74 and lower arrhythmic inducibility (PP3: 71%, PP1: 35%, p < 0.05) than PP3 mice.

75 defined by a covalent bond between TTN and a PP1-specific cysteine residue, Cys127.

76 st that I-2, despite its assumed action as a PP1 inhibitor, is a positive regulator of PP1 function i

77 SCRIB functions as a PP1-regulatory protein and antagonizes SHOC2-mediated RA

78 SHOC2 functions as a PP1-regulatory protein and as an effector of MRAS.

79 inal extension on yeast eIF2gamma contains a PP1-binding motif (KKVAF) that enables eIF2gamma to pull

80 ctivation of PP2A-B56 by dephosphorylating a PP1-docking site in PP2A-B56, thereby promoting the recr

81 ity to facilitate centrosome separation in a PP1- and PP2A-independent manner.

82 PP1 nuclear targeting subunit (PNUTS) is a PP1 targeting protein that, with PP1, plays a central ro

83 30 dephosphorylation because expression of a PP1-binding peptide cdNIPP1 increased VP30 phosphorylati

84 horylation through selective disruption of a PP1-PPP1R15A holophosphatase complex.

85 he waning of stress responses and requires a PP1 catalytic subunit and a regulatory subunit, PPP1R15A

86 Ska1 lacking its CTD fused to a PP1-binding peptide or fused directly to PP1 rescues mit

87 4) is induced downstream of ATF4, binds to a PP1-targeting subunit GADD34 at the endoplasmic reticulu

88 1alpha (PP1alpha) interacts with BRCA1 via a PP1-binding motif (898)KVTF(901), and can dephosphorylat

89 cal, yet novel mechanism, interacting with a PP1 pocket that is engaged only by these two PP1 regulat

90 tase targeting subunit 1 (MYPT1) to activate PP1 associated with the IGF1R-IRS1 complex.

91 Activated PP1 is sufficient to dephosphorylate at least four IRS1

92 we demonstrate that Rif1 is a high-affinity PP1 adaptor, able to out-compete the well-established PP

93 , whereas WT PKCdelta was insensitive to all PP1 analogs.

94 ed regulation between CaMKII (activator) and PP1 (inhibitor) and then the model performance was valid

95 ficance of the interaction between BRCA1 and PP1, and indicate that the K898E variant may render carr

96 urning assays with inhibitions of CaMKII and PP1.

97 ent, which is tonically regulated by CK2 and PP1 anchored to the KCNQ2 channel complex.

98 cell cycle-dependent association of Gwl and PP1, Gwl and PPP1R3B dissociate in M phase.

99 on current (I(Ks)) and recruits both PKA and PP1 to regulate I(Ks) phosphorylation and gating.

100 Thus, PNUTS and PP1 together fine-tune the dynamic phosphorylation of DN

101 ylated sites and is accomplished by PP2A and PP1 serine/threonine protein phosphatases.

102 ubR1-associated PP2A, unlike KNL1-associated PP1, plays a significant role in end-on conversion.

103 At PP1 and PP2, a high proportion of Hg escapes from the el

104 l transport through the activation of axonal PP1 and GSK3beta in the axon.

105 itated with PP1-alpha but not with PP1-beta, PP1-gamma1, or PP2A.

106 dict how these PP1 interacting proteins bind PP1 from sequence alone is still missing.

107 n a quarter of the known PP1 regulators bind PP1.

108 data also reveal that Ki-67 and RepoMan bind PP1 using an identical, yet novel mechanism, interacting

109 NA recognition motif 1 (RRM1) in SRSF1 binds PP1 and represses its catalytic function through an allo

110 cruitment requires the Ska1 CTD, which binds PP1 in vitro and in human HeLa cells.

111 ents by MPF and the NIMA kinase Fin1 blocked PP1(Dis2) recruitment, thereby promoting recruitment of

112 lex to kinetochores where Ska1 can bind both PP1 and microtubules to promote anaphase onset.

113 lation of eIF2alpha by interacting with both PP1 and eIF2alpha through independent binding motifs.

114 PPP1R3B bridges PP1 and Gwl association and promotes Gwl Ser-883 dephosp

115 arious steps, including dephosphorylation by PP1 phosphatases, which induces their activation.

116 n of HTTex1 single phosphorylation events by PP1 could constitute an efficient and direct molecular t

117 ibutor to suppression of memory formation by PP1 may provide a novel therapeutic target for memory-re

118 The inhibition of Src by PP1, as well as the perturbation of RhoA activity and me

119 measles V protein is mediated by a conserved PP1-binding motif in the C-terminal region of the V prot

120 enzymes and the sequences of these conserved PP1-docking motifs suggest that PP1 regulates PP2A-B55 a

121 Ska1 fusion to catalytically dead PP1 mutant does not rescue and shows dominant negative e

122 The R658C mutation decreases PP1 binding and eIF2alpha dephosphorylation and results

123 1R3B) as a targeting subunit that can direct PP1 activity toward Gwl.

124 However, how these proteins direct PP1 specificity and the ability to predict how these PP1

125 remains to be determined how GADD34 directs PP1 to specifically dephosphorylate eIF2alpha.

126 g PP1, how they distinguish between distinct PP1 isoforms and how the assembly of these two holoenzym

127 hat, in contrast to the paradigm of distinct PP1-targeting or regulatory subunits, the unique N termi

128 P-32 to dampen Ca(2+) release by eliminating PP1 inhibition to enable it to dephosphorylate the InsP3

129 hat in anaphase, when the spindle elongates, PP1/Repo-Man promotes the accumulation of NuMA at the co

130 vel probes targeting single PPPs, especially PP1.

131 or, able to out-compete the well-established PP1-inhibitor I2 in vitro.

132 During mitotic exit, PP1-dependent dephosphorylation of Gwl Ser-883 occurs pr

133 lso partially in agreement with the extended PP1-binding motif K(V/I)FF-X5-8Phi1Phi2-X8-9-R.

134 hrough a mechanism involving competition for PP1 molecules within the same macromolecular complex.

135 ra protein kinase is a critical function for PP1.

136 ntified a functional KVXF consensus site for PP1 binding in the N-terminal tail of KCNQ2 subunit: mut

137 Consequently, GADD34-PP1 holoenzymes are unable to dephosphorylate RIG-I and

138 n response to TNF, and this increased GADD34-PP1 phosphatase activity, dephosphorylating eukaryotic t

139 a adaptation pathway by inhibition of Gadd34-PP1 phosphatase with guanabenz protects oligodendrocytes

140 association of PP1 inhibitor I-1 with GADD34-PP1 holoenzymes, thereby inhibiting phosphatase activity

141 o signalling triggers assembly of the GADD34/PP1 complex in a negative feedback loop to inhibit Yap a

142 tion of the eIF2alpha holophosphatase GADD34:PP1, increases the phosphorylation of eIF2alpha in Schwa

143 tream aspects of synaptic signaling, but how PP1 activity is controlled in different forms of synapti

144 However, how PP1 is activated is not clear.

145 However, how PP1 might be regulated in memory is still not clear.

146 Together, these results identified PP1-alpha as a regulator of AS160 Thr(642) and Ser(588)

147 Moreover, we identified PP1 regulatory subunit 3B (PPP1R3B) as a targeting subun

148 This identifies PP1 antagonism as a mechanism employed by paramyxoviruse

149 In addition, we identify PP1/NIPP1 as a novel molecular compass that controls dir

150 in PP1c-R-subunit interactions, which impair PP1 targeting to proteins involved in electrical and Ca(

151 s expressing a mutant V protein deficient in PP1 binding is unable to antagonize MDA5 and is growth i

152 Subcellular heterogeneity in PP1 activity and downstream protein phosphorylation in A

153 ur work thus reveals a novel calcium-induced PP1 activation pathway critical for homeostatic synaptic

154 that the major effect of RSK-2 is to inhibit PP1 rather than to directly phosphorylate YB-1 on Ser(10

155 to an analog of the common kinase inhibitor PP1 (Csk(AS)).

156 erived from the promiscuous kinase inhibitor PP1 to search for analogs that could potentially target

157 sed by L-NAME, wortmannin, the Src inhibitor PP1, and tumor necrosis factor-alpha.

158 We show that a potent Src inhibitor, PP1, regulates expression of genes involved in the G1 to

159 MI mice were treated with c-Src inhibitors (PP1 or AZD0530), PP3 (an inactive analogue of PP1), or s

160 Phosphorylated DARPP-32 inhibits PP1, enhancing InsP3R phosphorylation and Ca(2+) release

161 4 at the endoplasmic reticulum, and inhibits PP1 activity to increase eIF2alpha phosphorylation and A

162 B kinase (Cdk1 also known as Cdc2) inhibits PP1 activity, but declining cyclin B levels later in mit

163 (low dose inhibits PP2A; high dose inhibits PP1) delayed AS160 Ser(588) (both doses) and Thr(642) (h

164 e identified PPP1R11, whose product inhibits PP1, as a target of MIR34A.

165 relationships between the WNK/SPAK and IRBIT/PP1 sites in the regulation of the transporters.

166 hway setting the resting state and the IRBIT/PP1 pathway setting the stimulated state.

167 predict how more than a quarter of the known PP1 regulators bind PP1.

168 Like PP1, G-actin associated with the functional core of PPP1

169 tivities of major protein phosphatases, like PP1 and PP2A, appear directly or indirectly repressed by

170 ortex at mid anaphase, kinetochore-localized PP1-Sds22 helps to break cortical symmetry by inducing t

171 Repo-Man/PP1 regulates the formation of heterochromatin, dephosph

172 After mitosis, Repo-Man/PP1 remains associated with chromatin but its function i

173 Meanwhile PP1, which functions as a phosphatase, is found to media

174 stasis by activating Yap through a RhoA/MYPT-PP1 pathway.

175 ther show that platelets activate RhoA-MYPT1-PP1-mediated YAP1 dephosphorylation and promote its nucl

176 ted by the ATP analogue 1-Naphthyl-PP1 (1-Na-PP1).

177 exclusively expressing the as-AurA with 1-Na-PP1, we discovered that Aurora A is required for central

178 lly inhibited by the ATP analogue 1-Naphthyl-PP1 (1-Na-PP1).

179 pothesized that a direct and functional NCX1-PP1 interaction is a prerequisite for pSer-68-PLM dephos

180 ase (pat1-as2) by adding the ATP analog 1-NM-PP1 in G1-arrested cells allows the induction of synchro

181 87B or depletion of a conserved noncatalytic PP1 phosphatase subunit Sds22 leads to defects in p-moes

182 , okadaic acid (OA), and fostriecin, but not PP1 selective inhibitors, NIPP-1, and inhibitor 2, block

183 Furthermore, knockdown of PP1-alpha but not PP1-beta or PP1-gamma1 by small interfering RNA caused g

184 ur findings, we propose that Rif1 is a novel PP1 substrate targeting subunit that counteracts DDK-med

185 suggesting that cytoplasmic accumulation of PP1 induces EBOV transcription.

186 timulation in neurons leads to activation of PP1 through a mechanism involving inhibitory phosphoryla

187 P1 or AZD0530), PP3 (an inactive analogue of PP1), or saline.

188 nase Raf-1, which induces the association of PP1 inhibitor I-1 with GADD34-PP1 holoenzymes, thereby i

189 ermore, TNFalpha enhances the association of PP1 with GABA(A)R beta3 subunits and dephosphorylates a

190 calcineurin were involved in the control of PP1 activity in response to synaptic NMDA receptor stimu

191 Depletion of PP1 impairs NHEJ in both Xenopus egg extracts and human

192 In mitosis, RNAi-induced depletion of PP1-87B or depletion of a conserved noncatalytic PP1 pho

193 g-term depression, whereas downregulation of PP1 activity is required for the normal induction of lon

194 e, p37 negatively regulates this function of PP1, resulting in lower cortical NuMA levels and correct

195 unclear how GLC7, the functional homolog of PP1 in yeast, is recruited to dephosphorylate eIF2alpha.

196 However, identification of PP1 inhibitor-2 as a critical contributor to suppression

197 Furthermore, we found that inhibition of PP1/PP2A decreased HCN1 surface expression, whereas tyro

198 Furthermore, knockdown of PP1-alpha but not PP1-beta or PP1-gamma1 by small interf

199 study, we aimed to analyze the mechanisms of PP1 targeting to the NCX1-pSer-68-PLM complex and hypoth

200 Unexpectedly, PNUTS blocks one of PP1's substrate binding grooves while leaving the active

201 The staged recruitment of PP1 (the Dis2 isoform) to the regulatory subunits of the

202 2A-B56, thereby promoting the recruitment of PP1.

203 ills a major gap regarding the regulation of PP1 in synaptic plasticity.

204 igned to impede MYPT1-mediated regulation of PP1, also decreased TEER in a reversible and non-toxic m

205 a PP1 inhibitor, is a positive regulator of PP1 function in memory formation.

206 ibitor-2 (I-2) is an endogenous regulator of PP1 in hippocampal and cortical neurons.

207 subunit (PNUTS), an inhibitory regulator of PP1, is also recruited to DNA damage sites to promote NH

208 E7-03, that targeted a non-catalytic site of PP1 and increased VP30 dephosphorylation.

209 a cytoplasm-shuttling regulatory subunit of PP1, and increased EBOV transcription, suggesting that c

210 ncreased auto-dephosphorylation of Thr320 of PP1.

211 es and microtubules and, instead, depends on PP1 phosphatase and its regulatory subunit Sds22.

212 taining the K(I/V)FF motif, had no effect on PP1 activity in an in vitro assay.

213 Among them, we focus here on PP1.

214 ially Rb, by blocking their binding sites on PP1, insights that are providing strategies for selectiv

215 , knockdown of PP1-alpha but not PP1-beta or PP1-gamma1 by small interfering RNA caused greater AS160

216 Other PP1 analogs failed to interact with either AS PKCdelta o

217 Other PP1 targets distant from the endoplasmic reticulum are u

218 ning cyclin B levels later in mitosis permit PP1 to auto-reactivate.

219 Phosphatase PP1 induced calcium desensitization in control and CRT-t

220 isoforms of the ser/thr protein phosphatase PP1, is a mammalian-specific splice variant of the Ppp1c

221 ivities of SRPK1 and the protein phosphatase PP1, thereby regulating the phosphoryl content of the RS

222 L5) and serine/threonine-protein phosphatase PP1-beta-catalytic subunit (PPP1CB) in CLL.

223 ols cortical NuMA levels via the phosphatase PP1 and its regulatory subunit Repo-Man, but it acts ind

224 o-dependent expulsion of type-1-phosphatase (PP1) from the spindle pole by Fin1 (NIMA) kinase ensures

225 The analysis of protein phosphatase (PP1) activity suggested that the degradation byproducts

226 Type I protein phosphatase (PP1), in particular, has been shown to constrain learnin

227 nal influence on type I protein phosphatase (PP1), likely resulting in negative regulation of cAMP/ca

228 eletal muscle serine/threonine phosphatases (PP1, PP2A, PP2B, and PP2C) on AS160 dephosphorylation.

229 te or purified G-actin, which joined PPP1R15-PP1 to form a stable ternary complex.

230 Surprisingly, PPP1R15-PP1 binary complexes reconstituted in vitro lacked subst

231 The abundance of the ternary PPP1R15-PP1-G-actin complex was responsive to global changes in

232 ditional conserved components of the PPP1R15-PP1 phosphatase identified monomeric G-actin.

233 nolide, destabilised the endogenous PPP1R15A-PP1 complex.

234 eutic value of inhibition of the PKA/PPP1R1A/PP1 pathway in the treatment of primary and metastatic E

235 kinase and phosphatase pathway, PKA/PPP1R1A/PP1, in ES pathogenesis.

236 rus interact with PP1alpha/gamma, preventing PP1-mediated dephosphorylation of MDA5 and thereby its a

237 osome movement, may instead serve to promote PP1 recruitment to kinetochores fully attached to spindl

238 polymerization of the major Phloem Protein1 (PP1) and PP2, which correlated with a decline in carbony

239 henyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP1) analogs tested, whereas WT PKCdelta was insensitive

240 form mitotic exit phosphatases by recruiting PP1, how they distinguish between distinct PP1 isoforms

241 complex, specifically the Ska1 CTD, recruits PP1 to kinetochores to oppose spindle checkpoint signali

242 selectively target the Ki-67:PP1 and RepoMan:PP1 holoenzymes.

243 tein kinase II (CaMKII), a process requiring PP1 activity.

244 m different systems have suggested that Rif1-PP1 interaction is conserved and has important biologica

245 Disruption of RRM1-PP1 interactions reduces the phosphorylation status of t

246 n velocity at the scar border (PP3: 32 cm/s, PP1: 41 cm/s, p < 0.05) and lower arrhythmic inducibilit

247 Recombinant inhibitor-2 protein (a selective PP1 inhibitor) delayed AS160 dephosphorylation on both p

248 Since PP1 interaction sites are evolutionarily conserved withi

249 Overexpression of the sole PP1, Glc7, in budding yeast, Saccharomyces cerevisiae, i

250 PKA phosphorylation at Thr35, and subsequent PP1 binding and inhibition, was required for PPP1R1A-med

251 e regulatory subunits GADD34 and CReP target PP1 to dephosphorylate eIF2alpha; however, as there are

252 Moreover, targeting PP1 mRNA by shRNA resulted in the overexpression of SIPP

253 Our findings suggest that targeting PP1 with small molecules is a feasible approach to achie

254 microtubule-dependent polarity landmark Tea4-PP1.

255 ally coimmunoprecipitated with a Tetrahymena PP1 ortholog (Ppo1p).

256 evealed that phosphatase activity other than PP1 continuously suppresses AurA(Thr-295) phosphorylatio

257 onfirm that Rif1 interacts with PP1 and that PP1 prevents premature Mcm4 phosphorylation.

258 Our previous work has elucidated that PP1 inhibitor-2 (I-2) is an endogenous regulator of PP1

259 In this study, we found that PP1 inhibitor-2 (I-2) is phosphorylated at serine 43 (S4

260 f this study was to test the hypothesis that PP1 is dysregulated in paroxysmal atrial fibrillation (P

261 tructure of the PP1:TTN complex reveals that PP1 selectivity is defined by a covalent bond between TT

262 ariety of molecular techniques, we show that PP1 catalytic subunit (PP1c) co-localized, co-fractionat

263 Previous studies suggest that PP1 is dysregulated in AF, but the mechanisms are unknow

264 Our findings suggest that PP1 modulates HTTex1 aggregation by regulating phosphory

265 se conserved PP1-docking motifs suggest that PP1 regulates PP2A-B55 and PP2A-B56 activities in a vari

266 The PP1 interaction with the measles V protein is mediated b

267 characterized AGC-family kinase Ypk3 and the PP1 phosphatase Glc7, whereas TORC2 regulates phosphoryl

268 composed of the AMPK homologue Snf1 and the PP1 phosphatase Glc7/Reg1.

269 A K898E germline missense variant in the PP1-binding motif of BRCA1 has been found in an Ashkenaz

270 ere we report that the lysine residue in the PP1-binding motif of BRCA1 is highly conserved across ma

271 , the structure shows how PNUTS inhibits the PP1-mediated dephosphorylation of critical substrates, e

272 K-regulated through phosphorylation near the PP1-interacting motifs.

273 s of fungal viability in the presence of the PP1 inhibitor.

274 and a targeted oxidative inactivation of the PP1 metal center, that sustains eIF2alpha phosphorylatio

275 hibition of RNA Pol II via activation of the PP1 phosphatase.

276 in vitro affecting neither stability of the PP1-PPP1R15A complex nor substrate-specific dephosphoryl

277 Our structure of the PP1:TTN complex reveals that PP1 selectivity is defined

278 Rather, the PP1 regulatory protein, inhibitor-2, formed a complex wi

279 Whereas the PP1-binding motif on GADD34 has been defined, it remains

280 ificity and the ability to predict how these PP1 interacting proteins bind PP1 from sequence alone is

281 ely that replication control by Rif1 through PP1 is a conserved mechanism.

282 monstrated restoration of Cx43 comparable to PP1.

283 o a PP1-binding peptide or fused directly to PP1 rescues mitotic defects caused by Ska1 depletion.

284 PP1 pocket that is engaged only by these two PP1 regulators.

285 enhance gene expression in other cell types, PP1 activation to relieve IRS1 inhibition may be a more

286 e arginine site, allowed us to define unique PP1 binding motifs, which advances our ability to predic

287 easing the phosphorylation levels of various PP1 substrates.

288 us of GADD34 in a region distinct from where PP1 binds to GADD34.

289 Moreover, it is not known whether PP1 plays a role in homeostatic synaptic scaling, anothe

290 Cdc42 signalling and suggest a way by which PP1/NIPP1 may contribute to the migratory properties of

291 escribe a mitotic phosphatase relay in which PP1 reactivation is required for the reactivation of bot

292 otic activation of Gwl, its association with PP1 is disrupted in mitotic cells and egg extracts.

293 AS160 was coimmunoprecipitated with PP1-alpha but not with PP1-beta, PP1-gamma1, or PP2A.

294 protein, inhibitor-2, formed a complex with PP1 that was controlled by synaptic stimulation.

295 omosome segregation via its interaction with PP1 at the kinetochore.

296 We confirm that Rif1 interacts with PP1 and that PP1 prevents premature Mcm4 phosphorylation

297 munoprecipitated with PP1-alpha but not with PP1-beta, PP1-gamma1, or PP2A.

298 The colorimetric PPIA with PP1-MP and the best ELIPA strategy have provided limits

299 ed in its free form, interacts strongly with PP1 in a highly extended manner.

300 PNUTS) is a PP1 targeting protein that, with PP1, plays a central role in the nucleus, where it regul