ライフサイエンスコーパス: PP2A

1 PP2A associated with the Rts1 regulatory subunit (PP2A(R

2 PP2A comprises catalytic (C), scaffolding (A), and regul

3 PP2A dephosphorylates MYPT1(pThr696) and thereby stimula

4 PP2A is a heterotrimer composed of a scaffold, catalytic

5 PP2A is a major negative regulator of v-akt murine thymo

6 PP2A is a master controller of multiple inflammatory sig

7 PP2A is activated by ceramides and dephosphorylates Akt.

8 PP2A is regulated by protein methylation, and impaired P

9 PP2A targeting is critical for the transforming properti

10 PP2A(B56) also stabilizes kinetochore-microtubule attach

11 PP2A(Cdc55) is a highly conserved serine-threonine prote

12 PP2A(Cdc55) prevents nucleolar release of the Cdk (Cycli

13 PP2A(Cdc55) specifically counteracts phosphorylation on

14 PP2A(Ppp2r2d) dephosphorylated Thr-172 in rat aortic and

15 PP2A-B55 is one of the major phosphatases regulating cel

16 The protein phosphatase 2 (PP2A) holoenzyme consists of a catalytic subunit, a scaf

17 tions in the Ser/Thr protein phosphatase 2A (PP2A) Aalpha scaffold subunit gene PPP2R1A are among the

18 Protein phosphatase 2A (PP2A) activity can be enhanced pharmacologically by PP2A

19 Here, we show that protein phosphatase 2A (PP2A) acts as opsin phosphatase in both rods and cones.

20 a lower activity of protein phosphatase 2A (PP2A) and augmented activity of protein kinase C (PKC)al

21 dephosphorylation by protein phosphatase 2A (PP2A) and inhibition of focal adhesion kinase by MEK/ERK

22 ivated ERK activates protein phosphatase 2A (PP2A) and lengthens cell cycle duration in embryonic ste

23 are affected by the protein phosphatase 2A (PP2A) and the PINOID kinase, which act antagonistically

24 cytoplasm-localized protein phosphatase 2A (PP2A) B' regulatory subunits interact with BRI1 to media

25 Protein phosphatase 2A (PP2A) complexes counteract many oncogenic kinase pathway

26 itively regulated by protein phosphatase 2A (PP2A) complexes targeted to c-Jun by the PR55alpha regul

27 regulatory subunit, protein phosphatase 2A (PP2A) dephosphorylates threonine 38 to activate CAR.

28 Observed deficits in protein phosphatase 2A (PP2A) function in a variety of human cancers have stimul

29 ol the biogenesis of protein phosphatase 2A (PP2A) holoenzymes that contain a common scaffold and cat

30 Phosphatase 2A (PP2A) inhibition or knock-down drastically reduces NLRP3

31 verexpression of the protein phosphatase 2A (PP2A) inhibitor protein PME-1 drives resistance of gliom

32 Protein phosphatase 2A (PP2A) is a member of the intracellular serine/threonine

33 lar serine/threonine protein phosphatase 2A (PP2A) is identified as a functional IN binding partner e

34 Protein phosphatase 2A (PP2A) participates in multiple molecular pathways implic

35 Protein phosphatase 2A (PP2A) plays important roles in controlling mitosis in al

36 Protein phosphatase 2A (PP2A) presents unique opportunities for analyzing molecu

37 of serine/threonine protein phosphatase 2A (PP2A) regulatory subunit, B56beta, due to increased stea

38 The protein phosphatase 2A (PP2A) subfamily of phosphatases, PP2A, PP4, and PP6, are

39 on in the regulatory protein phosphatase 2A (PP2A) subunit PPP2R2A.

40 /threonine (Ser/Thr) protein phosphatase 2A (PP2A) were identified in 16 individuals with mild to sev

41 the tumor suppressor protein phosphatase 2A (PP2A), a negative regulator of multiple oncogenic signal

42 tic gluconeogenesis, protein phosphatase 2A (PP2A), AMP-activated protein kinase (AMPK), and FoxO1 pr

43 T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p13

44 hrough regulation of protein phosphatase 2A (PP2A), but their functions in mammals in vivo have not b

45 PI3Kgamma sequesters protein phosphatase 2A (PP2A), disrupting ERK-PP2A interaction, as evidenced by

46 hosphatases, such as protein phosphatase 2A (PP2A), interestingly, also are components of this degrad

47 SH-BC-893 activated protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PI

48 ngs it together with protein phosphatase 2A (PP2A), leading to the dephosphorylation of YAP in the MT

49 Protein phosphatase 2A (PP2A), YAP, Src family tyrosine kinases, Shc, phosphatid

50 that MEF2 induces a Protein phosphatase 2A (PP2A)-mediated dephosphorylation of murine double minute

51 nomolar inhibitor of protein phosphatase 2A (PP2A).

52 tion and activity of protein phosphatase 2A (PP2A).

53 Protein phosphatase-2A (PP2A) is an abundant serine/threonine phosphatase with a

54 endent activation of protein phosphatase-2A (PP2A).

55 rine/threonine protein phosphatases type 2A (PP2A) are implicated in several physiological processes

56 We identified PROTEIN PHOSPHATASE 2A-3 (PP2A-3), a catalytic subunit of PP2A holoenzymes, as a p

57 A PP2A-mediated feedback mechanism controls Ca(2+)-depende

58 dense core vesicles and autophagosomes in a PP2A-dependent fashion.

59 in the expression of PR55alpha (PPP2R2A), a PP2A regulatory subunit, in pancreatic cancer cells comp

60 0, a small-molecule protein phosphatase 2 A (PP2A) inhibitor, as a monotherapy and chemosensitizing a

61 ic phospho-sites is protein phosphatase 2 A (PP2A).

62 f synthesis of the protein phosphatase 2A-A (PP2A-A), a key factor that facilitates the ubiquitin-pro

63 dding yeast model, we show that the abundant PP2A(Cdc55) phosphatase counteracts Cdk phosphorylation

64 ities to bind the PP2A-C subunit or activate PP2A and failed to reverse the tumorigenic phenotype ind

65 relays signals in the pathway by activating PP2A(Cdc55) We discovered that constitutively active Pkc

66 results reveal how PPP2R1A mutations affect PP2A function and oncogenic signaling, illuminating the

67 Although PP2A inhibition increases TTP mRNA expression, resultant

68 r-172 phosphorylation, and contained an Ampk-PP2A(Ppp2r2d) complex.

69 glucose, enhanced ceramide accumulation and PP2A activity in skeletal muscle.

70 without affecting ceramide accumulation and PP2A expression.

71 rough reciprocal regulation between ACR4 and PP2A-3 at the phosphorylation level.

72 ed for the reactivation of both PP2A-B55 and PP2A-B56 to coordinate mitotic progression and exit in f

73 inhibitor MCC at the mitotic checkpoint, and PP2A:B55 and its inhibitor, alpha-endosulfine, at the mi

74 EK/ERK to allow the binding between DLC1 and PP2A.

75 is mediated by various protein kinases, and PP2A plays a counter-regulatory role by deactivating the

76 PP2R1A on cell proliferation, migration, and PP2A phosphatase activity were investigated using ovaria

77 Thus an interplay of MP and PP2A is involved in the physiological regulation of EC f

78 show that ULK1-mediated phosphorylation and PP2A-mediated dephosphorylation of ATG4 regulates its ce

79 ivities of ULK1-mediated phosphorylation and PP2A-mediated dephosphorylation provide a phospho-switch

80 ity of FFAs to induce insulin resistance and PP2A hyperactivity without affecting ceramide accumulati

81 obilization stimulates both NO synthesis and PP2A-mediated eNOS dephosphorylation, thus constituting

82 18) protein kinase is inhibited by TORC1 and PP2A.B55 is active.

83 ncreased ERK-PP2A interaction and associated PP2A activity in PI3KgammaKO MEFs, resulting in decrease

84 phosphatases and find that BubR1-associated PP2A, unlike KNL1-associated PP1, plays a significant ro

85 ory subunits, to tolerate disease-associated PP2A mutations, resulting in reduced holoenzyme assembly

86 activity and reduces Tau phosphorylation at PP2A-dependent epitopes.

87 ecruitment of the protein phosphatase 2A B' (PP2A B').

88 B'-PP2A and HTLV-1 IN display nuclear co-localization, and

89 To examine further the link between PP2A and AD, we generated transgenic mice that overexpre

90 Because MT also binds PP2A, YAP bound to MT is dephosphorylated, stabilized, a

91 ion is required for the reactivation of both PP2A-B55 and PP2A-B56 to coordinate mitotic progression

92 Ube2S to the APC/C, removal of this mark by PP2A(B56) allows Ube2S to bind the APC/C and catalyze ub

93 ion was microtubule sensitive and opposed by PP2A-B56 phosphatases that stabilize chromosome-spindle

94 ctivity can be enhanced pharmacologically by PP2A-activating drugs (PADs).

95 of an increase of dephosphorylation rates by PP2A counter a series of previously published models for

96 The canonical PP2A holoenzyme regulates multiple eukaryotic signaling

97 In cancer cells, PP2A function can be compromised by several mechanisms,

98 requently through overexpression of cellular PP2A inhibitors.

99 ency of PPP2R4, a gene encoding the cellular PP2A activator PTPA.

100 ments using OP449 - a recently characterized PP2A-activating drug (PAD).

101 blocked tumor growth by stimulating cofilin/PP2A-mediated dephosphorylation of the guanine nucleotid

102 Protein phosphatase type 2A complex (PP2A) has been known as a tumor suppressor for over two

103 wings as a model, we find that compromising PP2A activity during the final cell cycle prior to a dev

104 Under nutrient-rich conditions, PP2A-B55(Pab1) dephosphorylates Gad8 Ser546, repressing

105 This reduction in PPP2R2A containing PP2A phosphatase holoenzyme was associated with decrease

106 ntaining PP2As, we found that B56-containing PP2As and Akt act antagonistically to control reversible

107 B56-containing PP2As dephosphorylate phospho-Ser-322 and promote nuclea

108 identify novel substrates of B56-containing PP2As, we found that B56-containing PP2As and Akt act an

109 hospho-Ser46-ARPP-16 acts to basally control PP2A in striatal medium spiny neurons but that dopamine

110 A new pathway controlling PP2A activity in mitosis has been recently described.

111 ogether, the data suggest that Pkc1 controls PP2A(Cdc55) by multiple overlapping mechanisms.

112 of the B' subunits revealed that cytoplasmic PP2A dephosphorylates BRI1 and inhibits the BR response,

113 UT decreased PP2A activity through posttranslational modification tha

114 on rescued K-fiber stability after depleting PP2A-B56.

115 dephosphorylation resulting from diminished PP2A activity toward P-Akt(T308).

116 of this "MEK/ERK-focal adhesion kinase-DLC1-PP2A" quartet provides a novel checkpoint in the spatiot

117 nteracting regions to HEAT (Huntingtin, EF3, PP2A, and TOR1) motifs in SF3B1 associated with disease

118 ess proteins containing HEAT (Huntingtin/EF3/PP2A/Tor1) repeat domains whose origin and distribution

119 Genes encoding PP2A subunits have expanded into multigene families in b

120 Genes encoding PP2A subunits in mammals represent ancient lineages that

121 Our strategy of reactivating endogenous PP2A may be applicable to the treatment of other disease

122 ential of combination therapies that enhance PP2A and inhibit proteasome activity as novel therapeuti

123 phosphorylated form, FTY720-P, also enhances PP2A activity independently of the sphingosine 1-phospha

124 Hence, FTY720-P enhances PP2A activity and that PADs can repress production of pr

125 We assessed whether enhancing PP2A activity with fingolimod (FTY720) or 2-amino-4-(4-(

126 rotein phosphatase 2A (PP2A), disrupting ERK-PP2A interaction, as evidenced by increased ERK-PP2A int

127 A interaction, as evidenced by increased ERK-PP2A interaction and associated PP2A activity in PI3Kgam

128 In addition, CKA-deficient flies exhibit PP2A-dependent motor coordination defects.

129 gamma-hydroxybutenolide that is critical for PP2A inhibition.

130 ning a high-penetrance genetic mechanism for PP2A inhibition in human cancer.

131 at LCMT-1 is the major methyltransferase for PP2A, PP4, and PP6 in mouse embryonic fibroblasts (MEFs)

132 (PKC)alpha/beta, which was dissociated from PP2A and increased its association with the adapter prot

133 Two Arabidopsis genes, PP2A-C5 and AVP1, and the gypsy insulator sequence were

134 T(reg) cells exhibited high PP2A activity, and T(reg) cell-specific ablation of the

135 However, PP2A has also been shown to facilitate the activation of

136 gulated by protein methylation, and impaired PP2A methylation is thought to contribute to increased A

137 d subunit to drive conformational changes in PP2A.

138 The increase in PP2A activity is caused by decreased expression of the M

139 expression led to a significant increase in PP2A-A protein synthesis and remarkable downregulation o

140 tural framework for the function of TIPRL in PP2A inhibition.

141 ng to disinhibition of ARPP-16 and increased PP2A action.

142 , we show that FTY720-P enhances TNF-induced PP2A phosphatase activity and significantly represses TN

143 eratrol, a polyphenol, significantly induces PP2A activity and reduces Tau phosphorylation at PP2A-de

144 s that activate Igo/ENSA to bind and inhibit PP2A are well understood, little is known about how Igo/

145 A phosphorylated by Greatwall kinase inhibit PP2A during mitosis.

146 Okadaic acid (low dose inhibits PP2A; high dose inhibits PP1) delayed AS160 Ser(588) (bo

147 sal phosphorylation by MAST3 kinase inhibits PP2A and regulates key components of striatal signaling.

148 mediating the kinase arm, PI3Kgamma inhibits PP2A by scaffolding and sequestering, playing a key para

149 functionally characterize the novel URI-KAP1-PP2A complex, demonstrating a role of URI in retrotransp

150 In budding yeast, meiotic cells lacking PP2A(Cdc55) activity undergo a premature exit from meios

151 o disassemble active holoenzymes into latent PP2A, strictly controlled by methylation.

152 ts, such as those found on phosphatases like PP2A, can provide effective insulation against phosphata

153 data identify a molecular mechanism linking PP2A to the development of AD-related cognitive impairme

154 nd IL-10 were significantly increased in lyM-PP2A(fl/fl) mice, and increased phosphorylation was obse

155 The myeloid-specific knockout mice (lyM-PP2A(fl/fl)) showed higher mortality in response to endo

156 Thus, PME-1-mediated PP2A inhibition is a novel mechanistic explanation for m

157 at creates a mechanism whereby cAMP mediates PP2A disinhibition.

158 en the expansion and diversification of most PP2A gene families, members of functionally specialized

159 assembly and enhanced inactivation of mutant PP2A.

160 nd inhibits the BR response, whereas nuclear PP2A dephosphorylates BZR1 and activates the BR response

161 ceramide associates with the inhibitor 2 of PP2A (I2PP2A) in the cytosol, which disrupts the associa

162 In the absence of PP2A, T(reg) cells altered their metabolic and cytokine

163 gulatory subunit, facilitating the access of PP2A catalytic subunit to CK1varepsilon and its activati

164 h suggests that Pkc1-dependent activation of PP2A(Cdc55) plays a critical role in checkpoint signalin

165 rally available small molecule activators of PP2A (SMAPs).

166 ly bioavailable small molecule activators of PP2A, termed SMAPs.

167 f BRD4 attributable to decreased activity of PP2A, identified here as a principal BRD4 serine phospha

168 ycle machinery by regulating the activity of PP2A.B55.

169 Analysis of PP2A and PP4 complexes by blue native polyacrylamide gel

170 osphorylation levels of S727STAT3 because of PP2A inactivation.

171 ver a role of the eEF-2K-mediated control of PP2A-A in tumor cell glycolysis, provide new insights in

172 Cundell et al. identify the determinants of PP2A-B55's dephosphorylation program, thereby influencin

173 t mTORC1 inhibitors triggers dissociation of PP2A from its inhibitor Alpha4.

174 To gain insight into the diversification of PP2A subunits, we used phylogenetic analyses to reconstr

175 Elimination of PP2A substantially slows pigment dephosphorylation, visu

176 nce, our data indicate that the expansion of PP2A subunit gene families in both flowering plants and

177 The activity of this form of PP2A can be inhibited by binding of conserved Igo/ENSA p

178 The form of PP2A that controls mitosis is associated with a conserve

179 nships between MEI-S332 and the two forms of PP2A by quantifying meiotic chromosome segregation defec

180 B56delta-containing heterotrimeric forms of PP2A.

181 xpression experiments showed that a group of PP2A B' regulatory subunits, represented by B'eta, negat

182 to reconstruct the evolutionary histories of PP2A gene families in Arabidopsis (Arabidopsis thaliana)

183 upon starvation leads to the inactivation of PP2A-B55(Pab1) through the Greatwall-Endosulfin pathway.

184 show that this suppression is independent of PP2A(Cdc55)'s FEAR function.

185 on by PKA also acts to prevent inhibition of PP2A by ARPP-16 phosphorylated by MAST3.

186 striatum, suggestive of basal inhibition of PP2A in striatal neurons.

187 tion of endosulfine (Igo1) and inhibition of PP2A.B55, which in turn allows full activation of Cdk1.C

188 ock-out mouse embryos have reduced levels of PP2A B regulatory subunit and PP4R1 relative to control

189 High levels of PP2A.B55 prevent the activation of mitotic Cdk1.Cyclin B

190 nstrate that the subcellular localization of PP2A specifies its substrate selection and distinct effe

191 We find that loss of PP2A-B55(Pab1) enhances the expression of differentiatio

192 nately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoe

193 ated for insulin signaling and modulation of PP2A.

194 Analysis of the interaction network of PP2A's adaptor domains reveals that although its adaptor

195 ARPP-16 leading to selective potentiation of PP2A signaling.SIGNIFICANCE STATEMENT We describe a nove

196 ressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.

197 lation is decreased following recruitment of PP2A by URI.

198 of apoptosis and biogenesis and recycling of PP2A, however, the underlying molecular mechanism is sti

199 We propose that Rim15/Gwl regulation of PP2A plays a hitherto unappreciated role in cell size ho

200 In metazoans, delineation of the role of PP2A B' in meiosis has been hindered by its myriad of ot

201 investigated the possible oncogenic role of PP2A in pancreatic cancer.

202 of this study was to investigate the role of PP2A in the tuberization induction in stolons.

203 s the first genetic evidence for the role of PP2A in tuberization, demonstrating that the catalytic s

204 s the first genetic evidence for the role of PP2A in tuberization, demonstrating that the catalytic s

205 tion effects on the formation of a subset of PP2A holoenzymes, we discovered that Aalpha mutants beha

206 results in dephosphorylation of a subset of PP2A substrates including phospho-Thr75-DARPP-32, phosph

207 he alpha isoform of the catalytic subunit of PP2A (PP2ACalpha).

208 HATASE 2A-3 (PP2A-3), a catalytic subunit of PP2A holoenzymes, as a previously unidentified regulator

209 and degradation of the catalytic subunit of PP2A when bound to microtubules.

210 CKA is a regulatory subunit of PP2A, a component of the STRIPAK complex.

211 in the truncation of a regulatory subunit of PP2A, B56alpha.

212 tly to both of the B' regulatory subunits of PP2A, Wdb and Wrd, in yeast two-hybrid experiments.

213 a mimic for the conserved C-terminal tail of PP2A, an important region of the phosphatase which regul

214 nhanced expression and membrane targeting of PP2A-C was observed in 5% O2, resulting in greater inter

215 that PP4 holoenzyme complexes, like those of PP2A, are differentially regulated by LCMT-1, with the P

216 triggered hyperphosphorylation of oncogenic PP2A-B56/B' substrates in the GSK3beta, Akt, and mTOR/p7

217 +)-sensitive and reversed by okadaic acid or PP2A-C siRNA.

218 -alpha but not with PP1-beta, PP1-gamma1, or PP2A.

219 mutants exhibit defects in binding to other PP2A subunits and contribute to cancer development by a

220 ory subunits of the key cellular phosphatase PP2A (PPP2R5A-E).

221 On the other hand, phosphatase PP2A-PP2R3B can remove this inhibitory phosphorylation.

222 lation of histones and the major phosphatase PP2A, dependency on cysteine, and sensitivity to oxidati

223 nism involving the impairment of phosphatase PP2A catalytic activity and the subsequent activation of

224 iated protein 1) and the protein phosphatase PP2A interact with URI.

225 d ENSA are inhibitors of protein phosphatase PP2A.

226 assembly by associating with the phosphatase PP2A and the kinase cyclin-dependent kinase 5.

227 are sequentially targeted by the phosphatase PP2A-B55, but what underlies substrate selection is uncl

228 ai, the kinase Aurora A, and the phosphatase PP2A.

229 irement for the serine-threonine phosphatase PP2A in the function of T(reg) cells.

230 activity of the serine/threonine phosphatase PP2A.

231 CycB inhibits its counteracting phosphatase (PP2A:B55).

232 hanism involving type 2 protein phosphatase (PP2A) dephosphorylation of endothelial nitric oxide synt

233 of the serine/threonine protein phosphatase, PP2A, and that phosphorylation of ARPP-16 at Ser46 by MA

234 of the serine/threonine protein phosphatase, PP2A, when phosphorylated by the kinase, MAST3.

235 phatase 2A (PP2A) subfamily of phosphatases, PP2A, PP4, and PP6, are multifunctional serine/threonine

236 RCA2, cav3, PKA regulatory subunit (PKARII), PP2A, and AKAP18 with PDE3A.

237 vertebrate evolution, while flowering plant PP2A subunit lineages evolved much more recently.

238 l muscle serine/threonine phosphatases (PP1, PP2A, PP2B, and PP2C) on AS160 dephosphorylation.

239 y G1 and helps promoting START by preventing PP2A(Cdc55) to dephosphorylate Whi5.

240 ed MST2 linker recruits STRIPAK and promotes PP2A-mediated dephosphorylation of MST2 at the activatio

241 The affinity-purified PP2A complex with RON3 as bait suggested that RON3 might

242 atase methylesterase 1 (PME-1) and regulates PP2A holoenzyme formation.

243 ed drug discovery efforts aimed at restoring PP2A function to inhibit tumor growth.

244 resented show that the disruption of the SET/PP2A complex by a novel FTY720-analog (MP07-66) devoid o

245 n cultivated potato (Solanum tuberosum), six PP2A catalytic subunits (StPP2Ac) were identified.

246 ion through counteracting the STRIPAK(SLMAP) PP2A phosphatase complex.

247 were reduced, selectively affecting specific PP2A holoenzymes.

248 licited resistance was dependent on specific PP2A complexes and was mediated by a decrease in cytopla

249 e FBXW7-binding domain of sT, but not the sT-PP2A binding domain.

250 Cka subunit of the Hippo-inhibitory STRIPAK PP2A complex.

251 verexpression of the PP2A catalytic subunit (PP2A-C).

252 associated with the Rts1 regulatory subunit (PP2A(Rts1)) is embedded in a feedback loop that controls

253 Thus, we demonstrate that PP2A plays an important role in regulating inflammation

254 Mass spectrometry revealed that PP2A associated with components of the mTOR metabolic-ch

255 ites across the MCV sT protein revealed that PP2A-binding domains lie on the opposite molecular surfa

256 These results show that PP2A can be activated in cancer cells to inhibit prolife

257 cally reduces NLRP3 activation, showing that PP2A can license inflammasome assembly via dephosphoryla

258 This work shows that PP2A C2, C5, andA2 subunits interact and colocalize with

259 viral antigens, limited studies suggest that PP2A is a putative tumor suppressor.

260 The PP2A signaling axis regulates multiple oncogenic drivers

261 ts exhibited decreased abilities to bind the PP2A-C subunit or activate PP2A and failed to reverse th

262 Blocking the PP2A-S727STAT3-collagen 17 pathway inhibits the suspensi

263 tantly, these effects can be reversed by the PP2A activators FTY720 and AAL(s), or more specifically

264 specifically dephosphorylated at S384 by the PP2A-B56 phosphatase, thereby uncoupling cyclin E degrad

265 ynamics of BR signaling are modulated by the PP2A-mediated feedback inactivation of BRI1.

266 here that CK1varepsilon is activated by the PP2A/PR61varepsilon phosphatase.

267 orylated CAR into its monomers, exposing the PP2A/RACK1 binding site for dephosphorylation.

268 Our findings not only identify the PP2A regulatory B subunits that mediate the binding and

269 Future studies that identify the PP2A-regulated events targeted by SMAPs should guide cri

270 ctrometry to determine how Pkc1 modifies the PP2A(Cdc55) complex.

271 th mutations in the SMAP-binding site of the PP2A A subunit displayed resistance to SMAPs.

272 r more specifically by overexpression of the PP2A catalytic subunit (PP2A-C).

273 Carboxyl methylation of the PP2A catalytic subunit (PP2Ac) C-terminal leucine is reg

274 rity establishment through regulation of the PP2A complex activity.

275 ty, and T(reg) cell-specific ablation of the PP2A complex resulted in a severe, multi-organ, lymphopr

276 we discover SAV1-mediated inhibition of the PP2A complex STRIPAK(SLMAP) as a key mechanism of MST1/2

277 OTUNDA3 (RON3) protein as a regulator of the PP2A phosphatase activity in Arabidopsis thaliana.

278 entially binds the unmodified version of the PP2A-tail mimetic peptide DYFL compared to its tyrosine-

279 phosphatase methylesterase-1 (PME-1), or the PP2A methyltransferase, leucine carboxyl methyltransfera

280 nerated transgenic mice that overexpress the PP2A methylesterase, protein phosphatase methylesterase-

281 We propose that the PP2A complex plays a novel role in differentiating tissu

282 We show that the PP2A:B55-inhibiting Greatwall (Gwl)-endosulfine (ENSA) p

283 y, we found that SMAPs act by binding to the PP2A Aalpha scaffold subunit to drive conformational cha

284 a homodimer in a configuration in which the PP2A/RACK1 binding site is buried within its dimer inter

285 integrative multibranching contacts with the PP2A catalytic subunit, selective for the unmethylated t

286 ue to gain-of-function interactions with the PP2A inhibitor TIPRL1.

287 Therefore, PP2A is required for the function of T(reg) cells and th

288 Thus, PP2A-B55(Pab1) enables a crosstalk between the two TOR c

289 , rather than MEI-S332 being hierarchical to PP2A B', these proteins reciprocally ensure centromere l

290 Total PP2A activity and PPP2R1A-associated PP2Ac activity were

291 mice showing residual PTPA expression, total PP2A activity and methylation were reduced, selectively

292 Based on loss-of-function analysis using PP2A catalytic inhibitors or inhibition via tumor viral

293 Thus, when PP2A activity is repressed, pro-inflammatory cytokines i

294 a; however the molecular mechanisms by which PP2A controls inflammation warrant further investigation

295 identify a novel genetic mechanism by which PP2A function is recurrently affected in human cancer, i

296 hway emerges from its mutual antagonism with PP2A:B55.

297 ld-type MT, the E349K mutant associates with PP2A, YAP, tyrosine kinases, Shc, PI3 kinase, and PLCgam

298 Compared with PP2A B'alpha and B'beta, which promote BR responses by d

299 hich disrupts the association of I2PP2A with PP2A leading to its translocation to the plasma membrane

300 Association of Igo2 with PP2A(Cdc55) is regulated during the cell cycle, yet muta