ライフサイエンスコーパス: PPAR-delta

1 PPAR delta likely mediates this antiapoptotic effect bec

2 PPAR-delta activation also reduced HTT-induced neurotoxi

3 PPAR-delta also has a relatively high expression in the

4 PPAR-delta overexpression in colonic epithelial cells pr

5 PPAR-delta promotes colonic tumorigenesis.

6 PPAR-delta+ NG2 cell numbers were significantly higher t

7 PPAR-delta+ oligodendrocyte numbers declined at 1 dpi an

8 e (P = 0.026), and 2.25 +/- 0.25 in 15-LOX-1-PPAR-delta-Gut mice (P = 0.0006).

9 ession in colonic epithelial cells (15-LOX-1-PPAR-delta-Gut mice) suppressed these effects: the numbe

10 MP-7, CCND1 (Cyclin D1), CX43 (Connexin 43), PPAR-delta, and ITF2 genes in OEAs with deregulated beta

11 ings indicate cyclin D1, MMP-7, connexin 43, PPAR-delta, and ITF-2, likely play important roles in th

12 ewal potential of these organoid bodies in a PPAR-delta-dependent manner.

13 Notably, HFD- and agonist-activated PPAR-delta signalling endow organoid-initiating capacity

14 oding other PPAR family members (PPAR alpha, PPAR delta, or NUC-1) were unchanged or decreased.

15 roliferator-activated receptor (PPAR)-alpha, PPAR-delta, PPAR-gamma, cd36/Fat, and Ucp2, which coinci

16 ator-activated receptors (PPARs; PPAR-alpha, PPAR-delta, and PPAR-gamma) comprise a family of nuclear

17 ceptor isoforms, PPAR gamma, PPAR alpha, and PPAR delta, encoded by different genes.

18 echanistic relationship between 15-LOX-1 and PPAR-delta was previously unknown.

19 phosphorylation, IL-6 promoter activity, and PPAR-delta mRNA and protein expression.

20 ivated receptors (PPAR-alpha, PPAR-gamma and PPAR-delta) exemplify this connection, regulating divers

21 ts that activate PPAR-alpha, PPAR-gamma, and PPAR-delta alone or in combination have the potential to

22 ceptors (PPARs), PPAR-alpha, PPAR-gamma, and PPAR-delta.

23 A-7 cells express this receptor, and another PPAR delta agonist, docosahexaenoic acid, mimics the eff

24 by sulindac sulfone but can be bound by both PPAR delta and PPAR gamma.

25 oligodendrocytes in uninjured spinal cords; PPAR-delta was also detected in NG2 cells (potential oli

26 on in skeletal muscle resulting in decreased PPAR-delta activation.

27 (i) 13-S-HODE binds to PPAR-delta, decreases PPAR-delta activation, and down-regulates PPAR-delta exp

28 We show that mice deficient in PPAR-delta (PPAR-delta(-/-)) develop a severe inflammatory response

29 isome proliferator-activated receptor delta (PPAR-delta) interacts with HTT and that mutant HTT repre

30 isome proliferator-activated receptor delta (PPAR-delta) signature in intestinal stem cells and proge

31 isome proliferator-activated receptor delta (PPAR-delta)-fatty-acid oxidation (FAO) pathway for the m

32 isome proliferator-activated receptor-delta (PPAR-delta) is induced when macrophages engulf apoptotic

33 isome proliferator-activated receptor-delta (PPAR-delta) may have important roles in FAO.

34 isome proliferator-activated receptor-delta (PPAR-delta), which is implicated in bile acid homoeostas

35 isome proliferator-activated receptor-delta (PPAR-delta).

36 isome proliferator-activated receptor-delta (PPAR-delta; also known as PPAR-beta) is expressed at hig

37 iating capacity to progenitors, and enforced PPAR-delta signalling permits these progenitors to form

38 played by PPAR nuclear receptors, especially PPAR-delta (Lee et al.), in the modulation of inflammato

39 A large proportion of NG2 cells expressed PPAR-delta after SCI, especially along lesion borders.

40 such that >20% of oligodendrocytes expressed PPAR-delta after SCI compared with approximately 10% in

41 ignificantly greater in mice nullizygous for PPAR-delta.

42 L >> LDL > HDL), PPAR isoform (PPAR alpha >> PPAR delta > PPAR gamma), and among fatty acid-releasing

43 resultant induction of apoptosis; and (iii) PPAR-delta is an important signaling receptor for 13-S-H

44 Our results implicate PPAR-delta in the regulation of intestinal adenoma growt

45 8 in wild-type littermates, 6.67 +/- 0.83 in PPAR-delta-Gut mice (P = 0.026), and 2.25 +/- 0.25 in 15

46 We show that mice deficient in PPAR-delta (PPAR-delta(-/-)) develop a severe inflammato

47 The most prominent increase in PPAR-delta+ oligodendrocytes was along lesion borders wh

48 cellular differentiation, the early rise in PPAR-delta+ NG2 cells followed by an increase in new PPA

49 Increased PPAR-delta transactivation ameliorated mitochondrial dys

50 These findings highlight how diet-modulated PPAR-delta activation alters not only the function of in

51 in liver and heart, in mouse skeletal muscle PPAR delta is severalfold more abundant than either PPAR

52 Thus, chronic myocardial PPAR-delta deficiency leads to lipotoxic cardiomyopathy.

53 Expression of dominant-negative PPAR-delta in the central nervous system of mice was suf

54 Expression of dominant-negative PPAR-delta specifically in the striatum of medium spiny

55 ta+ NG2 cells followed by an increase in new PPAR-delta+ oligodendrocytes suggests that this transcri

56 evious reports suggesting that activation of PPAR-delta potentiates colon polyp formation, here we sh

57 em cells), and pharmacological activation of PPAR-delta recapitulates the effects of a HFD on these c

58 se models of HD, pharmacologic activation of PPAR-delta using the agonist KD3010 improved motor funct

59 of mice with a synthetic ligand activator of PPAR-delta, GW0742, ameliorates experimental autoimmune

60 sion of these T helper subsets in the CNS of PPAR-delta(-/-) mice occurred as a result of a constella

61 Genetic deletion of PPAR-delta decreases expression of opsonins such as comp

62 ediated cardiomyocyte-restricted deletion of PPAR-delta in mice downregulates constitutive expression

63 We also show that the effect of PPAR-delta in inhibiting the production of IFN-gamma and

64 to examine the spatiotemporal expression of PPAR-delta in naive and injured spinal cords from adult

65 We have found that loss of PPAR-delta or inhibition of mitochondrial FAO induces lo

66 a critical step in NSAID down-regulation of PPAR-delta and the resultant induction of apoptosis; and

67 indings indicate that the down-regulation of PPAR-delta by 15-LOX-1 through 13-S-HODE is an apoptotic

68 We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-defi

69 Identification of 15-LOX-1 suppression of PPAR-delta to inhibit IL-6/STAT3 signaling-driven CAC tu

70 crease the affinity for the same peptides on PPAR delta and in one case on PPAR alpha.

71 liferator-activated receptor (PPAR)-alpha or PPAR-delta activation stimulates keratinocyte differenti

72 Overall PPAR-delta+ cell numbers declined at 1 day post injury (

73 Mechanistically, the PML-PPAR-delta-FAO pathway controls the asymmetric division

74 the tail group modifications imparted potent PPAR delta agonist activity, improvement of PPAR alpha a

75 es PPAR-delta activation, and down-regulates PPAR-delta expression in colorectal cancer cells; (ii) t

76 rs to terminate inflammation, down-regulates PPAR-delta.

77 As previously reported, PPAR-delta was expressed by neurons and oligodendrocytes

78 racts with HTT and that mutant HTT represses PPAR-delta-mediated transactivation.

79 After spinal cord injury (SCI), PPAR-delta mRNA and protein were present early and incre

80 an and rodent myocytes, the highly selective PPAR delta agonist GW742 increased fatty acid oxidation

81 NSAIDs suppress PPAR-delta activity in colon cancer cells.

82 ed from individuals with HD, indicating that PPAR-delta activation may be beneficial in HD and relate

83 tes colon polyp formation, here we show that PPAR-delta attenuates colon carcinogenesis.

84 Together, our data show that PPAR-delta is a crucial determinant of constitutive myoc

85 We suggest that PPAR-delta is a potential therapeutic target in treating

86 Collectively, these findings suggest that PPAR-delta serves as an important molecular brake for th

87 We report the crystal structure of the PPAR delta ligand-binding domain (LBD) bound to either t

88 Exposure of Apc(min) mice to the PPAR-delta ligand GW501516 resulted in a significant inc

89 ect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the numb

90 (2) promotes survival of colonocytes through PPAR delta activation.

91 Thus, PPAR-delta has a pivotal role in orchestrating the timel

92 rent study shows that (i) 13-S-HODE binds to PPAR-delta, decreases PPAR-delta activation, and down-re

93 of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice.

94 d oligodendrocytes (bromodeoxyuridine+) were PPAR-delta+.

95 ic commitment of HSC daughter cells, whereas PPAR-delta activation increased asymmetric cell division

96 But it remains unclear whether PPAR-delta is required for maintaining basal myocardial

97 Incubation of macrophages with PPAR-delta agonists was shown to inhibit foam cell forma

98 s of HSC maintenance, whereas treatment with PPAR-delta agonists improved HSC maintenance.