ライフサイエンスコーパス: PPAR-gamma

1 PPAR gamma is required for fat cell development and is t

2 PPAR gamma-deficient macrophages secreted elevated level

3 PPAR-gamma agonists modulate NF-kappaB-dependent inflamm

4 PPAR-gamma agonists reduce inflammation, in part, throug

5 PPAR-gamma agonists, like pioglitazone, appear antiprote

6 PPAR-gamma agonists, the thiazolidinediones, are clinica

7 PPAR-gamma and RXR-alpha form a non-symmetric complex, a

8 PPAR-gamma coactivator (PGC)-1alpha, a known regulator o

9 PPAR-gamma has been shown to act on both fronts, reducin

10 PPAR-gamma is the target of the thiazolidinedione (TZD)

11 PPAR-gamma ligands abrogated these effects.

12 in macrophages and T cells in vivo through a PPAR gamma-dependent mechanism.

13 rostaglandin E(2) and MCP-1 production via a PPAR gamma-dependent mechanism possibly involving activa

14 Ciglitazone, a PPAR-gamma agonist with anti-inflammatory properties, wa

15 Here we show that rosiglitazone, a PPAR-gamma agonist, rescued the dendrites and dendritic

16 Rosiglitazone (RSG), a PPAR-gamma agonist, has been shown to reduce inflammatio

17 tazone, in a manner inhibited by T0070907, a PPAR-gamma antagonist that also inhibited the ACEA effec

18 rine SMCs and in human macrophages through a PPAR-gamma-independent mechanism likely to be mediated b

19 erol in human SMCs and macrophages through a PPAR-gamma-independent mechanism.

20 PPAR-alpha-dependent metabolism and abnormal PPAR-gamma pathway in beating embryoid bodies (EBs) with

21 IL-10R blockage abolished PPAR-gamma-mediated inhibition of MyD88 expression.

22 n factor known to interact with and activate PPAR-gamma and NF-kappaB, is suppressed in the glomerula

23 cyte differentiation and partially activated PPAR gamma target genes involved in adipogenesis and, at

24 + T cell functions by endogenously activated PPAR-gamma remain unclear.

25 Therefore, microbiota-activated PPAR-gamma signaling is a homeostatic pathway that preve

26 mediated by the transcriptional co-activator PPAR-gamma co-activator-1 alpha (PGC1-alpha).

27 ike HL-60 cells with a constitutively active PPAR-gamma construct.

28 and specific dietary fatty acids can affect PPAR-gamma activity.

29 ipocyte differentiation in part by affecting PPAR gamma activity.

30 ferator-activated receptor-gamma and -alpha (PPAR-gamma/-alpha) in the NTS and NG in HFD rats were ma

31 FAS, PPAR-alpha, PPAR-gamma, and CB1-R were markedly altered in WT-FF.

32 Treatments that activate PPAR-alpha, PPAR-gamma, and PPAR-delta alone or in combination have

33 tor-activated receptors (PPARs), PPAR-alpha, PPAR-gamma, and PPAR-delta.

34 duced TauNuF-alpha release, it did not alter PPAR-gamma expression.

35 -6, and FIV RNA detection in brain, although PPAR-gamma in glia was increased compared with PBS-treat

36 ctivities were enhanced by n-3 LDL, DHA, and PPAR gamma agonist, whereas activity of a luciferase gen

37 tor-activated receptor delta (PPARdelta) and PPAR gamma coactivator 1 alpha (PGC1alpha), key transcri

38 d safety profile, of the dual PPAR-alpha and PPAR-gamma agonist aleglitazar.

39 mice showed higher levels of PPAR-alpha and PPAR-gamma gene expression, elevated abundance of mitoch

40 on of TGF-beta signaling by cPLA(2)alpha and PPAR-gamma may represent an important mechanism for cont

41 ferator-activated receptor (PPAR)-alpha, and PPAR-gamma.

42 ptor gamma in luciferase reporter assay, and PPAR-gamma selective antagonist completely inhibited MDS

43 eceptors (PPARs; PPAR-alpha, PPAR-delta, and PPAR-gamma) comprise a family of nuclear receptors that

44 e expression of hepatocyte growth factor and PPAR-gamma, have been demonstrated in blacks with SSc, a

45 mers with the retinoid X receptor (RXR), and PPAR-gamma has been intensively studied as a drug target

46 tiation through direct regulation of ST2 and PPAR-gamma expression.

47 vascular endothelium, with decreased TJ and PPAR-gamma expression, and increased pulmonary macrophag

48 As PPAR-gamma is also expressed in neurons, we generated mi

49 the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein

50 ylation of histone H3 at Lys27 (H3K27me3) at PPAR-gamma chromatin.

51 his is a clinically crucial question because PPAR-gamma agonists, "such as thiazolidinediones-" a cla

52 ly, and 4) associated with reduction of both PPAR-gamma and catalase activity, which are reversed by

53 Here we report that both PPAR-gamma and -beta/delta activators markedly stimulate

54 dized free fatty acids in the pups nursed by PPAR gamma-deficient mothers.

55 agonistic regulation of TGF-beta activity by PPAR-gamma ligands involves cellular PPAR-gamma, since 1

56 nt transcriptional responses were blocked by PPAR-gamma without preventing Smad2/3 activation.

57 Inhibition of chemotaxis by PPAR-gamma ligands correlated with decreases in extracel

58 n at the COL1A2 locus, were all prevented by PPAR-gamma.

59 paB promoter activity, which was reversed by PPAR-gamma agonist.

60 ying the abrogation of TGF-beta signaling by PPAR-gamma in normal human fibroblasts in culture.

61 ceptor-gamma (PPAR-gamma) ligand that causes PPAR-gamma dissociation from Smad2/3, allowing Smad2/3 a

62 In vascular endothelial cells, PPAR-gamma activation inhibits endothelial inflammation

63 In vascular smooth muscle cells, PPAR-gamma activation inhibits proliferation and migrati

64 vity by PPAR-gamma ligands involves cellular PPAR-gamma, since 15-deoxy-Delta12,14-prostaglandin J(2)

65 the concomitant down-regulation of cellular PPAR-gamma mRNA expression.

66 Blocking the endogenous activation of CNS PPAR-gamma with pharmacological antagonists or reducing

67 hat both acute and chronic activation of CNS PPAR-gamma, by either TZDs or hypothalamic overexpressio

68 nknown role for central nervous system (CNS) PPAR-gamma in the regulation of energy balance.

69 LPS treatment significantly decreased PPAR-gamma expression in vivo and in vitro and was assoc

70 activated receptor (PPAR)-alpha, PPAR-delta, PPAR-gamma, cd36/Fat, and Ucp2, which coincided with red

71 nents that control adipose cell development: PPAR-gamma, PGC1-alpha, and PRDM16.

72 atives were designed and synthesized as dual PPAR gamma agonist/angiotensin II antagonists for the po

73 conclusion, our data suggest that endogenous PPAR-gamma activation represents a Treg intrinsic mechan

74 part from reduced amounts of the endogenous PPAR-gamma ligand 15-keto-prostaglandin E(2) (15-keto-PG

75 ity, bind to PPAR-gamma and markedly enhance PPAR-gamma transcriptional activity.

76 y isolated human PMNs constitutively express PPAR-gamma, which is up-regulated by the sepsis-induced

77 ), a coactivator of the transcription factor PPAR-gamma that controls mitochondrial biogenesis and fu

78 elopment depends on the transcription factor PPAR-gamma; however, the environmental cues required for

79 Additional factors, PPAR-gamma related, may therefore predispose aged subjec

80 and AMG131) as a potent selective ligand for PPAR gamma that is structurally and pharmacologically di

81 s important novel physiological function for PPAR-gamma in connective tissue homeostasis.

82 isome proliferator-activated receptor gamma (PPAR gamma) and lanthionine synthetase C-like 2 (LANCL2)

83 isome proliferator-activated receptor gamma (PPAR gamma) and SIRT1 activities regulate secretion of a

84 isome proliferator-activated receptor gamma (PPAR gamma).

85 isome proliferator-activated receptor gamma (PPAR gamma).

86 isome proliferator-activated receptor gamma (PPAR gamma; NR1C3) plays a central role in adipogenesis

87 isome proliferator-activated receptor-gamma (PPAR gamma) is a ligand-activated transcription factor o

88 isome proliferator-activated receptor gamma (PPAR-gamma) activation underlie the pathogenesis of ARVD

89 isome-proliferator-activated receptor gamma (PPAR-gamma) and downstream target genes were down-regula

90 isome proliferator-activated receptor gamma (PPAR-gamma) and glucose transporter 1 (GLUT-1) levels in

91 isome proliferator-activated receptor gamma (PPAR-gamma) and lower expression of the profibrogenic fa

92 isome proliferator-activated receptor gamma (PPAR-gamma) and thus counteracts Smad2/3-mediated inhibi

93 isome proliferator-activated receptor gamma (PPAR-gamma) expression.

94 isome proliferator-activated receptor gamma (PPAR-gamma) improves ovulatory function in women with po

95 isome proliferator-activated receptor gamma (PPAR-gamma) is a downstream target of sildenafil in the

96 isome proliferator-activated receptor gamma (PPAR-gamma) is an important target in diabetes therapy,

97 isome proliferator-activated receptor gamma (PPAR-gamma) mRNA levels within the hypothalamus.

98 isome proliferator-activated receptor gamma (PPAR-gamma) possess anti-glial inflammation effects and

99 isome proliferator-activated receptor gamma (PPAR-gamma) signaling cascade using proteomics technolog

100 isome proliferator-activated receptor gamma (PPAR-gamma), which is suppressed by HIV-1 replication.

101 isome proliferator-activated receptor gamma (PPAR-gamma).

102 isome proliferator-activated receptor gamma (PPAR-gamma).

103 isome proliferator-activated receptor-gamma (PPAR-gamma) abrogate the stimulation of collagen gene tr

104 isome proliferator-activated receptor-gamma (PPAR-gamma) agonist, rosiglitazone, an insulin sensitize

105 isome proliferator-activated receptor-gamma (PPAR-gamma) agonist, troglitazone, in a manner inhibited

106 isome proliferator-activated receptor-gamma (PPAR-gamma) agonists not only improve metabolic abnormal

107 isome proliferator-activated receptor-gamma (PPAR-gamma) and sterol regulatory element binding protei

108 isome proliferator-activated receptor-gamma (PPAR-gamma) has been shown to inhibit osteoblast differe

109 isome proliferator-activated receptor-gamma (PPAR-gamma) in early proliferation and differentiation e

110 isome proliferator-activated receptor-gamma (PPAR-gamma) is a determinant of insulin sensitivity and

111 isome proliferator-activated receptor-gamma (PPAR-gamma) is a nuclear receptor that is activated by l

112 isome proliferator-activated receptor-gamma (PPAR-gamma) is involved in the modulation of pathogenic

113 isome proliferator-activated receptor-gamma (PPAR-gamma) ligand that causes PPAR-gamma dissociation f

114 isome proliferator-activated receptor-gamma (PPAR-gamma) or the nuclear corepressor NCoR2.

115 isome proliferator-activated receptor-gamma (PPAR-gamma) protein were found in Acc2(-/-) mutant mice

116 isome proliferator-activated receptor-gamma (PPAR-gamma) systems and propose that these systems may r

117 isome proliferator-activated receptor-gamma (PPAR-gamma), a ligand-activated nuclear transcription fa

118 isome proliferator-activated receptor-gamma (PPAR-gamma), a master regulator of adipocyte differentia

119 isome proliferator-activated receptor-gamma (PPAR-gamma), may counterregulate inflammation in a tissu

120 isome proliferator-activated receptor-gamma (PPAR-gamma), which is induced by exposure to granulocyte

121 isome proliferator-activated receptor-gamma (PPAR-gamma).

122 isome proliferator-activated receptor-gamma (PPAR-gamma).

123 isome proliferator-activated receptor-gamma (PPAR-gamma, encoded by Pparg) function that contributes

124 unction dominant-negative mutations in human PPAR gamma cause insulin resistance and severe early ons

125 e derivative, showed the highest activity in PPAR gamma transactivation assay (69% activation) with n

126 ity between telmisartan and rosiglitazone in PPAR gamma active site, two classes of benzimidazole der

127 LPS challenge studies in PPAR gamma-expressing and immune cell-specific PPAR gamm

128 We postulated that DNA sequence variation in PPAR gamma (PPARG) co-activator 1 alpha (PPARGC1A), a ge

129 These studies reveal a reversible defect in PPAR-gamma signaling in Cftr-deficient cells that can be

130 Also, the increase in PPAR-gamma activity was reversed in the presence of PPAR

131 eated with pioglitazone showed reductions in PPAR-gamma (Ser-273) phosphorylation.

132 ression of lipid metabolism genes, including PPAR-gamma, by directly methylating their promoters.

133 We found that IH increased PPAR-gamma activity and modulated the expression of PPAR

134 We demonstrate that ABA increases PPAR gamma reporter activity in RAW 264.7 macrophages an

135 Microbiota-induced PPAR-gamma signaling also limits the luminal bioavailabi

136 Here we present structures of intact PPAR-gamma and RXR-alpha as a heterodimer bound to DNA,

137 sults identify a signaling pathway involving PPAR-gamma, ERK, and MUC1 for TNF-alpha secretion induce

138 rior therapeutic potential compared to known PPAR gamma activating agents by favorably modulating lip

139 Three interfaces link PPAR-gamma and RXR-alpha, including some that are DNA de

140 ecame more severe in mice lacking macrophage PPAR gamma following high-fat feeding, and these mice we

141 e that ABA-mediated activation of macrophage PPAR gamma is dependent on lancl2 expression.

142 In macrophages, PPAR-gamma activation suppresses inflammation by regulat

143 Therefore, maternal PPAR gamma is pivotal for maintaining the quality of mil

144 cation may be independent of ligand-mediated PPAR-gamma activation.

145 Thus, INT131 appears to selectively modulate PPAR gamma responses in an in vivo preclinical model, sh

146 l stem-cell lineage allocation by modulating PPAR-gamma activity through nuclear translocation.

147 PPAR-gamma-specific inhibitor and a mutated PPAR-gamma dominant negative plasmid, supporting our hyp

148 Cotransfection with dominant-negative PPAR gamma DNA eliminated the increase in luciferase act

149 Neuronal PPAR-gamma signaling is also required for the hepatic in

150 ng depends in part on the effect of neuronal PPAR-gamma signaling to limit thermogenesis and increase

151 nockout (BKO)) to determine whether neuronal PPAR-gamma signaling contributes to either weight gain o

152 onstrate that PPAR-gamma-expressing, but not PPAR-gamma null Treg, prevent colitis induced by transfe

153 y, antisense knockdown of PPAR-beta, but not PPAR-gamma, abrogated the stimulatory effect of gemfibro

154 ncreased the expression of PPAR-beta but not PPAR-gamma.

155 beta-catenin content and normalized nuclear PPAR-gamma in Ob-MSCs.

156 t mechanism possibly involving activation of PPAR gamma and suppression of NF-kappaB and nuclear fact

157 an breast cancer cells through activation of PPAR gamma and that n-3 PUFA-induced apoptosis is mediat

158 Suppression of SIRT1 or activation of PPAR gamma enhances Ero1-L alpha expression and stimulat

159 due to increased expression and activity of PPAR gamma, while other transcription factor pathways in

160 with a K(i) = 13.4 nM, but it was devoid of PPAR gamma activity.

161 oes not bind to the ligand-binding domain of PPAR gamma.

162 un to specifically address the importance of PPAR gamma in the vasculature.

163 gand-binding domain-independent mechanism of PPAR gamma activation.

164 We investigated the role of PPAR gamma coactivator 1alpha (PGC-1alpha) in muscle dys

165 These findings reveal an essential role of PPAR gamma in macrophages for the maintenance of whole-b

166 inireview, evidence for a protective role of PPAR gamma in the endothelium and vascular smooth muscle

167 ide synthase, was elevated in the absence of PPAR-gamma signaling.

168 press TNF-alpha production in the absence of PPAR-gamma.

169 Moreover, ligand activation of PPAR-gamma by rosiglitazone exacerbates osteoclast diffe

170 tion and suggest that impaired activation of PPAR-gamma contributes to the chronic inflammatory state

171 ts suggest that CBD may induce activation of PPAR-gamma in mast cells leading to secretion of G-CSF a

172 Activation of PPAR-gamma prevented HIV-1-induced claudin-5 down-regula

173 Pharmacological activation of PPAR-gamma thus may represent a novel therapeutic approa

174 on of ZAG in the liver via the activation of PPAR-gamma.

175 nous administration of synthetic agonists of PPAR-gamma (pioglitazone and rosiglitazone) up-regulates

176 Both natural and synthetic agonists of PPAR-gamma abrogated the stimulation of collagen synthes

177 lts would encourage immediate application of PPAR-gamma agonists in treating patients with cortical d

178 a through cGMP- and PKG-dependent binding of PPAR-gamma to the TRPC6 promoter, which inhibits TRPC6 p

179 rotein response and suggest that blockade of PPAR-gamma (Ser-273) phosphorylation may prevent type 1

180 ot affect the anti-amyloidogenic capacity of PPAR-gamma.

181 expression of a fusion protein consisting of PPAR-gamma and the viral transcriptional activator VP16

182 uced responses in either primary cultures of PPAR-gamma-null murine embryonic fibroblasts, or in norm

183 To test the assertion that the deficiency of PPAR-gamma in Treg impairs their ability to prevent effe

184 rough mechanisms involving downregulation of PPAR-gamma and increased activation of NF-kappaB.

185 m and IP is associated with dysregulation of PPAR-gamma.

186 e uncovered a pro-osteoclastogenic effect of PPAR-gamma by using a Tie2Cre/flox mouse model in which

187 we explored the anti-inflammatory effect of PPAR-gamma stimulation in vivo in cystic fibrosis transm

188 The effects of PPAR-gamma in the vascular cells translate into the bene

189 This study aims to explore expression of PPAR-gamma and NF-kappaB in placentas of women with peri

190 roups and analyzed to quantify expression of PPAR-gamma and NF-kappaB using real-time polymerase chai

191 IH significantly increased the expression of PPAR-gamma in tumor tissues obtained from xenograft mode

192 R-defective biliary epithelium expression of PPAR-gamma is increased but that this does not result in

193 Increased local expression of PPAR-gamma paralleled these changes.

194 mma activity and modulated the expression of PPAR-gamma regulated genes in GC cells.

195 Expression of PPAR-gamma was downregulated in patients with preeclamps

196 Furthermore, PMN expression of PPAR-gamma was increased in sepsis patients and mice wit

197 These studies unravel a novel function of PPAR-gamma in controlling biliary epithelium inflammatio

198 Weighing the potential benefit and harm of PPAR-gamma activation and exploring the functional mecha

199 nic mice have demonstrated the importance of PPAR-gamma in these disorders.

200 ible for the AM/AMBP-1-mediated induction of PPAR-gamma and the anti-inflammatory effect.

201 hway and Pyk-2-ERK1/2-dependent induction of PPAR-gamma.

202 Thus, inhibition of PPAR-gamma and GLUT-1 by E. coli K1 is a novel pathogeni

203 Importantly, inhibition of PPAR-gamma partially prevents the increase in tumorigene

204 us carcinomas are sensitive to inhibition of PPAR-gamma.

205 fibroblasts with RNAi-mediated knockdown of PPAR-gamma.

206 allowing the ligand-binding domain (LBD) of PPAR-gamma to contact multiple domains in both proteins.

207 BMSCs) from KO mice express higher levels of PPAR-gamma and lower levels of Runx2 mRNA, and this corr

208 ur hypothesis that IH can act as a ligand of PPAR-gamma.

209 trating T cells showed a progressive loss of PPAR-gamma coactivator 1alpha (PGC1alpha), which program

210 o identify potential molecular mechanisms of PPAR-gamma in the islet, we treated diabetic or glucose-

211 residues within the ligand-binding pocket of PPAR-gamma that are reported to be critical for its acti

212 , which could be reversed in the presence of PPAR-gamma inhibitor.

213 ced stimulation of COL1A2 in the presence of PPAR-gamma ligands.

214 mma activity was reversed in the presence of PPAR-gamma-specific inhibitor and a mutated PPAR-gamma d

215 In turn, recruitment of PPAR-gamma-coactivator-1alpha (PGC-1alpha) and PGC-1beta

216 Thus, regulation of PPAR-gamma can be a therapeutic approach against HIV-1-i

217 onary barrier integrity), down-regulation of PPAR-gamma transcription, and expression in lung tissues

218 The role of PPAR-gamma in PMN responses, however, is not well charac

219 To characterize the role of PPAR-gamma in the fibrotic process in vivo, the syntheti

220 Stimulation of PPAR-gamma in vivo (rosiglitazone) significantly attenua

221 The suppression of PPAR-gamma and GLUT-1 by the bacteria in the brain micro

222 e after CSE induction through suppression of PPAR-gamma or ERK inhibited TACE activity and TNF-alpha

223 antly, NOC-mediated nuclear translocation of PPAR-gamma is blocked by a short peptide fragment of NOC

224 tant NOC facilitate nuclear translocation of PPAR-gamma.

225 ingitis, and pharmacological upregulation of PPAR-gamma and GLUT-1 levels may provide novel therapeut

226 esartan based on a partial agonist action on PPAR-gamma receptors.

227 iglitazone, suggesting that effect of NOC on PPAR-gamma nuclear translocation may be independent of l

228 down or application of antagonists of PKG or PPAR-gamma enhanced TRPC6 expression in podocytes and co

229 an angiotensin receptor blocker and partial PPAR-gamma agonist, has been shown to decrease visceral

230 scleroderma and suggest that pharmacological PPAR-gamma ligands, widely used as insulin sensitizers i

231 ediated effects of the hormone by preventing PPAR-gamma inhibition by leptin, with subsequent increas

232 Furthermore, the transfer of purified PPAR-gamma null CD4+ T cells into SCID recipients result

233 Rats receiving PPAR-gamma antagonists displayed proteinuria and increas

234 nsitizers that activate the nuclear receptor PPAR-gamma and have been shown to partially ameliorate a

235 h a mechanism involving the nuclear receptor PPAR-gamma.

236 pioglitazone and rosiglitazone) up-regulates PPAR-gamma-dependent genes, while inhibiting the activat

237 al activation of the mitochondrial regulator PPAR-gamma coactivator 1beta (PGC-1beta) but not PGC-1al

238 t with AM/AMBP-1 for 4 h completely restored PPAR-gamma levels in both models, resulting in TNF-alpha

239 Pretreatment with partial or selective PPAR-gamma agonists ameliorate the pathological outcomes

240 ogenesis and increasing insulin sensitivity, PPAR-gamma also plays critical roles in the vasculature.

241 Chromatin immunoprecipitation showed PPAR-gamma binding to the TRPC6 promoter.

242 GM-CSF and intact GM-CSF receptor signaling, PPAR-gamma was not sufficiently upregulated in developin

243 AR gamma-expressing and immune cell-specific PPAR gamma null mice demonstrate that ABA down-regulates

244 drugs thiazolidinediones (TZDs) are specific PPAR-gamma agonists.

245 e TRPC6 expression, as did podocyte-specific PPAR-gamma knockout mice, which were more sensitive to a

246 h enhanced susceptibility of tissue-specific PPAR-gamma null mice to trinitrobenzene sulfonic acid-in

247 oliferator-activated receptor gamma subunit (PPAR-gamma), the master activator of adipogenesis.

248 This suggests PPAR gamma pathways may be a fruitful drug target in PD.

249 nt of Cftr-deficient mice with the synthetic PPAR-gamma ligand rosiglitazone partially normalizes the

250 Genomic profiling reveals that PPAR gamma deficiency leads to increased expression of l

251 Increasing evidence suggests that PPAR gamma is involved in the regulation of vascular fun

252 We conclude that PPAR-gamma agonists exert a direct effect in diabetic is

253 vitro studies of INS-1 cells confirmed that PPAR-gamma binds to the putative PPRE sequence and regul

254 Our results demonstrate that PPAR-gamma activation directly improves beta cell functi

255 These studies demonstrate that PPAR-gamma-expressing, but not PPAR-gamma null Treg, pre

256 Collectively, these results indicate that PPAR-gamma blocked Smad-mediated transcriptional respons

257 This study indicates that PPAR-gamma activation is involved in PMN chemotactic res

258 We show that PPAR-gamma coactivator (PGC)-1alpha and PGC-1beta are cr

259 Collectively, these studies suggest that PPAR-gamma agonists may be beneficial in the treatment o

260 These results suggest that PPAR-gamma agonists may benefit aging-related renal inju

261 of the underlying mechanisms suggested that PPAR-gamma functions as a direct regulator of c-fos expr

262 The PPAR-gamma coactivator (PGC)-1 family of proteins plays

263 The PPAR-gamma LBD cooperates with both DNA-binding domains

264 itazone exerts this effect by activating the PPAR-gamma pathway.

265 f peroxisomes in POMC neurons induced by the PPAR-gamma agonist rosiglitazone decreased ROS levels an

266 This effect was abolished by the PPAR-gamma-specific antagonist, GW9662, suggesting that

267 IH may be mediated through modulation of the PPAR-gamma activation pathway in GC.

268 e effects resulting from the presence of the PPAR-gamma agonist may be secondary to improvements in e

269 the deleterious bone loss side effect of the PPAR-gamma agonist rosiglitazone.

270 In contrast, hepatic levels of the PPAR-gamma and PPAR-alpha proteins were significantly lo

271 be partly due to increased expression of the PPAR-gamma co-activator 1-alpha.

272 asculature and the modulatory effects of the PPAR-gamma ligands.

273 lpha homodimer is different from that of the PPAR-gamma-RXR-alpha heterodimer, even when both NR comp

274 Here, we found that the PPAR-gamma agonist pioglitazone protected against renal

275 In BMSCs exposed to the PPAR-gamma (peroxisome proliferator-activated receptor-g

276 diabetic or glucose-intolerant mice with the PPAR-gamma agonist pioglitazone or with a control.

277 apsigargin-treated INS-1 beta cells with the PPAR-gamma agonist resulted in the reduction of endoplas

278 Treatment with the PPAR-gamma agonist rosiglitazone reversed the phenotype.

279 Finally, treatment with the PPAR-gamma antagonist GW9662 significantly reversed the

280 -dependently inhibited by treatment with the PPAR-gamma ligands troglitazone and 15-deoxy-Delta(12,14

281 Therefore, PPAR-gamma and its ligands have a previously unrecognize

282 Thiazolidinediones, PPAR gamma agonists, lower blood pressure and have prote

283 bolism, and cell signaling, in part, through PPAR gamma.

284 hibits TRPC6 expression in podocytes through PPAR-gamma-dependent mechanisms, thereby counteracting p

285 at hyperactive PPAR signaling, either due to PPAR gamma gene amplification or RXRA hot-spot mutation

286 stinct pattern of coregulator recruitment to PPAR gamma.

287 m, which lacks deadenylase activity, bind to PPAR-gamma and markedly enhance PPAR-gamma transcription

288 its activity and could competitively bind to PPAR-gamma.

289 stimulates brown adipogenesis by binding to PPAR-gamma (peroxisome-proliferator-activated receptor-g

290 FRE exhibited 82.6% binding to PPAR-gamma.

291 that promote reverse cholesterol transport (PPAR-gamma, LXR-alpha, and ABCG1) and macrophage emigrat

292 Unexpectedly, PPAR-gamma expression by VAT Treg cells was necessary fo

293 l fibrosis, and subcutaneous lipoatrophy via PPAR-gamma in a mouse model of scleroderma and suggest t

294 atty acids in MC3T3 cells increased in vitro PPAR-gamma activity and inhibited beta-catenin activity.

295 e viral transcriptional activator VP16 (VP16-PPAR-gamma), led to positive energy balance in rats.

296 by using a Tie2Cre/flox mouse model in which PPAR-gamma is deleted in osteoclasts but not in osteobla

297 While PPAR gamma is known to promote adipogenesis and lipogene

298 lography revealed that INT131 interacts with PPAR gamma through a distinct binding mode, forming prim

299 that inhibits its physical interaction with PPAR-gamma.

300 o-PGE2 signaling cascade that interacts with PPAR-gamma, Smad2/3, and TAP63.