ライフサイエンスコーパス: PPARGC1A

1 a coactivator 1alpha (PGC-1alpha, encoded by Ppargc1a).

2 and transcription regulation (INSIG1, PPARG, PPARGC1A).

3 ogenesis and known to interact with PPARs or PPARGC1A.

4 vity and combinatorial binding patterns with PPARGC1A.

5 and had a parallel pattern of expression to PPARGC1A.

6 PARG G allele (rs1801282) and noncarriers of PPARGC1A A allele (rs8192678) had 21 and 13% lower hepat

7 ceptor gamma-coactivator 1alpha; also called PPARGC1A) a coactivator of the Kdm5a target genes, is su

8 ctivated receptor gamma coactivator 1-alpha (PPARGC1A), a coactivator of the transcription factor PPA

9 in PPAR gamma (PPARG) co-activator 1 alpha (PPARGC1A), a gene encoding a co-activator of the LCPUFA-

10 ctivated receptor-gamma coactivator-1 alpha (PPARGC1A), a master transcriptional regulator of mitocho

11 Here we show that PGC-1alpha (Ppargc1a), a transcriptional coactivator that regulates

12 ARGC1a (also known as PGC-1alpha; encoded by Ppargc1a), a transcriptional coactivator that regulates

13 Expression of Ppargc1a, a central molecule for mitochondrial metabolis

14 Here we leveraged PPARGC1a (also known as PGC-1alpha; encoded by Ppargc1a)

15 PPARGC1A and CREB3L3 bound the Hamp promoter to activate

16 nistration of small interfering RNAs against Ppargc1a and Creb3l3.

17 ap of targets including a novel link between PPARGC1A and HSF1, a TF regulating the conserved heat sh

18 tudies have focused on the interplay between PPARGC1A and individual TFs, but little is known about h

19 to 8-br-cAMP with a 200% greater increase in Ppargc1a and Pck1 expression, and a 30% increase in G6pc

20 eta (PGC-1alpha and PGC-1beta, also known as Ppargc1a and Ppargc1b, respectively) and the downstream

21 inhibits, whereas Notch inhibition induces, Ppargc1a and Prdm16 transcription in white adipocytes.

22 epG2 cells were transfected with variants of PPARGC1A and protein and messenger RNA levels were measu

23 pathways, including expression of the genes Ppargc1a and Ucp1.

24 tor (MC2R), MC3R, PPARG coactivator 1 alpha (PPARGC1A), and tumor necrosis factor (TNF), was changed

25 tal role for a concerted action among PPARG, PPARGC1A, and INSIG1.

26 50 directly targets and represses Prdm16 and Ppargc1a, and that forced expression of miR-150 attenuat

27 iptional regulators of metabolism, PPARG and PPARGC1A, as well as SCD1, the rate-limiting enzyme for

28 a coactivator-1alpha (PGC-1alpha, encoded by Ppargc1a) by SIRT1 activators, our results illustrate ho

29 their co-activators Pgc1alpha (also known as Ppargc1a), CBP/p300 (Crebbp) and Src1 (Ncoa1) to the PPR

30 Another PPARGC1A coding variant (rs8192678) showed statistical i

31 ndividual TFs, but little is known about how PPARGC1A combines with all of its partners across the ge

32 ficient hearts, suggesting that up-regulated Ppargc1a confers increased mitochondrial metabolism and

33 s of down-regulated genes (e.g. AMPK, TORC2, PPARGC1A) correspond to a single common pathway importan

34 PPARGC1A DNA methylation percentages in muscle and SAT w

35 atment did not affect the heart size of Flcn/Ppargc1a doubly inactivated hearts, further supporting t

36 Deletion of Ppargc1a dramatically increased RGC loss, in association

37 d is required for the transcription of Ucp1, Ppargc1a (encoding PGC-1alpha), and oxidative phosphoryl

38 nhibition of HNF-1beta significantly reduced PPARGC1A expression and altered mitochondrial morphology

39 We also demonstrated downregulation of renal PPARGC1A expression in a patient with an HNF1B germinal

40 clear factor-1beta (HNF-1beta) in regulating PPARGC1A expression in AKI.

41 yperglycemia may contribute to the decreased PPARGC1A expression in O-GDM.

42 Increasing physical activity, which induces PPARGC1A expression, is a potential strategy to slow DNA

43 zygous or homozygous disruption of Ppargc1a (Ppargc1a(f/+)Alb-cre(+/0) and Ppargc1a(f/f) Alb-cre(+/0)

44 Oxidative damage was observed in livers from Ppargc1a(f/+)Alb-cre(+/0) mice of each sex, in a cell-au

45 he increased liver damage observed in female Ppargc1a(f/+)Alb-cre(+/0) mice; while, compensatory incr

46 n of Ppargc1a (Ppargc1a(f/+)Alb-cre(+/0) and Ppargc1a(f/f) Alb-cre(+/0) mice, respectively) were fed

47 ed with complete loss of PGC1A expression in Ppargc1a(f/f)Alb-cre(+/0) female mice.

48 ne distributions of DNA sequence variants in PPARGC1A for association with NV AMD and interaction of

49 a Tug1-binding element (TBE) upstream of the Ppargc1a gene and showed that Tug1 binds with the TBE to

50 The PPARGC1A gene encodes PGC-1alpha, which regulates cellul

51 Decreased PPARGC1A gene expression in muscle has previously been a

52 The unaltered PPARGC1A gene expression in muscle of O-T1D suggests tha

53 PPARGC1A gene expression in muscle was lower in O-GDM co

54 n and examined the relationship between nine PPARGC1A genetic variants, DNA damage, type 2 diabetes,

55 variants showed significant association, and PPARGC1A haplotypes exhibited significant association af

56 ion of key lipid metabolism genes, including PPARGC1A, HMGCS2, and ABHD5.

57 deficient hearts and indeed, inactivation of Ppargc1a in Flcn-deficient hearts significantly reduced

58 We confirm the role of PPARGC1A in muscle and show some support for inflammatio

59 , and gene expression and DNA methylation of PPARGC1A in skeletal muscle and SAT.

60 activated receptor-gamma coactivator-1alpha (PPARGC1A) in skeletal muscle and subcutaneous adipose ti

61 he expression of thermogenic genes (Ucp1 and Ppargc1a) in subcutaneous WAT.

62 Ppargc1a inactivation restored phospho-AMPK-alpha levels

63 nteraction domains important for Ucp1 versus Ppargc1a induction by PRDM16.

64 PPARGC1A influences activation of the AMD-associated com

65 We propose that PPARGC1A influences development of type 2 diabetes and C

66 induced early and transient inflammation and PPARGC1A inhibition, which overlapped with downregulatio

67 A SNP in PPARGC1A interacted with alcohol consumption in African

68 activated receptor gamma-coactivator 1alpha (PPARGC1A) into myonuclei.

69 PPARGC1A is a transcriptional coactivator that binds to

70 ted hearts, further supporting the idea that Ppargc1a is the critical element leading to deregulation

71 a) coactivator alpha (PGC-1alpha, encoded by Ppargc1a) is functionally regulated by the lncRNA taurin

72 Vehicle-treated and naive Ppargc1a(-/-) mice also showed mild RGC loss, and surpri

73 nal ischaemia, Pgc1alpha(-/-) (also known as Ppargc1a(-/-)) mice develop local deficiency of the NAD

74 of starved mice also had increased levels of Ppargc1a mRNA and Creb3l3 mRNA, which encode a transcrip

75 ence motifs corresponding to known and novel PPARGC1A network partners.

76 els of antioxidant enzymes compared with the Ppargc1a(+/+) on the same diet.

77 d receptor-gamma (PPARG) coactivator 1alpha (PPARGC1A or PGC1A) is inversely correlated with liver fa

78 TH did not blunt fibrosis in Ppargc1a- or Pink1-knockout mice, suggesting dependence

79 transcription factor MITF drives PGC1alpha (PPARGC1A) overexpression in a subset of human melanomas

80 Induction of the gluconeogenic genes Ppargc1a, Pck1, and G6pc by glucagon or 8-br-cAMP was su

81 with liver-specific hemizygous disruption of Ppargc1a placed on an obesogenic diet expressed increase

82 PPARGC1A plays a pivotal role in regulating energy metab

83 cific hemizygous or homozygous disruption of Ppargc1a (Ppargc1a(f/+)Alb-cre(+/0) and Ppargc1a(f/f) Al

84 owed that Tug1 binds with the TBE to enhance Ppargc1a promoter activity.

85 analysis confirmed HNF-1beta binding to the Ppargc1a promoter in mouse kidneys.

86 MEF2A also bound the MEF2A and PPARGC1A promoters in ChIP, placing it within a feedback

87 PGC-1alpha (encoded by PPARGC1A) regulates adaptive metabolism and oxidative st

88 ligo patients, whereas its predicted targets PPARGC1A, RRM2, and TAOK1 were reciprocally up-regulated

89 Subjects with the PPARGC1A rs8192678 risk A allele had an increase in the

90 The PPARGC1A rs8192678 risk A allele is associated with an i

91 e evaluated the independent influence of the PPARGC1A rs8192678 risk A allele on pediatric NAFLD afte

92 , sex, and PNPLA3 rs738409 polymorphism, the PPARGC1A rs8192678 risk A allele was an independent risk

93 We aimed to test the hypothesis that the PPARGC1A rs8192678 risk A allele would influence the ris

94 ochondrial dysfunction during AKI partly via PPARGC1A signaling.

95 mong 9 genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, SLC2A2, TCF7L2, and UCP2) associated with type

96 ed that seven genes (CDKN1A, ESR1, MAX, MYC, PPARGC1A, SP1, and STK11) and one novel MYC-centered pat

97 cription factor (PPARG co-activator 1 alpha, PPARGC1A) to age-related macular degeneration (AMD) and

98 r demonstrate that SCF/Kit directly promotes Ppargc1a transcription and mitochondrial biogenesis.

99 In this study, we describe a core PPARGC1A transcriptional regulatory network operating in

100 ic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synt

101 irst mapped the genome-wide binding sites of PPARGC1A using chromatin-IP followed by high-throughput

102 Two independent PPARGC1A variants associated significantly with type 2 d

103 With respect to urinary 8-OHdG, PPARGC1A variants showed significant association, and PP

104 Carriers of minor alleles of two other PPARGC1A variants, both in strong linkage disequilibrium

105 in African Americans, and a different SNP in PPARGC1A was nominally associated in Caucasians.

106 erator-activated receptor gamma cofactor 1A (PPARGC1A) was 1.75-fold reduced with insulin resistance

107 eceptor-gamma coactivator (PGC)-1alpha gene (PPARGC1A) was identified to be associated with nonalcoho

108 17590046) in the transcriptional coactivator PPARGC1A were associated with essential tremor.

109 R-resident regulatory variant (rs3774923) in PPARGC1A were independently associated with NV AMD (exac