ライフサイエンスコーパス: PPK

1 PPK associated with PC is extremely painful and compromi

2 PPK is specifically expressed in nociceptive, class IV m

3 PPK-1 is posteriorly enriched in the one-celled embryo t

4 PPK-1 is strongly expressed in the nervous system, and c

5 PPKs phosphorylate light-signaling proteins and histones

6 Tryptic digests of [32P]PPK contain a predominant 32P-labeled peptide that inclu

7 scoideum, the social slime mold, possesses a PPK activity (DdPPK1) with sequence similarity to bacter

8 ned spontaneous skin lesions and accelerated PPK development in footpad skin.

9 These data demonstrate that tPA activates PPK in plasma and PKal inhibition reduces cerebral compl

10 Although PPK did not form channels on its own, it associated with

11 y detect in vivo physical interactions among PPK and Balboa subunits.

12 The requirement for Balboa and PPK in mechanical nociception behaviors and their specif

13 Remarkably, another PPK in Dictyostelium discoideum (PPK2) is an actin-relat

14 consistently causes oral lesions as well as PPK-like hyperkeratotic calluses on Krt16(-/-) front and

15 The defining features of PC-associated PPK are reproduced in mice null for keratin 16 (Krt16),

16 - 2) (Equation 4); and autophosphorylation, PPK + ATP --> PPK-P + ADP (Equation 5).

17 dPPK1) with sequence similarity to bacterial PPKs.

18 t for antibiotics, with low toxicity because PPK is not found in higher eukaryotes.

19 pose that asymmetric generation of PIP(2) by PPK-1 directs the posterior enrichment of GPR-1/2 and LI

20 phosphate and for the regeneration of ATP by PPK in the degradosome.

21 of a phosphate from polyphosphate to GDP by PPK to produce GTP was the predominant reaction, the enz

22 Chemical modification of RNA by PPK, for example the addition or removal of 3' or 5' ter

23 mon mechanism whereby Cx26 mutations causing PPK and deafness transdominantly influence multiple func

24 In contrast, PPK was found in sensory dendrites of a subset of periph

25 The gene (ppk) that encodes PPK is highly conserved among many bacterial pathogens,

26 he polyphosphate kinase (ppk) gene, encoding PPK responsible for the synthesis of inorganic polyphosp

27 gamma CSNK-1 and a PIP(2) synthesis enzyme (PPK-1) transduce PAR polarity to asymmetric Galpha regul

28 Once neurons are established, PPK-1 overexpression results in progressive membrane ove

29 Among deletion mutants, some lost all five PPK activities, but others retained partial activity for

30 hich mutations have been identified in focal PPK families who show no increased cancer risk.

31 In PC, focal PPK (FPPK) is the most painful and debilitating phenotyp

32 The order of substrate specificity for PPK was: ADP > GDP > UDP, CDP; activity with ADP was 2-6

33 n 4); and autophosphorylation, PPK + ATP --> PPK-P + ADP (Equation 5).

34 hanical nociception function for heteromeric PPK and Balboa channels in vivo.

35 Loss of CSNK-1 causes uniformly high PPK-1 levels, high symmetric cortical levels of GPR-1/2

36 ncipal functional unit of the homotetrameric PPK is a dimer.

37 e adverse effects of tPA were ameliorated in PPK (Klkb1)-deficient and FXII-deficient mice and in wil

38 Of the 16 histidine residues in PPK of E. coli, 4 are conserved among several bacterial

39 Follow-up studies reveal a temporal shift in PPK onset in Krt16(-/-) females, coinciding with sex-spe

40 ter tracheal tube formation, with individual PPK genes showing distinct temporal and spatial expressi

41 non-epidermolytic palmoplantar keratoderma (PPK or palmoplantar ectodermal dysplasia type III) is as

42 x26-S183F, causing palmoplantar keratoderma (PPK) and deafness.

43 Palmoplantar keratoderma (PPK) are debilitating lesions that arise in individuals

44 in SLURP1 cause a palmoplantar keratoderma (PPK) known as mal de Meleda.

45 eratin 5), striate palmoplantar keratoderma (PPK), and ichthyosis hystrix Curth-Macklin (different fr

46 de Meleda, a rare palmoplantar keratoderma (PPK).

47 eukokeratosis, and palmoplantar keratoderma (PPK).

48 Painful palmar-plantar keratoderma (PPK) severely impairs mobility in pachyonychia congenita

49 Palmoplantar keratodermas (PPKs) are a group of disorders that are diagnostically a

50 The palmoplantar keratodermas (PPKs) are a large group of clinically and genetically he

51 nderwent pediatric penetrating keratoplasty (PPK) for herpes simplex virus (HSV) keratitis.

52 ic polyphosphate (poly P) and poly P kinase (PPK), the enzyme principally responsible for its synthes

53 Poly P kinase (PPK), the enzyme that synthesizes poly P from ATP, is en

54 bolism of poly-P, namely, (i) poly-P kinase (PPK), which synthesizes poly-P reversibly from ATP, (ii)

55 TP is catalyzed reversibly by poly P kinase (PPK, now designated PPK1) initially isolated from Escher

56 to assess the role of polyphosphate kinase (PPK) in the physiology of Porphyromonas gingivalis, a pp

57 ty of Escherichia coli polyphosphate kinase (PPK) that can convert poly P and ADP to ATP and of a yea

58 ity in the capacity of polyphosphate kinase (PPK) to use inorganic polyphosphate as the donor in plac

59 Polyphosphate kinase (PPK), encoded by the ppk gene, is the principal enzyme i

60 The ppk gene encodes polyphosphate kinase (PPK), the principal enzyme in many bacteria responsible

61 Polyphosphate kinase (PPK), the principal enzyme required for the synthesis of

62 nt of the degradosome, polyphosphate kinase (PPK), which catalyses the reversible polymerization of t

63 te (polyP) from ATP by polyphosphate kinase (PPK; EC 2.7.4.1) of Escherichia coli, an N-P-linked phos

64 discovery of at least four distinct kinases (PPKs, CK2, BIN2, and phytochrome itself) and four famili

65 The ppk mutant, lacking PPK and thus severely deficient in poly P, also fails to

66 ngenita, develop pachyonychia congenita-like PPK.

67 The gene defects underlying many PPKs still need to be resolved to facilitate definitive

68 In developing neurons, PPK-1 overexpression leads to growth cones that become s

69 amily with severe, diffuse, nonepidermolytic PPK and verrucous hyperkeratotic plaques over the joints

70 rameric state for the autophosphorylation of PPK (Equation 5) at low ATP concentrations.

71 The conservation of PPK among many bacterial pathogens and its absence in eu

72 f Krt16-/- mice prevented the development of PPK and normalized redox balance via regeneration of GSH

73 The highly conserved homology of PPK among 18 microorganisms was used to determine import

74 Western blot analysis to quantify levels of PPK and PPX and found that these enzymes differentially

75 hemichannel activity in the pathogenesis of PPK and further highlight an emerging role for Cx43 in g

76 of virulence on poly P and the potential of PPK as a target for antimicrobial drugs.

77 ion of glutathione levels, and prevention of PPK in female Krt16(-/-) mice.

78 ity suggests a crucial and essential role of PPK or polyP in bacterial pathogenesis.

79 The predicted amino acid sequence of PPK is 701 residues (81.6 kDa), with 64% identity to tha

80 nside a host, the dependence for motility on PPK reveals important roles for poly P in diverse proces

81 rosophila DEG/ENaC genes, called pickpocket (PPK) genes, we found 9 expressed in the tracheal system.

82 l Drosophila DEG/ ENaC proteins, Pickpocket (PPK) and Ripped Pocket (RPK).

83 2 (NRF2)-dependent gene expression precedes PPK onset, which can be prevented by topical sulforaphan

84 the effects of tPA on plasma prekallikrein (PPK) activation and the role of PKal on cerebral outcome

85 treatment fails to activate NRF2 and prevent PPK in female Krt16(-/-) mice despite a similar set of m

86 18 families with autosomal dominant punctate PPK, we report heterozygous loss-of-function mutations i

87 Punctate PPKs are characterized by circumscribed hyperkeratotic l

88 onas aeruginosa as well as with the purified PPK from E. coli; the activity was absent from the membr

89 call into question the view that PC-related PPK arises exclusively as a gain-of-function on account

90 Promoters for several PPK genes drove reporter gene expression in the larval a

91 Slurp1(-/-) mice developed severe PPK characterized by increased keratinocyte proliferatio

92 Purified His-tagged PPK was shown to bind RNA, and RNA binding was prevented

93 We show that PPK-1 purified from C. elegans can generate PIP(2)in vit

94 Here, we have shown that PPK onset is preceded by oxidative stress in footpad ski

95 These results suggest that PPK may be a channel subunit involved in mechanosensatio

96 These results suggest that PPK may be important for incorporation of these organism

97 s and its absence in eukaryotes suggest that PPK might be an attractive target for antimicrobial drug

98 l microRNA-expressing lines demonstrate that PPKs catalyse blue light-dependent CRY2 phosphorylation

99 analyses of these mutant lines indicate that PPKs may have additional substrates, including those inv

100 In these families, the PPK is inherited as autosomal dominant and has a late on

101 ced to <5% of the WT; in the ppx mutant, the PPK activity is elevated 10-fold, and the accumulation o

102 The high degree of homology of the PPK sequence in many bacteria, including some of the maj

103 uded 9 eyes; median age at the moment of the PPK was 14 years.

104 in the Drosophila tracheal system where the PPK proteins likely play a role in Na(+) absorption.

105 This reaction was observed with the PPK activity present in crude membrane fractions from Es

106 xpand the genetic testing repertoire for the PPKs.

107 Genetic analyses demonstrate that the PPKs are collectively necessary for the normal light-ind

108 These data establish that the PPKs are directly involved in catalysing the photoactiva

109 Thus PPK may prove, as it has with P. aeruginosa, to be an at

110 Thus, PPK in the degradosome appears to maintain an appropriat

111 d neuromuscular abnormalities in addition to PPK.

112 ss and dysfunctional NRF2 as contributors to PPK pathogenesis, identify K16 as a regulator of NRF2 ac

113 nit highly similar in amino acid sequence to PPK.

114 Other sensory-related genes such as TRPs, PPKs and mechanoreceptors had consistent levels of expre

115 have discovered a previously uncharacterized PPK activity (designated PPK2) distinguished from PPK1 b

116 with history of HSV keratitis that underwent PPK and were followed in a single institution.

117 We find here a previously unrecognized PPK (DdPPK2) in D. discoideum with the sequences and pro

118 codependent as balboa-RNAi eliminates Venus::PPK from the sensory dendrites of nociceptors.

119 ly expressed in other neuron subtypes (where PPK is not expressed).

120 The long-term outcomes with PPK for HSV keratitis in children provide improvement in