ライフサイエンスコーパス: PR domain

1 PR domain containing 1 with zinc finger domain (PRDM1)/B

2 PR domain-containing 16 (PRDM16) induces expression of b

3 PR domain-containing protein 7 (PRDM7) is a primate-spec

4 PR-domain-containing proteins (PRDMs) are zinc-finger se

5 ding frame of 796 amino acids and contains a PR domain in the middle region and six zinc finger motif

6 ding frame of 630 amino acids and contains a PR domain in the NH-terminal region followed by 16 zinc

7 er gene, which also normally gives rise to a PR domain-lacking product, EVI1, because of an internal

8 reverse regulation of B-cell lymphoma 6 and PR domain containing 1 and differential BTB and CNC homo

9 Homozygous mutations in ZNF469 and PR domain-containing protein 5 (PRDM5) genes result in b

10 -induced maturation protein-1 (also known as PR domain-containing 1, with ZNF domain (PRDM1)).

11 nger transcriptional repressor Prdm1/Blimp1 (PR domain containing 1, with ZNF domain; previously name

12 e RIZ is a member of the recently discovered PR domain family that includes the MDS1-EVI1 breakpoint

13 new protein, PRDI-BF1 beta, has a disrupted PR domain and lacks the amino-terminal 101 aa of the ori

14 CL6 mRNA and protein expression by elevating PR domain-containing 1 with ZNF domain (PRDM1) levels in

15 ecreased basal expression of PRDM1 (encoding PR domain containing 1, with ZNF domain) and impaired in

16 ke their mouse counterparts, did not express PR domain containing protein 16, a key factor present in

17 sed by mutations in the transcription factor PR domain containing 5 (PRDM5) hypothesized to exert epi

18 oteins lacking the PRDI-BF1-RIZ1 homologous (PR) domain, similar to what is observed in human leukemi

19 We identified rare missense mutations in PR domain-containing 1 (PRDM1) and associated these with

20 Interestingly, PR-domain containing 16 emerged as a target gene that is

21 rized function of PRDM16 that depends on its PR domain activity.

22 dies, N-terminal sequencing of the liberated PR domain was carried out to exactly identify the site o

23 which eliminates Mds1-Evi1 (ME), the longer, PR-domain-containing isoform produced by the gene (also

24 activity of a histone H3 methyltransferase, PR domain containing 9 (PRDM9), the product of the only

25 We describe here a new PR-domain-containing gene designated as PRDM5 (PFM2).

26 dermotomal precursors through the action of PR domain containing protein 16 (PRDM16) transcriptional

27 Epidermal-specific deletion of PR domain containing 1, with ZNF domain (Prdm1), the gen

28 ) mice because of the elevated expression of PR domain containing 16 and peroxisome proliferator-acti

29 The induction of PR domain-containing protein 1 (PRDM1; also known as Bli

30 tudies clearly indicate an essential role of PR-domain protein ME in MFP leukemia, suggesting that ME

31 sults clearly demonstrate a critical role of PR-domain-containing ME in linking p57-kip2 regulation t

32 phocyte-induced maturation protein-1)/PRDM1 (PR domain-containing 1, with ZNF domain) binding site, a

33 PRDM16 (PR domain containing 16) is a 140 kDa zinc finger protei

34 A coding polymorphism in Prdm16 (PR-domain-containing 16) underlies Tb2r1 and differentia

35 able HKG (in order of stability) were Prdm4 (PR domain 4) > Ube4a (Ubiquitin-Conjugating Enzyme 4a) >

36 PRDM9 (PR domain-containing protein 9) is a meiosis-specific pr

37 atin-remodeling proteins and named it PRISM (PR domain in smooth muscle).

38 trix (MA), the capsid (CA), or the protease (PR) domain did not abrogate packaging, although the MA d

39 Blimp1 are members of the recently realized PR domain family that includes the retinoblastoma intera

40 We demonstrated that the Pseudo-Receiver (PR) domain of PRR5 interacts directly with the F box pro

41 rotein motif called the positive regulatory (PR) domain has been described.

42 Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich

43 istinct role of the C-terminal proline-rich (PR) domain to obstruct the engagement of allosteric Ras

44 We show here that RIZ1 PR domain mediates protein-protein interaction.

45 e differ by the presence of a PRDI-BF1-RIZ1 (PR) domain with histone methyltransferase activity in th

46 This SET-PR domain protein can form complexes with various chroma

47 o the nucleus and contains an amino-terminal PR domain and four Kruppel-like zinc fingers at the carb

48 full-length Gag missing only the C-terminal PR domain, as well as similar proteins missing in additi

49 Mutation in the N-terminal PR domain of PRDM16 abolishes the intrinsic enzymatic ac

50 250-kDa RIZ2 product lacked the NH2-terminal PR domain of RIZ1; it comigrated with a truncated RIZ1 p

51 We and others showed previously that PR domain-containing 16 (Prdm16) is a transcriptional re

52 The PR domain is a newly recognized protein motif that chara

53 The PR domain of MDS1-EVI1 is disrupted by translocations li

54 The PR domain, first noted as the PRDI-BF1 (HGMW-approved sy

55 The PR domain, first noted as the PRDI-BF1-RIZ1 homologous r

56 site between the upstream NC domain and the PR domain, the proteolytic liberation of PR previously w

57 presence of its zinc finger domains and the PR domain.

58 is clear that processing is initiated by the PR domain that is embedded within the precursor itself.

59 precursor processing are accomplished by the PR domain within GagPol in cis, before it is released fr

60 uces two protein products that differ by the PR domain.

61 reverse transcriptase residues flanking the PR domain.

62 Furthermore, the PR domain comprises largely intrinsically disordered seg

63 this activity is reduced by mutations in the PR domain found in human cancers.

64 ngth, and the smaller protein RIZ2 lacks the PR domain of RIZ1 but is otherwise identical to RIZ1.

65 The smaller protein RIZ2 lacks the PR domain of RIZ1 but is otherwise identical to RIZ1.

66 each express a truncated protein missing the PR domain.

67 independently described sequence motif, the PR domain.

68 hrough a conserved amino-terminal motif, the PR domain.

69 Here we show that prdm12b, a member of the PR domain containing-family of transcriptional regulator

70 Members of the PR domain family have been shown to play important roles

71 g that the cleavage at the N terminus of the PR domain from the precursor leads to the stabilization

72 This inhibitory role of the PR domain limits Grb2-independent recruitment of SOS to

73 t on the budding defect, but deletion of the PR domain of Gag restored normal budding.

74 ay serve as a model for the structure of the PR domain of the Gag polyprotein and may thus give clues

75 d a previously uncharacterized member of the PR domain-containing family of tumor suppressors, PRDM5.

76 erved 1p alterations, with impairment of the PR domain-mediated function through either frameshift mu

77 mino-terminal region of PFM1 and part of the PR domain.

78 en PRR5 and ZTL levels, which depends on the PR domain.

79 and lacks an NH2-terminal motif of RIZ1, the PR domain conserved in a subfamily of zinc finger genes

80 Our data suggest that the PR domain is a derivative of SET domain and may function

81 Further, we show that the PR domain is essential for MFP-induced transformation.

82 We also found that the PR domain shares significant sequence identity to the SE

83 Our data demonstrate that the PR domain within GagPol is constrained in its ability to

84 show and characterize binding of SAM to the PR domain of PRDM2, a lysine methyltransferase with puta

85 NA was isolated based on its homology to the PR domain of RIZ1 (PRDM2).

86 s been isolated based on its homology to the PR domain.

87 0% homology at the amino acid level with the PR domain of the retinoblastoma-interacting zinc-finger

88 of the three divergent residues between the PR domains of PRDM7 and PRDM9.

89 mer; enzyme activation is initiated when the PR domains in two GagPol precursors dimerize.

90 The PR-domain (PRDM) family of genes encodes transcriptional

91 y consistent with the known functions of the PR-domain family.

92 depletion of the previously uncharacterized PR-domain family member Prdm11 and overexpression of MYC