ライフサイエンスコーパス: PRBC

1 PRBCs activate inflammatory genes in circulating leukocy

2 utcome when comparing patients who had a 1:1 PRBC:FFP ratio with those who did not receive any FFP.

3 27 patients, 942 (31.1%) received at least 1 PRBC transfusion, intraoperatively in 264 patients (8.7%

4 A total of 5901 PRBC units were transfused for a median of 2 (interquart

5 A total of 5901 PRBC units were transfused for a median of 2 (interquart

6 .037) and transfusional requirements (2 vs 6 PRBC; P = 0.08) and SAEs lower (15% vs. 47%; P = 0.077)

7 protein expressed on the surface of adherent PRBCs.

8 ight percent (n = 250) of them received both PRBCs and FFP.

9 Patients were stratified by PRBC:FFP transfusion ratio over the first 24 hours.

10 impact of transfused packed red blood cell (PRBC) age on perioperative morbidity among patients unde

11 transfusion for each packed red blood cell (PRBC) transfused was recorded, in minutes, for all patie

12 of patients receiving packed red blood cell (PRBC) using a liberal trigger hemoglobin concentration (

13 and transfusions of packed red blood cells (PRBC).

14 for a single unit of packed red blood cells (PRBCs) based on actual institutional acquisition costs (

15 P) in a 1:1 ratio to packed red blood cells (PRBCs) has led many civilian trauma centers to adopt thi

16 usion of plasma from packed red blood cells (PRBCs) or antibodies (OX18 and OX27) against MHC class I

17 more than 6 units of packed red blood cells (PRBCs) within the first 12 hours of injury is the strong

18 od, whole blood, and packed red blood cells (PRBCs).

19 ter than 10 units of packed red blood cells [PRBCs] in less than 24 hrs) than civilian injured.

20 d LPRBCs and provides a mechanism to deliver PRBCs in a wide variety of settings.

21 d cytoadherence of parasitized erythrocytes (PRBC) to endothelial cells.

22 smodium falciparum parasitized erythrocytes (PRBCs) to microvascular endothelium contributes directly

23 consideration should be given to 1 : 1 FFP :PRBC transfusion, and in severe cases, rFVIIa.

24 ication of PfEMP1 as a malarial receptor for PRBC adherence to host proteins.

25 ve risk factors for renal failure, including PRBC transfusion data.

26 Mild trypsinization of intact PRBCs of P. falciparum strains shown to express antigeni

27 he potential confounding affect of numerical PRBC data on ARF.

28 Estimated total costs of PRBC transfusion ranged from $880,000 to $3,040,000, wit

29 throcytes by merozoites and cytoadherence of PRBC to endothelial cells by increasing negative repulsi

30 The effect of PRBC age (ie, storage duration before transfusion) on pe

31 The effect of PRBC age (ie, storage duration before transfusion) on pe

32 lyses were performed to assess the effect of PRBC age on perioperative morbidity.

33 lyses were performed to assess the effect of PRBC age on perioperative morbidity.

34 Preadsorption of PRBC extracts with anti-PfEMP1 antibodies, CD36, or TSP

35 Because preincubation of PRBC with sulfated glycosaminoglycans and treatment of t

36 erance of data indicates that transfusion of PRBC in the population of patients with ischemic heart d

37 ly increased with increasing transfusions of PRBC (P<0.001).

38 Transfusions of PRBC are known to directly increase the risk of new onse

39 (31.4%) patients received at least 1 unit of PRBC that had been stored for >/=35 days ("older" blood)

40 (31.4%) patients received at least 1 unit of PRBC that had been stored for >/=35 days ("older" blood)

41 hed for all studies investigating the use of PRBC in medical and surgical patients with cardiac disea

42 core to determine if early aggressive use of PRBC:FFP improved outcome.

43 ic approach to block or reverse adherence of PRBCs to host cell receptors can now be pursued with the

44 Data regarding the storage duration of PRBCs, clinicopathologic characteristics, and perioperat

45 Data regarding the storage duration of PRBCs, clinicopathologic characteristics, and perioperat

46 Mean number of PRBCs and FFP transfused were 7.7 +/- 12 U, 6 U, and 5 +

47 efine a liberal Hb trigger as transfusion of PRBCs for an intraoperative Hb level of 10 g/dL or great

48 lorectal resection and received >/=1 unit of PRBCs between 2009 and 2014 at the Johns Hopkins Hospita

49 lorectal resection and received >/=1 unit of PRBCs between 2009 and 2014 at the Johns Hopkins Hospita

50 an 24-hour transfusion volume was 4 units of PRBCs (IQR 2-8), and mortality was 14%.

51 A total of 4000 units of PRBCs (range, 0-167 units/patient) were transfused in th

52 atelets, often given well before 10 units of PRBCs have been transfused; the early use of recombinant

53 More than 1 in 10 units of PRBCs were transfused using a liberal Hb trigger.

54 dopting a restrictive trigger, total overall PRBC transfusion costs may have been reduced by $100,320

55 detergent extracts of surface-radioiodinated PRBCs using several endothelial cell receptors known to

56 ients undergoing major surgery often receive PRBC transfusions.

57 ients undergoing major surgery often receive PRBC transfusions.

58 Numbers of surgical patients who received PRBC transfusion, estimated cost per transfusion, and es

59 associated with 23% lower odds of receiving PRBC transfusion (odds ratio = 0.77, 95% confidence inte

60 was associated with fewer patients receiving PRBC transfusion using a liberal trigger hemoglobin conc

61 ease in the proportion of patients receiving PRBC using a restrictive trigger hemoglobin concentratio

62 received 3.5 mL each of leuko-reduced stored PRBC and SS (simulating a major transfusion).

63 trated ALI in response to plasma from stored PRBCs, both prestorage leukoreduced and unmodified, and

64 endothelial cell receptors known to support PRBC adherence, including CD36, thrombospondin (TSP), an

65 The PRBC group had a significantly different expression prof

66 ntrolling for all significant variables, the PRBC:FFP ratio did not predict intensive care unit days,

67 correlated with the binding phenotype of the PRBCs from which PfEMP1 was extracted.

68 PRBC variable (P<0.0001; OR=1.23/transfused PRBC) to the model attenuates the purported independent

69 After adding transfused PRBC data 11,198 patients remained for risk-adjusted ass

70 th, and without, consideration of transfused PRBC.

71 ddition of the highly significant transfused PRBC variable (P<0.0001; OR=1.23/transfused PRBC) to the

72 Risk-adjusted analysis without transfused PRBC in the model suggests that aprotinin significantly

73 roups 2 and 3 received greater than 15 units PRBCs-the former as early resuscitation, whereas the lat

74 thawed plasma in ratios approaching 1:1 with PRBCs; the early use of platelets, often given well befo