ライフサイエンスコーパス: PRC1

1 ontext of the Polycomb repressive complex 1 (PRC1).

2 ontext of the Polycomb repressive complex 1 (PRC1).

3 a subunit of polycomb repressive complex 1 (PRC1).

4 by canonical polycomb repressive complex 1 (PRC1).

5 complex) and polycomb-repressive complex 1 (PRC1).

6 with the core Polycomb repressive complex 1 (PRC1).

7 holog of protein regulator of cytokinesis 1 (PRC1)].

8 lular processes are specifically targeted by PRC1.

9 and much of the gene repression activity of PRC1.

10 Polycomb-group protein that associates with PRC1.

11 ally interacts with and functions as part of PRC1.

12 g TCF7L2, IGFBP2, CDKN2A, CDKN2B, GRB10, and PRC1.

13 y of KIF4A and promotes its interaction with PRC1.

14 bx7 interacts robustly with other members of PRC1.

15 G) pathway controls the human Ase1p ortholog PRC1.

16 nts for three key proteins: MKLP1, KIF4, and PRC1.

17 D binding factor required to recruit PCGF3/5-PRC1.

18 nd the participation of a yet poorly defined PRC1.

19 een MTs cross-linked by full-length, dimeric PRC1.

20 he geometry of the MT arrays cross-linked by PRC1.

21 nstrating cat7l genetically interacts with a PRC1.

22 Polycomb group protein that associates with PRC1.2 (containing PCGF2/MEL18) and PRC1.4 (containing P

23 tes with PRC1.2 (containing PCGF2/MEL18) and PRC1.4 (containing PCGF4/BMI1), modulates the localizati

24 e localization of USP7 and bridges USP7 with PRC1.4, allowing for the stabilization of BMI1.

25 of RING1B and BMI1, a specific component of PRC1.4.

26 of the function of an atypical PRC1 complex (PRC1.6), in which MAX is one of the components.

27 e show that this pathway is mediated by RYBP-PRC1, a complex comprising catalytic subunits of PRC1 an

28 ion, RNF2, the dominant catalytic subunit of PRC1, activates transcription of Sall4, which codes for

29 ncRNAs), but few specific lncRNAs that guide PRC1 activity are known.

30 ich PcG protein BMI1 is overexpressed or the PRC1 activity is deregulated.

31 fficiently down-regulate BMI1 expression and PRC1 activity, and induce premature senescence in breast

32 indings reveal a natural means of subverting PRC1 activity, linking key epigenetic modulators with ne

33 We propose a model whereby PRC1 acts in concert with specific lncRNAs and that CAT7

34 Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regul

35 change factor coordinating the activities of PRC1 and 2.

36 fly embryos, with analogous co-occupancy of PRC1 and a Br140 ortholog, BRD1, at bivalent loci in hum

37 t are crucial for central spindle formation, PRC1 and centralspindlin.

38 et of midbody regulatory proteins, including PRC1 and CYK4/MKLP1.

39 We found PRC1 and EB3 in the bridging fibre, suggesting that it c

40 necessary for H2A ubiquitination activity of PRC1 and for clonogenic potential of U2OS cells.

41 est that Cg can recruit Ph in the absence of PRC1 and illustrate the diversity and redundancy of PcG

42 istone H2A (H2Aub), the catalytic product of PRC1 and key for its repressive activity.

43 s during monopolar cytokinesis, depletion of PRC1 and KIF4A displayed different phenotypes.

44 n the conserved cytokinesis midzone proteins Prc1 and Kif4A.

45 ow using in vitro reconstitution assays that PRC1 and kinesin-4, two microtubule-associated proteins

46 upon the Polyhomeotic component of canonical PRC1 and occurred independently of PRC1-catalyzed ubiqui

47 The expression of cell cycle genes, cdc2, PRC1 and PCNA and one of transcription factors that cont

48 ing the expression of cell cycle genes cdc2, PRC1 and PCNA, and the transcription factor - NRF-1.

49 pins an activity-based communication between PRC1 and Polycomb repressive complex 2 (PRC2) which is r

50 Pull-downs of BioTAP-Scm captured PRC1 and PRC2 and additional repressive complexes, inclu

51 s on targeting, modulation, and functions of PRC1 and PRC2 and progress on defining the transcription

52 They form multiple complexes of which PRC1 and PRC2 are evolutionary conserved and obligatory

53 The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silenc

54 Polycomb group (PcG) complexes PRC1 and PRC2 are well known for silencing specific deve

55 uitment of the Polycomb repressive complexes PRC1 and PRC2 by Xist RNA is an important paradigm for c

56 PcG repression is targeted and suggest that PRC1 and PRC2 can communicate independently of histone m

57 Components of PRC1 and PRC2 compete for EED binding.

58 the Polycomb group (PcG) proteins within the PRC1 and PRC2 complexes, and the Trithorax group (TrxG)

59 t GAGA-binding factors in the recruitment of PRC1 and PRC2 components to Polycomb-responsive DNA elem

60 Thus, these findings uncover that PRC1 and PRC2 employ distinct mechanisms to assemble on

61 n loss of ubiquitinated H2A, dissociation of PRC1 and PRC2 from target promoters, and transcriptional

62 Piwi interacts with Polycomb group complexes PRC1 and PRC2 in niche and germline cells to regulate ov

63 )-PRC1 complex initiates recruitment of both PRC1 and PRC2 in response to Xist RNA expression.

64 Jarid2 and define a key mechanism that links PRC1 and PRC2 in the establishment of Polycomb domains.

65 The targeting of PRC1 and PRC2 is poorly understood and was proposed to b

66 The Polycomb repressive complexes PRC1 and PRC2 maintain embryonic stem cell (ESC) pluripo

67 PRC1 and PRC2 modify chromatin by catalysing histone H2A

68 The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental gene

69 The Polycomb-repressive complexes PRC1 and PRC2 play a key role in chromosome silencing in

70 es inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation,

71 Furthermore, we find that subunits of the PRC1 and PRC2 polycomb group complexes are similarly req

72 Our data support a model in which PRC1 and PRC2 reinforce each other's binding but suggest

73 both polycomb repressive component classes (PRC1 and PRC2) and grouped into four distinct clusters w

74 interact with polycomb repressive complexes (PRC1 and PRC2) and the transcription factor NF-YA to eit

75 Polycomb complexes (PRC1 and PRC2) are essential regulators of epigenetic ge

76 et several members of the polycomb complexes PRC1 and PRC2, and its knockdown results in the de-repre

77 modification-dependent communication between PRC1 and PRC2, repressive Polycomb chromatin domains can

78 SCML2 works with PRC1 and promotes RNF2-dependent ubiquitination of H2A,

79 he data are consistent with a model in which PRC1 and TFIID could co-occupy genes poised for activati

80 rolled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A.

81 , a complex comprising catalytic subunits of PRC1 and the protein RYBP.

82 oup complexes polycomb repressive complex 1 (PRC1) and 2 (PRC2) is associated with human cancers.

83 ponent of the polycomb repressive complex 1 (PRC1) and emerging data support a role of BMI1 in cancer

84 iquitin-ligase polycomb repressor complex 1 (PRC1) and H2A-deubiquitinating enzymes (H2A-DUBs).

85 ponent of the Polycomb Repressive Complex 1 (PRC1) and is involved in the pathogenesis of multiple ca

86 protein 1 (HP1), polycomb protein complex 1 (PRC1) and methyl CpG binding protein 2 (MeCP2), at the C

87 Polycomb-repressive complex 1 (PRC1) and PRC2 maintain repression at many developmental

88 ar organisms, Polycomb Repressive Complex 1 (PRC1) and PRC2 repress target genes through histone modi

89 e interaction for three nonmotor MAPs (NuMA, PRC1, and EB1) required for cell division.

90 Prc1E, the egg orthologue of Prc1, and Kif4A were recruited to anti-parallel bundles

91 , even in the absence of spindle bipolarity, PRC1 appears to be essential for polarizing parallel mic

92 TRIM37, PRC2 and PRC1 are co-bound to specific target genes, resulting in

93 local load-bearing observed, whereas Eg5 and PRC1 are not detectably required, suggesting specializat

94 components of polycomb repressive complex 1 (PRC1)] are predominantly utilized in antimesometrial dec

95 Simulation and experiments using PRC1 as a model substrate show that the first threshold

96 o major cross-linkers of the conserved MAP65/PRC1/Ase1 family drastically decrease MT rigidity.

97 equires the microtubule antiparallel bundler PRC1/Ase1 to recruit CLASP/Cls1 to stabilize microtubule

98 e canonical role of PRC1 in gene repression, PRC1-AUTS2 activates transcription.

99 tudies demonstrate that the CK2 component of PRC1-AUTS2 neutralizes PRC1 repressive activity, whereas

100 art of a previously identified PRC1 complex (PRC1-AUTS2), and in the context of neurodevelopment.

101 epressor and the presence of a non-canonical PRC1-BCOR-CBX8 complex.

102 th PRC1 was required for KAP1 enhancement of PRC1 binding and for KAP1 repression of transcription at

103 se domains changed during differentiation as PRC1 binding changed.

104 AP1 was not required for KAP1 suppression of PRC1 binding or for KAP1 derepression of transcription a

105 uripotency-associated genes, did not enhance PRC1 binding, and derepressed their transcription.

106 KAP1 and PRC1 bound cooperatively at the promoters of differentia

107 -A-resolution cryo-EM structure of monomeric PRC1 bound to MTs.

108 We propose that identification of PRC1-Br140 "bivalent complexes" in fly embryos supports

109 Here we confirm PRC1-Br140 and PRC1-Fs(1)h interactions and identify the

110 PRC1-Br140 bind developmental genes in fly embryos, with

111 We find that PRC1 can bind PREs in the absence of PRC2 but at many PR

112 canonical PRC1 and occurred independently of PRC1-catalyzed ubiquitylation.

113 findings provide evidence for site-specific PRC1 chromatin recruitment by core binding transcription

114 bromodomain inhibitor JQ1 or a peptide-based PRC1 chromodomain ligand, which are capable of recruitin

115 of AUTS2 as part of a previously identified PRC1 complex (PRC1-AUTS2), and in the context of neurode

116 to impairment of the function of an atypical PRC1 complex (PRC1.6), in which MAX is one of the compon

117 n of DPPA4 and other subunits of the variant PRC1 complex at both mRNA and protein levels.

118 s reveal that targeting of the variant PCGF1/PRC1 complex by KDM2B to CpG islands is required for nor

119 l previously reported members of the variant PRC1 complex containing PCGF1, as well as proteins linke

120 cal Polycomb group RING finger 3/5 (PCGF3/5)-PRC1 complex initiates recruitment of both PRC1 and PRC2

121 PCGF1 is a component of a variant PRC1 complex that also contains the BCL6 co-repressor BC

122 PRC1 or PRC2, and Cbx2 is needed to recruit PRC1 complex to mitotic chromosomes.

123 comb recruitment is initiated by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine

124 YAF2 bridges interaction between YY1 and the PRC1 complex.

125 (uH2AK119) through its association with the PRC1 complex.

126 structural and functional complexity of the PRC1 complex.

127 ponent of the polycomb repressive complex 1 (PRC1) complex that is overexpressed in breast and other

128 2A signals recruitment of other noncanonical PRC1 complexes and of PRC2, the latter leading to deposi

129 Because PRC1 complexes localize to the promoters of a specific s

130 may provide an important link connecting the PRC1 complexes to their target genes.

131 tency genes, such as Sox2 and Nanog, through PRC1 complexes to ubiquitinate histone H2A at their prom

132 This activity is restricted to variant PRC1 complexes, and genetic ablation experiments reveal

133 iquitylation, signaling recruitment of other PRC1 complexes, and PRC2.

134 or the E3 ubiquitin ligase activity found in PRC1 complexes, but not RNF8 nor RNF168.

135 analysis that uncovered six major groups of PRC1 complexes, each containing a distinct PCGF subunit,

136 ralog family members of which many reside in PRC1 complexes, likely in a mutually exclusive manner, p

137 re consistent with reports of a diversity of PRC1 complexes.

138 confirmed the existence of multiple specific PRC1 complexes.

139 Here we show an essential role for the PRC1 component Bmi1 in motor neuron (MN) subtype differe

140 Conversely, the PRC1 component EMBRYONIC FLOWER (EMF1) participates in t

141 Here, we show that the PRC1 component polycomb group ring finger 6 (Pcgf6) is r

142 latory silencing mechanism that requires the PRC1 component polyhomeotic, resulting in a transformati

143 OTEIN1 (LHP1) is so far the only known plant PRC1 component that directly binds to H3K27me3, the hist

144 with like heterochromatin protein1 (LHP1), a PRC1 component, and associates with vernalization2 (VRN2

145 uman CAT7 RNA, enhanced by interference of a PRC1 component, and suppressed by interference of a know

146 le nuclear foci in a manner dependent on the PRC1 components BMI1, RNF1 (RING1a), and RNF2 (RING1b).

147 rt that the post-translational regulation of PRC1 components CBX4 and CBX6 by ubiquitination influenc

148 Previous results showed that apparent PRC1 components perform discrete roles during plant deve

149 we did not find evidence for recruitment of PRC1 components to AsiSI-induced DSBs.

150 Thus, not only does USP7 stabilize PRC1 components, its catalytic activity is also necessar

151 chiometry of Cbx2 on chromatin but not other PRC1 components.

152 homolog (BMI1) POLYCOMB REPRESSIVE COMPLEX1 (PRC1) components participate in the repression of microR

153 ssociation of Polycomb repressive complex 1 (PRC1) components with DSBs generated by inducible expres

154 mologs of the Polycomb repressive complex 1 (PRC1) components, including five orthologs of the Drosop

155 tes for other Polycomb repressive complex 1 (PRC1) components, others are not.

156 variations of Polycomb repressive complex 1 (PRC1) comprise a core assembly of Polycomb group protein

157 Residues in the spectrin domain of PRC1 contacting the MT are highly conserved and interact

158 The polycomb repressive complex 1 (PRC1), containing the core BMI1 and RING1A/B proteins, m

159 the mammalian Polycomb repressive complex 1 (PRC1), contains a compaction region that has the biochem

160 Overall, Cbx4/Ring1B-containing PRC1 controls decidualization via regulation of extracel

161 of PRC1 subunits, suggesting that Usp16 and PRC1 counterbalance each other to regulate cellular ubH2

162 nd functionally associated to both canonical PRC1 (cPRC1) and non-canonical PRC1 (ncPRC1) complexes.

163 There are six versions of PRC1 defined by the association of one of the PCGF homol

164 nic stem cells we unexpectedly discover that PRC1-dependent H2AK119ub1 leads to recruitment of PRC2 a

165 These observations provide a surprising PRC1-dependent logic for PRC2 occupancy at target sites

166 nd threshold, as well as associated delay in PRC1 dephosphorylation and initiation of cytokinesis, by

167 we show that Polycomb-repressive complex 1 (PRC1) directs timely activation of germline genes during

168 PRC1 domains differ from topologically associating domai

169 We find that canonical PRC1 E3 ligases such as PCGF4-RING1B have intrinsically

170 subunit of a Polycomb repressive complex 1 (PRC1), establishes the unique epigenome of the male germ

171 netic disruption of the complex formation of PRC1 facilitates the targeting of Cbx7 to chromatin.

172 Cells depleted of PRC1 failed to form a polarized microtubule array or ect

173 ns cohesin also controls the availability of PRC1 for gene silencing.

174 eened for lncRNAs, which co-precipitate with PRC1 from chromatin and found candidates that impact pol

175 Here we confirm PRC1-Br140 and PRC1-Fs(1)h interactions and identify their genomic bind

176 NA-seq studies showed that the inhibition of PRC1 function affects 238 genes (154 up and 84 down) dur

177 ngs reveal that Mel18 is required to specify PRC1 function in both a context- and stage-specific mann

178 ignaling to the chromatin template regulates PRC1 function.

179 We show that PRC1 functions as a master regulator of mouse ESC genome

180 We conclude that PRC1 functions to block or dissociate PICs by interferin

181 nd rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P=4.25x10(-8)).

182 In humans, each of the 5 subunits of PRC1 has paralog family members of which many reside in

183 Polycomb-repressive complex 1 (PRC1) has a central role in the regulation of heritable

184 We determine the crystal structure of the PRC1 homodimer and map the protein-protein interactions

185 factor, linking MUC1-C with function of the PRC1 in epigenetic gene silencing.

186 In contrast to the canonical role of PRC1 in gene repression, PRC1-AUTS2 activates transcript

187 that UBR5 functions in a linear pathway with PRC1 in inducing gene silencing at lesions.

188 Inactivation of PRC1 in male germ cells results in the gradual loss of a

189 suggesting a role for Cbx4/Ring1B-containing PRC1 in these processes.

190 e activity of Polycomb repressive complex 1 (PRC1) in coordination with SCML2.

191 functions of polycomb repressive complex 1 (PRC1) in development and gene silencing are thought to i

192 Furthermore, RYBP is required for PRC1-independent recruitment of OCT4 to the promoter of

193 (PRC1)-mediated gene silencing and also via PRC1-independent transcriptional activities.

194 Recombinant PRC1 inhibited transcription, but had little effect on b

195 th-dependent microtubule plus-end-tagging by PRC1 is also observed in dividing cells.

196 It is, however, assumed that the PRC1 is excluded from constitutive heterochromatin in so

197 ect physical evidence that the nucleoplasmic PRC1 is monomeric, whereas PRC2 can dimerize in the nucl

198 lar mechanism for recognition of H3K27me3 by PRC1 is well defined, the interaction of PRC2 with H2AK1

199 The polycomb repressive complex 1 (PRC1) is a multi-subunit complex that plays critical rol

200 e activity of Polycomb repressive complex 1 (PRC1) is defined by the composition of its catalytic sub

201 Polycomb repressive complex-1 (PRC1) is essential for the epigenetic regulation of gene

202 Polycomb repressive complex 1 (PRC1) is required for ubiquitination of histone H2A lysi

203 inding but suggest that the key functions of PRC1 lie beyond the enzymatic capabilities of RING1B.

204 reveals that UbE2E1 is an in vivo E2 for the PRC1 ligase complex and thus plays an important role in

205 dentify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor.

206 stinct PcG complex, termed EMF1c, that plays PRC1-like roles and is crucial for regulation of the flo

207 htly associated to chromatin, contributes to PRC1 localization and also directly enforces repression

208 Promoters located at PRC1 loop anchors regulate some of the most important de

209 ess likely to be expressed than those not at PRC1 loop anchors.

210 Polycomb group (PcG) complexes such as PRC1 mediate transcriptional repression.

211 functions via polycomb repressive complex 1 (PRC1)-mediated gene silencing and also via PRC1-independ

212 Polycomb-repressive complex 1 (PRC1)-mediated histone ubiquitylation plays an important

213 geting independent of H3K27me3, nonenzymatic PRC1-mediated compaction, and connections between PRCs a

214 ized, the structure of Scml2 and its role in PRC1-mediated gene silencing remain unknown.

215 o recruit PRC1 to H3K27me3 loci and enhances PRC1-mediated H2A ubiquitin E3 ligase activity.

216 1,3-dione (PRT4165) is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro.

217 nt of RNF8 to DSBs, our results suggest that PRC1-mediated monoubiquitylation is required for subsequ

218 Ezh2 prevents the transformation of AML via PRC1-mediated repression of Hoxa9.

219 PCGF3/5-PRC1-mediated ubiquitylation of histone H2A signals recr

220 Immunofluorescence analyses revealed that PRC1 members are co-localized with its functional histon

221 duced lesions on chromatin, depletion of the PRC1 members or UBR5 alone derepressed transcription elo

222 efine discrete Polycomb Repressor Complex 1 (PRC1) multi-protein complexes with diverse subunit compo

223 oth canonical PRC1 (cPRC1) and non-canonical PRC1 (ncPRC1) complexes.

224 of 11 overexpressed ARE-mRNAs (CDC6, KIF11, PRC1, NEK2, NCAPG, CENPA, NUF2, KIF18A, CENPE, PBK, TOP2

225 namic and developmentally regulated model of PRC1 occupancy at constitutive heterochromatin, and wher

226 t required for the assembly stoichiometry of PRC1 on chromatin.

227 anism of nucleosome substrate recognition by PRC1 or other chromatin enzymes is unclear.

228 that of trithorax group proteins, but not of PRC1 or PRC2 complexes, suggesting that Pcgf6 functions

229 Depletion of PRC1 or PRC2 protein has no effect on the immobilization

230 bx2 to mitotic chromosomes is independent of PRC1 or PRC2, and Cbx2 is needed to recruit PRC1 complex

231 ], we captured all PcG-repressive complex 1 (PRC1) or PRC2 core components and Sex comb on midleg (Sc

232 Taken together, our data show that different PRC1 paralog family members have nonredundant and locus-

233 e from Drosophila argue that cohesin and the PRC1 PcG complex interact to control transcription of ma

234 In contrast to canonical PRC1, Pcgf6 acts as a positive regulator of transcriptio

235 Thus, PRC1 physically constrains developmental transcription f

236 he antiparallel microtubule-bundling protein PRC1 plays a key role in organizing the midzone complex.

237 The Polycomb PRC1 plays essential roles in development and disease pa

238 is a part of a multisubunit protein complex, PRC1 (Polycomb repressive complex 1), which is responsib

239 We show that, in contrast to PRC1, PRC2 is a tumor suppressor in Emicro-myc lymphomag

240 in expression and colocalization of Scm with PRC1, PRC2, and H3K27me3 in embryos and cultured cells u

241 ropose that Scm is a key mediator connecting PRC1, PRC2, and transcriptional silencing.

242 Furthermore, this colocalization requires PRC1, PRC2, and TrxG complexes, which are essential regu

243 We additionally found that PRC1 promotes MT assembly even in the presence of the MT

244 g protein MAP65-1-a member of the MAP65/Ase1/PRC1 protein family, implicated in central spindle forma

245 One example is PRC1 (protein regulator of cytokinesis 1), which cross-l

246 nd deep sequencing (ChIP-seq), which detects PRC1 proteins at common sites throughout the genome, we

247 after photobleaching analysis indicates that PRC1 proteins rapidly exchange at interphasic chromatin.

248 fluorescent staining, the co-localization of PRC1 proteins with components of the DNA damage response

249 tead, we found that Pc-repressive complex 1 (PRC1) purifies with coactivators Fs(1)h [female sterile

250 n et al. report a mechanism of non-canonical PRC1 recruitment by BCL6 in collaboration with EZH2-medi

251 However, the molecular mechanism for PCGF3/5-PRC1 recruitment by Xist RNA is not understood.

252 ant SCML2A lacking the RBR causes defects in PRC1 recruitment.

253 y recruiting a Polycomb Repressive Complex1 (PRC1)-related complex, resembling the previously describ

254 t lncRNAs that independently evolved to tune PRC1 repression at individual loci.

255 the CK2 component of PRC1-AUTS2 neutralizes PRC1 repressive activity, whereas AUTS2-mediated recruit

256 The E3 ligase activity of PRC1 resides in the RING1A/B subunit when paired with on

257 zymatic activity compared with non-canonical PRC1 RING dimers.

258 inus ends, EB1's lower toward plus ends, and PRC1's exhibiting no directional preference.

259 owth, resulting in the generation of shorter PRC1-stabilized microtubule overlaps in vitro.

260 ion of the non-canonical polycomb complex 1 (PRC1) subunit RYBP.

261 EIN1 (LHP1), a Polycomb Repressive Complex1 (PRC1) subunit.

262 Although the majority of PRC1 subunits have been recently characterized, the stru

263 UbE2E1 interacts with PRC1 subunits including Ring1A and Ring1B.

264 xpression was partly rescued by knockdown of PRC1 subunits, suggesting that Usp16 and PRC1 counterbal

265 ions describing the intrinsic flexibility of PRC1, suggests that the MT-spectrin domain interface det

266 t, and suppressed by interference of a known PRC1 target gene, demonstrating cat7l genetically intera

267 Recent findings emphasize PRC1 targeting independent of H3K27me3, nonenzymatic PRC

268 cause loss of direct binding between BAF and PRC1 that occurs independently of chromatin.

269 component of Polycomb repressive complex 1 (PRC1), the E3 ligase complex responsible for histone H2A

270 Subunits of polycomb repressive complex 1 (PRC1), the major histone H2A ubiquitin ligase, are criti

271 y is also necessary to maintain a functional PRC1, thereby ensuring appropriate levels of repressive

272 inheritance of chromatin proteins including PRC1 through DNA replication to maintain chromatin state

273 T domains, RNA binding, and interaction with PRC1 through the SPM domain.

274 plexes with polycomb repressive complexes 1 (PRC1) through an interaction that was mediated by the KA

275 sence of PRC2 but at many PREs PRC2 requires PRC1 to be targeted.

276 Targeting of PRC1 to chromatin is thought to be mediated by the Cbx f

277 ing H2A deubiquitinases functions along with PRC1 to control H2A ubiquitination (ubH2A) level and reg

278 igenetic silencing of PcG targets by linking PRC1 to formation of a repressive higher-order structure

279 EED functions to recruit PRC1 to H3K27me3 loci and enhances PRC1-mediated H2A ubi

280 ch coordinates with the H2A ubiquitin ligase PRC1 to regulate hematopoiesis, and revealed cell cycle

281 one of six Pcgf paralogs, uniquely regulates PRC1 to specify mesoderm cell fate in embryonic stem cel

282 inant model of PRC2-dependent recruitment of PRC1 to target genes.

283 Recruitment of PRC1 to target sites has been proposed to occur through

284 itment of the polycomb-repressive complex 1 (PRC1) to a subset of its target loci.

285 tional maintenance, mostly in the absence of PRC1, to fully transform hematopoietic progenitors.

286 t the ability of RING1B, a core component of PRC1, to ubiquitinate histone H2A is dispensable for ear

287 ntact, highlighting a specific mechanism for PRC1 transcriptional silencing.

288 PRC1-type complexes also have global roles.

289 ates histone H3 on lysine 27 (H3K27me3), and PRC1-type complexes ubiquitylate histone H2A and compact

290 egions, dependent on the RING/Sce subunit of PRC1-type complexes.

291 human Ring1B-Bmi1-UbcH5c E3-E2 complex (the PRC1 ubiquitylation module) bound to its nucleosome core

292 if EMF1, LHP1, and AtBMI1 exist in a common PRC1 variant, their role in repression depends on the fu

293 different regulatory roles of two functional PRC1 variants coordinate the acquisition of flowering co

294 ant development, suggesting the existence of PRC1 variants; however, it is not clear in how many proc

295 SCML2A binds to PRC1 via its SPM domain and interacts with ncRNAs throug

296 n of KAP1 that mediated the interaction with PRC1 was required for KAP1 enhancement of PRC1 binding a

297 a subunit of polycomb repressive complex 1 (PRC1), we find that TRIM37 associates with polycomb repr

298 ponent of the Polycomb Repressive Complex 1 (PRC1), which plays a key role in maintaining epigenetic

299 includes the Polycomb repressive complex 1 (PRC1), which ubiquitylates nucleosomal histone H2A Lys 1

300 er, evidence indicates that diverse forms of PRC1, with shared components, are a common theme in plan