ライフサイエンスコーパス: PRDM1

1 as PR domain-containing 1, with ZNF domain (PRDM1)).

2 other molecules, and the absence of Blimp-1 (prdm1).

3 gnaling through the protein PR/SET domain 1 (PRDM1).

4 e transcription factor Blimp1 (also known as Prdm1).

5 izing the anti-proliferative factor Blimp-1 (Prdm1).

6 igh PRDM1alpha mRNA levels but low levels of PRDM1.

7 igh PRDM1alpha mRNA expression and unmutated PRDM1.

8 phocyte-induced maturation protein (Blimp-1)/PRDM1.

9 yhc3, and all differentiate independently of Prdm1.

10 nner in differentiating B cells and targeted Prdm1.

11 importance of Bcl-6-dependent repression of prdm1.

12 ntrolled, including GRHL3, ZNF750, KLF4, and PRDM1.

13 cis-regulatory elements, including those of Prdm1.

14 urthermore, we show that Blimp1 (also called Prdm1), a let-7 target and a master regulator of PGC spe

15 own to interact and repress transcription of PRDM1, a key driver of plasma cell differentiation.

16 r responses triggered by VLVs and found that PRDM1, a master regulator in cell differentiation, was s

17 Here, we show that nrd is a mutation in prdm1, a SET/zinc-finger domain transcription factor.

18 cus, E-proteins contributed to Igk, Igh, and Prdm1 activation in plasmablasts.

19 Additionally, Prdm1 activity is essential for proper development of sl

20 itch fibre characteristics in the absence of Prdm1 activity, whereas those that do not express smyhc1

21 We show that Prdm1 acts independently of Aire, a crucial transcriptio

22 In mouse embryos, mutation of Prdm1 affects branchial arch development and leads to pe

23 h either deletion or silencing of the paired PRDM1 allele.

24 by the activity of the transcription factor Prdm1 (also called Ubo or Blimp1) in response to Hedgeho

25 monstrate that the transcriptional repressor PRDM1 (also known as Blimp-1 or PRDI-BF1) is a critical

26 induction of PR domain-containing protein 1 (PRDM1; also known as Blimp-1), a critical regulator of p

27 Higher concentration of IRF-4 induced Prdm1 and consequently the transition from a germinal ce

28 Ezh2 activates Id3 while silencing Id2, Prdm1 and Eomes, promoting the expansion of memory precu

29 oliferation of memory CD8(+) T cells through Prdm1 and Id3.

30 ates that the functional interaction between PRDM1 and IFN-regulated pathways antedates the evolution

31 igen presentation in DCs, demonstrating that PRDM1 and IRF8/PU.1 counter-regulate expression.

32 f GWAS and provide evidence that variants in PRDM1 and NDP52 determine susceptibility to CD.

33 on-associated molecules such as Tim-3, Lag3, Prdm1 and Pbx3, and Bat3 knockdown in myelin-antigen-spe

34 hat NANOG can bind and activate enhancers of Prdm1 and Prdm14 in EpiLCs in vitro; BLIMP1 (encoded by

35 and CD38(-) EB cells significantly expressed PRDM1 and TFAP2C, although PRDM1 mRNA in CD38(-) cells l

36 issense mutations in PR domain-containing 1 (PRDM1) and associated these with CD.

37 noted as the PRDI-BF1 (HGMW-approved symbol PRDM1) and RIZ (HGMW-approved symbol PRDM2) homologous r

38 including BiP (HSPA5), IRE1 (ERN1), Blimp-1 (PRDM1), and X-box binding protein 1 (XBP1).

39 hese genes provide evidence that nfat5, fos, prdm1, and dusp16 are novel direct targets of Blimp-1.

40 Inducible, Cre-mediated deletion of Hspa5, Prdm1, and Xbp1 consistently induces cellular stress and

41 ion activators, including HOPX, GRHL3, KLF4, PRDM1, and ZNF750.

42 ive regulation of NK activation and position PRDM1 as a common regulator of the adaptive and innate i

43 nd the MHC, and identifies a unique role for PRDM1 as a key regulator of Ag presentation by MHC class

44 Our results identify PRDM1 as a potential modifier of phenotypic severity in

45 enetic defect in DLBCL cells and establishes PRDM1 as a potential tumor suppressor gene in DLBCL.

46 transcription factor binding motifs SRF and PRDM1 as important regulators of PIP3-sensitive mRNAs in

47 ified the transcriptional repressor Blimp-1 (PRDM1) as a downstream effector of the NF-kappaB, RelB/B

48 identified the transcription factor Blimp-1 (Prdm1) as a key IL-23-induced factor that drove the infl

49 n through the BCR rapidly induces endogenous PRDM1 at the level of transcription with minor changes i

50 ession has been confirmed at the mRNA level: PRDM1, ATG5, AIM1, and HACE1.

51 Mutations and methylation in PRDM1, ATG5, and AIM1 have been reported in NKTCL cell l

52 domain containing 1 with zinc finger domain (PRDM1)/B lymphocyte-induced maturation protein 1 (BLIMP1

53 Furthermore, although prdm1-/- B cells fail to induce XBP-1, XBP-1 cannot resc

54 oma cell lines express the highest levels of PRDM1 beta mRNA relative to the full-length form, while

55 nes have very low, but detectable, levels of PRDM1 beta.

56 PRDM1 binding also blocks IRF8-mediated activation depen

57 in LCLs inhibition of CDKN2C (p18INK4c) and PRDM1 (BLIMP-1) transcription results from direct bindin

58 cells in primary HL cases showed weak or no PRDM1/Blimp-1 expression.

59 Prdm1/Blimp-1 is a master regulator of gene expression i

60 Our studies here demonstrate that PRDM1/blimp-1 is also a target for microRNA (miRNA)-medi

61 Over-expression of miR-9 or let-7a reduced PRDM1/Blimp-1 levels in U266 cells by 30% to 50%, wherea

62 MiRNA-mediated down-regulation of PRDM1/Blimp-1 may contribute to the phenotype maintenanc

63 nding sites in the 3' untranslated region of PRDM1/blimp-1 mRNA and repressed luciferase reporter act

64 ound activators paralleled by recruitment of PRDM1/Blimp-1 to the promoter.

65 PRDM1/Blimp-1, a master regulator for B cell terminal di

66 PRDM1/Blimp-1, a master regulator in terminal B-cell dif

67 HL cell lines correlated with low levels of PRDM1/Blimp-1.

68 ed in an approximately 2.6-fold induction in PRDM1/Blimp-1.

69 ube and colleagues have identified FOXO3 and PRDM1 (Blimp1) as tumor suppressor genes with a potentia

70 nd Igh enhancers and a distal element at the Prdm1 (Blimp1) locus, E-proteins contributed to Igk, Igh

71 AIOLOS), TBX21 (T-bet), NFIL3 (E4BP4), ZEB2, PRDM1 (BLIMP1), and RORA mRNA levels are higher in CD56(

72 factors in B-cell differentiation: LMO2 and PRDM1 (Blimp1).

73 ng the zinc finger transcriptional repressor Prdm1/Blimp1 (PR domain containing 1, with ZNF domain; p

74 at the zinc finger transcriptional repressor Prdm1/Blimp1 is essential for specification of spiral ar

75 Later in development Prdm1/Blimp1 is expressed in many other tissues, includi

76 misexpression and dominant-negative studies, Prdm1/Blimp1 was proposed to promote anterior endomesode

77 by the zinc finger transcriptional repressor Prdm1/Blimp1, an essential regulator of placenta develop

78 5b down-regulates the expression of IRF4 and PRDM1/BLIMP1, and memory B cell-enriched hsa-miR-223 dow

79 between MHC II and plasma cell markers MUM1, PRDM1/Blimp1, and XBP1s.

80 a differentiation-related BCL6 target gene (PRDM1), but not target genes involved in survival.

81 Thus, abnormal epigenetic down-regulation of PRDM1 by let-7 and other microRNAs may represent an alte

82 n experiments support a role of targeting of PRDM1 by microRNA let-7 family in mediating this down-re

83 In support of this role, knockdown of PRDM1 by shRNA in normal NK cells resulted in the positi

84 dritic cell-specific conditional knockout of Prdm1 (CKO mice) altered the presentation of antigen to

85 We show that PRDM1 co-repressors, G9a and HDAC2, are recruited to CII

86 inc-finger transcriptional repressor Blimp1 (Prdm1) controls gene expression patterns during differen

87 PRDM1 coordinately suppresses the release of IFN-gamma,

88 ine-specific deletion of Utf1 resulting from Prdm1-Cre mediated recombination are born with significa

89 neage tracing experiments exploiting a novel Prdm1.Cre-LacZ allele demonstrate that these Blimp1(+) c

90 Here we exploit a Prdm1.CreERT2-LacZ reporter allele for lineage tracing e

91 d partially ameliorated the inflamed skin in Prdm1-deficient mice.

92 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among oth

93 The ability to induce PRDM1 did correlate with differential transcriptional an

94 subsets characterized by high levels of PD1: Prdm1(+) effector regulatory T cells expressing immunore

95 ediated regulation of key PCD factors (IRF4, PRDM1, ELL2 and ARID3A).

96 The induced PRDM1-encoded protein localizes to its target genes in v

97 Prdm1 encodes a transcriptional repressor that we show i

98 , STAT1 directly regulates the expression of Prdm1 (encodes BLIMP-1) by binding to its promoter, and

99 lupus susceptibility genes such as IRF5 and PRDM1 (encoding for IFN regulatory factor 5 [IRF]5 and B

100 ssociated with decreased basal expression of PRDM1 (encoding PR domain containing 1, with ZNF domain)

101 Mice with a T cell-specific deletion of Prdm1, encoding Blimp-1, have aberrant T cell homeostasi

102 and functional characterization of zebrafish prdm1 exhibiting a dynamic and evolutionarily conserved

103 ion pressure with progressive elimination of PRDM1-expressing cells, which was enhanced when IL-2 con

104 an autoregulatory loop by which IL-2 induces Prdm1 expression and thus represses its own expression a

105 Accordingly, MTA3 and PRDM1 expression are mutually exclusive in germinal cent

106 drugs may offer possibilities to reactivate PRDM1 expression as part of novel differentiation therap

107 des BLIMP-1) by binding to its promoter, and Prdm1 expression is reduced in Stat1(-/-) MZ B cells.

108 Ablation of PRDM1 expression leads to enhanced production of IFN-gam

109 Commensurately higher Blimp1/PRDM1 expression was detected in ERalpha-negative breast

110 tantly, we demonstrated that by upregulating PRDM1 expression, VLVs triggered differentiation signali

111 We observed a progressive increase in PRDM1 expression--in particular, PRDM1alpha--in normal N

112 AT3 and IRF4, which are required for optimal Prdm1 expression.

113 Analysis of prdm1 function by overexpression indicates that prdm1 fu

114 an alternative mechanism of reducing normal PRDM1 function in a subset of DLBCL with relatively high

115 2-expressing fibres, although independent of Prdm1 function, require Hh activity to form.

116 ss smyhc1 can differentiate independently of Prdm1 function.

117 In this article, we demonstrate that Prdm1 functions in TECs to prevent autoimmunity in mice.

118 ECs, but not wild-type TECs, indicating that Prdm1 functions in TECs to regulate autoantibody product

119 m1 function by overexpression indicates that prdm1 functions to promote the cell fate specification o

120 These newly described features of the PRDM1 gene are highly analogous to the PRDM2 (RIZ) and P

121 IRF-5 stimulates transcription of the Prdm1 gene encoding Blimp-1 and binds to the IRF site in

122 Induction of PRDM1 gene expression was mediated by interaction of Bcl

123 a novel BCL6 binding site on intron 3 of the PRDM1 gene, and show that BCL6 recruits MTA3 to this sit

124 l development, which is transcribed from the PRDM1 gene.

125 nce of an alternative protein product of the PRDM1 gene.

126 scriptional and epigenetic regulation of the PRDM1 gene.

127 6, including cis-regulatory sequences of the PRDM1 gene.

128 the smyhc1-positive fibres express the ubo (prdm1) gene and adopt fast twitch fibre characteristics

129 Accordingly, the murine Irf5 and Prdm1 genes have been shown to play a role in lupus susc

130 17p13 and at 6q21, encompassing the TP53 and PRDM1 genes, respectively.

131 controlling the expression of the Aicda and Prdm1 genes, which encode AID and Blimp-1, respectively.

132 The transcription factor Prdm1 has been implicated in autoimmune diseases in huma

133 Inactivating mutations of PRDM1 have been previously identified in a subset of non

134 ing intermediate expression of FOXP3, Bcl-6, PRDM1, IL-10, and IL-21.

135 of alternative mechanisms of down-regulating PRDM1 in a cohort of 25 primary DLBCL and six DLBCL cell

136 t of mouse TECs, and conditional deletion of Prdm1 in either Keratin 14- or Foxn1-expressing cells in

137 GWAS, correlated with reduced expression of PRDM1 in ileal biopsy specimens and peripheral blood mon

138 Our studies reveal essential roles for prdm1 in limiting the function of the gastrula organizer

139 e required for the BCR-induced expression of PRDM1 in lymphoma cells and in PU.1-positive myeloma cel

140 that this is not due to a direct function of Prdm1 in neural crest cells.

141 We identified MYC and 4-1BBL as targets of PRDM1 in NK cells.

142 tumor suppressor gene, the reconstitution of PRDM1 in PRDM1-null NK cell lines led to G2/M cell cycle

143 highlight a previously unrecognized role for Prdm1 in regulating thymic epithelial function.

144 The activity of PRDM1 in silencing all three cell type-specific CIITA pr

145 in mice using cell type-specific deletion of Prdm1 in T and dendritic cells.

146 identified clonal inactivating mutations in PRDM1 in the diffuse large B-cell lymphoma (DLBCL) cell

147 Deletion of Prdm1 in the epidermis of adult mice also led to stronge

148 gene-exposure interaction that may implicate PRDM1 in the etiology of radiation therapy-induced SMNs.

149 ively, these data demonstrate a key role for PRDM1 in the negative regulation of NK activation and po

150 Mutation of Prdm1 in the SHF does not result in PTA, but leads to ar

151 produced by keratinocytes after deletion of Prdm1 in vitro was mediated by the transcriptional activ

152 This study identifies PRDM1 inactivation as a recurrent genetic defect in DLBC

153 PRDM1 induction was inversely correlated with the extent

154 Misexpression of prdm1 inhibits the formation of dorsoanterior structures

155 that FOXP1 directly represses expression of PRDM1, IRF4, and XBP1, transcriptional master regulators

156 PRDM1 is a transcriptional repressor with essential role

157 tro and in vivo experiments showed that that PRDM1 is a tumor suppressor gene in ALCL models, likely

158 Here we show that PRDM1 is a tumor suppressor gene in NKCLs that is inacti

159 Activation of PRDM1 is associated with loss of the corepressor transdu

160 zinc finger transcriptional repressor Blimp1/PRDM1 is essential for the establishment of epithelial c

161 prdm1 is expressed at the border of the neural plate wit

162 Prdm1 is expressed by a subset of mouse TECs, and condit

163 These findings indicate that PRDM1 is poised for activation in lymphoma cells and the

164 In sum, the transcriptional repressor Blimp1/Prdm1 is required for terminal differentiation of SpA-TG

165 (PRDI-BF1-RIZ) domain zinc finger protein 1 (PRDM1) is a transcription repressor with a pivotal role

166 or fate determination, we found that Blimp1 (Prdm1) is expressed transiently in developing photorecep

167 Three distinct PRDM1 isoforms are selectively induced in the CD56(dim)

168 luding IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1.

169 ting PR domain-containing 1 with ZNF domain (PRDM1) levels in macrophages.

170 We observed monoallelic deletion of PRDM1 loci in 8 of 18 (44%) NKCL cases.

171 In the human PRDM1 locus, CD40L treatment enhanced the ability of STA

172 oprecipitation (ChIP)-on-chip mapping of the PRDM1 locus, identifying a novel BCL6 binding site on in

173 PRDM1 maps adjacent to a CD interval identified in GWAS

174 Disruption of homeostatic control by PRDM1 may be an important pathogenetic mechanism for NKC

175 At the end of the gastrula period, prdm1 morphant embryos have enlarged animal-vegetal and

176 icantly expressed PRDM1 and TFAP2C, although PRDM1 mRNA in CD38(-) cells lacked the 3'-UTR harboring

177 d mutation, and conversely overexpression of prdm1 mRNA rescues the nrd RB sensory neuron and neural

178 Developmental arrest of Blimp1/Prdm1 mutant embryos at around embryonic day 10.5 (E10.5

179 a Tbx1 heterozygote background, conditional Prdm1 mutants have more pronounced arterial pole defects

180 were identified in a subset of DLBCL without PRDM1 mutations, the primarily non-GCB type, consistent

181 oped anti-nuclear Abs when transplanted with Prdm1 null TECs, but not wild-type TECs, indicating that

182 pressor gene, the reconstitution of PRDM1 in PRDM1-null NK cell lines led to G2/M cell cycle arrest,

183 Expression of FOXP1, Blimp-1/PRDM1, or BCL-2 was not correlated with the outcome in p

184 Using the sea urchin prdm1 ortholog, we demonstrate that the capacity of PRDM

185 A Morpholino-mediated depletion of prdm1 phenocopies the nrd mutation, and conversely overe

186 (B lymphocyte-induced maturation protein-1)/PRDM1 (PR domain-containing 1, with ZNF domain) binding

187 and butyrate dampened AICDA/Aicda (AID) and PRDM1/Prdm1 (Blimp-1) mRNAs by upregulating miR-155, miR

188 HM), and Bcl6, Bach2, or Pax5 (repressors of PRDM1/Prdm1 expression), as well as unchanged expression

189 ibitor-mediated silencing of AICDA/Aicda and PRDM1/Prdm1 was emphasized by unchanged expression of Ho

190 nd miR-23b, miR-30a, and miR-125b to silence PRDM1/Prdm1, in human and mouse B cells.

191 ich are not known to regulate AICDA/Aicda or PRDM1/Prdm1.

192 ession of key germline transcription factors Prdm1, Prdm14 and Tfap2c, directly induce PGC-like cells

193 ic expression of the germ line-related genes PRDM1, PRDM14, LIN28A, DAZL, VASA and SYCP3 induced dire

194 In vivo genomic footprinting of the PRDM1 promoter in unstimulated lymphoma and myeloma cell

195 ing Blimp-1 and binds to the IRF site in the Prdm1 promoter.

196 RNA analysis and analysis of the PRDM1 promoters demonstrate that PRDI-BF1 beta is genera

197 th ZNF domain) and impaired induction of the PRDM1 protein after radiation exposure.

198 the transcription factor Blimp-1 (encoded by Prdm1) repressed expression of the gene encoding catheps

199 Here we investigate Blimp1/Prdm1 requirements in the trophoblast cell lineage.

200 PRDM1 response elements are defined at the IFNG and TNF

201 PRDM1 responsiveness was associated with other markers o

202 ession of ERAP1, TAPASIN, MECL1, and LMP7 by PRDM1 results in failure to up-regulate surface MHC clas

203 -6) replication, P = 1 x 10(-9) overall) and PRDM1 (rs548234, P = 1 x 10(-5) replication, P = 2 x 10(

204 r Gfi1, Sox4, Brca2, Snf1lk, Nfkb1, Pou2af1, Prdm1, Stat6, and Blnk.

205 fied an IL-21 response element downstream of Prdm1 that binds the transcription factors STAT3 and IRF

206 egulatory domain zinc finger protein 1 gene (PRDM1) that encodes the positive regulatory domain I bin

207 of PR domain containing 1, with ZNF domain (Prdm1), the gene encoding Blimp-1, in adult mice caused

208 Blimp1 (Prdm1), the key determinant of primordial germ cells (PG

209 ave identified two intronic regions of mouse prdm1, the gene encoding B lymphocyte-induced maturation

210 ted genetic manipulation of cells expressing Prdm1, the gene encoding Blimp-1.

211 ated mice with a B cell-specific deletion of prdm1, the gene encoding Blimp-1.

212 e is currently known about the regulation of PRDM1, the gene encoding PRDI-BF1.

213 rdm14 in EpiLCs in vitro; BLIMP1 (encoded by Prdm1) then directly induces Tfap2c.

214 rtholog, we demonstrate that the capacity of PRDM1 to repress the IFN response of such promoters is e

215 red fluorescent protein, under regulation by Prdm1 transcriptional elements, and we achieved transduc

216 Conversely, interference with Prdm1 translation using antisense morpholino oligonucleo

217 Third, Prdm1:TVB-mRFP transgenic animals could provide an inval

218 noncanonical TTCnnnTAA GAS motif critical in Prdm1 was broadly used for STAT3 binding.

219 emonstrated that VLV-induced upregulation of PRDM1 was necessary and sufficient to reactivate KSHV by

220 Losses of TP53 and/or PRDM1 were present in 52% of ALK(-)ALCL, and in 29% of a

221 ed excess Bcl-6 to repress its direct target Prdm1 (which encodes the transcriptional repressor Blimp

222 transcription factor Blimp-1 (also known as Prdm1), which is a widely conserved bilaterian gene know

223 n of transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell differentiation and

224 expression of key plasma cell genes such as Prdm1, Xbp1, and CD138.