ライフサイエンスコーパス: PRS

1 PRS absolute specific activities (activity per mg of PRS

2 PRS and a history of infections have independent effects

3 PRS and RP increased significantly with temperature and

4 PRS did not explain variance in HCC.

5 PRS had good discriminative ability of case-control stat

6 PRS is a sensitive and robust polymorphism detection met

7 PRS mice also showed a marked decrease in metabotropic g

8 PRS rats also showed a greater behavioral response to th

9 PRS was a powerful predictor of case-control status in a

10 PRS was defined by three criteria: mean arterial pressur

11 PRS was significantly different between those case subje

12 PRSs from this pathway showed competitive predictive acc

13 PRSs were calculated using discovery effect size estimat

14 We identified a PRS that increases discrimination and net reclassificati

15 ides real-time noninvasive information about PRS-110 distribution and tumor accumulation in preclinic

16 For all abstracts, PRS was 2.76 (95% CI, 2.75 to 2.77) with FCOIs compared

17 Omitting publish-only abstracts, PRS was 2.62 (95% CI, 2.61 to 2.63) with FCOIs compared

18 w to moderate basal levels of Nck-accessible PRS ("open-CD3"), although most TCR-CD3 complexes were i

19 other cohorts, while applying more accurate PRSs based on a larger discovery sample.

20 We analyzed the association between AD PRSs and brain imaging parameters using T1-weighted stru

21 e found a significant association between AD PRSs and left hippocampal volume, with higher risk assoc

22 We further hypothesized that AD PRSs would affect the microstructure of fiber tracts con

23 ht cingulum was inversely correlated with AD PRSs (p = .009).

24 Adding PRS, which was robustly associated with schizophrenia (b

25 Findings were specific to PRS for ADHD; PRS for other psychiatric conditions did not differ acro

26 Adult PRS offspring demonstrate behavioral abnormalities sugge

27 Adult "PRS rats," i.e., the offspring of mothers exposed to res

28 r H7N9 infection and (TEM 2-22 degrees C and PRS 980-1025 kPa) for H5N1 infection.

29 uman clefting disorders, especially NSCP and PRS-like CP.

30 Because patients with psychosis and PRS mice show similar epigenetic signature, PRS mice may

31 Women scoring high in both TCRS and PRS had a lower risk of distant metastasis (HR, 0.69; 95

32 USCHEL-RELATED HOMEOBOX (WOX) genes WOX1 and PRS are expressed in the leaf marginal domain to enable

33 al-enriched ARF repressors suppress WOX1 and PRS expression, also through direct binding.

34 MP directly binds to the WOX1 and PRS promoters and activates their expression.

35 The anticalin PRS-110 was rationally engineered to target the oncogene

36 ncestry-informative variables, and can apply PRS across multiple traits in a single run.

37 tiology among traits has become appreciated; PRS can also be used to establish the presence of a gene

38 12%, LC-80% and A7-8% after injection of AVV-PRS-EGFP to the dorsal horn of L4-L5.

39 a catecholaminergic-selective promoter (AVV-PRS) to retrogradely label the noradrenergic neurons pro

40 more prominent meeting placement and better PRSs.

41 bstracts with FCOIs had significantly better PRSs compared with those without FCOIs.

42 thermore, there were no interactions between PRS and infections on the risk of developing schizophren

43 normal translated region sequences for both PRS isoforms and revealed no differences in catalytic pr

44 ated positively with social approach in both PRS mice and nonstressed mice.

45 onent of the neuroplastic program induced by PRS, and that strategies aimed at enhancing glutamate re

46 nia, and the common genetic risk measured by PRS did not account for the association with infection i

47 PRSice can calculate PRS at a large number of thresholds ("high resolution")

48 enomics Consortium were applied to calculate PRS at thresholds from P < .05 to P </= .99 in each AD G

49 rms and species, users are able to calculate PRS scores, along with a corresponding z-score for compa

50 To calculate PRSs, we used the results from the latest Psychiatric Ge

51 that the interaction between the CD3epsilon PRS and Nck, or any other Src homology 3 domain-containi

52 e inability of Nck to bind to the CD3epsilon PRS in thymocytes from mutant mice after TCR ligation.

53 nd prolonged accessibility of the CD3epsilon PRS to Nck.

54 e physiological importance of the CD3epsilon PRS, we have generated mice that lack this motif (CD3eps

55 erated mice that lack this motif (CD3epsilon.PRS(M)).

56 re, the proliferative response of CD3epsilon.PRS(M) T cells to staphylococcal enterotoxin B and anti-

57 In contrast, PRS weighted on ER-negative disease was associated with

58 Here we present the first dedicated PRS software, PRSice ('precise'), for calculating, apply

59 ssion of normal subject- and patient-derived PRS cDNAs predicted normal translated region sequences f

60 Neither did PRS affect the risk of acquiring infections among patien

61 gene located downstream of multimerized e5, PRS-9, or CD19 DNA-binding sites in three cell lines.

62 As expected, PRS was worse for early versus late relapse, marrow vers

63 to bind to the nonphosphorylated and exposed PRS, that is, the first ITAM tyrosine has to be in the u

64 yrosine kinase (Nck) can bind to the exposed PRS of CD3epsilon, but the molecular mechanism of how fu

65 quartile of risk, based on genetic factors (PRS), had a 2-fold higher risk of BE (odds ratio, 2.22;

66 e the importance of identifying the best-fit PRS and estimate a P-value significance threshold for hi

67 ("high resolution") to provide the best-fit PRS, as well as provide results calculated at broad P-va

68 Furthermore, PRS distinguished European ancestry case subjects who we

69 tive accuracy compared with the whole-genome PRSs when using area under the curve statistics, logisti

70 A higher PRS was also associated with having children (p = 0.01),

71 MRPs showed higher PRS and RP than BHA.

72 general population is associated with higher PRS for ADHD.

73 hoinositide-binding capability, might impact PRS accessibility is not clear.

74 In PRS catalytic superactivity, overexpression of the norma

75 Most neurochemical abnormalities in PRS rats are found in the ventral hippocampus, a region

76 e and associated behavioral abnormalities in PRS rats.

77 ral hippocampus and anxiety-like behavior in PRS rats.

78 ppocampus abolished anxiety-like behavior in PRS rats.

79 Resistance to catalepsy in PRS rats did not depend on reductions in blood or striat

80 ventral motor thalamic nuclei was higher in PRS rats than in unstressed controls, both under basal c

81 r depressive disorder (OR per SD increase in PRS, 1.02; 95% CI, 0.91-1.13; R(2) = 0.00005).

82 psychotic experiences (OR per SD increase in PRS, 1.08; 95% CI, 0.98-1.19; R(2) = 0.001) or depressiv

83 and anxiety disorder (OR per SD increase in PRS, 1.17; 95% CI, 1.06- 1.29; R(2) = 0.005).

84 symptoms (odds ratio [OR] per SD increase in PRS, 1.21; 95% CI, 1.08-1.36; R(2) = 0.007) and anxiety

85 In addition, modulated relative increases in PRS activities at suboptimal Pi concentration and in rat

86 ke behavior and social memory performance in PRS rats.

87 emical and behavioral abnormalities shown in PRS mice.

88 GABA release was unaffected in PRS rats.

89 Including PRSs with these data only minimally increased the AUC va

90 mice, whereas disruption of CRF(2) increased PRS-induced colonic contractile activity and CRF-induced

91 Based on its PRS predictive power, GEP analysis should be an integral

92 However, KI-PRS preselection DP thymocytes show impaired tyrosine ph

93 Most important, KI-PRS mice are partly protected against the development of

94 have generated a new knockin mouse line (KI-PRS) bearing a conservative mutation in the PRS resultin

95 ed of studying a knockin (KI) mouse line (KI-PRS) bearing a conservative mutation in the PRS that mak

96 Thymocytes of KI-PRS mice are partly arrested at each step at which pre-T

97 analyzed ex vivo using fluorescently labeled PRS-110.

98 nd analyze biodistribution of (89)Zr-labeled PRS-110 in human tumor-bearing mice.

99 Study of the two X-linked PRS isoforms (PRS1 and PRS2) in cells from certain affec

100 whereas relapse hyperdiploidy predicted long PRS (hazard ratio = 0.37, P = .022, cumulative R(2) = 41

101 prevented by a similar effort in the lowest PRS quartile (P(additive) = 1 x 10(-4)).

102 Anxiety-like behavior in male PRS (and control) rats was inversely related to the exte

103 wherein antigenic engagement induces maximum PRS exposure.

104 Association between MDD PRS and AD.

105 Higher MDD PRS was associated with a significantly increased risk o

106 After recalculating MDD PRS using MDD GWAS data sets without comorbid MDD-AD cas

107 observed for an association between the MDD PRS and AD in the meta-analysis of 3 GWAS AD samples wit

108 MDD-PRS were based on a discovery sample of approximately 11

109 This study aims to meta-analyze MDD-PRS x CT interaction results across these two and other

110 nalytic evidence for interaction between MDD-PRS and CT was found.

111 No interaction was found between MDD-PRS and the two-domain and five-domain CT measure (OR =

112 PRS1 comprised >80% of measurable PRS isoforms in all fibroblast strains, but PRS1 concent

113 appropriately termed overactivity of normal PRS.

114 ts from patients with overactivity of normal PRS.

115 The application of PRS has grown in recent years as their utility for detec

116 ls of PRS1 isoform as the enzymatic basis of PRS catalytic superactivity.

117 In addition, this new class of PRS provides a 2-fold enhancement in the number of ion g

118 rum of EDs and to examine the correlation of PRS scores with quality measures.

119 ss Survey (PRS); however, the correlation of PRS scores with the quality of simulated or real patient

120 to PRS, we explored the long-term effects of PRS on behavior and on the expression of key chromatin r

121 ning the absence of phenotypic expression of PRS catalytic superactivity in these cells.

122 Differences in the extent of PRS mutation could explain the phenotypic differences in

123 iated proteins in the ventral hippocampus of PRS rats.

124 -18, and Rab3A in the ventral hippocampus of PRS rats.

125 ost hemodynamically stable; the incidence of PRS in group 1 was 2/31 (7%) at 1 min and 8/31 (25%) usi

126 caval venting provided a lower incidence of PRS than any other technique.

127 these definitions, the overall incidence of PRS was 21%, 8%, and 43%, respectively.

128 persistence of ADHD symptoms independent of PRS.

129 lute specific activities (activity per mg of PRS isoforms) were comparable in all fibroblast strains

130 orescence revealed intracellular presence of PRS-110.

131 nuclei nicely explains the refractoriness of PRS rats to haloperidol-induced catalepsy.

132 intact allosteric mechanism of regulation of PRS activity, PRPS1 transcription is a major determinant

133 ying, evaluating and plotting the results of PRS.

134 (FEP) patients, we estimated the ability of PRSs to discriminate case-control status and to predict

135 We examined the association of PRSs with case-control status and with schizophrenia ver

136 omen at high risk for breast cancer based on PRS and/or TCRS were significantly more likely to be dia

137 CompEx (based on PRS) was the algorithm that best fulfilled our two-set c

138 dual in the lowest quartile of risk based on PRS.

139 Adult unstressed or PRS rats were treated daily with either agomelatine (40

140 e named 'prenatal restraint stress mice' or 'PRS mice') developed a schizophrenia-like phenotype, cha

141 associated with individual SNPs and overall PRS, and stratified by menopausal and receptor status.

142 phenyl-2-picryl-hydrazyl (DPPH-RS), peroxyl (PRS), and hydroxyl radical scavenging (HRS) and reducing

143 correlate with TEM and atmospheric pressure (PRS).

144 Urocortin 2 reduced PRS-induced colonic contractile activity in wild-type an

145 a consequence of reduced glutamate release, PRS rats were also highly resistant to kainate-induced s

146 e significance threshold for high-resolution PRS studies.

147 Women with at least partial responses (PRS) to induction received melphalan (140 or 180 mg/ m2)

148 igher (p<0.05) reduction in pH, BI, DPPH-RS, PRS and RP than FL model systems, with no considerable d

149 nd then used perturbation response scanning (PRS), where we introduced a random Brownian kick to a po

150 r (RP), DPPH and peroxyl radical scavenging (PRS) evaluated indirect antioxidant activity (AA).

151 ound of an association between schizophrenia PRS and psychotic experiences (OR per SD increase in PRS

152 ssess associations between the schizophrenia PRS and (1) psychotic experiences (Psychosis-Like Sympto

153 TLAB that yields a Pathway Regulation Score (PRS) by considering signalling pathway topology, and the

154 financial relationships, peer review score (PRS), and meeting placement prominence (descending order

155 conducted between MDD polygenic risk score (PRS) and AD case-control status in European ancestry sam

156 A polygenic risk score (PRS) composed of single nucleotide polymorphisms from th

157 We created a polygenic risk score (PRS) comprising 28 common obesity-related single-nucleot

158 EAC, and constructed a polygenic risk score (PRS) for cases and controls by summing the risk allele c

159 A higher polygenic risk score (PRS) for DZ twinning, calculated based on the results of

160 eptibility burden, the polygenic risk score (PRS) for each individual was defined by the weighted sum

161 A polygenic risk score (PRS) is a sum of trait-associated alleles across many ge

162 ucleotide polymorphism polygenic risk score (PRS) were associated with breast cancer tumor prognostic

163 A polygenic risk score (PRS), calculated as the sum of the log odds ratios for e

164 ally and combined as a polygenic risk score (PRS).

165 We included genetic polygenic risk scores (PRS) for schizophrenia, bipolar disorder, BMI, waist-hip

166 genetic methods, i.e. polygenic risk scores (PRS).

167 r interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions.

168 othesized that higher polygenic risk scores (PRSs) for AD would be associated with reduced volume of

169 Polygenic risk scores (PRSs) for schizophrenia generated for individuals in the

170 he possible effect of polygenic risk scores (PRSs) for schizophrenia on the association between infec

171 Polygenic risk scores (PRSs) have successfully summarized genome-wide effects o

172 for ADHD (indexed by polygenic risk scores [PRS]), but not for other psychiatric disorders, is assoc

173 Mean (SE) PRS for ADHD were higher in children in the persistent t

174 ion trapping and the pseudorandom sequence (PRS) used for the MP experiment, we have eliminated the

175 The CD3epsilon proline-rich sequence (PRS) binds to the cytosolic adaptor molecule Nck after T

176 its SH3.1 domain to a proline-rich sequence (PRS) in CD3epsilon after TCR engagement.

177 ology 3.1 domain to a proline-rich sequence (PRS) in CD3epsilon.

178 obic motif within the proline-rich sequence (PRS) of MEK1 and MEK2 that is required for constitutive

179 rylation sites in the proline-rich sequence (PRS) of MEK1.

180 contains a conserved proline-rich sequence (PRS) that influences TCR-CD3 expression and signaling.

181 D3epsilon cytoplasmic proline-rich sequence (PRS).

182 gue, resembling human Pierre Robin sequence (PRS)-like cleft secondary palate.

183 Polymorphism ratio sequencing (PRS) combines the advantages of high-throughput DNA sequ

184 e in 104 patients, high risk conferred short PRS (hazard ratio = 4.00, P < .001, R(2) = 33%), whereas

185 PRS mice show similar epigenetic signature, PRS mice may be a suitable model for understanding the b

186 for G2/3, treatment with PR and Sofosbuvir (PRS) for G1/4 and treatment with Sofosbuvir and ribaviri

187 Prenatal stress (PRS) is considered a risk factor for several neurodevelo

188 Rats exposed to prenatal restraint stress (PRS) develop enduring biochemical and behavioral changes

189 n induced by acute partial-restraint stress (PRS), and/or intraperitoneal injection of CRF ligands.

190 the rat model of prenatal restraint stress (PRS).

191 Prenatally restraint stressed (PRS) rats develop long-lasting biochemical and behaviora

192 For 432 subjects PRS scores for plasma cortisol, major depression, and ne

193 nctions in the proline racemase superfamily (PRS; InterPro IPR008794).

194 Ds completed the Pediatric Readiness Survey (PRS); however, the correlation of PRS scores with the qu

195 pportunity to evaluate postrelapse survival (PRS) in 272 relapsed patients who had received randomly

196 stic implications for post-relapse survival (PRS) of a gene expression profiling (GEP)-defined risk s

197 sion techniques on postreperfusion syndrome (PRS) and postoperative graft function, 100 transplants w

198 Parry-Romberg syndrome (PRS) is a rare disorder characterized by unilateral faci

199 nked phosphoribosylpyrophosphate synthetase (PRS) catalytic superactivity, we measured concentrations

200 osphoribosylpyrophosphate (PRPP) synthetase (PRS) superactivity is an X-linked disorder characterized

201 aqueous system and pasta resembling system (PRS).

202 mor size, and grade was performed with TCRS, PRS, and percent MD as exposures.

203 s a p210 Bcr-Abl-responsive sequence, termed PRS.

204 We report here that PRS rats showed a selective impairment of depolarization

205 ceptor agonist, apomorphine, suggesting that PRS causes enduring neuroplastic changes in the basal ga

206 traint stress of pregnant mice suggests that PRS induces epigenetic changes in specific GABAergic and

207 Our data show for the first time that PRS induces a schizophrenia-like phenotype in mice, and

208 The PRS tool provides a filter in the isolation of biologica

209 The PRS was negatively related to satiety responsiveness (be

210 Although the PRS can bind the SH3.1 domain of the cytosolic adapter N

211 We examined associations among the PRS, adiposity, and satiety responsiveness.

212 combinations of non-genetic factors and the PRS were compared for their accuracy in identifying pati

213 Associations between the PRS and adiposity were significantly mediated by satiety

214 Polygenic risk (measured by the PRS) was greater in women who tested negative for a BRCA

215 We demonstrate the PRS method by screening two human mitochondrial genomes

216 Ns reduction (81-100%) were evidenced in the PRS after the treatments at 5, 10 and 15 min of incubati

217 In the PRS method, dideoxy-terminator extension ladders generat

218 -PRS) bearing a conservative mutation in the PRS resulting from the replacement of the two central pr

219 -PRS) bearing a conservative mutation in the PRS that makes the TCR incompetent to recruit Nck.

220 vities for 51 proteins in 12 families in the PRS that represent approximately 85% of the sequences; i

221 Activated ERK can phosphorylate T292 in the PRS, and this blocks the ability of PAK to phosphorylate

222 epends on PAK phosphorylation of S298 in the PRS.

223 in mutant bearing an 8-aa replacement of the PRS have indicated that Nck binding to the TCR is consti

224 urrent smokers in the lowest quartile of the PRS to 9.9% for current smokers in the upper quartile.

225 The correlation of the PRS was moderate for simulation-based measures of qualit

226 risks and risk differences by levels of the PRS were estimated for U.S. males aged 50 years.

227 More children in the top 25% of the PRS were overweight than in the lowest 25% (18.5% vs 7.2

228 It was suggested that the PRS is important for TCR signaling and T cell activation

229 bility to activate transcription through the PRS.

230 In contrast to the PRS, an important reduction of the ENs was obtained in t

231 in of the cytosolic adapter Nck, whether the PRS is constitutively available for Nck binding or inste

232 The PRSs created using single-nucleotide polymorphisms with

233 Including the PRSs in the model developed based on non-genetic factors

234 The binding of Egr-1 to PRS is suppressed by p210 Bcr-Abl due to the inhibition

235 roteins, namely Sp1, Sp3, and Egr-1, bind to PRS.

236 As compared to PRS/SR, treating with an all oral regimen of Sofosbuvir

237 1 and $25 405 per QALY gained as compared to PRS/SR.

238 The correlation of CQS to PRS was moderate (r = 0.51; P < .001).

239 Findings were specific to PRS for ADHD; PRS for other psychiatric conditions did n

240 dult offspring of pregnant mice subjected to PRS, we explored the long-term effects of PRS on behavio

241 10 mug of (89)Zr-PRS-110, with no unlabeled PRS-110.

242 (89)Zr-PRS-110 (with 0-490 mug of unlabeled PRS-110) were injected into BALB/c mice bearing high MET

243 smoking occurred in 100,000 men in the upper PRS quartile compared with 2,000 cases prevented by a si

244 The primary exposure variables, PRS, were generated using results of a genome-wide assoc

245 etween CQS and individual domain scores with PRS.

246 identified 26 patients with superior 3-year PRS of 61% versus 9% among 32 with relapse high-risk (P

247 additional GEP baseline information, 3-year PRS was 71% in 40 patients with low risk present both at

248 However, no difference in 3-year PRS was detected for having received augmented versus st

249 after injection of tracer) 10 mug of (89)Zr-PRS-110 (with 0-490 mug of unlabeled PRS-110) were injec

250 ata revealed specific tumor uptake of (89)Zr-PRS-110 in the MET-expressing H441 and U87-MG tumors whe

251 and 96 h after injection of 50 mug of (89)Zr-PRS-110 into mice bearing H441, primary glioblastoma U87

252 (89)Zr-PRS-110 specifically accumulates in MET-expressing tumor

253 fractional tumor uptake at 10 mug of (89)Zr-PRS-110, with no unlabeled PRS-110.

254 owed a dose-dependent tumor uptake of (89)Zr-PRS-110, with the highest fractional tumor uptake at 10