ライフサイエンスコーパス: PSC

1 PSCs are also transiently induced by growth factors (GF)

2 PSCs have become an important tool for probing developme

3 PSCs provide an essential platform for RAS-induced phosp

4 c regions and contained approximately 30,000 PSC and 27,000 WRA.

5 systems on predicting composite endpoints 1 (PSC-related death and liver transplantation), 2 (liver t

6 A total of 119 PSC patients were identified, and the median follow-up w

7 tely 1.7 million people and partners with 14 PSCs located between 6.4 and 73.6 km away.

8 sicles (EV) were isolated from CCA (n = 43), PSC (n = 30), or HCC (n = 29) patients and healthy indiv

9 nants of Anemia (BRINDA) project from 29,765 PSC in 16 surveys and 25,731 WRA in 10 surveys were used

10 The incorporation of 8% PSC powder in biscuits (GI=49) could be an effective way

11 nants of Anemia (BRINDA) project from 11,913 PSC in 11 surveys and from 11,173 WRA in 7 surveys were

12 ch repair gene MLH1 CGI, we could generate a PSC model of a cancer-related epimutation.

13 To describe the association of a PSC protocol focused on 3 key steps (early CSC notificat

14 s with suspected ELVO who first present to a PSC.

15 detected on the plasma membrane of activated PSCs isolated from chronic pancreatitis tissues and in p

16 All-polymer solar cells (all-PSCs) offer unique morphology stability for the applicat

17 and applied in all-polymer solar cells (all-PSCs).

18 ies (PCE) of 8.59% has been achieved for all-PSCs.

19 the highest value thus far reported for all-PSCs.

20 develop efficient polymer acceptors for all-PSCs.

21 The all-PSCs with the wide-band-gap polymer PBDB-T as donor and

22 owed a record-high PCE of 9.19 % for the all-PSCs.

23 hysiology of primary biliary cholangitis and PSC in the hope that these new drugs can be used more ef

24 PSC and IBD diagnoses, phenotypes of IBD and PSC, and date and indication of IBD-related surgeries.

25 ifferent pathogenic features of BA, PBC, and PSC.

26 s on large-area substrates (18.4 cm(2) ) and PSCs with the total active area of 6 cm(2) (1 cm(2) x 6

27 combining gene editing with CRISPR/Cas9 and PSCs complementation could result in a powerful approach

28 ully implemented, a standardized protocol at PSCs for patients with suspected ELVO consisting of earl

29 The limitations of ZnO ETM-based PSCs and some solutions to these challenges are also dis

30 As a result, the PM6:IDIC-based PSCs without extra treatments show an outstanding power

31 The LBSO-based PSCs could retain 93% of their initial performance after

32 e knowledge of ZnO-based PSCs to TiO2 -based PSCs.

33 PSCs by extending the knowledge of ZnO-based PSCs to TiO2 -based PSCs.

34 , progenitor cell activation differs between PSC and PBC and is characterized by a divergent fate com

35 genome-wide genetic correlation (rG) between PSC and ulcerative colitis (UC) (rG = 0.29) was signific

36 was significantly greater than that between PSC and Crohn's disease (CD) (rG = 0.04) (P = 2.55 x 10(

37 Analyses of variance of FA and BOLD PSC were used to determine main or interaction effects o

38 yers with lower FA tended to have lower BOLD PSC across three levels of a working memory task.

39 Analysis of working memory-task BOLD PSC revealed a similar interaction between concussion hi

40 ion, the adjusted mean TBI decreased in both PSC and WRA compared with unadjusted values.

41 subjected to DDC and in patients affected by PSC.

42 termine the effects of Pleurotus sajor-caju (PSC) powder addition at 0, 4, 8 and 12% levels on the nu

43 atures, and drug response of cardiomyocytes (PSC-CMs) and endothelial cells (PSC-ECs) derived from ge

44 %, which is the record value for the as-cast PSC devices reported in the literature to date.

45 oteomic signatures found in serum EV of CCA, PSC, and HCC patients show potential usefulness as diagn

46 his work, a nonfullerene polymer solar cell (PSC) based on a wide bandgap polymer donor PM6 containin

47 ce, to better understand polymer solar cell (PSC) optimization approaches.

48 standard architecture perovskite solar cell (PSC).

49 richment of xenogenic pluripotent stem cell (PSC) derivatives.

50 Through pluripotent stem cell (PSC) technology, human intestinal organoids (HIOs) with

51 clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons.

52 Pluripotent stem cell (PSC)-derived organoids are miniature, three-dimensional

53 ause the rejection of pluripotent stem cell (PSC)-derived products in allogeneic recipients.

54 diomyocytes (PSC-CMs) and endothelial cells (PSC-ECs) derived from genetically relevant sets of human

55 Mixed ion perovskite solar cells (PSC) are manufactured with a metal-free hole contact bas

56 indings implicate pancreatic stellate cells (PSC) as prominent mediators of inflammatory and fibrotic

57 ) in human pancreatic cancer stellate cells (PSC), key mediators of the PDAC stroma.

58 udies showed porcine muscle satellite cells (PSCs) are important for postnatal skeletal muscle growth

59 Perovskite solar cells (PSCs) exceeding a power conversion efficiency (PCE) of 2

60 Perovskite solar cells (PSCs) have developed rapidly over the past few years, an

61 rting layer (HTL) in perovskite solar cells (PSCs) provides higher carrier mobility, better-energy le

62 the establishment of perovskite solar cells (PSCs), there has been an intense search for alternative

63 ) in inverted planar perovskite solar cells (PSCs).

64 (SMA) for nonfullerene polymer solar cells (PSCs).

65 Conventional perovskite solar cells (PSCs); however, suffer the issue that lead is toxic to t

66 Pancreatic stellate cells (PSCs) are key mediators in the production of this fibrot

67 Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (

68 yofibroblast-like pancreatic stellate cells (PSCs) plays a predominant role in the formation of desmo

69 larly encountered in pluripotent stem cells (PSCs) and their differentiated progeny.

70 Patient-specific pluripotent stem cells (PSCs) can be generated via nuclear reprogramming by tran

71 Human pluripotent stem cells (PSCs) exist in naive and primed states and provide impor

72 s (HSPCs) from human pluripotent stem cells (PSCs) has been a long-sought-after goal for use in hemat

73 Pluripotent stem cells (PSCs) have major potential as an unlimited source of fun

74 ing to generate from pluripotent stem cells (PSCs) in part because there are limited model systems av

75 d NKX2-1GFP reporter pluripotent stem cells (PSCs) in vitro to generate and isolate human primordial

76 s to differentiating pluripotent stem cells (PSCs) into neurons currently face two major challenges-(

77 tion of T cells from pluripotent stem cells (PSCs) is attractive for investigating T cell development

78 d differentiation of pluripotent stem cells (PSCs) or direct conversion, and to suggest specific hypo

79 Human pluripotent stem cells (PSCs) provide a unique entry to study species-specific a

80 red stem cell types, pluripotent stem cells (PSCs) sit atop the landscape of developmental potency an

81 d differentiation of pluripotent stem cells (PSCs) through stimulation of developmental signaling pat

82 conversion of human pluripotent stem cells (PSCs) to a more naive developmental status.

83 In order for pluripotent stem cells (PSCs) to appropriately respond to differentiation signal

84 mbryonic and induced pluripotent stem cells (PSCs) to generate human intestinal tissue containing a f

85 erentiation of human pluripotent stem cells (PSCs) toward progeny with trophectoderm characteristics,

86 Pluripotent stem cells (PSCs), including induced PSCs, hold great potential for

87 entire CGI in human pluripotent stem cells (PSCs).

88 specific organs from pluripotent stem cells (PSCs).

89 enesis in vitro from pluripotent stem cells (PSCs).

90 lymph gland, the posterior signaling center (PSC) acts as a niche to regulate the hematopoietic respo

91 ho first present to a primary stroke center (PSC).

92 evel-dependent (BOLD) percent signal change (PSC) were measured with diffusion-weighted and task-rela

93 lammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age

94 of low TBI (<0 mg/kg) in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age

95 lammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age

96 lammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age

97 nthropometric status, in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age

98 predictors of anemia in preschool children (PSC) (age range: 6-59 mo) by country and infection-burde

99 data from 16 surveys for preschool children (PSC) (n = 29,765) and from 10 surveys for nonpregnant wo

100 sk factors for anemia in preschool children (PSC) and women of reproductive age (WRA).The BRINDA data

101 ogression of primary sclerosing cholangitis (PSC) and is characterized by accumulation of extracellul

102 Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are human pri

103 specific for primary sclerosing cholangitis (PSC) are not validated.

104 Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disorder characteriz

105 Primary sclerosing cholangitis (PSC) is a chronic, fibroinflammatory cholangiopathy (dis

106 Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct

107 OUND & AIMS: Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with

108 atients with primary sclerosing cholangitis (PSC) may be at higher risk of malignancy after liver tra

109 ons, such as primary sclerosing cholangitis (PSC), are risk factors.

110 langitis and primary sclerosing cholangitis (PSC), evolve over time with anatomically an ascending co

111 on exists in primary sclerosing cholangitis (PSC).

112 es including primary sclerosing cholangitis (PSC).

113 en linked to primary sclerosing cholangitis (PSC).

114 n particular primary sclerosing cholangitis (PSC).

115 s [PBC], and primary sclerosing cholangitis [PSC]), we built a comprehensive platform of published da

116 k of LTD or malignancy compared with classic PSC (HR, 0.30 and HR, 0.15, respectively; both P < .001)

117 and mouse pluripotent stem cell-derived CMs (PSC-CMs) were transduced with the neurogenic transcripti

118 ably, these perinuclear signaling complexes (PSC) are present in tumor cell lines, mouse lung tumors,

119 r modules, under partial shading conditions (PSCs).

120 Patterns of structural covariance (PSCs) derived by NMF were highly reproducible over a ran

121 anding frames using polymer single crystals (PSCs) as the template.

122 Treatment of cultured PSC with the Jak1/2 inhibitor ruxolitinib reduced STAT3

123 maging modality that can be used to diagnose PSC and detect disease related complications.

124 knowledge has been applied to differentiate PSCs into muscle fibers and their progenitors in vitro.

125 s assessing the primary endpoint, small-duct PSC characterized a low-risk phenotype in both sexes (ad

126 Small-duct PSC was associated with a lower risk of LTD or malignanc

127 activity in the pluripotent state and during PSC-differentiation for several of the CBX3 subfragments

128 nd practical application of highly efficient PSCs.

129 Here, we employ PSCs to identify the key minimal signaling pathways (Wnt

130 These HLA-engineered PSCs and their differentiated derivatives are not recogn

131 Besides, the PM6:IDIC-based flexible PSCs with a large device area of 1.25 cm(2) exhibit a hi

132 for CCA stage I-II versus control, 0.789 for PSC versus control, 0.806 for noncirhottic PSC versus co

133 Accurate noninvasive biomarkers for PSC, CCA, and HCC are not available.

134 age range: 15-49 y).Cross-sectional data for PSC (8 surveys; n = 8413) and WRA (4 surveys; n = 4258)

135 creased as CRP and AGP deciles decreased for PSC and WRA, but the effect was more pronounced for AGP

136 All adult patients underwent LT for PSC without cholangiocarcinoma from 1984 to 2012, with f

137 nd 2-8 absolute median percentage points for PSC and WRA, respectively, compared with unadjusted valu

138 cts.Cross-sectional data from 15 surveys for PSC (n = 27,865) and 8 surveys for WRA (24,844), from th

139 ects.Cross-sectional data from 8 surveys for PSC (n = 8803) and 4 surveys for WRA (n = 4191) from the

140 represent a potential therapeutic target for PSC treatment.

141 ated with a reduction in the median time for PSC arrival to CSC groin puncture (from 151 minutes [95%

142 m(2) ), the PCEs deteriorate drastically for PSCs of larger areas because of the incomplete film cove

143 ecent developments in the use of ZnO ETM for PSCs.

144 Here, we review recent progress on lead-free PSCs in terms of the theoretical insight and experimenta

145 Liver biopsies from PSC patients were collected from seven European institut

146 y related to an improvement in the time from PSC door in to door out that reduced from a median time

147 were efficiency measures including time from PSC door in to PSC door out, time from PSC door to CSC g

148 from PSC door in to PSC door out, time from PSC door to CSC groin puncture, and 90-day modified Rank

149 However, cells differentiated from PSCs remain immature in a dish, and thus there are serio

150 Furthermore, PSCs showed divergent developmental associations, with P

151 with other countries) and population group (PSC compared with WRA).

152 tes has implications for bulk-heterojunction PSC morphology optimization via optimized spin-casting p

153 However, PSCs show limited contribution to the extraembryonic pla

154 axis and miR-200b were up-regulated in human PSC samples.

155 ion was increased in cholangiocytes of human PSC livers and in the Abcb4 (Mdr2)(-/-) mouse model of P

156 set of molecular markers to define the human PSC state and allows new insights into the molecular eve

157 Here we transplanted human PSC-derived cortical neuronal precursors into the brain

158 In the past five years, human PSC-derived organoids with components of all three germ

159 in vitro differentiation of mouse and human PSCs into cardiac progenitor cells, followed by intramyo

160 teristics of differentiated cells from human PSCs are primarily attributed to the genetic composition

161 of exclusively GABAergic neurons from human PSCs with a high degree of synaptic maturation.

162 to generate glutamatergic neurons from human PSCs.

163 tive progenitors of lung alveoli, from human PSCs.

164 fforts to derive functional HSPCs from human PSCs.

165 optimize the production of HSPCs from human PSCs.

166 ock in HLA-E genes at the B2M locus in human PSCs in a manner that confers inducible, regulated, surf

167 by flow cytometry in naive and primed human PSCs.

168 To date, however, whether human PSCs (hPSCs) can contribute to chimera formation in non-

169 ntestinal ENS development by combining human-PSC-derived neural crest cells (NCCs) and developing hum

170 knowledge, the first demonstration of human-PSC-derived intestinal tissue with a functional ENS and

171 Here, we utilized primary and immortalized PSC obtained from mice and patients with CP or pancreati

172 In PSC with anemia, 50%, 30%, 55%, and 58% of children had

173 In PSC, inflammation was consistently positively associated

174 ta underline the potential role of Cad-11 in PSC activation and pancreatic cancer metastasis.

175 The inflammation prevalence was 6.0-40.2% in PSC and 7.9-29.5% in WRA (elevated CRP) and 21.2-64.3% i

176 9.5% in WRA (elevated CRP) and 21.2-64.3% in PSC and 7.1-26.7% in WRA (elevated AGP).

177 iral oncogene homolog (NRAS) is activated in PSC cholangiocytes.

178 ere explored to adjust RBP concentrations in PSC in inflammation and malaria settings as follows: 1)

179 associated with elevated AGP but not CRP in PSC, and obesity was associated with both elevated CRP a

180 he secretion of proinflammatory cytokines in PSC of the PDAC tumor microenvironment, whereas downregu

181 and TBI were generally linear, especially in PSC.

182 AD (defined as <0.7 mumol/L) was examined in PSC.The relation between estimated VAD and CRP and AGP d

183 is in the development of hepatic fibrosis in PSC is unknown.

184 on changed the estimated prevalence of ID in PSC by a median of +25 percentage points (pps) when SF c

185 stores (ferritin concentration <12 mug/L in PSC and <15 mug/L in WRA) in inflammation and malaria se

186 onents characterize progenitor cell niche in PSC compared with PBC.

187 Previously, we linked the CD28 pathway in PSC disease pathology and found that vitamin D could mai

188 and AGP deciles followed a linear pattern in PSC.

189 by 4.4-14.6 and 0.3-9.5 percentage points in PSC and WRA, respectively, compared with unadjusted valu

190 ed by a median of 11-18 percentage points in PSC compared with unadjusted values.

191 when SF concentrations were used by 3 pps in PSC and by 7 pps in WRA.

192 a median of 4-14 percentage points (pps) in PSC and 1-3 pps in WRA compared with unadjusted TBI.

193 ducibility of staging disease progression in PSC using the Nakanuma, Ishak, and Ludwig staging system

194 angiocyte senescence features prominently in PSC and that neuroblastoma RAS viral oncogene homolog (N

195 e Jak/STAT pathway plays a prominent role in PSC proliferation and activation.

196 Endoscopic stenting in PSC should be reserved for situations of intercurrent ch

197 gitis patients, with no effective therapy in PSC.

198 mation, to estimate the prevalence of VAD in PSC in regions with inflammation and malaria is supporte

199 histone modifications, tend to colocalize in PSCs.

200 We found miR-34c is decreased in PSCs overexpressed N1ICD.

201 n though these genes are hardly expressed in PSCs.

202 11 expression was significantly increased in PSCs and pancreatic cancer cells.

203 le combinations of metals to replace lead in PSCs.

204 (ETMs) used in PSCs play a critical role in PSCs performance.

205 ectron transporting materials (ETMs) used in PSCs play a critical role in PSCs performance.

206 liver fibrosis in cholangiopathies including PSC.

207 lly corrected aberrant imprinting in induced PSCs derived from an Angelman syndrome patient.

208 ipotent stem cells (PSCs), including induced PSCs, hold great potential for personalized disease mode

209 i-34c, we demonstrated that miR-34c inhibits PSCs proliferation and promotes PSCs differentiation.

210 Members of the International PSC Study Group and radiologists from North America and

211 Moreover, PSCs were largely symmetric and showed correspondence to

212 ming the reverse experiment, injecting mouse PSCs into Pdx-1-deficient rat blastocysts, we generated

213 erated rat-sized pancreata composed of mouse-PSC-derived cells.

214 use and reproducibility across a multicenter PSC cohort.

215 The protocol is effective across multiple PSC lines and can proceed without karyotype change.

216 the context of lentiviral vectors and murine PSCs.

217 ulated this finding in co-cultures of murine PSCs and PDA organoids, and demonstrated that organoid-a

218 r PSC versus control, 0.806 for noncirhottic PSC versus control, 0.796 for CCA versus PSC, 0.956 for

219 olecular design, SFBRCN enables nonfullerene PSCs with a high efficiency of 10.26%, which is the high

220 e clinical application of MRI in the care of PSC patients and imaging standards vary across instituti

221 arding the application of MRI in the care of PSC patients, minimum imaging standards, and future area

222 atement about the role of MRI in the care of PSC patients, quality imaging standards, and its potenti

223 in disease progression, characterisation of PSC activation has been extensive, however one aspect th

224 n sex, clinician-reported age at and date of PSC and IBD diagnoses, phenotypes of IBD and PSC, and da

225 advance in understanding of the genetics of PSC.

226 onducted after 2004, 2) had target groups of PSC, WRA, or both, and 3) used a similar laboratory meth

227 AC progression and survival via induction of PSC activation and fibrosis, suggesting that direct mech

228 Elevated incorporation levels of PSC powder increased the dietary fibre (DF) content and

229 smooth muscle actin (alpha-SMA), a marker of PSC activation.

230 onatal rat system that enables maturation of PSC-derived cardiomyocytes into cardiomyocytes analogous

231 Herein, using the mouse model of PSC (multidrug resistance gene 2 knockout), the hepatic

232 and in the Abcb4 (Mdr2)(-/-) mouse model of PSC.

233 e gene 2-knockout (Mdr2(-/-)) mouse model of PSC.

234 le evidence for the therapeutic potential of PSC-derived islets generated by blastocyst complementati

235 f hepatic fibrosis during the progression of PSC.

236 the largest genome-wide association study of PSC (4,796 cases and 19,955 population controls) and ide

237 x stiffness, whilst observing the ability of PSCs to durotactically respond to stiffness variations w

238 We show the ability of PSCs to undergo phenotypic transition solely as a result

239 otprint-free CRISPR-based gene correction of PSCs derived from patients carrying a homozygous surfact

240 potentially motivates further development of PSCs by extending the knowledge of ZnO-based PSCs to TiO

241 replace lead for the further development of PSCs.

242 ears, and the power conversion efficiency of PSCs has exceeded 20%.

243 ence of different ZnO ETMs on performance of PSCs is then reviewed.

244 ting that direct mechanical reprogramming of PSCs may be a viable alternative in the treatment of thi

245 However, TiO2 can reduce the stability of PSCs under illumination (including ultraviolet light).

246 This study emphasises the value of PSCs for disease modelling and underlines the significan

247 itor, MEK162, had less consistent effects on PSC proliferation and no impact on activation.

248 ng of the influence of different ZnO ETMs on PSCs performance and potentially motivates further devel

249 is concept may be expanded to maturing other PSC-derived cell types, including those containing mutat

250 compared with lowest CRP deciles for pooled PSC and WRA, respectively, with similar results for AGP)

251 cells diverges markedly from that of primed PSCs and shares features with human inner cell mass (ICM

252 %), which is the highest value for printable PSCs with a total active area larger than 1 cm(2) .

253 34c inhibits PSCs proliferation and promotes PSCs differentiation.

254 Purified PSC-derived SFTPC+ cells form monolayered epithelial "al

255 te genome editing and show enrichment of rat PSC-derivatives in several tissues of gene-edited organo

256 this retrospective cohort study, 14 regional PSCs unfamiliar with the management of patients with ELV

257 101 patients were transferred from regional PSCs to the CSC between July 1, 2015, and May 31, 2016,

258 The addition of DF-rich PSC powder also interfered with the integrity of the sta

259 an innovative method of fabricating scalable PSCs on all types of organic CTLs is reported.

260 ree histological scoring systems in a single PSC cohort.

261 isolation from untargeted, patient-specific PSCs for further in vitro differentiation and future app

262 is a promising HTL for efficient and stable PSCs.

263 e risk of cancer after LT for advanced-stage PSC was 18.7%, with posttransplant lymphoproliferative d

264 bilities are compared with those of standard PSCs employing spin-coated Spiro-OMeTAD and a thermally

265 tively, our findings indicate that sustained PSC formation is a critical feature of oncogenic RAS/BRA

266 This study demonstrates that PSC-CMs are amenable to partial neuronal conversion, yie

267 on clinical severity, vessel imaging at the PSC, and cloud-based image sharing) with the efficiency

268 By controlling the PSC growth, we were able to, for the first time, precise

269 Homozygotes for the PSC disease risk allele (AA) showed significantly lower

270 ipheral cytoplasmic domain distinct from the PSC region.

271 hat Toll/NF-kappaB pathway activation in the PSC in response to wasp parasitism non-cell autonomously

272 ppaB and EGFR signaling by ROS levels in the PSC/niche controls lymph gland hematopoiesis under paras

273 ed tomographic angiography on arrival to the PSC, and cloud-based image sharing is associated with a

274 e divided into 2 groups based on whether the PSC protocol was partially or fully executed.

275 Here, we assessed whether the PSC-associated CD28 risk variant A (rs7426056) affects C

276 The PSCs fabricated with LBSO and methylammonium lead iodide

277 ncy (PCE) to a value lower than those of the PSCs based on fullerene derivative or organic small mole

278 Thus, PSC-derived AEC2s provide a platform for disease modelin

279 measures including time from PSC door in to PSC door out, time from PSC door to CSC groin puncture,

280 nd in this study have differentiated them to PSC-macrophages (pMac), which recapitulate many features

281 to each other (rG = 0.56) than either was to PSC (P < 1.0 x 10(-15)).

282 on of developmental biological principles to PSCs in vitro The approach to generate organoids uses a

283 tic PSC versus control, 0.796 for CCA versus PSC, 0.956 for CCA stage I-II versus PSC, 0.904 for HCC

284 versus PSC, 0.956 for CCA stage I-II versus PSC, 0.904 for HCC versus control, and 0.894 for intrahe

285 zed progenitor cell activation in PBC versus PSC.

286 her proliferation index in PBC compared with PSC.

287 outcome analysis of patients diagnosed with PSC from 1980 through 2010 at 37 centers in Europe, Nort

288 liver donors (n = 5) and from patients with PSC (n = 20) or PBC (n = 20).

289 rm cancer-related mortality in patients with PSC after LT.

290 melatonin treatment or in male patients with PSC and healthy controls.

291 ed to estimate risk levels for patients with PSC and select patients for clinical trials.

292 ncreased in Mdr2(-/-) mice and patients with PSC compared with controls and decreased in Mdr2(-/-) mi

293 Of all patients with PSC studied, 65.5% were men, 89.8% had classical or larg

294 Mortality of patients with PSC who developed cancer was higher than that of patient

295 cancer was higher than that of patients with PSC without cancer (hazard ratio, 2.2; P < 0.01).

296 alysis of data from individual patients with PSC worldwide, we found significant variation in clinica

297 tes, in both murine models and patients with PSC.

298 large international cohort of patients with PSC.

299 d divergent developmental associations, with PSCs in higher-order association cortex networks showing

300 ritically, such developmental changes within PSCs were significantly associated with the degree of ev