ライフサイエンスコーパス: PSF

1 PSF (a.k.a. SFPQ) is a ubiquitously expressed, essential

2 PSF also contains two RNA-binding domains (RBD) that for

3 PSF also stimulates early steps of HR in vitro.

4 PSF and p54(nrb) are RNA recognition motif-containing pr

5 PSF binds PGC-1alpha and suppresses its transcriptional

6 PSF enhances N30 inclusion in a UGCAUG-dependent manner,

7 PSF expression was constitutive in retinal pericytes (RP

8 PSF is 210 times as potent as phenylmethylsulfonyl fluor

9 PSF is phosphorylated at two sites by the Mnks.

10 PSF represses transcription of the insulin-like growth f

11 PSF was expressed in all retinal cell types examined in

12 paralogs and that the B. fragilis NCTC 9343 PSF repeat unit contains xylose.

13 in the endogenous NMHC II-B transcript in a PSF-dependent manner.

14 notype, but deletion of both genes abrogates PSF synthesis, strongly suggesting that they are functio

15 In the patient study, again, PSF increased the detected activity in the patient's les

16 Although PSF-TFE3 has no effect on the nuclear localization of wi

17 Here we show that DJ-1 and PSF bind and regulate the human tyrosine hydroxylase (TH

18 ins and provides evidence that the Fox-3 and PSF interaction is an integral part of the mechanism by

19 RNA-binding proteins, including TLS/FUS and PSF, co-purify with EWS.

20 O-binding proteins such as FUS/TLS (FUS) and PSF/SFPQ (PSF).

21 nagement strategies for patients with HF and PSF.

22 The associations of hnRNP L and PSF with the ESS1 complex are largely independent of eac

23 on of TFE3 chimeras of PRCC, RCC17, NonO and PSF (PTB-associated splicing factor).

24 onsistent to this, we show that p54(nrb) and PSF induce CoAM splice variant through the cis-regulatin

25 Our finding that both p54(nrb) and PSF, which bind the C-terminal domain of the largest sub

26 P54nrb and PSF belong to Drosophila behavior/human splicing (DBHS)

27 Thus, p54nrb and PSF have properties of key factors mediating INS functio

28 to cells can reduce the levels of P54nrb and PSF proteins through proteasome-mediated degradation.

29 ator that may act in concert with p54nrb and PSF to regulate the expression of a neuroprotective gene

30 teomics and metabolomics profiles of PLF and PSF groups were acquired for the hippocampus and plasma

31 pathway activity differences between PLF and PSF mice.

32 eudosylvian and suprasylvian fields (PPF and PSF), suggesting that these connections are frequency sp

33 targeting the posterior bank fields PPF and PSF, which in turn project to the ventral posterior fiel

34 (polypyrimidine tract binding protein), and PSF (PTB associated splicing factor)--that bind to two s

35 on of the splicing factors RBM8A, SRSF9, and PSF as well as the nucleolar proteins NPM1 and PHF6, and

36 uld be partially blocked using the antisense PSF ODN.

37 t cubic splines can capture the shape of any PSF with high accuracy and that they can be used for fit

38 ate with two proteins which we identified as PSF (polypyrimidine tract-binding protein-associated spl

39 in vitro, and identified one such protein as PSF (the PTB (polypyrimidine tract-binding protein)-asso

40 e several proteins identified so far such as PSF (PTB associated splicing factor), NonO, PRCC, CLTC a

41 ther transcription/splicing factors, such as PSF and TLS, as well as transcription factors that inter

42 ion involving formation of a complex between PSF protein and mouse VL30 (mVL30) retrotransposon RNA.

43 NA; however, in resting cells, TRAP150 binds PSF and prevents access to the CD45 RNA, though the mech

44 production, a response inhibited by blocking PSF with a specific antisense oligodeoxynucleotide (ODN)

45 Use of both PSF+TOF together provided a cumulative benefit in lesion

46 odel (PSF), baseline plus TOF, and with both PSF+TOF.

47 not detected to bind N-CoR although it bound PSF and Sin3A as effectively as TR, and this association

48 e presence of ligand, the levels of TR-bound PSF and Sin3A appear to remain unchanged, indicating tha

49 Here we demonstrate that in resting T cells PSF is directly phosphorylated by GSK3, thus promoting i

50 In stimulated T cells, PSF binds to and suppresses the inclusion of CD45 exon 4

51 n a large nuclear-protein complex containing PSF-NonO (polypyrimidine-tract-binding-protein-associate

52 olution was applied to the PSF +/- TOF data (PSF +/- TOF.EQ) to harmonize SUVs with the OSEM values.

53 In contrast, a SUMOylation-deficient PSF mutant exhibits reduced binding to PGC-1alpha and pr

54 small interfering RNA (siRNA) that degrades PSF transcripts.

55 (2 microm) by finding the center of the 2 DH-PSF lobes.

56 repeated imaging of sparse subsets with a DH-PSF microscope provides superresolution imaging of high

57 its a double-helix point spread function (DH-PSF).

58 The DH-PSF design features high and uniform Fisher information

59 odel in which TRAP150 interacts with dimeric PSF to block access of RNA to RRM2, thereby regulating t

60 formance, significantly outperforming either PSF or TOF alone (P < 0.002).

61 ework for noisy, aberrated and/or engineered PSF imaging.

62 hood estimator using a particular engineered PSF microscope demonstrates unmatched low-photon-count 3

63 This experimental PSF allows the approach to take into account the laser b

64 carcinoma cells, which endogenously express PSF-TFE3, siRNA complementary to the PSF-TFE3 fusion jun

65 ma-derived cells, which endogenously express PSF-TFE3.

66 ed high cytotoxicity but the floret extract (PSF) found to be most effective with IC(5)(0) value of 2

67 the heterogeneous capsular polysaccharide F (PSF) biosynthesis locus.

68 More importantly, the splicing factor PSF is recruited to the ESS1 complex in an activation-de

69 inding protein p54(nrb), the splicing factor PSF, and the inner nuclear matrix structural protein mat

70 -binding protein-associated splicing factor (PSF) and a 54-kDa nuclear RNA-binding protein (p54(nrb))

71 binding protein-associated splicing factor (PSF) as an interacting protein with Fox-3 by affinity-ch

72 -binding protein-associated splicing factor (PSF) as OEE-binding factors, which was confirmed by ChIP

73 onO(p54)-protein-associated splicing factor (PSF), multifunctional proteins involved in several nucle

74 -binding protein-associated splicing factor (PSF), two multifunctional regulators of transcription an

75 -binding protein-associated splicing factor (PSF).

76 -binding protein-associated splicing factor (PSF).

77 Prostacyclin-stimulating factor (PSF) acts on vascular endothelial cells to stimulate the

78 the past 25 years, the plant-soil feedback (PSF) framework has catalyzed our understanding of how be

79 and paroxetine-treated short-time floating (PSF) groups were stratified as proxies for drug non-resp

80 potent inhibitor, palmitylsulfonyl fluoride (PSF), was found to have an IC50 of 50 nM.

81 tivity and 1.3 cm(3) in volume estimates for PSF images and up to 20% and 2.5 cm(3) for the SFS-RR im

82 s in human cell lines, indicating a role for PSF as a human tumor-suppressor protein.

83 air-entry suction in the pore-solid fractal (PSF) model, which additionally considered the hysteresis

84 ptical-bench-measured point spread function (PSF) and glare sources were compared.

85 A point spread function (PSF) could be derived from topography maps of single pul

86 orrected SPECT versus point-spread function (PSF) model-based and time-of-flight (TOF) PET.

87 struction algorithms, point-spread function (PSF) modeling increases SUVs significantly in tumors but

88 e impact of including point-spread function (PSF) modeling into the process of iterative PET image re

89 ion (OSEM), OSEM with point-spread function (PSF) modeling, and the Q.Clear algorithm (which also inc

90 Gaussian model of the point spread function (PSF) of an ECAT EXACT was developed.

91 that reshapes the 3D point spread function (PSF) of an XYZ image stack into a narrow Gaussian profil

92 that approximates the point spread function (PSF) of the microscope.

93 technology using the point-spread function (PSF) of the scanner in the reconstruction procedure.

94 reconstructed with a point spread function (PSF) or PSF + time-of-flight (TOF) for optimal tumor det

95 scale, and the system point-spread function (PSF) serves as the key for encryption and decryption.

96 hree-dimensional (3D) point spread function (PSF) through additional optics has been demonstrated to

97 and that of the axial point spread function (PSF) was 115 microm.

98 gical tissue, and the point spread function (PSF) was assessed off the reflector.

99 ution to the measured point spread function (PSF), and can retrieve the 3D subpixel position of the f

100 vity of fMRI, unknown point spread function (PSF), and lack of comparison with independent techniques

101 s, of the microscope point spread function (PSF).

102 techniques, including point-spread-function (PSF) engineering(5-9) -namely, encoding the axial (z) po

103 rt failure with preserved systolic function (PSF) is common but not well understood.

104 ilure (HF) with preserved systolic function (PSF).

105 ues with complicated point spread functions (PSF) such as differential interference contrast (DIC) mi

106 with truly invariant point spread functions (PSF), a property critical for accurate deconvolution.

107 Phosphate solubilizing fungi (PSF) have huge potentials in enhancing release of phosph

108 tions (PSFs), the three-dimensional Gaussian PSF conventionally employed in confocal detection and th

109 ts in the fusion of the splicing factor gene PSF located at 1p34 to the TFE3 helix-loop-helix transcr

110 mortality in both systolic function groups (PSF: 4.8%; systolic dysfunction: 8.4%; p < 0.0001), and

111 tation maps, suggesting that the hemodynamic PSF is narrower than intercolumn distances.

112 recognition motif domains in the heteromeric PSF.p54(nrb) complex cooperate to align separate DNA mol

113 similar lesion detectability between (124)I PSF TOF PET/CT and (131)I SPECT/CT for small spheres (</

114 s purified from mouse tissues and identified PSF (polypyrimidine tract-binding protein-associated spl

115 This study is the first to identify PSF as a coactivator of Fox proteins and provides eviden

116 In whole-body PET/MR hybrid imaging, PSF-based PET reconstructions can improve activity recov

117 Thus, the DBD and RBD in PSF are linked by a mechanism of reversible gene regulat

118 TFE3 fusion junction leads to a reduction in PSF-TFE3 and redistribution of endogenous TFE3 and p53 f

119 d the Q.Clear algorithm (which also includes PSF modeling).

120 conserved RVxF PP1-binding motif (including PSF/SFPQ, Tra2-beta1 and SF2/ASF).

121 om was measured, and the impact of including PSF modeling in ordinary Poisson ordered-subset expectat

122 weight sumoylated protein species, including PSF, accumulate in the lymphoblast cells from the patien

123 Indeed, PSF associates specifically with the TNFalpha mRNA in li

124 nd middle primary and secondary fiber layer (PSF).

125 Likewise, PSF-TFE3 and NONO-TFE3 also bind this promoter.

126 on and the square of the Gaussian-Lorentzian PSF for two photon excitation, is explicitly treated.

127 The modified pore-solid fractal (M-PSF) model was tested using 26 soil samples from Yanglin

128 The M-PSF model demonstrated good performance particularly at

129 The derivation results showed that the M-PSF model is user-friendly and flexible for a wide range

130 Furthermore, the M-PSF model, used the fractal dimension of the particle si

131 PSF of any microscope and uses the measured PSF to perform 3D single molecule localization microscop

132 lt, variation in reconstruction methodology (PSF +/- TOFPET1/OSEMPET2 or OSEM PET1/PSF +/- TOFPET2) l

133 algorithm plus point spread function model (PSF), baseline plus TOF, and with both PSF+TOF.

134 ee of four species experienced weak negative PSF whereas, in contrast, all four species experienced s

135 To model the experimental z-scan data, a new PSF model had to be introduced.

136 Lastly, for all 20 patients, when PSF and no-PSF reconstructions were compared, an identical number o

137 For no-PSF no-TOF PET, DEP was 3.6%, 2.1%, 3.5%, 7.8%, 15.1%, a

138 bility for large lesions (>10 mm) and for no-PSF no-TOF PET, since DEPs are greater than 1%.

139 5% for lesion diameters of up to 17 mm on no-PSF no-TOF PET, (124)I activities as high as 170 MBq may

140 tions was rated better when compared with no-PSF data.

141 Our studies point to a novel PSF/Sin3-mediated pathway for nuclear hormone receptors,

142 p54(nrb), PSF, and PSP1 alpha are all expressed in hESCs, but para

143 complexes containing the proteins p54(nrb), PSF, and PSP1 alpha.

144 to RRM2, thereby regulating the activity of PSF toward a broad set of splicing events in T cells.

145 ted phosphorylation increases the binding of PSF to the TNFalpha mRNA in living cells.

146 , regulation, and hemodynamic bioactivity of PSF both in whole retina and in cultured cells derived f

147 Identification of possible causes of PSF abnormalities and solutions to improve microscope pe

148 es not appear to inhibit the dimerization of PSF with other Drosophila Behavior, Human Splicing (DBHS

149 -TFE3 became evident by stable expression of PSF-TFE3 in NIH-3T3 mouse fibroblast cells, which leads

150 In addition, the expression of PSF-TFE3 in normal renal proximal tubular epithelial cel

151 This suggests that the expression of PSF-TFE3 in renal epithelial cells plays an important ro

152 FDG PET/MR) were selected, and the impact of PSF on lesion activity concentration and image noise for

153 d; and for all 20 patients, the influence of PSF modeling was investigated on visual image quality an

154 We show that the inhibition of PSF-TFE3 expression through siRNA or shRNA leads to impa

155 0's PID directly inhibits the interaction of PSF RRMs with RNA, which is mediated through RRM2.

156 However, interaction of PSF with TRAP150 does not appear to inhibit the dimeriza

157 lated by GSK3, thus promoting interaction of PSF with TRAP150, which prevents PSF from binding CD45 p

158 st that the Mnk-catalyzed phosphorylation of PSF may regulate the fate of specific mRNAs by modulatin

159 The oncogenic potential of PSF-TFE3 became evident by stable expression of PSF-TFE3

160 nclusion by Fox-3 depends on the presence of PSF.

161 rolled, in large part, by the recruitment of PSF to the pre-mRNA substrate upon T cell activation; ho

162 In this study, we explored the role of PSF-TFE3 fusion protein in mediating cell transformation

163 present study documents the central role of PSF-TFE3 in oncogenic transformation.

164 passing the RNA recognition motifs (RRMs) of PSF using a previously uncharacterized, 70 residue regio

165 expression by inhibiting the sumoylation of PSF and preventing its sumoylation-dependent recruitment

166 Specifically, the use of PSF is not an issue in routine clinical processes or in

167 The use of PSF reconstruction affected classification of tumor resp

168 They are dependent on PSF/SFPQ, whose phosphorylation is regulated by PyrCer.

169 The combination of optical PSF design and digital postprocessing with photoactivata

170 ely 3 x 10(-3) times the size of the optical PSF.

171 ructed with a point spread function (PSF) or PSF + time-of-flight (TOF) for optimal tumor detection a

172 Unlike wild-type TFE3 or PSF, which are nuclear proteins, PSF-TFE3 is not a nucle

173 Conversely, OSEM PSF was ranked second highest for lesion detectability i

174 Poor lesion detectability on OSEM PSF was seen in cases of mildly (18)F-FDG-avid mediastin

175 CT scans were reconstructed using OSEM, OSEM PSF, and Q.Clear using B values of 200, 300, 400, and 50

176 The least preferred reconstruction was OSEM PSF in all cases.

177 9 of 15 (67%) and 10 of 15 (73%), with OSEM PSF ranked lowest.

178 laudin-5, and barrier induction, and the p54/PSF heterodimer may contribute to normal blood-retinal b

179 with paraspeckle proteins, including P54nrb, PSF, PSPC1 and hnRNPK.

180 gag mRNA is a high-affinity ligand of p54nrb/PSF, a heterodimeric transcription/splicing factor.

181 Together, our data indicate that p54nrb/PSF functions in recruitment of XRN2 to facilitate pre-m

182 l image data of the microspheres and perform PSF measurements.

183 ology (PSF +/- TOFPET1/OSEMPET2 or OSEM PET1/PSF +/- TOFPET2) led to 13 of 86 (15%) and 17 of 86 (20%

184 3 (hTIM3) and its ligand phosphatidylserine (PSF).

185 Mnks phosphorylate PSF at two sites in vitro, and our data show that PSF is

186 as identified a complex of two polypeptides, PSF and p54(nrb), as a stimulatory factor in a reconstit

187 biofilm-forming bacterium, and polysulfone (PSF) ultrafiltration (UF) membranes to unravel the mecha

188 were made from proximal stop flow pressure (PSF) during orthograde loop perfusion from the proximal

189 eraction of PSF with TRAP150, which prevents PSF from binding CD45 pre-mRNA.

190 The mammalian protein PSF contains a DNA-binding domain (DBD) that coordinatel

191 achinery through the multifunctional protein PSF.

192 ype TFE3 or PSF, which are nuclear proteins, PSF-TFE3 is not a nuclear protein and is targeted to the

193 tion, reduced GSK3 activity leads to reduced PSF phosphorylation, releasing PSF from TRAP150 and allo

194 The complex with mVL30 RNA releases PSF, allowing transcription to proceed.

195 ds to reduced PSF phosphorylation, releasing PSF from TRAP150 and allowing it to bind CD45 splicing r

196 a noncoding VL30 retroelement RNA, releasing PSF from a gene and reversing repression.

197 ation with co-activator p54nrb and repressor PSF.

198 We examined hemodynamic response PSF by comparing these CBV-based signals with oxygen met

199 blood flow, and that alterations in retinal PSF expression may explain the biphasic changes in RBF o

200 RBF, both correlated with levels of retinal PSF.

201 o, but immunohistochemical analysis revealed PSF mainly associated with retinal vessels.

202 images were compared with the manufacturer's PSF-based reconstruction using the standardized uptake v

203 We designed a side-lobe-free SB-PSF and implemented a two-channel detection scheme to en

204 uce a self-bending point spread function (SB-PSF) based on Airy beams for three-dimensional (3D) supe

205 gation-dependent lateral bending make the SB-PSF well suited for precise 3D localization of molecules

206 licing (DBHS) family include mammalian SFPQ (PSF), NONO (p54nrb), PSPC1, and invertebrate NONA and Hr

207 proteins such as FUS/TLS (FUS) and PSF/SFPQ (PSF).

208 oteomics screen, we recently identified SFPQ/PSF as an interacting partner with the RAD51 paralogs, R

209 In addition, the transcriptional silencer PSF induces neuronal apoptosis, which can be reversed by

210 In the phantom study, PSF modeling significantly improved activity recovery an

211 and resulting TFE3 gene fusions (PRCC-TFE3, PSF-TFE3, NONO-TFE3, ASPL-TFE3), encoding related aberra

212 ally associated with p54nrb in vivo and that PSF inhibited its expression, acting via INS.

213 We conclude that PSF expressed by ocular cells can induce PGI2, retinal v

214 We also demonstrate that PSF, together with its partner, p54(nrb), binds RNAs tha

215 We find that PSF fundamentally alters the electrostatic environment w

216 an infectious molecular clone, we found that PSF affected specifically the INS-containing, Rev-depend

217 Our studies indicate that PSF is a novel repressor which interacts with Sin3A and

218 Our results indicate that PSF-TFE3 acts through a novel mechanism, and exports TFE

219 Our analysis indicates that PSF within the PER complex recruits SIN3A, a scaffold fo

220 t two sites in vitro, and our data show that PSF is an Mnk substrate in vivo.

221 The PSF geometry is used as an indicator to identify problem

222 The PSF was determined in the presence of no ultrasound, pul

223 The PSF-NonO complex is involved in the regulation of many c

224 The PSF.p54(nrb) complex cooperates with Ku protein to form

225 rm up), whereas collecting and analyzing the PSF images require an additional 2-3 h.

226 ordance (Cohen unweighted kappa) between the PSF and the PSFEARL DS was 0.82 (95% confidence interval

227 inexpensive, may not accurately capture the PSF shape leading to reduced fitting accuracy.

228 al functions that can accurately capture the PSF shape, such as those based on pupil functions, can b

229 cy and that they can be used for fitting the PSF with only a 2-3x increase in computation time as com

230 understand the function of hysteresis in the PSF theory, the role of allowable and accessible pores m

231 eak/background activity were included in the PSF using three adjusting factors.

232 en-source software package that measures the PSF of any microscope and uses the measured PSF to perfo

233 simulations showed reduced broadening of the PSF due to collimator penetration for the PC collimator

234 Extension of the PSF framework to the phyllosphere is needed to more full

235 The analysis of the PSF is used to determine the resolution of the microscop

236 The observed dependence of the PSF on random coincidences and measured-peak/background

237 The overall image quality of the PSF reconstructions was rated better when compared with

238 emaining greater than 5-10% (5-10 nm) of the PSF size.

239 he transcriptional silencing activity of the PSF.

240 on with a Taylor series approximation of the PSF.

241 onsidered the hysteresis effect based on the PSF theory.

242 For example, taking the PSF +/- TOFPET1/OSEMPET2 scenario increased the apparent

243 erized, 70 residue region we have termed the PSF-interacting domain (PID).

244 human blastocyst cells, indicating that the PSF-VL30 RNA regulatory mechanism also could function in

245 of DSBs in vivo in human cells and that the PSF.p54(nrb) complex may thus be a potential target for

246 rietary software solution was applied to the PSF +/- TOF data (PSF +/- TOF.EQ) to harmonize SUVs with

247 E3 transcription factor becomes fused to the PSF and NonO pre-mRNA splicing factors and most commonly

248 express PSF-TFE3, siRNA complementary to the PSF-TFE3 fusion junction leads to a reduction in PSF-TFE

249 e use the intensity z scan together with the PSF model to determine the geometry of the sample and th

250 mprovement similar to that obtained with the PSF model.

251 rate that the interaction of N-WASP with the PSF-NonO complex can couple N-WASP with RNA polymerase I

252 wn, and show that for the majority of these, PSF's effect is antagonized by TRAP150.

253 Thus, PSF-TFE3 is a promising target for the treatment for a s

254 Additionally, a 6-mm filter was applied to PSF images to meet the requirements of the EANM Research

255 pecific mRNAs by modulating their binding to PSF.p54(nrb).

256 ic small interfering RNA sensitizes cells to PSF-induced apoptosis.

257 lose sequence relatedness of this protein to PSF, which is required for pre-mRNA splicing in vitro, w

258 e male courtship song, is closely related to PSF and also believed to be involved in RNA splicing.

259 ately 40 T cell splicing events sensitive to PSF knockdown, and show that for the majority of these,

260 Two PSF (NJDL-03 and NJDL-12) were isolated and identified a

261 ect on the nuclear localization of wild-type PSF, it sequesters wild-type TFE3 as well as p53 in the

262 data were reconstructed with the unfiltered PSF method.

263 For Eot-PET, patients were classified using PSF and PSFEARL as responders and nonresponders in 69 an

264 For i-PET, using PSF and PSFEARL, we classified patients as responders an

265 Lastly, for all 20 patients, when PSF and no-PSF reconstructions were compared, an identic

266 his work also highlights strategies by which PSF-mediated conformational change could be controlled,

267 atient scans reconstructed with PSF and with PSF+TOF.

268 er mVL30 RNA tracts that form a complex with PSF or a small interfering RNA (siRNA) that degrades PSF

269 Heart failure with PSF is common and is characterized by a unique patient p

270 Heart failure with PSF was present in 50.4% of patients with in-hospital as

271 processes of mice, by complex formation with PSF.

272 registry reveal a high prevalence of HF with PSF, and these patients have a similar post-discharge mo

273 The SUVs of the detected lesions with PSF were substantially increased in the range of 6%-75%,

274 ospital mortality was lower in patients with PSF (EF > or =40%) (2.9% vs. 3.9%; p < 0.0001).

275 -day post-discharge follow-up, patients with PSF (EF > or =40%) had a similar mortality risk (9.5% vs

276 Patients with PSF (EF > or =40%) were more likely to be older, female,

277 dysfunction (LVSD) and 21,149 patients with PSF (left ventricular ejection fraction [EF] > or =40%).

278 ospital mortality was lower in patients with PSF compared with patients with systolic dysfunction (2.

279 Analyses of patients with PSF defined as EF >50% were also performed for compariso

280 nts with systolic dysfunction, patients with PSF were more likely to be older, women, and hypertensiv

281 and rehospitalization rates in patients with PSF.

282 llustrative patient scans reconstructed with PSF and with PSF+TOF.

283 Findings were comparable with those with PSF defined as EF >50%.