ライフサイエンスコーパス: PTHrP receptor

1 d-molecular region that does not use the PTH/PTHrP receptor.

2 e two genes share a common receptor, the PTH/PTHrP receptor.

3 H-2 receptor, but a full agonist for the PTH/PTHrP receptor.

4 PTHrP) are thought to be mediated by the PTH/PTHrP receptor.

5 tes in the growth plate that express the PTH/PTHrP receptor.

6 ent and they require the presence of the PTH/PTHrP receptor.

7 ptide (PTHrP), act on cells via a common PTH/PTHrP receptor.

8 f hPTH-(1-34) and hPTHrP-(1-34) with the PTH/PTHrP receptor.

9 onditioned medium and express the type I PTH/PTHrP receptor.

10 de (PTHrP) bind to and activate the same PTH/PTHrP receptor.

11 vasion by a mechanism independent of the PTH/PTHrP receptor.

12 xpress abundant transfected human or rat PTH/PTHrP receptors.

13 disorder caused by constitutively active PTH/PTHrP receptors.

14 of the parathyroid hormone-related peptide (PTHrP) receptor.

15 e parathyroid hormone (PTH)-related peptide (PTHrP) receptor, a signaling molecule that also regulate

16 calcium was significantly reduced in HOM PTH/PTHrP receptor-ablated fetuses.

17 to investigate how constitutively active PTH/PTHrP receptors affect the program of chondrocyte matura

18 Analogs I and III are the first cyclic PTH/PTHrP receptor agonists and amongst the most potent PTHr

19 of differentiation is dependent upon the PTH/PTHrP receptor and that the regulation of proliferation

20 ions that oppose the dominant effects of PTH/PTHrP receptors and that involve cAMP-dependent signalin

21 sion of parathyroid hormone-related peptide (PTHrP) receptor and Indian Hedgehog (IHH:), suggesting a

22 lated peptide (PTHrP), its receptor, the PTH/PTHrP receptor, and Indian hedgehog are implicated in th

23 n ROS 17/2.8 cells, which express native PTH/PTHrP receptors, and in LLCPK-1 cells stably transfected

24 e, a PTHrP analog PTH (7-34), which is a PTH/PTHrP receptor antagonist, was given intraperitoneally t

25 ycin yielded completely nonglycosylated hPTH/PTHrP receptor (approximately 60 kDa).

26 hormone-related protein (PTHrP) and the PTH/PTHrP receptor are expressed in most normal tissues, inc

27 r potential N-glycosylation sites in the PTH/PTHrP receptor are glycosylated.

28 e-related protein (PTHrP) and the type I PTH/PTHrP receptor are necessary for the proper development

29 Here we show that PTHrP and the PTH/PTHrP receptor are products of cerebellar granule cells

30 PTHrP and the PTH/PTHrP receptor are widely expressed in both adult and fe

31 e PTHrP1-173 and PTHrP33-173 lacking the PTH/PTHrP receptor-binding domain induced a 3-fold stimulati

32 The PTH/PTHrP receptor binds to two ligands with distinct functi

33 iferating cell nuclear antigen staining, PTH/PTHrP receptor, bone morphogenetic protein-7, and fibrob

34 unctional relationships of PTHrP and the PTH/PTHrP receptor, bones of knockout mice were analyzed ear

35 HrP(1-34) and PTHrP(1-141), acting via a PTH/PTHrP receptor cAMP signaling pathway.

36 Thus, generation of IPs by the activated PTH/PTHrP receptor can be selectively abolished without affe

37 rast, signaling by constitutively active PTH/PTHrP receptor (caPPR), whose expression was regulated b

38 Site-directed mutagenesis of the rat PTH/PTHrP receptor cDNA was performed at single or combinati

39 LCPK-1 cells stably transfected with the PTH/PTHrP receptor cDNA.

40 meric mice containing both wild-type and PTH/PTHrP receptor (-/-) cells, and analyzed cell-cell inter

41 sequence are essential for generating a PTH/PTHrP receptor-compatible bioactive conformation.

42 The PTH/PTHrP receptor-deficient (PTH/PTHrP-R(-/-)) mice exhibit

43 Thus, the PTH/PTHrP receptor directly controls the pace and synchrony

44 ressing exclusively a mutant form of the PTH/PTHrP receptor (DSEL) that activates adenylyl cyclase no

45 rmore, we demonstrate that activation of PTH/PTHrP receptors, either by stimulation with PTH or throu

46 phosphorylation sites using recombinant PTH/PTHrP receptors expressed in LLCPK-1 and COS-7 cells.

47 1/2 mesenchymal cells transfected with a PTH/PTHrP receptor expressing plasmid.

48 S7 cells transfected with both SOX9- and PTH/PTHrP receptor-expressing vectors.

49 e embryonic mammary epithelial cells and PTH/PTHrP receptor expression to the mammary mesenchyme usin

50 Both demonstrated PTH/PTHrP receptor expression.

51 the pannus expressed both PTHrP and the PTH/PTHrP receptor, findings that were confirmed by in vitro

52 of amino-terminal PTHrP, acting via the PTH/PTHrP receptor, for ablation of the PTH/PTHrP receptor g

53 tant roles for N-linked glycosylation in PTH/PTHrP receptor functions.

54 ulture and induced downregulation of IHH and PTHrP receptor gene expression.

55 Deletion of either the PTHrP gene or the PTH/PTHrP receptor gene leads to acceleration of differentia

56 PTH/PTHrP receptor, for ablation of the PTH/PTHrP receptor gene recapitulates the phenotype of PTHrP

57 performed on fetal mice that lacked the PTH/PTHrP receptor gene.

58 ompletely reversed by disruption of the PTH/ PTHrP receptor gene.

59 HH) and parathyroid hormone-related protein (PTHrP) receptor genes, both of which are important for b

60 A constitutively active mutant PTH/PTHrP receptor has been found in Jansen-type human metap

61 one (PTH)-related peptide (PTHrP) or the PTH/PTHrP receptor have been ablated by homologous recombina

62 embryonic kidney cells transfected with hPTH/PTHrP receptor (HEK-293/C-21).

63 third intracellular loop of the opossum PTH/PTHrP receptor in coupling to two signal transduction pa

64 the mammary mesenchyme must express the PTH/PTHrP receptor in order to support mammary epithelial ce

65 tions that are known to downregulate the PTH/PTHrP receptor in ROS 17/2.8 cells.

66 Mosaic ablation of the PTH/PTHrP receptor in the growth plate caused upregulation o

67 To further explore the role of the PTH/PTHrP receptor in this process, we generated transgenic

68 The expression of constitutively active PTH-PTHrp receptors in kidney, bone, and growth-plate chondr

69 Native PTH/PTHrP receptors in ROS 17/2.8 cells are downregulated af

70 peptide (PTHrP) and the parathyroid hormone-PTHrP receptor increase chondrocyte proliferation and de

71 dentify the "contact domain" within the hPTH/PTHrP receptor involved in binding of (125)I-all-R-K13,

72 The human (h) PTH/PTHrP receptor is a membrane glycoprotein with an appare

73 The type I PTH/PTHrP receptor is expressed in both the adjacent dental

74 roduced by epithelial cells, whereas the PTH/PTHrP receptor is expressed on stromal cells.

75 ings indicate that glycosylation of the hPTH/PTHrP receptor is not essential for its effective expres

76 These data indicate that the PTH/PTHrP receptor is phosphorylated after PTH stimulation o

77 The data show that the PTH/PTHrP receptor is rapidly phosphorylated in ROS 17/2.8 c

78 eted expression of constitutively active PTH/PTHrP receptors led to delayed mineralization, decelerat

79 rresponds to amino acids 173-189 of the hPTH/PTHrP receptor, located at the C-terminal region of the

80 that the phosphorylated residues of the PTH/PTHrP receptor map to two regions of the carboxyl-termin

81 ines did not demonstrate parathyroid hormone/PTHrP receptor-mediated binding of iodinated PTHrP or st

82 Interactions between FGFR3- and PTHrP-receptor-mediated signals during endochondral ossi

83 These results suggest that the PTH/PTHrP receptor mediates the effects of Indian Hedgehog a

84 Most PTH/PTHrP receptor (-/-) mutant mice died in mid-gestation,

85 rathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor necessary for activation of phospholipas

86 Thus, PLC signaling via the PTH/PTHrP receptor normally slows the proliferation and hast

87 the growth plate or any chondrocytes of PTH/PTHrP receptor null mutants.

88 shows that PTHrP directly signals to the PTH/PTHrP receptor on proliferating chondrocytes to slow the

89 ve receptor phosphorylation, we examined PTH/PTHrP receptor phosphorylation in ROS 17/2.8 cells and w

90 PTH/PTHrP receptor phosphorylation in ROS 17/2.8, COS-7, and

91 ich express native clacitonin receptors, PTH/PTHrP receptor phosphorylation was stimulated by calcito

92 f second messenger-stimulated kinases in PTH/PTHrP receptor phosphorylation.

93 vement of other kinase(s) in PTH-induced PTH/PTHrP receptor phosphorylation.

94 artially decreased the effects of PTH on PTH/PTHrP receptor phosphorylation.

95 previous evidence of PTHrP expression by PTH/PTHrP receptor-positive neurons, our demonstration of re

96 ficant decreases in the tissue influx of PTH/PTHrP receptor-positive neutrophils and in SCW-induced n

97 Gnas(E2-/E2-) chondrocytes phenocopied PTH/PTHrP receptor (PPR)(-/-) cells by prematurely undergoin

98 y Indian hedgehog and acting through the PTH/PTHrP receptor (PPR), is crucial for normal cartilage de

99 chondrocyte differentiation through the PTH/PTHrP receptor (PPR).

100 or signaling at the PTH/PTH-related protein (PTHrP) receptor (PPR) in intramembranous bone formation

101 e (PTH)/parathyroid hormone-related protein (PTHrP) receptor (PPR) signaling inhibits proliferation a

102 ted protein (PTHrP) or its receptor, the PTH/PTHrP receptor (PPR1), it fails due to a lack of mesench

103 o produce osteoblast-specific, activated PTH/PTHrP receptors (PPRs).

104 ed peptide (PTHrP) bind and activate the PTH/PTHrP receptor (PTH-1R).

105 ne (PTH) related peptide (PTHrP) and the PTH/PTHrP receptor (PTH/PTHrP-R) show prominent cutaneous ex

106 enes, such as type II collagen (Col2a1), PTH/PTHrP receptor (Pth1r) and type X collagen (Col10a1), is

107 ulated through the parathyroid hormone (PTH)/PTHrP receptor (PTH1R) signaling pathway.

108 respectively, through activation of the PTH/PTHrP receptor (PTH1R), a class B G protein-coupled rece

109 essed type I and XII collagen and type I PTH/PTHrP receptor (PTH1R).

110 arched for zebrafish (z) homologs of the PTH/PTHrP receptor (PTH1R).

111 47-52% identity with mammalian and frog PTH/PTHrP receptors (PTH1R), and less than 37% with other me

112 via the type I PTH/PTH-related peptide (PTH/PTHrP) receptor (PTH1R).

113 dicular skeleton, post-natal deficits in Pth/Pthrp receptor (Pthr) signalling and in expression of ma

114 rathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor (PTHR) are N-terminally truncated or N-t

115 rathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor (PTHR1) and is characterized by widening

116 rathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor (PTHR1) in cells of the renal proximal t

117 wn-regulates the expression of CSF-1 and the PTHrP receptor (PTHrP-R).

118 can be mediated by the G-protein-coupled PTH/PTHrP receptor, PTHrP also has intracrine actions mediat

119 The nonglycosylated hPTH/PTHrP receptor remains fully functional with regard to b

120 e results demonstrate that PTHrP and the PTH/PTHrP receptor represent an epithelial/mesenchymal signa

121 In contrast, the PTH-1 receptor (PTH/PTHrP receptor) responds fully to both ligands.

122 rathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor (rP1R) interacts with the carboxyl-termi

123 A mutant in which the wild type (WT) rat PTH/PTHrP receptor sequence EKKY (amino acids 317-320) was r

124 ndicated that constitutive activation of PTH/PTHrP receptor signaling in osteoblastic cells suppresse

125 d roles of parathyroid hormone receptor (PTH/PTHrP receptor) signaling in osteoblasts in unloading-in

126 sslinks specifically to the recombinant hPTH/PTHrP receptor stably transfected into human embryonic k

127 ostate cancer cells, the parathyroid hormone/PTHrP receptor status of the cells was determined.

128 rathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor-stimulated cAMP generation and inhibited

129 rathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor that mediate G-protein activation of ade

130 PTH-related peptide (PTHrP) activate the PTH/PTHrP receptor to trigger parallel increases in adenylyl

131 Exons encoding the PTH-PTHrP receptor were amplified by the polymerase chain re

132 oid hormone-related peptide (Pthrp), and Pth/Pthrp receptor were expressed, their expression was down

133 The functions of the PTH/PTHrP receptor were investigated by deletion of the muri

134 By comparing PTH/PTHrP receptor(-/-)/wild-type (PPR(-/-)/wild-type) chime

135 In COS-7 cels expressing PTH-PTHrP receptors with the T410P or H223R mutation, basal