ライフサイエンスコーパス: PTPN1

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1 PTPN1 is located in 20q13, a genomic region linked to ty

2 ein tyrosine phosphatase nonreceptor type 1 (PTPN1) and PTPN2, whose expression is significantly high

3 Dephosphorylation of the substrate by PTPN1 and PTPN2 obeyed Michaelis-Menten kinetics, with K

4 We replicated the ADO-EGR2, IRF8, and CEBPB-PTPN1 loci by genotyping 969 Iranian cases and 826 contr

5 ee new risk loci, IL1A-IL1B, IRF8, and CEBPB-PTPN1, with genome-wide significance (P < 5 x 10(-8)) by

6 Our data establish PTPN1 mutations as new drivers in lymphomagenesis.

7 the first intron of the PTP1B encoding gene PTPN1, correlating with an AR-mediated increase in RNA p

8 erase reporter assay revealed that the genes PTPN1, HOXA1, and TP53I11 were miR-210 target genes regu

9 ee single nucleotide polymorphisms (SNPs) in PTPN1 were genotyped and assessed for association with I

10 Genetic variation in PTPN1, a diabetes susceptibility gene, was investigated

11 This led to increased PTPN1 (PTP1b)-mediated dephosphorylation of VEGFR2 at Y(

12 with SNPs spanning the 3' end of intron 1 of PTPN1 through intron 8 (P values ranging from 0.043 to 0

13 This comprehensive genetic analysis of PTPN1 reveals significant association with metabolic tra

14 ast, there is no evidence for association of PTPN1 polymorphisms with acute insulin response (a measu

15 The genetic contribution of PTPN1 to measures of glucose homeostasis has been assess

16 hed the AR as a transcriptional regulator of PTPN1 transcription and implicated PTP1B in a tumor-prom

17 ilibrium encompassing the coding sequence of PTPN1 were significantly associated with CorCP (P values

18 Moreover, silencing of PTPN1 by RNA interference in Hodgkin lymphoma cell line

19 effects of miR-210, coordinate silencing of PTPN1, HOXA1, and TP53I11 dramatically decreased tumor c

20 phosphatases, five of which - DUSP6, PPTC7, PTPN1, PTPN13 and PPP3CA - promote differentiation by ne

21 ylated SRC and its regulators CSK and PTP1B (PTPN1) was conducted in 30 synovial sarcomas.

22 The protein-tyrosine phosphatase 1B (PTP1B; PTPN1) is an important regulator of mammalian metabolism

23 S1, CD44, GET4, IL4R, KIAA0226L, MID1, RCC1, PTPN1 and segments of the immunoglobulin loci.

24 re coamplified in metastatic tumors and that PTPN1 amplification was associated with a subset of high

25 We demonstrate that PTPN1 mutations lead to reduced phosphatase activity and

26 We found that PTPN1 and AR genes were coamplified in metastatic tumors

27 These results suggest that PTPN1 is a significant contributor to type 2 diabetes su

28 The PTPN1 gene codes for protein tyrosine phosphatase 1B (PT

29 The PTPN1 gene encodes protein tyrosine phosphatase-1B, whic

30 yrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, catalyzes the dephosphorylation of proteins

31 ms (SNPs) spanning 161 kb and containing the PTPN1 gene were genotyped and tested for association.

32 0.1 in a single haplotype block covering the PTPN1 genomic sequence show significant association with

33 100-kb haplotype block that encompasses the PTPN1 gene.

34 DNA arrays to genotype 6 SNP markers in the PTPN1 gene and 10 mutations in the cystic fibrosis trans

35 ent somatic coding-sequence mutations in the PTPN1 gene.

36 he 161-kb genomic region, which includes the PTPN1 gene.

37 We demonstrated that the PTPN1 gene, which encodes PTP1B, was a target of MECP2 a

38 ease in RNA polymerase II recruitment to the PTPN1 transcriptional start site.

39 response of CML cells to imatinib treatment: PTPN1, NF1, SMARCB1, and SMARCE1, and 5 regulators of th

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