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1 PZ accelerates the inhibition reaction approximately 200
2 PZ ADCs show significant interpatient variation, which h
3 PZ cells from GFP+ donor mouse embryos were transplanted
4 PZ is administered prophylactically for respiratory sync
5 PZ is given as prophylaxis against infection with respir
6 PZ mice developed the highest concentrations of interleu
7 PZ neurons monosynaptically innervated and released syna
8 PZ pipsqueak mutants produce a putative fusion protein c
9 PZ production is regulated in part by the PhzR/PhzI quor
10 PZ-128 is a cell-penetrating pepducin inhibitor of PAR1
11 PZ-235 significantly suppressed liver fibrosis, collagen
12 PZ-235 was distributed to liver and other mouse tissues
14 ion for a system operated with a 25% AMP/15% PZ solvent, but only 0.73 muM for a 35% MEA solvent.
15 e-promoting medial parabrachial nucleus; (2) PZ neurons express c-Fos after sleep but not after wakef
16 te with PZ was studied in 0.1 to 5 mol/dm(3) PZ with 0.001 to 0.8 mol CO2/mol PZ at 50 to 135 degrees
17 ecular basis for mechanism of action; and 4) PZ(Vgat) neurons represent a key cell population for SWS
19 mal ridge; ZPA, zone of polarizing activity; PZ, progress zone; SHH, sonic hedgehog; OSX, osterix tra
20 ial of RSV to resist prophylaxis, additional PZ-resistant viruses were selected in cell culture and w
28 uman prostate epithelial cell lines EP12 and PZ-HPV-7, respectively, and in human prostatic epitheliu
29 22Rnu1 than in human prostate epithelial and PZ-HPV-7 (virally transformed cells derived from normal
30 xpression of S100A2 was observed in NHPE and PZ-HPV-7 cells, whereas its complete absence was observe
32 tor Xa in a calcium ion-, phospholipid-, and PZ-dependent fashion, but also directly inhibits coagula
33 flow cell analyses demonstrated that QS and PZs are involved in biofilm formation in P. chlororaphis
35 he initial assembly of a membrane-associated PZ-ZPI-FXa Michaelis complex (K(M) 53+/-5 nM) followed b
36 spinocerebellar mossy fibers in the mouse AZ/PZ, whereas in rat CART immunoreactive mossy fibers term
38 ntrast between cancerous sextants and benign PZ was significantly greater for D or K than ADC (0.25+/
39 ficantly different (P < .001) between benign PZ (23.7 and 7.7, 8.83, and 1.58 x 10(-3) mm(2)/sec, res
40 fferentiating cancerous sextants from benign PZ than ADC or D (93.3% vs 78.5% and 83.5%, respectively
41 greater in cancerous sextants than in benign PZ (0.96+/-0.24 vs 0.57+/-0.07, P<.001), as well as in c
42 n-related factors VII, IX, and X and PC, but PZ differs from these other proteins in that it is not t
43 omote the inactivation of factor Xa (fXa) by PZ-dependent protease inhibitor (ZPI) by three orders of
44 terminants of catalytic activation of ZPI by PZ and suggest novel strategies for ameliorating hemophi
46 te tissues including peripheral zone cancer (PZ-C); peripheral zone noncancer; and benign tissue from
47 rally transformed prostate epithelial cells (PZ-HPV-7); several human prostate carcinoma cells (22Rv1
48 ng differentiation of peripheral zone cells (PZ), which surround the CZ, into CZ cells and restricts
49 glutamic acid domain (GD-PZ), and a chimeric PZ mutant in which both Gla and EGF-like domains of the
50 However, the apparent K(D) for the chimeric PZ-mediated ZPI inhibition of fXa was elevated 6-fold on
51 esponse in human plasma and that concomitant PZ deficiency dramatically increases the severity of the
52 tor deficient (ZPI) and protein Z deficient (PZ) mice, as well as their wild-type littermates (ZPI, P
54 rmined the x-ray structure of Gla-domainless PZ (PZ(DeltaGD)) complexed with protein Z-dependent prot
55 tion of four ZPI contact residues eliminated PZ binding and membrane-dependent PZ acceleration of fXa
59 significantly with tumor-muscle SI ratio for PZ tumors on corrected and uncorrected images (P = .006
62 d conformational change in ZPI resulted from PZ binding, which contributed only approximately 2-fold
63 a circuit substrate through which GABAergic PZ neurons can potently trigger SWS and modulate the cor
64 ng the gamma-carboxyglutamic acid domain (GD-PZ), and a chimeric PZ mutant in which both Gla and EGF-
74 pectroscopic imaging had similar accuracy in PZ cancer localization (AUC, 0.60 vs 0.58, respectively;
76 re many more ribbons and afferent boutons in PZ than in CZ, whereas efferent innervation is relativel
83 (3 + 3) vs. GS >/=7 for cancers occurring in PZ and TZ and 63% for cancers occurring in PZ alone.
84 e of 4 or modified DCE score of positive; in PZ or TZ, upgrading category 4 to 5 based on size of 10-
99 cancer cell line DU-145 (but not for normal PZ-HPV-7 prostate cells) and for the pancreatic cancer c
101 used to assess whether incorporating normal PZ ADCs improves the prediction of cancer aggressiveness
102 orter (Vgat)-GFP], we then show that >50% of PZ sleep-active neurons are inhibitory (GABAergic/glycin
104 studies in both the presence and absence of PZ revealed that Arg-143, Lys-147, and Arg-154 of the au
109 nowledge gap, we asked whether activation of PZ(Vgat) neurons could attenuate or block the wake-promo
111 her with native PAGE and kinetic analyses of PZ binding to ZPI, that Tyr240 and Asp293 of ZPI are cru
116 cific interaction between the Gla domains of PZ and fXa contributes approximately 6-fold to the accel
121 determined that an uncharacterized family of PZ genes encoding orthologs of eukaryotic and prokaryoti
123 roscopic imaging for sextant localization of PZ prostate cancer is equal to that of MR imaging alone.
125 ntly rated the likelihood of the presence of PZ cancer in each sextant by using a five-point scale-fi
127 n cell culture for growth in the presence of PZ develops F gene mutations and can be resistant to PZ
128 monary replication of RSV in the presence of PZ was followed by the appearance of viruses resistant t
131 elet inhibition and reversible properties of PZ-128 are well suited to the acute interventional setti
134 uggest that: (i) the ZPI interactive site of PZ is located within the C-terminal domain of the cofact
138 examined the effect of altering the ratio of PZs produced by P. chlororaphis on biofilm formation and
139 onal or radiation treatment and at least one PZ lesion (volume, >0.1 cm(3)) at whole-mount pathologic
140 omy for prostate cancer and had at least one PZ tumor larger than 0.1 cm(3) at surgical pathologic ex
145 cy for cancers occurring in both peripheral (PZ) and transition (TZ) zones and 92% for cancers occurr
148 The biosensor comprises a piezoimmunosensor (PZ) displaying a specially constructed recombinant antib
150 e higher for the secondary amine piperazine (PZ) than for the primary amines 2-amino-2-methyl-1-propa
151 Blends of tertiary amines with piperazine (PZ) showed n-nitrosopiperazine (MNPZ) yields close to un
153 ownstream circuitry engaged by SWS-promoting PZ neurons, and we found that this circuit uniquely and
155 ed the x-ray structure of Gla-domainless PZ (PZ(DeltaGD)) complexed with protein Z-dependent proteina
156 of fXa with ZPI, we expressed wild-type PZ, PZ lacking the gamma-carboxyglutamic acid domain (GD-PZ)
159 Both in vitro and in vivo, individual RSV PZ escape mutants varied in their susceptibility to PZ.
160 Experimental data show that the scFv SAM PZ is superior to Fab fragment, Fab fragment containing
163 s a significantly more severe phenotype than PZ deficiency, implying that factor XIa inhibition by ZP
164 ith FXa, and kinetic analyses confirmed that PZ acted catalytically to accelerate the membrane-depend
168 Native PAGE and immunoblotting showed that PZ dissociated from ZPI once ZPI forms a stable complex
169 ructure of the ZPI-PZ complex has shown that PZ binds to a unique site on ZPI centered on helix G.
172 e relative ratios of cells in the CZ and the PZ are maintained, despite a constant displacement of ce
175 % accuracy for cancers occurring in both the PZ and TZ and with 93% for cancers occurring in the PZ a
182 S 7(3 + 4) from GS 7(4 + 3) occurring in the PZ and TZ and 60% for cancers occurring in PZ alone.
184 maging and as positive at DCE imaging in the PZ showed a higher probability of cancer detection than
186 addition of DCE imaging to DW imaging in the PZ was beneficial (OR, 2.0; P = .027), with an increase
187 n of DCE imaging to DW imaging scores in the PZ yields meaningful improvements in probability of canc
191 1 domain may not play a dominant role in the PZ-dependent recognition of fXa by the serpin on phospho
195 aging outperforms T2-weighted imaging in the PZ; T2-weighted imaging did not show a significant diffe
196 t displacement of cells from the CZ into the PZ, and subsequent allocation of cells within the PZ to
197 sting membrane potential within and near the PZ and action potential duration shortening throughout t
199 ZPI binding and the cofactor function of the PZ derivatives were characterized in both binding and ki
201 e; and (3) cell-body-specific lesions of the PZ result in large and sustained increases (50%) in dail
203 e revealed changes in helices A and G of the PZ-binding site relative to native ZPI that rationalized
205 ncreased cell division rates in cells of the PZ; conversely, decreases in WUS level lead to a smaller
208 and PNF act to restrict organogenesis to the PZ by maintaining a boundary between the CZ and PZ.
210 Using flow cell assays, we found that these PZ-altered derivatives of strain 30-84 differed from the
219 orced expression of SIRT1 in non-transformed PZ-HPV-7 prostate epithelial cells disrupts the epitheli
220 x 10(-3) mm(2)/sec, respectively) and tumor PZ tissue (11.4 and 12.5, 5.13, and 1.20 x 10(-3) mm(2)/
222 vity of fXa with ZPI, we expressed wild-type PZ, PZ lacking the gamma-carboxyglutamic acid domain (GD
223 specific proteinases is insignificant unless PZ binds and localizes ZPI and fXa on the membrane, wher
225 expressed in mammalian cell lines, both Na(V)PZ and Na(V)SP were Na(+)-selective and voltage-dependen
226 ed as voltage-dependent Na(+) channels (Na(V)PZ from Paracoccus zeaxanthinifaciens and Na(V)SP from S
229 chronizing, but not behavioral, effects when PZ(Vgat) neurons are activated, inferring a shared and d
230 cannot exert its wake-promoting effects when PZ(Vgat) neurons are activated, intimating a possible sh
239 iffusion-limited rate with fXa, even without PZ, and predominantly as substrate, reflecting both rapi
241 ent kinetic analyses of ZPI-PZ and factor Xa-PZ-membrane complex formation suggested that assembly of
247 olipid vesicles and calcium ions, protein Z (PZ) serves as a cofactor for the inhibition of coagulati
248 e show that ZPI and its cofactor, protein Z (PZ), inhibit procoagulant membrane-bound factor Xa by th
249 chimera by ZPI in the presence of protein Z (PZ), negatively charged membrane vesicles, and calcium i
251 n of factor Xa in the presence of protein Z (PZ), procoagulant phospholipids, and Ca(++) (t(1/2) less
252 ically activated by its cofactor, protein Z (PZ), to regulate the function of blood coagulation facto
255 ctivation of GABA-releasing parafacial zone (PZ(Vgat)) neurons in behaving mice produces slow-wave-sl
256 ic neurons in the medullary parafacial zone (PZ) are needed for normal SWS, it remains unclear whethe
257 erve-a region we termed the parafacial zone (PZ)-project to the wake-promoting medial parabrachial nu
258 both infarct regions, the periinfarct zone (PZ) and the scar; six scenarios were modeled: 0%, 10%, a
260 nd 64 benign regions in the peripheral zone (PZ) and 19 malignant and 56 benign regions in the transi
261 cores was calculated in the peripheral zone (PZ) and transition zone (TZ) by using generalized estima
263 ced towards the surrounding peripheral zone (PZ) divide at a faster rate and enter into differentiati
265 are formed in the circular peripheral zone (PZ) from stem cell descendants in which differentiation
266 Z) and organogenesis in the peripheral zone (PZ) is essential for the integrity, function, and mainte
267 n score of at least 7 among peripheral zone (PZ) lesions seen at 3-T multiparametric magnetic resonan
268 on rules was 30.0%-33.3% in peripheral zone (PZ) lesions upgraded from category 3 to 4 based on dynam
269 nign and malignant prostate peripheral zone (PZ) tissue retrospectively by using a commercial magneti
270 nd cytoplasm and stroma for peripheral zone (PZ), transition zone (TZ), and tumor tissue in both zone
272 index tumors and nontumoral peripheral zone (PZ): apparent diffusion coefficient (ADC) obtained with
273 n Chlamydia spp. termed the plasticity zone (PZ) may encode niche-specific virulence determinants tha
276 ectodermal ridge (AER) to the progress zone (PZ), which in response proliferates and lays down the pa
277 ons of the telencephalic proliferative zone (PZ) to give rise to neurochemically defined interneuron
278 e (transition zone [TZ] and peripheral zone [PZ]) fosfomycin concentrations using liquid chromatograp
279 ently scored 18 regions (12 peripheral zone [PZ], six transition zone [TZ]) using PI-RADS (range, sco
280 e; AZ) and VIII-anterior IX (posterior zone; PZ), whereas the small heat shock protein 25 (HSP25) is
281 as well as their wild-type littermates (ZPI, PZ), kinetics of light/dye-induced thrombus formation an
282 of the Michaelis complex through either ZPI-PZ-lipid or factor Xa-PZ-lipid intermediates was rate-li
283 her with independent kinetic analyses of ZPI-PZ and factor Xa-PZ-membrane complex formation suggested
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