ライフサイエンスコーパス: Paget

1 Paget disease is a common bone disease characterized by

2 Paget disease is the most exaggerated example of abnorma

3 Paget disease of bone (PD) is characterized by excessive

4 Paget disease of bone (PDB) is a skeletal disorder chara

5 Paget disease of bone, or "osteitis deformans," is a bon

6 Paget's disease (PD) is characterized by focal and drama

7 Paget's disease is characterized by highly localized are

8 Paget's disease is often asymptomatic but can be associa

9 Paget's disease of bone (PDB) is a common disorder chara

10 Paget's disease of bone (PDB) is a common disorder chara

11 Paget's disease of bone (PDB) is a common disorder with

12 Paget's disease of bone (PDB) is a common disorder with

13 Paget's disease of bone (PDB) is the second most common

14 Paget's disease of bone is a common disease characterise

15 Although Paget disease is diagnosed economically with conventiona

16 static and nonmetastatic prostate cancer and Paget's disease.

17 iseases, including myopathies, dementias and Paget disease of bone (PDB), as it may define a new comm

18 in osteoclasts, we hypothesized that FEO and Paget disease are allelic versions of the same locus.

19 , including cancer-related hypercalcemia and Paget's disease of bone, studies have been initiated to

20 , including cancer-related hypercalcemia and Paget's disease of bone, studies were initiated to explo

21 tion (FTLD) with inclusion body myopathy and Paget disease of bone is a rare, autosomal dominant diso

22 as been used in therapy for osteoporosis and Paget's disease for decades, human calcitonin (hCT) form

23 e treatment of osteopenia, osteoporosis, and Paget's disease of bone.

24 Otosclerosis and Paget disease are CT diagnoses.

25 ral" diseases such as multiple sclerosis and Paget's disease, and the controversy surrounding MV vacc

26 eat osteoporosis in postmenopausal women and Paget's disease of bone.

27 indings suggest that the association between Paget disease and osteosarcoma is the result of a single

28 ave been identified in four genes that cause Paget's disease and related syndromes.

29 Besides, our cases challenge Paget's seed - soil theory for sites of metastasis.

30 Extramammary Paget disease (EMPD) is commonly refractory to surgical

31 embers of four families with FEO or familial Paget disease of bone (PDB).

32 D18S42, a region tightly linked to familial Paget disease.

33 occur in one-third of patients with familial Paget disease and in a minority of patients with sporadi

34 the gene(s) responsible for FEO and that for Paget disease are either closely linked or the same locu

35 ed bones compared with uninvolved bones from Paget's patients.

36 ugs that treat osteoporosis, hypercalcaemia, Paget's disease, type II diabetes, and obesity and are b

37 rugs used in the treatment of hypercalcemia, Paget's disease, osteoporosis, and malignancy.

38 n (VCP) cause inclusion body myopathy (IBM), Paget's disease of the bone, and frontotemporal dementia

39 f Paget disease was examined to determine if Paget disease was linked to genetic markers in the same

40 Moreover, as in Paget disease, serum levels of interleukin-6 are markedl

41 ontribute to the elevated numbers of OCLs in Paget's disease.

42 Osteoclasts (OCLs) in Paget's disease are markedly increased in number and siz

43 Osteosarcoma in Paget patients is the underlying basis for a significant

44 re not coordinately increased, as is seen in Paget disease.

45 Radiation-induced, Paget, metastatic, and multifocal osteosarcoma were excl

46 Juvenile Paget's disease can result from osteoprotegerin deficien

47 Juvenile Paget's disease, an autosomal recessive osteopathy, is c

48 protegerin deficiency could explain juvenile Paget's disease because osteoprotegerin suppresses bone

49 ntly unrelated Navajo patients with juvenile Paget's disease for defects in the gene encoding osteopr

50 ride therapy (n = 20) and patients with mild Paget's disease (n = 5).

51 analysis of families with multigenerational Paget disease shows linkage to a region of chromosome 18

52 multisystem disease inclusion body myopathy, Paget disease of the bone and frontotemporal dementia (I

53 nt disease known as inclusion body myopathy, Paget disease with frontotemporal dementia (IBMPFD) and

54 ed in families with Inclusion Body Myopathy, Paget disease, and Frontotemporal Dementia (IBMPFD).

55 ition, resulting in Inclusion Body Myopathy, Paget disease, and Frontotemporal Dementia (IBMPFD).

56 mutant that causes inclusion body myopathy, Paget's disease of bone, and frontotemporal dementia in

57 ns are the cause of inclusion body myopathy, Paget's disease of the bone, and frontotemporal dementia

58 insonism, frontotemporal dementia, myopathy, Paget's disease, or a combination of these.

59 Approximately 1% of Paget patients develop osteosarcoma, which represents an

60 62 gene have been identified in up to 30% of Paget's patients.

61 ion in marrow samples from affected bones of Paget's patients with that in normal marrow.

62 SQSTM1 gene, coding for p62, are a cause of Paget disease of bone and amyotrophic lateral sclerosis

63 culoskeletal and neurologic complications of Paget disease, including fracture, basilar impression, s

64 prevent the development of complications of Paget's disease of bone, and further work is needed to a

65 cause a predisposition to the development of Paget disease by increasing the sensitivity of osteoclas

66 e yields samples which permit a diagnosis of Paget's disease without surgical biopsy.

67 re, a large kindred with a high incidence of Paget disease was examined to determine if Paget disease

68 Medical management of Paget's disease of bone is based on giving inhibitors of

69 role of MV in the abnormal OCL phenotype of Paget's disease, we transduced normal OCL precursors wit

70 FTD; only 1 family had clinical symptoms of Paget disease of bone, and only 1 family had clinical sy

71 en shown to be effective in the treatment of Paget disease of bone and other metabolic bone diseases

72 and inclusion body myopathy with early-onset Paget disease and fronto-temporal dementia.

73 on body myopathy associated with early-onset Paget disease of bone and frontotemporal dementia (hIBMP

74 destruction in postmenopausal osteoporosis, Paget's disease, bone metastasis, and hypercalcemia of m

75 asts are valuable for treating osteoporosis, Paget's disease, and inflammation of bone associated wit

76 We report a case of polyostotic Paget's disease of bone that caused an unusual pattern o

77 ene linked to amyotrophic lateral sclerosis, Paget disease of bone, and glaucoma, a major blinding di

78 Patients with SQSTM1 mutations have severe Paget's disease of bone and a high degree of penetrance

79 are a common cause of familial and sporadic Paget's disease of bone.

80 and in a minority of patients with sporadic Paget disease, with the P392L amino acid substitution be

81 Stephen Paget initially identified the role of host-tumor intera

82 Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has re

83 Recognizing that Paget's disease can not only cause absent but also expan

84 This case suggests that Paget's disease should be considered as a diagnostic pos

85 l primary human marrow stromal cells and the Paget's marrow-derived PSV10 stromal cell line to induce

86 Of 264 patients with effort thrombosis (Paget-Schroetter syndrome), 211 were treated by urokinas

87 is evidence for a major genetic component to Paget disease, with up to 40% of patients having affecte

88 ent evidence suggests that predisposition to Paget disease may have a genetic component.

89 lled inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPF

90 Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPF

91 ease inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia, the m

92 ajor inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia-linked

93 der, inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia/amyotr

94 variants in SQSTM1 have been associated with Paget disease of the bone and might contribute to neurod

95 low/intermediate-grade DCIS associated with Paget disease were true positive only at scintigraphy.

96 Inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBM

97 Inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBM

98 Inclusion body myopathy associated with Paget's disease of the bone and fronto-temporal dementia

99 ause inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia

100 n as inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia.

101 nclusion body myopathy (IBM) associated with Paget's disease of the bone, fronto-temporal dementia an

102 mutations cause inclusion body myopathy with Paget disease and frontotemporal dementia.

103 Inclusion body myopathy with Paget disease of the bone and frontotemporal dementia (I

104 ted syndrome of inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementia

105 es that include inclusion body myopathy with Paget's disease of the bone and frontotemporal dementia,

106 Analysis of osteosarcomas from patients with Paget disease revealed that these tumors also undergo LO

107 Of 45 patients with Paget disease who underwent MR imaging, 33 (26 men, seve

108 of SQSTM1 occur in about10% of patients with Paget's disease of bone (PDB), but it is unclear whether

109 ding p62 are commonly found in patients with Paget's disease of bone and largely cluster within the C