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1 induced expression of peptide transporter 1 (PEPT1).
2 etitively binding to the external surface of PepT1.
3 nsmembrane domain (TMD) topological model of PEPT1.
4 etitively binding to the external surface of PepT1.
5  H(2)O or with RNA encoding SGLT1, NKCC2, or PepT1.
6 edly, some dipeptides were not substrates of PEPT1.
7 tides could not bind to or be transported by PEPT1.
8  were unimpaired in macrophages deficient in PepT1, a peptide transporter previously implicated in MD
9 in animal models of type 2 diabetes/obesity, PepT1 activity and expression were markedly reduced.
10    A 7-day rosiglitazone treatment increased PepT1 activity and prevented the 2-fold HFD-induced redu
11               Metformin alone did not modify PepT1 activity but counteracted rosiglitazone-induced Pe
12 betic drugs, rosiglitazone and metformin, on PepT1 activity/expression in a murine diet-induced obesi
13        Studies of expression and function of PepT1 along the crypt-villus axis demonstrated that this
14  taste receptors to coordinate regulation of PepT1 and apical GLUT2 reciprocally through a common ent
15 ip between the H(+)/oligopeptide transporter PepT1 and apical GLUT2, reflecting the fact that traffic
16 UT2, reflecting the fact that trafficking of PepT1 and GLUT2 to the apical membrane is inhibited and
17 dicates tht KPV is transported into cells by PepT1 and might be a new therapeutic agent for IBD.
18  distinct properties of PepT2, compared with PepT1 and other ion-coupled transporters.
19                                              PepT1 and PepT2 are major facilitator superfamily (MFS)
20 lly target two peptide transporters (namely, PEPT1 and PEPT2) upregulated in several tumor cells.
21 e intestinal and renal peptide transporters (PEPT1 and PEPT2, respectively) from different animal spe
22                                              PepT1 and PepT2, the mammalian proton coupled peptide tr
23     In mammals, peptide transport occurs via PepT1 and PepT2, which belong to the proton-dependent ol
24  mammalian peptide transport as catalysed by PepT1 and PepT2.
25 es for the H(+)-coupled peptide transporters PEPT1 and PEPT2.
26 e recognized by OCTN2, did not interact with PEPT1 and PEPT2.
27  intestinal H+-coupled peptide cotransporter PepT1 and recorded the dependence of transient charge mo
28 es of the mammalian oligopeptide transporter PepT1 and the Na(+)- and K(+)-coupled epithelial and neu
29 oth Xenopus laevis oocytes expressing rabbit PepT1 and through PepT1 in rat renal brush border membra
30 oth Xenopus Laevis oocytes expressing rabbit PepT1 and through PepT1 in rat renal brush border membra
31  that transport of the dipeptide Trp-Gly via PepT1 and transport of Na+ and K+ via EAAC1 across the o
32                                  Thus, R282E-Pept1 appears to have been changed from a proton-driven
33 ncluded that peptide-evoked charge fluxes of PepT1 are entirely due to H+ movement.
34    This molecule is not translocated through PepT1 as measured both by direct HPLC analysis in PepT1-
35    This molecule is not translocated through PepT1 as measured both by direct HPLC analysis in PepT1-
36 ectrode voltage clamping revealed that R282E-PepT1 behaved as a peptide-gated non-selective cation ch
37 ort of protons and peptides of the wild-type PepT1 but also creates a peptide-gated cation channel in
38 e maximum velocity for dipeptide uptake (via PepT1), but they act by different mechanisms.
39       Collectively, our results suggest that PepT1 contributes to maintain balance of homeostasis and
40                                              PepT1 did not display the substrate-gated anion conducta
41  intestinal H(+)-coupled peptide transporter PepT1, displays a broad substrate specificity and accept
42 amma agonist compensated for the HFD-induced PepT1 down-regulation, whereas metformin reversed rosigl
43  as measured both by direct HPLC analysis in PepT1-exp ressing oocytes and indirectly by its failure
44                   We found that KPV acts via PepT1 expressed in immune and intestinal epithelial cell
45                 The oligopeptide transporter PepT1 expressed in inflamed colonic epithelial cells tra
46  as measured both by direct HPLC analysis in PepT1-expressing oocytes and indirectly by its failure t
47             Furthermore, metformin decreased PepT1 expression (mRNA and protein) and its transport ac
48 stigated the long term leptin treatments, on PepT1 expression and activity in Caco2-BBE cells, and be
49                                 EPEC induced PepT1 expression and activity in HT29-Cl.19A cells by in
50 ts revealed that C rodentium induced colonic PepT1 expression and that, compared with their wild-type
51                                 Induction of PepT1 expression by EPEC required the transcription fact
52                                              PepT1 expression reduced binding of EPEC to lipid rafts,
53 he effects of pathogenic bacteria on colonic PepT1 expression together with its functional consequenc
54 chanism underlying the regulation of colonic PepT1 expression under pathologic conditions and reveal
55                                              PepT1 expression was high in the apical region of duoden
56 e human intestinal oligopeptide transporter (PEPT1) facilitates the absorption of dipeptides, tripept
57 nd crypts samples, we found that ablation of PepT1 further directly or indirectly altered expression
58 arginine 282 with a glutamate residue (R282E-PepT1) gave a protein at the plasma membrane of Xenopus
59                                Here, a novel PepT1 gene product has been identified in the rat pineal
60                              We propose that PepT1 has a single proton binding site that is symmetric
61  Expression of the di/tripeptide transporter PepT1 has been observed in the colon under inflammatory
62 roton-coupled di- and tripeptide transporter PepT1 has been shown by site-directed mutagenesis to be
63 of 12 membrane-spanning domain transporters; PepT1 has proton/peptide cotransport activity and is sel
64 th and expression of the peptide transporter PepT1 in adults with or without SBS.
65 logic conditions and reveal a novel role for PepT1 in host defense via its capacity to modulate bacte
66 ns-stimulate labelled peptide efflux through PepT1 in oocytes and in renal membrane vesicles.
67 s-stimulate labelle d peptide efflux through PepT1 in oocytes and in renal membrane vessicle s.
68  oocytes expressing rabbit PepT1 and through PepT1 in rat renal brush border membrane vesicles.
69  oocytes expressing rabbit PepT1 and through PepT1 in rat renal brush border membrane vesicles.
70                     Up-regulation of colonic PepT1 in SBS may adaptively improve accrual of malabsorb
71                                              PepT1 is a di/tripeptide transporter normally expressed
72                                              PepT1 is abundant along the small-bowel brush border in
73                                              PepT1 is an intestinal epithelial apical membrane transp
74                              In the jejunum, PepT1 is particularly enriched in the well-differentiate
75   In addition, a substrate binding model for PepT1 is proposed.
76              The oligopeptide transporter 1, PepT1, is a member of the Slc15 family of 12 membrane-sp
77                 An oligopeptide transporter, PepT1, is transcriptionally upregulated by certain dieta
78  with previous data on the ion dependence of PepT1, it can therefore be concluded that peptide-evoked
79 the COOH terminus of a warm-adapted (rabbit) PEPT1, it conferred cold adaptation to the receiving pro
80  Ac-Phe-NH2 had a very weak interaction with PepT1 (Ki = 16.8+/-5.64 mM); neither Phe nor Phe-NH2 int
81 yr and Ac-Phe-Tyr-NH2 interacted weakly with PepT1 (Ki = 8.41+/-0.11 and 9.97+/-4.01 mM, respectively
82              In this study, we observed that PepT1 knockout (KO) mice exhibited reduced body weight a
83                                We found that PepT1 KO altered the distribution of miRNAs along the cr
84 along the crypt-villi axis in the jejunum of PepT1 KO mice.
85 ch activated PKC betaII and decreased apical PepT1 levels and absorption of the hydrolysis-resistant
86 ransport of VLPVPQK suggested involvement of PepT1 like transporters/SOPT2 while BCM 5, its hydrolyti
87 ver, we previously demonstrated that colonic PepT1 may be expressed during chronic inflammation.
88  whether the KPV anti-inflammatory effect is PepT1-mediated in intestinal epithelian and immune cells
89  while GLUT5-mediated fructose transport and PepT1-mediated peptide transport were substantially redu
90 ivity but counteracted rosiglitazone-induced PepT1-mediated transport.
91 eptidyl peptidase IV and peptide transporter PepT1 messenger RNA levels were determined before and af
92 ation of mucosal dipeptidyl peptidase IV and PepT1 messenger RNA.
93                    However, the abundance of PepT1 mRNA in the colon of SBS patients was more than 5-
94                                          The PepT1-NOD2 signaling pathway is involved in aggravation
95  studied to determine the involvement of the PepT1-NOD2 signaling pathway.
96 gh most of the peptides tested could bind to PEPT1, not all were substrates.
97  reverse trans-stimulation through expressed PepT1 of labelled peptid efflux induced by unlabelled pe
98  reverse trans-stimulation through expressed PepT1 of labelled peptide efflux induced by unlabelled p
99                   We recently exhibited that PepT1 plays an important role in multiple biological fun
100 The intestinal H(+)/peptide cotransporter 1 (PepT1) plays a major role in nitrogen supply to the body
101  show that at physiological pH (pHo 5.5-6.0) PepT1 prefers neutral and acidic peptides.
102 al 3 membrane-spanning domains of intestinal PepT1 protein, with 3 additional N-terminal residues.
103 performed using cold KPV as a competitor for PepT1 radiolabelled substrate or using [(3)H]KPV to dete
104                   Its homologues in mammals, PEPT1 (SLC15A1) and PEPT2 (SLC15A2), not only transport
105      In addition, peptide transport by R282E-PepT1 still induced depolarization as measured by microe
106 at contain a diaminophilic acid, such as the PepT1 substrate Tri-DAP.
107  in contrast to the low-affinity transporter PepT1 that couples transport of one peptide to one H+.
108 (Chionodraco hamatus) peptide transporter 1 (PEPT1), the first transporter cloned from a vertebrate l
109          We investigated the contribution of PepT1 to intestinal inflammation in mouse models of coli
110  compared with their wild-type counterparts, PepT1 transgenic mice infected with C rodentium exhibite
111                                Wild-type and PepT1 transgenic mice or cultured colonic tissues derive
112                              In other words, PepT1 transport activity plays an important role in cont
113 tudies, rosiglitazone treatment up-regulated PepT1 transport activity with concomitant induction of S
114 diabetic drugs exert opposite effects on the PepT1 transport function probably through direct action
115 r results identify key features required for PEPT1 transport in contrast to most previously described
116 revented the 2-fold HFD-induced reduction in PepT1 transport.
117 stigate the structural features required for PEPT1 transport.
118 gether with their potential active uptake by PEPT1 transporter, intestinal permeability, and metaboli
119 illus width were measured, and expression of PepT1 was determined by Northern blotting, in situ hybri
120 parameters on extracellular pH (pHo), rabbit PepT1 was expressed in Xenopus laevis oocytes and used f
121 he wild type, the rate of transport by R282E-PepT1 was independent of the extracellular pH level, and
122 Slc15a1, a peptide transporter also known as Pept1, was predominantly present in peritubular myoid ce
123 the mammalian intestinal peptide transporter PepT1 were investigated, using the Xenopus laevis expres
124 nal peptide Phe-Tyr-NH2 also interacted with PepT1 with a relatively high affinity (Ki = 0.94+/-0.38
125 mM); neither Phe nor Phe-NH2 interacted with PepT1 with measurable affinity.

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