ライフサイエンスコーパス: PhIP

1 means of parahydrogen-induced polarization (PHIP).

2 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

3 uch as in parahydrogen-induced polarization (PHIP).

4 lication origin binding protein RepID/DCAF14/PHIP.

5 gents for both homogeneous and heterogeneous PHIP.

6 o clarify the reaction pathways that produce PhIP.

7 and alanine reduced significantly (p < 0.05) PhIP.

8 etaldehyde as a key step in the formation of PhIP.

9 sms related to the cooking compounds BaP and PhIP.

10 hat significantly increased the formation of PhIP.

11 ffect the generation and amount of MeIQx and PhIP.

12 ic and heterocyclic amine mutagens including PhIP.

13 a significant role in detoxifying N-hydroxy-PhIP.

14 thylimidazo[4,5-f]quinoxaline (DiMeIQx), and PhIP.

15 were resistant to mammary carcinogenesis by PhIP.

16 arcinogenic insult by compounds such as N-OH-PhIP.

17 es to form the carcinogenic metabolite N2-OH-PhIP.

18 lease of PhIP molecules from the particulate PhIP.

19 , known to mediate tissue damage observed in PHIP.

20 gut could contribute to the toxic effects of PhIP.

21 cals that interferes with the measurement of PhIP.

22 all fried patties, MeIQx (0.3-1.0 ng/g), and PhIP (0.02-0.3 ng/g).

23 after oral or intravenous administration of PhIP (1 mg/kg), the PhIP levels in the small intestine w

24 ogenative parahydrogen induced polarization (PHIP) (1-3) and detection with an optical atomic magneto

25 ned using parahydrogen-induced polarization (PHIP), (13)C labeling, and comparison to the related com

26 o-3,8 dimethylimidazo 4,5-f quinoxaline) and PhIP (2-amino-1-methyl-6 phenylimidazo (4,5-b pyridine)

27 midazo [4,5-f]quinoxaline) (1.5-5.6ng/g) and PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) (

28 5-f]quinoxaline) n.d.-1.5 (n.d.-2.2)ng/g and PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) 0

29 The food-derived carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) i

30 mino-3,8-dimethylimidazo[4,5-f]quinoxaline), PhIP (2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine), N

31 /-) mice, the carcinogenic metabolites N2-OH-PhIP (2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyri

32 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (Me

33 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-9H-pyrido[2,3-b]indole (AalphaC), 2-amino

34 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP); 2-amino-3,8-dimethylimidazo[4,5-b]quinoxaline (Me

35 ammalian and bacterial metabolites N-hydroxy-PHIP, 4-OH-PHIP and PHIP-M1 in biological samples.

36 although ribose and arabinose produced more PhIP (44-46 pmol of PhIP/mumol of creatinine).

37 ministered a dietary relevant dose of [(14)C]PhIP 48 to 72 hours before surgery to remove colon tumor

38 1-methyl-6-phenylimidazo[4,5-b]pyridine) and PhIP-5-sulfate (a genotoxicity marker) accumulated in li

39 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a carcinogen found in the human diet.

40 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a carcinogenic HAA produced in cooked meats, and

41 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a compound found in cooked meat, is a mammary gla

42 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic amine found in cooked meat, induce

43 s, such as Rfx7, a transcription factor, and Phip, a chromatin regulator, which suppress lymphomagene

44 The levels of PhIP accrued in dyed hair from volunteers on a semicontr

45 els of PhIP were comparable to the levels of PhIP accrued in hair of subjects with natural hair color

46 ckstrin homology domain interacting protein (PHIP), acting through effects on the force transduction

47 hosphatase and tensin homolog, demonstrating PHIP activation in triple-negative melanoma.

48 Using conditions optimized to give the C8-dG-PhIP adduct as the major product, sufficient material wa

49 Our results show that the dG-C8-PhIP adduct can be accommodated in the spacious major gr

50 but unmodified controls, suggesting that the PhIP adduct enhances incorporation of these mismatches.

51 In addition to the C8-dG-PhIP adduct, at least eight polar adducts are found afte

52 G1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others.

53 no-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), an HCA, were associated with a significant 20-30%

54 The sulfonamide adducts of PhIP and 4-ABP were identified, by liquid chromatography

55 rption of PHIP-M1 is comparable with that of PHIP and a moderate to high bioavailability has to be ex

56 osition and biliary and fecal elimination of PhIP and its carcinogenic metabolites and may affect PhI

57 ction for the simultaneous quantification of PHIP and its mammalian and bacterial metabolites N-hydro

58 drug transporters on the pharmacokinetics of PhIP and its metabolites.

59 The limit of quantification (LOQ) values for PhIP and MeIQx were about 5 pg/mL, whereas the LOQ value

60 icrosomes prepared from the human liver; the PhIP and N2-OH-PhIP formed were isolated from the biomat

61 s)), so prediction of the carcinogenicity of PhIP and other HCAs or AAs based primarily on log(k(az)/

62 suggesting that reduced biliary excretion of PhIP and PhIP metabolites leads to increased urinary exc

63 d bacterial metabolites N-hydroxy-PHIP, 4-OH-PHIP and PHIP-M1 in biological samples.

64 PhIP and PhIP@OA did not show significant cytotoxic effe

65 defense against cancer formation induced by PhIP and related HCAs.

66 tion revealed a physical interaction between PHIP and VCL.

67 ations in parahydrogen-induced polarization (PHIP) and signal amplification by reversible exchange (S

68 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and polycyclic aromatic hydrocarbons, such as ben

69 e (PhIP), N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP); and the dG adducts of the NOC 4-(methylnitrosamin

70 mino-1-methyl-6-phenylmidazo[4,5-b]pyridine (PhIP); and the lipid peroxidation products acrolein (AC)

71 between meat and meat mutagens, specifically PhIP, and prostate cancer risk in the Prostate, Lung, Co

72 nterest for those pursuing a wide variety of PHIP applications, including those involving the product

73 Heterocyclic aromatic amines such as PHIP are formed during the heat processing of food.

74 amics, and tumor cell motility, and identify PHIP as a key driver of glioblastoma migration and invas

75 These results provide further support for PHIP as a molecular prognostic marker of melanoma, and r

76 to the animal studies, which have implicated PhIP as a prostate carcinogen.

77 particles, including individual particulate PhIP as simulated fumes from meat cooking, were constant

78 ectively, with dyed hair samples spiked with PhIP at 200 and 600 ppt.

79 he mutagenic response to mixtures of BaP and PhIP at concentrations relevant to human exposure (micro

80 dye, the consecutive reaction monitoring of PhIP at the MS(3) scan stage was employed to selectively

81 metric as opposed to purely catalytic use of PHIP-available complexes with an unsaturated payload pre

82 BRWD2/PHIP binds directly to H3K4 methylation through a previo

83 Bcrp1 and Mdr1a limited PhIP brain accumulation.

84 Thus, not only the human metabolites of PHIP but also the bacterial metabolite PHIP-M1 formed in

85 fibroblast cells compared with the dissolved PhIP but clearly induced premature senescence activities

86 ddition of the lipid did not seem to produce PhIP by an alternative mechanism because PhIP was formed

87 PHIP by pairwise replacement has the potential to signif

88 C-labeled, unsaturated precursors to perform PHIP by side arm hydrogenation has recently opened new p

89 These results suggest that PhIP can be produced by several alternative reaction pat

90 cules, a long-lived singlet state created by PHIP can be stored for several minutes on protons in hig

91 ers is carried out in a pairwise manner, and PHIP can be used for understanding the activation mechan

92 The use of naturally colored hair containing PhIP can serve as a long-term biomarker of exposure to t

93 parahydrogen-induced polarization (4-6) (NH-PHIP) can also dramatically enhance the sensitivity of z

94 Following metabolic activation, PhIP causes bulky DNA lesions at the C8-position of guan

95 family members differentially regulate BRWD2/PHIP chromatin occupancy.

96 The combined impact of increased PHIP copy number and tumor vascularity on ulceration sta

97 Increased PHIP copy number was an independent predictor of ulcerat

98 Elevated PHIP copy number was associated with significantly reduc

99 PHIP copy number was determined using fluorescence in si

100 PHIP copy number was elevated in the classical glioblast

101 -overexpressing melanomas harbored increased PHIP copy number.

102 ckstrin homology domain-interacting protein (PHIP) copy number and its relationship to ulceration.

103 and 17 are frequently gained whereas VPRBP, PHIP, DCAF10, 12 and 15 are frequently lost.

104 In the C8-dG-PhIP-deletion duplex, the smaller size of the aromatic r

105 e DNA adduct of PhIP, N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP) was identified in 11 out of 35 patient

106 ,5-b]pyridine (PhIP), N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP); and the dG adducts of the NOC 4-(meth

107 First, we demonstrate that PhIP induced C8-PhIP-dG adducts and DNA strand breaks.

108 Although C8-PhIP-dG adducts are mutagenic, their interference with t

109 The glycosidic torsion angle of the [PhIP]dG residue is syn, and the displaced guanine base i

110 tial reduction in the concentration of MeIQ, PhIP, DiMeIQx, IQ, IQx, and norharman was achieved in ch

111 In rats of different ages, PhIP-DNA adduct levels detected by the (32)P-post-labeli

112 PhIP-DNA adduct levels, adduct removal, and mutation bur

113 e age-related differences in susceptibility, PhIP-DNA adduct levels, mutations, and gene expression w

114 PhIP-DNA adducts also were recovered quantitatively from

115 PhIP-DNA adducts isolated from LNCaP-derived cells and p

116 2)-glucuronide had the lowest level of colon PhIP-DNA adducts.

117 From 3 hours to 6 weeks after PhIP dosing, the number of clones showing altered expres

118 methyl-6-phenylimidazo[4,5-b]pyridine (C8-dG-PhIP), embedded in either full or 'deletion' duplexes (t

119 In 150-day-old rats, PhIP enhanced the expression of genes associated with di

120 Biliary PhIP excretion was reduced 41-fold in Bcrp1;Mdr1a/b;Mrp2

121 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) exhibited a chromosomal instability (CIN), whereas

122 ated in a parahydrogen-induced polarization (PHIP) experiment by a 508-fold enhancement (+/-78) of a

123 Most PHIP experiments, however, are performed on asymmetric m

124 PHIP FISH scores were independently predictive of DMFS (

125 the substrates that can be hyperpolarized by PHIP for biomedical utilization.

126 nts using parahydrogen induced polarization (PHIP) for biomedical and other applications is presented

127 totally inhibited MeIQ and reduced MeIQx and PhIP formation by 40 and 70%, respectively.

128 as the two additional reactants required for PhIP formation from both phenylacetaldehyde/creati(ni)ne

129 athway is suggested to be the main route for PhIP formation in foods.

130 A general pathway for PhIP formation is proposed.

131 also be considered as a potential inducer of PhIP formation under appropriate conditions.

132 ough unoxidised lipids did not contribute to PhIP formation, their oxidation produced many compounds

133 lipid-derived reactive carbonyls to promote PhIP formation.

134 IQ formation and to reduce by half MeIQx and PhIP formation.

135 for 24-144 h at 60 degrees C also increased PhIP formation.

136 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation in mixtures of creatinine, phenylalanine

137 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation, this study analyzes the role of twenty-

138 eased significantly (p < 0.05) the amount of PhIP formed in comparison to the control.

139 red from the human liver; the PhIP and N2-OH-PhIP formed were isolated from the biomatrices by solid-

140 ormaldehyde and ammonia to the production of PhIP from phenylacetaldehyde and creatinine were studied

141 trixes and showed good linearity (40-1000 pg PhIP/g hair) with a goodness-of-fit regression value of

142 The human PHIP gene resides on 6q14.1, and although 6q loss has be

143 PHIP had extensive lymphocytosis marked by massive expan

144 PHIP has been found to be amplified in wild-type melanom

145 ftware environment to completely control the PHIP hyperpolarization process including remotely trigge

146 Detection of PHIP hyperpolarized gas by low-field NMR is demonstrated

147 This PHIP hyperpolarizer utilizes an Arduino microcontroller

148 d 5.75 mT parahydrogen induced polarization (PHIP) hyperpolarizer.

149 e assays, which were compared with dissolved PhIP in dimethyl sulfoxide.

150 However, the measurement of PhIP in dyed hair, a cosmetic treatment commonly used by

151 ass spectrometer were employed to biomonitor PhIP in dyed hair.

152 tial contribution of LOP to the formation of PhIP in food products.

153 Stable suppression of PHIP in human melanoma cells resulted in significantly r

154 n of melanoma, whereas stable suppression of Phip in melanoma cell lines suppressed metastatic potent

155 method was successfully employed to measure PhIP in nondyed and dyed hair biospecimens of participan

156 lts describe previously unreported roles for PHIP in predicting and promoting melanoma metastasis, an

157 a ZYX-GFP construct demonstrated a role for PHIP in regulating focal adhesion dynamics.

158 mined in mammary gland carcinomas induced by PhIP in Sprague-Dawley (SD)xWistar Furth F1 hybrid rats.

159 to the study of the metabolic activation of PhIP in various human tissues.

160 ped with glutathione to induce heterogeneous PHIP in water.

161 rized via parahydrogen-induced polarization (PHIP) in an aqueous solution with signal enhancement of

162 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in both creatinine/phenylalanine (CRN/Phe) and cre

163 o-1-methyl-6-phenylimidazo[4, 5-b] pyridine (PhIP) in grilled meat, by on-line coupling of LOC-FLEME

164 namic nuclear polarization NMR spectroscopy (PHIP) in ionic liquids leads to weak or no polarization

165 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the DinB family polymerase, Dpo4, using molecul

166 In this study, for the first time, PhIP-incorporated oleic acid (OA, simulating cooking oil

167 abolically competent) were exposed to BaP or PhIP individually or in mixtures.

168 es versus 194, respectively) suggesting that PhIP induced a cascade of gene expression alterations on

169 First, we demonstrate that PhIP induced C8-PhIP-dG adducts and DNA strand breaks.

170 ino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP)-induced colon tumors in the rat have increased bet

171 its carcinogenic metabolites and may affect PhIP-induced carcinogenesis as a result.

172 ndirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc

173 g oncogenic mutants of beta-catenin found in PhIP-induced colon tumors.

174 Inhibition of ATR in the presence of PhIP-induced DNA damage strongly promoted the formation

175 tions at this locus were not associated with PhIP-induced rat mammary gland cancer.

176 D1/Cdk4, phospho-Rb as a central pathway in PhIP-induced rat mammary gland carcinogenesis.

177 Comparative genomic hybridization of PhIP-induced rat mammary gland carcinomas revealed loss

178 By real time PCR analysis, PhIP-induced rat mammary gland carcinomas showed statist

179 alterations in the proximal region of 2q in PhIP-induced rat mammary gland carcinomas.

180 ohistochemistry (IHC) across a large bank of PhIP-induced SD rat mammary gland carcinomas.

181 In rodents, a high intake of PhIP induces prostate tumors.

182 In contrast, in 43-day-old rats, PhIP inhibited the expression of differentiation genes a

183 Systemic, plasmid-based shRNA targeting of Phip inhibited the metastatic progression of melanoma, w

184 tion were 1.4, 0.9, 1.7 and 1.3 ng g(-1) for PhIP, IQ, MeIQ and MeIQx, respectively.

185 PhIP is an abundant heterocyclic aromatic amine (HCA) an

186 inoimidazoazarenes are produced similarly to PhIP is discussed, including their formation by cyclizat

187 ility of lipid oxidation products to produce PhIP is related to their capacity to induce the Strecker

188 A significant application of PHIP is to generate contrast agents for biomedical imagi

189 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a carcinogenic heterocyclic aromatic amine form

190 Parahydrogen-induced polarization (PHIP) is a method for enhancing NMR sensitivity.

191 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a suspected human breast carcinogen found in co

192 Para-hydrogen-induced polarization (PHIP) is a technique capable of producing spin polarizat

193 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is considered as a human carcinogenic or mutagenic

194 Para-hydrogen induced polarization (PHIP) is particularly suitable, because para-H(2) posses

195 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine, PhIP, is often generated in the highest concentration of

196 PHIP knockdown produced substantial suppression of tumor

197 largest gas-phase NMR signal enhancement by PHIP known to date.

198 ma, and reveal a significant linkage between PHIP levels and ulceration.

199 venous administration of PhIP (1 mg/kg), the PhIP levels in the small intestine were reduced 4- to 6-

200 ormational exchange is observed in which the PhIP ligand either intercalates into the DNA helix by de

201 h 6q loss has been observed in melanoma, the PHIP locus was preserved in melanoma cell lines and pati

202 es of PHIP but also the bacterial metabolite PHIP-M1 formed in the gut could contribute to the toxic

203 al metabolites N-hydroxy-PHIP, 4-OH-PHIP and PHIP-M1 in biological samples.

204 rapidly crosses the cell monolayer and that PHIP-M1 is a substrate for P-glycoprotein and the multip

205 The intestinal absorption of PHIP-M1 is comparable with that of PHIP and a moderate t

206 The experiments show that PHIP-M1 rapidly crosses the cell monolayer and that PHIP

207 hod was used to investigate the transport of PHIP-M1 through a Caco-2 cell monolayer.

208 4,5]imidazo[1,2-a]pyri midin-5-ium chloride (PHIP-M1) as main metabolite.

209 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) may contribute to the etiology of human diet-assoc

210 Because the NH-PHIP mechanism is nonreactive, operates in situ, and eli

211 heme iron (1% in diet), heterocyclic amines (PhIP + MeIQx, 50 + 25 mug/kg in diet), and NOC (induced

212 and interday precisions of the estimates of PhIP, MeIQx, and their metabolites, reported as the coef

213 ASE exerted antimutagenicity against PhIP, MelQ, and MelQx in TA98 and TA100 Salmonella strai

214 was used to assess the relationship between PhIP metabolism and DNA adduct formation.

215 g that reduced biliary excretion of PhIP and PhIP metabolites leads to increased urinary excretion of

216 risk from exposure to HCAs, the chemistry of PhIP metabolites that presumably react with DNA to initi

217 Twelve PhIP metabolites were detected in the urine samples.

218 Biliary and small intestine levels of PhIP metabolites were reduced in Bcrp1;Mrp2-deficient mi

219 ey levels and urinary excretion of genotoxic PhIP-metabolites were significantly increased, suggestin

220 s that may be caused by a limited release of PhIP molecules from the particulate PhIP.

221 find that although the highly conserved PhiW PhiP motif is the largest determinant of binding, energe

222 ry, we propose a mechanism by which the PhiW PhiP motif of RAM and EBNA2 compete with one another for

223 Interestingly, PHIP mounted efficient innate and adaptive immune respon

224 It produced 32.48 pmol of PhIP/mumol of creatinine in comparison with the 7.92 pmo

225 eatinine in comparison with the 7.92 pmol of PhIP/mumol of creatinine produced by the control phenyla

226 arabinose produced more PhIP (44-46 pmol of PhIP/mumol of creatinine).

227 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP); and the

228 The DNA adduct of PhIP, N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP) was ident

229 The potential barrier height Phip-n is an enhanced tuning factor, and Phip-p is a sel

230 enotype and high levels of urinary N-hydroxy-PhIP-N(2)-glucuronide had the lowest level of colon PhIP

231 The levels of urinary N-hydroxy-PhIP-N(2)-glucuronide were negatively correlated to colo

232 t metabolite in all volunteers was N-hydroxy-PhIP-N(2)-glucuronide.

233 ge in molecular structure, producing intense PHIP NMR signals on the alkene.

234 hydrogenation catalysts can yield detectable PHIP NMR signals.

235 eriments, parahydrogen induced polarization (PHIP) NMR, and comparison with a molecular analog.

236 PhIP and PhIP@OA did not show significant cytotoxic effects on SH

237 ted oleic acid (OA, simulating cooking oil) (PhIP@OA) particles, including individual particulate PhI

238 ursor for parahydrogen-induced polarization (PHIP) of 1-(13)C-phospholactate-d2, is reported.

239 of overcoming this limitation, we implement PHIP on a microfluidic device with a 2.5 muL detection v

240 the epidemiological observations implicating PhIP, one of the most mass-abundant heterocyclic aromati

241 lic derivative will inhibit the formation of PhIP, or not, based on its structure.

242 In addition, a high proportion of PHIP-overexpressing melanomas harbored increased PHIP co

243 PHIP-overexpressing melanomas include tumors with wild-t

244 ght Phip-n is an enhanced tuning factor, and Phip-p is a selective tuning factor.

245 ve is to produce hyperpolarized fumarate via PHIP (parahydrogen-induced polarization).

246 The PhIP phenyl ring interacts with the phosphodiester-sugar

247 when at the Earth's magnetic field) from the PHIP polarizer to the 47.5 mT low-field MRI.

248 Mixtures of BaP and PhIP produced dose responses different from those of the

249 ole of twenty-five phenolic compounds on the PhIP produced in phenylalanine/creatinine/oxidised lipid

250 eased significantly (p < 0.05) the amount of PhIP produced, while histidine, cysteine, lysine, trypto

251 d lipid increased considerably the amount of PhIP produced.

252 ckstrin homology domain-interacting protein (PHIP), promotes melanoma metastasis, can be used to clas

253 olox-equivalents (MeIQx, R(2)=0.85, p<0.001; PhIP, R(2)=0.83, p<0.001) was found.

254 Targeted suppression of PHIP resulted in significant down-regulation of these fo

255 However, the PhIP ring system on the minor groove side would seriousl

256 These results demonstrate PHIP's role in regulating the actin cytoskeleton, focal

257 Our study highlights the utility of PhIP-Seq for extensively interrogating antigenic reperto

258 oped a phage immunoprecipitation sequencing (PhIP-Seq) methodology to identify known and previously u

259 ed proteome-wide programmable phage-display (PhIP-Seq) on sera from a cohort of people with APS1 and

260 imaging, parahydrogen-induced polarization (PHIP) shows promise due to its low cost and fast speed o

261 d metal catalysts were not expected to yield PHIP signals given the rapid diffusion of H atoms on the

262 PHIP silencing significantly suppressed the migratory an

263 The PHIP study of this system leads to unusual and unexpecte

264 in previous ASD candidates (ARHGAP32, NCOR1, PHIP, STXBP1, CDKL5 and SHANK1).

265 igher than in previous aqueous heterogeneous PHIP systems are presented.

266 PhIP, the most prevalent heterocyclic aromatic amine for

267 Humans are exposed to PhIP through ingestion of well-done cooked meats, and th

268 Confocal microscopy specifically localized PHIP to the force transduction layer, together with TLN1

269 Immunofluorescence analysis localized PHIP to the leading edge of glioblastoma cells, together

270 2)H, and para-hydrogen induced polarization (PHIP) transfer NMR spectroscopy revealed cis-hydrogenati

271 ned from para-hydrogen induced polarization (PHIP) transfer NMR studies revealed that the pairwise hy

272 nd parahydrogen (p-H2) induced polarization (PHIP) transfer NMR studies to elucidate catalytically re

273 amined in glands from 43-day and 150-day-old PhIP-treated rats.

274 ver, cDNA microarray analysis indicated that PhIP treatment differentially altered the profile of gen

275 In proliferating cells, PhIP treatment increased the frequency of stalled replic

276 e and enhanced chromosomal aberrations after PhIP treatment, while ATM and DNA-PK inhibition had only

277 Here, we analyzed PhIP-triggered replicative stress and elucidated the rol

278 PHIP undergoes bacterial metabolism leading to 7-hydroxy

279 o 0.08 ng/g), 4,8-DiMeIQx (up to 4.95 ng/g), PhIP (up to 6.24 ng/g) and AalphaC (up to 0.20 ng/g) wer

280 The limit of quantification (LOQ) of PhIP was 84 parts-per-trillion (ppt) employing 50 mg of

281 h MeIQx and DiMeIQx, the highest quintile of PhIP was associated with a 1.2-fold increased risk of pr

282 uce PhIP by an alternative mechanism because PhIP was formed analogously in both CRN/Phe and CRN/Phe/

283 ng/g and in fish 44.06 +/- 1.499 ng/g while PhIP was found in higher amount in mutton 40.21 +/- 0.65

284 PhIP was incubated with microsomes prepared from the hum

285 PhIP was not formed before 240 degrees C except in chick

286 Although PhIP was produced to some extent in the CRN/Phe system,

287 Fecal excretion of PhIP was reduced 8- to 20-fold in knockouts.

288 of PhIP, N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP) was identified in 11 out of 35 patients, at levels

289 Parahydrogen-induced polarization (PHIP) was used to demonstrate the concept that highly po

290 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), was used to assess the relationship between PhIP

291 man prostate tissue cultures exposed to N-OH-PhIP were analyzed by liquid chromatography/electrospray

292 d feeding study who ingested known levels of PhIP were comparable to the levels of PhIP accrued in ha

293 The content of MeIQx and PhIP were significantly reduced by approx. 57% and 90% (

294 Twenty primary HCMV-infected patients (PHIP) were enrolled, as well as 26 HCMV-seronegative and

295 fy an evolutionarily conserved factor, BRWD2/PHIP, which colocalizes with histone H3K4 methylation ge

296 as an independent variable predict log m for PhIP with good accuracy in both TA 98 and TA 100.

297 dducts are found after reaction of N-acetoxy-PhIP with the oligonucleotide.

298 ning parahydrogen-induced hyperpolarization (PHIP) with a high-sensitivity transmission line microdet

299 yde and ammonia were simultaneously present, PhIP yield was multiplied by fifty and the Ea of the rea

300 ixture of phenylacetaldehyde and creatinine, PhIP yield was multiplied by nineteen.