ライフサイエンスコーパス: PhIP

1 means of parahydrogen-induced polarization (PHIP).

2 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

3 uch as in parahydrogen-induced polarization (PHIP).

4 o clarify the reaction pathways that produce PhIP.

5 and alanine reduced significantly (p < 0.05) PhIP.

6 etaldehyde as a key step in the formation of PhIP.

7 sms related to the cooking compounds BaP and PhIP.

8 hat significantly increased the formation of PhIP.

9 ffect the generation and amount of MeIQx and PhIP.

10 ic and heterocyclic amine mutagens including PhIP.

11 a significant role in detoxifying N-hydroxy-PhIP.

12 thylimidazo[4,5-f]quinoxaline (DiMeIQx), and PhIP.

13 were resistant to mammary carcinogenesis by PhIP.

14 arcinogenic insult by compounds such as N-OH-PhIP.

15 es to form the carcinogenic metabolite N2-OH-PhIP.

16 thod for the determination of PhIP and N2-OH-PhIP.

17 -dG adduct formed by reaction with N-acetoxy-PhIP.

18 lease of PhIP molecules from the particulate PhIP.

19 gut could contribute to the toxic effects of PhIP.

20 cals that interferes with the measurement of PhIP.

21 , known to mediate tissue damage observed in PHIP.

22 gents for both homogeneous and heterogeneous PHIP.

23 all fried patties, MeIQx (0.3-1.0 ng/g), and PhIP (0.02-0.3 ng/g).

24 after oral or intravenous administration of PhIP (1 mg/kg), the PhIP levels in the small intestine w

25 ogenative parahydrogen induced polarization (PHIP) (1-3) and detection with an optical atomic magneto

26 ned using parahydrogen-induced polarization (PHIP), (13)C labeling, and comparison to the related com

27 o-3,8 dimethylimidazo 4,5-f quinoxaline) and PhIP (2-amino-1-methyl-6 phenylimidazo (4,5-b pyridine)

28 midazo [4,5-f]quinoxaline) (1.5-5.6ng/g) and PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) (

29 5-f]quinoxaline) n.d.-1.5 (n.d.-2.2)ng/g and PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) 0

30 The food-derived carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) i

31 mino-3,8-dimethylimidazo[4,5-f]quinoxaline), PhIP (2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine), N

32 /-) mice, the carcinogenic metabolites N2-OH-PhIP (2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyri

33 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (Me

34 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-9H-pyrido[2,3-b]indole (AalphaC), 2-amino

35 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP); 2-amino-3,8-dimethylimidazo[4,5-b]quinoxaline (Me

36 ammalian and bacterial metabolites N-hydroxy-PHIP, 4-OH-PHIP and PHIP-M1 in biological samples.

37 although ribose and arabinose produced more PhIP (44-46 pmol of PhIP/mumol of creatinine).

38 ministered a dietary relevant dose of [(14)C]PhIP 48 to 72 hours before surgery to remove colon tumor

39 1-methyl-6-phenylimidazo[4,5-b]pyridine) and PhIP-5-sulfate (a genotoxicity marker) accumulated in li

40 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a carcinogen found in the human diet.

41 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a carcinogenic HAA produced in cooked meats, and

42 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a compound found in cooked meat, is a mammary gla

43 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic amine found in cooked meat, induce

44 The levels of PhIP accrued in dyed hair from volunteers on a semicontr

45 els of PhIP were comparable to the levels of PhIP accrued in hair of subjects with natural hair color

46 hosphatase and tensin homolog, demonstrating PHIP activation in triple-negative melanoma.

47 Using conditions optimized to give the C8-dG-PhIP adduct as the major product, sufficient material wa

48 Our results show that the dG-C8-PhIP adduct can be accommodated in the spacious major gr

49 but unmodified controls, suggesting that the PhIP adduct enhances incorporation of these mismatches.

50 In addition to the C8-dG-PhIP adduct, at least eight polar adducts are found afte

51 G1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others.

52 no-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), an HCA, were associated with a significant 20-30%

53 The sulfonamide adducts of PhIP and 4-ABP were identified, by liquid chromatography

54 rption of PHIP-M1 is comparable with that of PHIP and a moderate to high bioavailability has to be ex

55 osition and biliary and fecal elimination of PhIP and its carcinogenic metabolites and may affect PhI

56 ction for the simultaneous quantification of PHIP and its mammalian and bacterial metabolites N-hydro

57 drug transporters on the pharmacokinetics of PhIP and its metabolites.

58 The limit of quantification (LOQ) values for PhIP and MeIQx were about 5 pg/mL, whereas the LOQ value

59 icrosomes prepared from the human liver; the PhIP and N2-OH-PhIP formed were isolated from the biomat

60 The detection limit of PhIP and N2-OH-PhIP was 1 and 10 pg, respectively.

61 LC-ESI/ITMS) method for the determination of PhIP and N2-OH-PhIP.

62 s)), so prediction of the carcinogenicity of PhIP and other HCAs or AAs based primarily on log(k(az)/

63 suggesting that reduced biliary excretion of PhIP and PhIP metabolites leads to increased urinary exc

64 d bacterial metabolites N-hydroxy-PHIP, 4-OH-PHIP and PHIP-M1 in biological samples.

65 PhIP and PhIP@OA did not show significant cytotoxic effe

66 defense against cancer formation induced by PhIP and related HCAs.

67 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and polycyclic aromatic hydrocarbons, such as ben

68 e (PhIP), N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP); and the dG adducts of the NOC 4-(methylnitrosamin

69 mino-1-methyl-6-phenylmidazo[4,5-b]pyridine (PhIP); and the lipid peroxidation products acrolein (AC)

70 between meat and meat mutagens, specifically PhIP, and prostate cancer risk in the Prostate, Lung, Co

71 Heterocyclic aromatic amines such as PHIP are formed during the heat processing of food.

72 These results provide further support for PHIP as a molecular prognostic marker of melanoma, and r

73 to the animal studies, which have implicated PhIP as a prostate carcinogen.

74 particles, including individual particulate PhIP as simulated fumes from meat cooking, were constant

75 ectively, with dyed hair samples spiked with PhIP at 200 and 600 ppt.

76 he mutagenic response to mixtures of BaP and PhIP at concentrations relevant to human exposure (micro

77 dye, the consecutive reaction monitoring of PhIP at the MS(3) scan stage was employed to selectively

78 metric as opposed to purely catalytic use of PHIP-available complexes with an unsaturated payload pre

79 BRWD2/PHIP binds directly to H3K4 methylation through a previo

80 -dG-PhIP oligonucleotide adduct, may contain PhIP bound to the N2 position of guanine.

81 Bcrp1 and Mdr1a limited PhIP brain accumulation.

82 Thus, not only the human metabolites of PHIP but also the bacterial metabolite PHIP-M1 formed in

83 fibroblast cells compared with the dissolved PhIP but clearly induced premature senescence activities

84 LNCaP and LNCaP-GSTP1 cells exposed to N-OH-PhIP, but not parent PhIP, for 24 h showed a dose-depend

85 ddition of the lipid did not seem to produce PhIP by an alternative mechanism because PhIP was formed

86 PHIP by pairwise replacement has the potential to signif

87 This evidence confirms that N-OH-PhIP can be bioactivated to a DNA binding species in hum

88 These results suggest that PhIP can be produced by several alternative reaction pat

89 cules, a long-lived singlet state created by PHIP can be stored for several minutes on protons in hig

90 ers is carried out in a pairwise manner, and PHIP can be used for understanding the activation mechan

91 The use of naturally colored hair containing PhIP can serve as a long-term biomarker of exposure to t

92 parahydrogen-induced polarization (4-6) (NH-PHIP) can also dramatically enhance the sensitivity of z

93 Following metabolic activation, PhIP causes bulky DNA lesions at the C8-position of guan

94 family members differentially regulate BRWD2/PHIP chromatin occupancy.

95 The combined impact of increased PHIP copy number and tumor vascularity on ulceration sta

96 Increased PHIP copy number was an independent predictor of ulcerat

97 Elevated PHIP copy number was associated with significantly reduc

98 PHIP copy number was determined using fluorescence in si

99 -overexpressing melanomas harbored increased PHIP copy number.

100 ckstrin homology domain-interacting protein (PHIP) copy number and its relationship to ulceration.

101 and 17 are frequently gained whereas VPRBP, PHIP, DCAF10, 12 and 15 are frequently lost.

102 In the C8-dG-PhIP-deletion duplex, the smaller size of the aromatic r

103 led ions consistent with a spirobisguanidino-PhIP derivative and a ring-opened adduct.

104 2-347 nm, confirming the presence of PhIP or PhIP derivative.

105 e DNA adduct of PhIP, N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP) was identified in 11 out of 35 patient

106 ,5-b]pyridine (PhIP), N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP); and the dG adducts of the NOC 4-(meth

107 First, we demonstrate that PhIP induced C8-PhIP-dG adducts and DNA strand breaks.

108 Although C8-PhIP-dG adducts are mutagenic, their interference with t

109 The glycosidic torsion angle of the [PhIP]dG residue is syn, and the displaced guanine base i

110 tial reduction in the concentration of MeIQ, PhIP, DiMeIQx, IQ, IQx, and norharman was achieved in ch

111 In rats of different ages, PhIP-DNA adduct levels detected by the (32)P-post-labeli

112 PhIP-DNA adduct levels, adduct removal, and mutation bur

113 e age-related differences in susceptibility, PhIP-DNA adduct levels, mutations, and gene expression w

114 PhIP-DNA adducts also were recovered quantitatively from

115 PhIP-DNA adducts isolated from LNCaP-derived cells and p

116 2)-glucuronide had the lowest level of colon PhIP-DNA adducts.

117 From 3 hours to 6 weeks after PhIP dosing, the number of clones showing altered expres

118 methyl-6-phenylimidazo[4,5-b]pyridine (C8-dG-PhIP), embedded in either full or 'deletion' duplexes (t

119 In 150-day-old rats, PhIP enhanced the expression of genes associated with di

120 Biliary PhIP excretion was reduced 41-fold in Bcrp1;Mdr1a/b;Mrp2

121 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) exhibited a chromosomal instability (CIN), whereas

122 ated in a parahydrogen-induced polarization (PHIP) experiment by a 508-fold enhancement (+/-78) of a

123 Most PHIP experiments, however, are performed on asymmetric m

124 PHIP FISH scores were independently predictive of DMFS (

125 the substrates that can be hyperpolarized by PHIP for biomedical utilization.

126 nts using parahydrogen induced polarization (PHIP) for biomedical and other applications is presented

127 1 cells exposed to N-OH-PhIP, but not parent PhIP, for 24 h showed a dose-dependent decrease in cell

128 as the two additional reactants required for PhIP formation from both phenylacetaldehyde/creati(ni)ne

129 athway is suggested to be the main route for PhIP formation in foods.

130 A general pathway for PhIP formation is proposed.

131 also be considered as a potential inducer of PhIP formation under appropriate conditions.

132 ough unoxidised lipids did not contribute to PhIP formation, their oxidation produced many compounds

133 lipid-derived reactive carbonyls to promote PhIP formation.

134 for 24-144 h at 60 degrees C also increased PhIP formation.

135 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation in mixtures of creatinine, phenylalanine

136 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation, this study analyzes the role of twenty-

137 eased significantly (p < 0.05) the amount of PhIP formed in comparison to the control.

138 red from the human liver; the PhIP and N2-OH-PhIP formed were isolated from the biomatrices by solid-

139 ormaldehyde and ammonia to the production of PhIP from phenylacetaldehyde and creatinine were studied

140 trixes and showed good linearity (40-1000 pg PhIP/g hair) with a goodness-of-fit regression value of

141 The human PHIP gene resides on 6q14.1, and although 6q loss has be

142 PHIP had extensive lymphocytosis marked by massive expan

143 PHIP has been found to be amplified in wild-type melanom

144 PhIP has been found to induce tumors in rats and is a su

145 ftware environment to completely control the PHIP hyperpolarization process including remotely trigge

146 Detection of PHIP hyperpolarized gas by low-field NMR is demonstrated

147 This PHIP hyperpolarizer utilizes an Arduino microcontroller

148 d 5.75 mT parahydrogen induced polarization (PHIP) hyperpolarizer.

149 e assays, which were compared with dissolved PhIP in dimethyl sulfoxide.

150 However, the measurement of PhIP in dyed hair, a cosmetic treatment commonly used by

151 ass spectrometer were employed to biomonitor PhIP in dyed hair.

152 tial contribution of LOP to the formation of PhIP in food products.

153 Stable suppression of PHIP in human melanoma cells resulted in significantly r

154 n of melanoma, whereas stable suppression of Phip in melanoma cell lines suppressed metastatic potent

155 method was successfully employed to measure PhIP in nondyed and dyed hair biospecimens of participan

156 lts describe previously unreported roles for PHIP in predicting and promoting melanoma metastasis, an

157 mined in mammary gland carcinomas induced by PhIP in Sprague-Dawley (SD)xWistar Furth F1 hybrid rats.

158 to the study of the metabolic activation of PhIP in various human tissues.

159 ped with glutathione to induce heterogeneous PHIP in water.

160 rized via parahydrogen-induced polarization (PHIP) in an aqueous solution with signal enhancement of

161 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in both creatinine/phenylalanine (CRN/Phe) and cre

162 namic nuclear polarization NMR spectroscopy (PHIP) in ionic liquids leads to weak or no polarization

163 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the DinB family polymerase, Dpo4, using molecul

164 In this study, for the first time, PhIP-incorporated oleic acid (OA, simulating cooking oil

165 abolically competent) were exposed to BaP or PhIP individually or in mixtures.

166 es versus 194, respectively) suggesting that PhIP induced a cascade of gene expression alterations on

167 First, we demonstrate that PhIP induced C8-PhIP-dG adducts and DNA strand breaks.

168 le of this enzyme in protection against N-OH-PhIP induced DNA damage in prostate carcinogenesis.

169 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced carcinogenesis.

170 ino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP)-induced colon tumors in the rat have increased bet

171 its carcinogenic metabolites and may affect PhIP-induced carcinogenesis as a result.

172 ndirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc

173 g oncogenic mutants of beta-catenin found in PhIP-induced colon tumors.

174 Inhibition of ATR in the presence of PhIP-induced DNA damage strongly promoted the formation

175 PRT exon 3, where a total of 23 (27%) of all PhIP-induced mutations occurred.

176 tions at this locus were not associated with PhIP-induced rat mammary gland cancer.

177 D1/Cdk4, phospho-Rb as a central pathway in PhIP-induced rat mammary gland carcinogenesis.

178 Comparative genomic hybridization of PhIP-induced rat mammary gland carcinomas revealed loss

179 By real time PCR analysis, PhIP-induced rat mammary gland carcinomas showed statist

180 alterations in the proximal region of 2q in PhIP-induced rat mammary gland carcinomas.

181 ohistochemistry (IHC) across a large bank of PhIP-induced SD rat mammary gland carcinomas.

182 In rodents, a high intake of PhIP induces prostate tumors.

183 In contrast, in 43-day-old rats, PhIP inhibited the expression of differentiation genes a

184 Systemic, plasmid-based shRNA targeting of Phip inhibited the metastatic progression of melanoma, w

185 PhIP is an abundant heterocyclic aromatic amine (HCA) an

186 ility of lipid oxidation products to produce PhIP is related to their capacity to induce the Strecker

187 A significant application of PHIP is to generate contrast agents for biomedical imagi

188 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a carcinogenic heterocyclic aromatic amine form

189 Parahydrogen-induced polarization (PHIP) is a method for enhancing NMR sensitivity.

190 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a suspected human breast carcinogen found in co

191 Para-hydrogen-induced polarization (PHIP) is a technique capable of producing spin polarizat

192 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is considered as a human carcinogenic or mutagenic

193 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed during the cooking of various meats.

194 Para-hydrogen induced polarization (PHIP) is particularly suitable, because para-H(2) posses

195 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic aromatic amine f

196 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine, PhIP, is often generated in the highest concentration of

197 largest gas-phase NMR signal enhancement by PHIP known to date.

198 ma, and reveal a significant linkage between PHIP levels and ulceration.

199 venous administration of PhIP (1 mg/kg), the PhIP levels in the small intestine were reduced 4- to 6-

200 ormational exchange is observed in which the PhIP ligand either intercalates into the DNA helix by de

201 helix, whilst in the minor conformation the PhIP ligand is probably solvent exposed.

202 h 6q loss has been observed in melanoma, the PHIP locus was preserved in melanoma cell lines and pati

203 es of PHIP but also the bacterial metabolite PHIP-M1 formed in the gut could contribute to the toxic

204 al metabolites N-hydroxy-PHIP, 4-OH-PHIP and PHIP-M1 in biological samples.

205 rapidly crosses the cell monolayer and that PHIP-M1 is a substrate for P-glycoprotein and the multip

206 The intestinal absorption of PHIP-M1 is comparable with that of PHIP and a moderate t

207 The experiments show that PHIP-M1 rapidly crosses the cell monolayer and that PHIP

208 hod was used to investigate the transport of PHIP-M1 through a Caco-2 cell monolayer.

209 4,5]imidazo[1,2-a]pyri midin-5-ium chloride (PHIP-M1) as main metabolite.

210 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) may contribute to the etiology of human diet-assoc

211 Because the NH-PHIP mechanism is nonreactive, operates in situ, and eli

212 heme iron (1% in diet), heterocyclic amines (PhIP + MeIQx, 50 + 25 mug/kg in diet), and NOC (induced

213 and interday precisions of the estimates of PhIP, MeIQx, and their metabolites, reported as the coef

214 was used to assess the relationship between PhIP metabolism and DNA adduct formation.

215 g that reduced biliary excretion of PhIP and PhIP metabolites leads to increased urinary excretion of

216 risk from exposure to HCAs, the chemistry of PhIP metabolites that presumably react with DNA to initi

217 been shown to inhibit adduction of activated PhIP metabolites to DNA in cell-free systems.

218 Twelve PhIP metabolites were detected in the urine samples.

219 Biliary and small intestine levels of PhIP metabolites were reduced in Bcrp1;Mrp2-deficient mi

220 d DNA adduct formation mediated by activated PhIP metabolites.

221 ey levels and urinary excretion of genotoxic PhIP-metabolites were significantly increased, suggestin

222 In the main conformer, the covalently bound PhIP molecule intercalates in the helix, whilst in the m

223 s that may be caused by a limited release of PhIP molecules from the particulate PhIP.

224 find that although the highly conserved PhiW PhiP motif is the largest determinant of binding, energe

225 ry, we propose a mechanism by which the PhiW PhiP motif of RAM and EBNA2 compete with one another for

226 Interestingly, PHIP mounted efficient innate and adaptive immune respon

227 It produced 32.48 pmol of PhIP/mumol of creatinine in comparison with the 7.92 pmo

228 eatinine in comparison with the 7.92 pmol of PhIP/mumol of creatinine produced by the control phenyla

229 arabinose produced more PhIP (44-46 pmol of PhIP/mumol of creatinine).

230 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP); and the

231 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), N-acetoxy-PhIP, with a single-stranded 11mer olig

232 The DNA adduct of PhIP, N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP) was ident

233 The potential barrier height Phip-n is an enhanced tuning factor, and Phip-p is a sel

234 enotype and high levels of urinary N-hydroxy-PhIP-N(2)-glucuronide had the lowest level of colon PhIP

235 The levels of urinary N-hydroxy-PhIP-N(2)-glucuronide were negatively correlated to colo

236 t metabolite in all volunteers was N-hydroxy-PhIP-N(2)-glucuronide.

237 on site because of the location of the bulky PhIP-N-methyl and phenyl ring in the minor groove; this

238 ge in molecular structure, producing intense PHIP NMR signals on the alkene.

239 hydrogenation catalysts can yield detectable PHIP NMR signals.

240 eriments, parahydrogen induced polarization (PHIP) NMR, and comparison with a molecular analog.

241 PhIP and PhIP@OA did not show significant cytotoxic effects on SH

242 ted oleic acid (OA, simulating cooking oil) (PhIP@OA) particles, including individual particulate PhI

243 ursor for parahydrogen-induced polarization (PHIP) of 1-(13)C-phospholactate-d2, is reported.

244 adduct, which has the same mass as the C8-dG-PhIP oligonucleotide adduct, may contain PhIP bound to t

245 the epidemiological observations implicating PhIP, one of the most mass-abundant heterocyclic aromati

246 range 342-347 nm, confirming the presence of PhIP or PhIP derivative.

247 lic derivative will inhibit the formation of PhIP, or not, based on its structure.

248 In addition, a high proportion of PHIP-overexpressing melanomas harbored increased PHIP co

249 PHIP-overexpressing melanomas include tumors with wild-t

250 ght Phip-n is an enhanced tuning factor, and Phip-p is a selective tuning factor.

251 The PhIP phenyl ring interacts with the phosphodiester-sugar

252 when at the Earth's magnetic field) from the PHIP polarizer to the 47.5 mT low-field MRI.

253 Mixtures of BaP and PhIP produced dose responses different from those of the

254 ole of twenty-five phenolic compounds on the PhIP produced in phenylalanine/creatinine/oxidised lipid

255 eased significantly (p < 0.05) the amount of PhIP produced, while histidine, cysteine, lysine, trypto

256 d lipid increased considerably the amount of PhIP produced.

257 ckstrin homology domain-interacting protein (PHIP), promotes melanoma metastasis, can be used to clas

258 olox-equivalents (MeIQx, R(2)=0.85, p<0.001; PhIP, R(2)=0.83, p<0.001) was found.

259 However, the PhIP ring system on the minor groove side would seriousl

260 oped a phage immunoprecipitation sequencing (PhIP-Seq) methodology to identify known and previously u

261 d metal catalysts were not expected to yield PHIP signals given the rapid diffusion of H atoms on the

262 The PHIP study of this system leads to unusual and unexpecte

263 in previous ASD candidates (ARHGAP32, NCOR1, PHIP, STXBP1, CDKL5 and SHANK1).

264 igher than in previous aqueous heterogeneous PHIP systems are presented.

265 PhIP, the most prevalent heterocyclic aromatic amine for

266 Humans are exposed to PhIP through ingestion of well-done cooked meats, and th

267 ols showed that enzymatic activation of N-OH-PhIP to a DNA binding species was dependent on ATP and c

268 2)H, and para-hydrogen induced polarization (PHIP) transfer NMR spectroscopy revealed cis-hydrogenati

269 ned from para-hydrogen induced polarization (PHIP) transfer NMR studies revealed that the pairwise hy

270 nd parahydrogen (p-H2) induced polarization (PHIP) transfer NMR studies to elucidate catalytically re

271 amined in glands from 43-day and 150-day-old PhIP-treated rats.

272 ver, cDNA microarray analysis indicated that PhIP treatment differentially altered the profile of gen

273 In proliferating cells, PhIP treatment increased the frequency of stalled replic

274 e and enhanced chromosomal aberrations after PhIP treatment, while ATM and DNA-PK inhibition had only

275 Here, we analyzed PhIP-triggered replicative stress and elucidated the rol

276 PHIP undergoes bacterial metabolism leading to 7-hydroxy

277 o 0.08 ng/g), 4,8-DiMeIQx (up to 4.95 ng/g), PhIP (up to 6.24 ng/g) and AalphaC (up to 0.20 ng/g) wer

278 The detection limit of PhIP and N2-OH-PhIP was 1 and 10 pg, respectively.

279 The limit of quantification (LOQ) of PhIP was 84 parts-per-trillion (ppt) employing 50 mg of

280 h MeIQx and DiMeIQx, the highest quintile of PhIP was associated with a 1.2-fold increased risk of pr

281 uce PhIP by an alternative mechanism because PhIP was formed analogously in both CRN/Phe and CRN/Phe/

282 ng/g and in fish 44.06 +/- 1.499 ng/g while PhIP was found in higher amount in mutton 40.21 +/- 0.65

283 PhIP was incubated with microsomes prepared from the hum

284 PhIP was not formed before 240 degrees C except in chick

285 Although PhIP was produced to some extent in the CRN/Phe system,

286 Fecal excretion of PhIP was reduced 8- to 20-fold in knockouts.

287 of PhIP, N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP) was identified in 11 out of 35 patients, at levels

288 Parahydrogen-induced polarization (PHIP) was used to demonstrate the concept that highly po

289 ino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), was used to assess the relationship between PhIP

290 man prostate tissue cultures exposed to N-OH-PhIP were analyzed by liquid chromatography/electrospray

291 d feeding study who ingested known levels of PhIP were comparable to the levels of PhIP accrued in ha

292 The content of MeIQx and PhIP were significantly reduced by approx. 57% and 90% (

293 Twenty primary HCMV-infected patients (PHIP) were enrolled, as well as 26 HCMV-seronegative and

294 rposely made into CIN cells are resistant to PhIP, whereas MIN cells are resistant to MNNG.

295 fy an evolutionarily conserved factor, BRWD2/PHIP, which colocalizes with histone H3K4 methylation ge

296 as an independent variable predict log m for PhIP with good accuracy in both TA 98 and TA 100.

297 dducts are found after reaction of N-acetoxy-PhIP with the oligonucleotide.

298 enylimidazo[4,5-b]pyridine (PhIP), N-acetoxy-PhIP, with a single-stranded 11mer oligodeoxyribonucleot

299 yde and ammonia were simultaneously present, PhIP yield was multiplied by fifty and the Ea of the rea

300 ixture of phenylacetaldehyde and creatinine, PhIP yield was multiplied by nineteen.