ライフサイエンスコーパス: Photofrin

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1 than sulfonated dithiaporphyrin 30, HPPH, or Photofrin.

2 of HSP-70 for all photosensitizers including Photofrin.

3 ficantly lower for bacteriochlorins than for Photofrin.

4 Tumor-bearing mice were administered Photofrin (5 mg/kg) 24 h before PDT illumination at 75 m

5 kill in vitro at a lower concentration than Photofrin [5.7 mg (9 micromol)/kg].

6 Our results showed almost similar uptake of photofrin after 24 h in different glioblastoma cells, bu

7 AG in human BT-474 breast cancer cells using Photofrin and NPe6 as photosensitizers.

8 ar to the response in animals given 10 mg/kg Photofrin and the same light dose (20%).

9 after DMXAA plus low-dose PDT (1.5 mg.kg(-1) Photofrin) appeared to be dependent on TNF-alpha because

10 ) of 694 nm light was comparable to PDT with Photofrin at 2.5 mg (4 micromol)/kg and 135 J cm(-2) of

11 Further, photofrin based PDT followed by miR-99a transfection dra

12 Photofrin based PDT induced apoptosis, inhibited cell in

13 Western blotting showed that photofrin based PDT was efficient to block the angiogene

14 lts indicated that the anti-tumor effects of photofrin based PDT was strongly augmented by miR-99a ov

15 the molecular mechanisms how the efficacy of photofrin based photodynamic therapy (PDT) was enhanced

16 tosensitization conditions with a porphyrin (Photofrin)-based sensitizer failed to induce a cellular

17 gated the activity of DMXAA as a modifier of Photofrin-based PDT of implanted murine RIF-1 tumors.

18 e cells were more sensitive to radiation and photofrin doses than p53 mutant cells.

19 following an affinity of the photosensitizer Photofrin for collagen-containing vascular basement memb

20 mouse feet after low-dose PDT (1.5 mg.kg(-1) Photofrin); however, there was some enhancement of norma

21 at longer wavelengths than either TPPS(4) or Photofrin (lambda(max) of 630 nm for both).

22 pared with controls such as the FDA-approved Photofrin (LD(50) approximately 10 microM) and clinicall

23 ndard clinical treatment conditions (1 mg/kg Photofrin, light at 630 nm and 150 mW/cm2), which are hi

24 nce in response to systemically administered Photofrin, measured noninvasively using an in vivo fluor

25 Photofrin-mediated PDT combined with either celecoxib or

26 the present study, we evaluated the role of Photofrin-mediated PDT in eliciting expression of matrix

27 ble BA mouse mammary carcinoma, we show that Photofrin-mediated PDT induced expression of the hypoxia

28 nduced fibrosarcoma tumors were treated with Photofrin-mediated PDT to a total dose of 135 J/cm(2), d

29 Control animals received EF3 alone, EF3 plus Photofrin, or EF3 plus illumination.

30 2) was measured immediately before and after Photofrin-PDT (135 J/cm(2), 38 mW/cm(2)).

31 Photofrin (PF), 10 mg/kg, was injected by tail vein, and

32 The porphyrin-based photosensitizer Photofrin, the only Food and Drug Administration-approve

33 in 2, sulfonated thiaporphyrin 30, HPPH, and Photofrin were also evaluated against Colo-26 cells in c

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