ライフサイエンスコーパス: Piwi-interacting RNA

1 A (miRNA), short-interfering RNA (siRNA) and Piwi-interacting RNA.

2 obile genetic elements, acting together with Piwi-interacting RNAs.

3 RNA intermediates to achieve optimally sized piwi-interacting RNAs.

4 enomenon to paramutation that is mediated by piwi-interacting RNAs.

5 widespread non-coding RNAs such as microRNA, Piwi-interacting RNA and antisense RNAs.

6 nd micro-RNA pathways; whereas PIWIs bind to PIWI-interacting RNAs and regulate germ line development

7 RNAs analogous to Drosophila TE silencing by PIWI-interacting RNAs and siRNAs.

8 is of some small RNAs (sRNAs), including the PIWI-interacting RNAs and some microRNAs.

9 fs that are overrepresented in comparison to Piwi-interacting RNAs and transcription start site-assoc

10 Piwi-interacting RNAs are restricted to the gonad, and a

11 Piwi-interacting RNAs are small regulatory RNAs with key

12 r-dependent miRNAs and the Dicer-independent Piwi-interacting RNAs, associate with Argonaute family p

13 A second endogenous small RNA class, the Piwi-interacting RNAs, bind Piwi proteins and suppress t

14 , these results define PNLDC1 as a mammalian piwi-interacting RNA biogenesis factor that protects the

15 ce, here we show that PNLDC1 is required for piwi-interacting RNA biogenesis, transposon silencing, a

16 have shown that proteins involved in piRNA (PIWI-interacting RNA) biogenesis are necessary for retro

17 ld), known epigenetic regulators (2.3-fold), piwi-interacting RNA clusters (3.6-fold) and curated tra

18 ansposable element spread and the associated piwi-interacting RNAs defense mechanisms.

19 elfish genetic elements in the soma, much as Piwi-interacting RNAs do in the germ line.

20 ll as a large population of putative piRNAs (piwi-interacting RNAs) had dynamic accumulation profiles

21 d small interfering RNAs (siRNAs) in plants, Piwi-interacting RNAs in animals and siRNAs in Drosophil

22 nsion, leading to severe reduction of mature piwi-interacting RNAs in the testis.

23 The Piwi-interacting RNA interference pathway plays an impor

24 ng RNAs requires a critical step of trimming piwi-interacting RNA intermediates to achieve optimally

25 rimming and causes accumulation of untrimmed piwi-interacting RNA intermediates with 3' end extension

26 previously that Piwi plays a crucial role in Piwi-interacting RNA-mediated epigenetic regulation and

27 ring RNAs (siRNAs)--and we refer to them as 'Piwi-interacting RNAs' or piRNAs.

28 uted to the nuage proteins, which engage the Piwi-interacting RNA pathway and other posttranscription

29 ion in stabilization of RNP granules and the Piwi-interacting RNA pathway.

30 "cancer/testis antigens" (CTAs), and piRNA (PIWI-interacting RNA) pathway proteins are found among C

31 ally interacts with components of the piRNA (piwi-interacting RNA) pathway.

32 are sterile, and phenocopy mutations in the PIWI interacting RNA (piRNA) pathway, which silences tra

33 The Piwi protein subfamily is essential for Piwi-interacting RNA (piRNA) biogenesis, transposon sile

34 nsposon insertions negatively correlate with Piwi-interacting RNA (piRNA) levels for most transposon

35 In recent years, the Piwi-interacting RNA (piRNA) pathway also has been impli

36 mutant animals, we probed the roles of known Piwi-interacting RNA (piRNA) pathway components in the i

37 The Piwi-interacting RNA (piRNA) pathway defends the germlin

38 spite exciting progress in understanding the Piwi-interacting RNA (piRNA) pathway in the germ line, l

39 The PIWI-interacting RNA (piRNA) pathway is a conserved defe

40 The Piwi-interacting RNA (piRNA) pathway is a small RNA-base

41 The PIWI-interacting RNA (piRNA) pathway is essential for re

42 The Piwi/Piwi-interacting RNA (piRNA) pathway protects the germli

43 , to participate in the previously described PIWI-interacting RNA (piRNA) pathway that promotes trans

44 facets-1)(Kr(If-1)) allele, we show that the Piwi-interacting RNA (piRNA) pathway, but not the short

45 ermline-specific RNAi mechanism known as the Piwi-interacting RNA (piRNA) pathway, which specifically

46 efense mechanism targeting TEs is termed the Piwi-interacting RNA (piRNA) pathway.

47 The Piwi-interacting RNA (piRNA) proteins Aubergine and Argo

48 uman extracellular RNAs including microRNAs, piwi-interacting RNA (piRNA), and small nucleolar RNAs.

49 erfering RNA (siRNA), micro-RNA (miRNA), and piwi-interacting RNA (piRNA), play important roles in ma

50 f proteins containing tudor domains with the piwi-interacting RNA (piRNA)-binding Piwi proteins, and

51 binds the histone ubiquitin ligase RNF8 in a Piwi-interacting RNA (piRNA)-independent manner, and MIW

52 The Piwi-interacting RNA (piRNA)-interacting protein Mili wa

53 NAs map within annotated genes, but some are PIWI-interacting RNA (piRNA)-like and map to piRNA clust

54 singly, zuc/MitoPLD activity is required for Piwi-interacting RNA (piRNA)-mediated silencing of trans

55 PIWI-directed gene silencing, we employed a Piwi-interacting RNA (piRNA)-targeted reporter assay in

56 nterfering RNA (siRNA), microRNA (miRNA) and piwi-interacting RNA (piRNA).

57 on a 180-kb heterochromatic locus producing Piwi-interacting RNAs (piRNA cluster), the flamenco (fla

58 Piwi-interacting RNAs (piRNA) are small regulatory RNAs

59 P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) represent a class of sma

60 croRNAs, small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs and rasiRNAs).

61 fection: short interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs) [1, 2].

62 lencing effectors for approximately 26-32 nt Piwi-interacting RNAs (piRNAs) [1], and piwi mutants exh

63 complex class of small noncoding RNAs called Piwi-interacting RNAs (piRNAs) [8].

64 Small RNAs called PIWI-interacting RNAs (piRNAs) act as an immune system t

65 include small interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs) and are implicated in nuc

66 ermore, we showed that tsRNAs are similar to Piwi-interacting RNAs (piRNAs) and demonstrated that ts-

67 The PIWI proteins bind to PIWI-interacting RNAs (piRNAs) and function in epigeneti

68 In Drosophila, Piwi proteins associate with Piwi-interacting RNAs (piRNAs) and protect the germline

69 Recently, 25- to 31-nt PIWI-interacting RNAs (piRNAs) and repeat-associated siR

70 ures our current understandings of mammalian PIWI-interacting RNAs (piRNAs) and their role in TE regu

71 Piwi-interacting RNAs (piRNAs) are 26-30-nucleotide germ

72 Piwi-interacting RNAs (piRNAs) are a class of short ( 26

73 Piwi-interacting RNAs (piRNAs) are a class of small non-

74 Piwi-interacting RNAs (piRNAs) are a new class of small

75 Piwi-interacting RNAs (piRNAs) are approximately 24-30 n

76 Piwi-interacting RNAs (piRNAs) are approximately 30 nucl

77 Piwi proteins and Piwi-interacting RNAs (piRNAs) are essential for gametog

78 Piwi proteins and Piwi-interacting RNAs (piRNAs) are essential for germ ce

79 Piwi-interacting RNAs (piRNAs) are essential for silenci

80 PIWI proteins and their bound PIWI-interacting RNAs (piRNAs) are found in animal germl

81 Piwi-interacting RNAs (piRNAs) are gonad-specific small

82 Piwi proteins and their bound Piwi-interacting RNAs (piRNAs) are predominantly express

83 PIWI-interacting RNAs (piRNAs) are responsible for maint

84 PIWI-interacting RNAs (piRNAs) are small non-coding RNAs

85 PIWI-interacting RNAs (piRNAs) are small noncoding RNAs

86 Piwi-interacting RNAs (piRNAs) are small RNAs required t

87 Short deletions over sites with homology to PIWI-interacting RNAs (piRNAs) are sufficient to comprom

88 PIWI-interacting RNAs (piRNAs) are thought to silence tr

89 Here, we examine piwi-interacting RNAs (piRNAs) associated with each Dros

90 Piwi-interacting RNAs (piRNAs) comprise a broad class of

91 In Drosophila ovarian germ cells, PIWI-interacting RNAs (piRNAs) direct Aubergine and Argo

92 Piwi-interacting RNAs (piRNAs) engage Piwi proteins to s

93 interfering RNAs (siRNAs) as well as animal piwi-interacting RNAs (piRNAs) from degradation and 3' t

94 PIWI-interacting RNAs (piRNAs) guide PIWI proteins to su

95 The conserved Piwi family of proteins and piwi-interacting RNAs (piRNAs) have a central role in ge

96 ince their discovery less than a decade ago, Piwi-interacting RNAs (piRNAs) have been shown to repres

97 Piwi-interacting RNAs (piRNAs) have emerged as central p

98 In a broad range of organisms, Piwi-interacting RNAs (piRNAs) have emerged as core comp

99 Piwi-interacting RNAs (piRNAs) help defend host genomes

100 iRNAs), small interfering RNAs (siRNAs), and piwi-interacting RNAs (piRNAs) impact numerous biologica

101 We also report detection of virus-derived PIWI-interacting RNAs (piRNAs) in Drosophila melanogaste

102 dentification and characterization of 12,903 Piwi-interacting RNAs (piRNAs) in Drosophila, showing th

103 ssion of retrotranspons with the presence of piwi-interacting RNAs (piRNAs) in fetal male germ cells

104 p to low-copy, intergenic regions similar to PIWI-interacting RNAs (piRNAs) in mammalian testis.

105 Fang et al. now reveal a set of Piwi-interacting RNAs (piRNAs) in Oxytricha trifallax th

106 oding RNAs (sncRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs) in particular, define sev

107 Endogenous siRNAs (endo-siRNAs) and Piwi-interacting RNAs (piRNAs) mainly control gene and t

108 Piwi Argonautes and Piwi-interacting RNAs (piRNAs) mediate genome defense by

109 Piwi-interacting RNAs (piRNAs) of approximately 23 to 30

110 PIWI-interacting RNAs (piRNAs) play a crucial role in tr

111 Germline-specific Piwi-interacting RNAs (piRNAs) protect animal genomes ag

112 PIWI-interacting RNAs (piRNAs) protect the animal germ l

113 PIWI-interacting RNAs (piRNAs) protect the germ line by

114 azoan germline, piwi proteins and associated piwi-interacting RNAs (piRNAs) provide a defense system

115 Small noncoding piwi-interacting RNAs (piRNAs) recognize and silence a d

116 These Piwi-interacting RNAs (piRNAs) represent a distinct smal

117 Piwi proteins and Piwi-interacting RNAs (piRNAs) repress transposable elem

118 Piwi proteins and Piwi-interacting RNAs (piRNAs) repress transposition, re

119 Piwi-interacting RNAs (piRNAs) silence these genome path

120 Piwi-interacting RNAs (piRNAs) silence transposons and m

121 Piwi-interacting RNAs (piRNAs) silence transposons in an

122 PIWI-interacting RNAs (piRNAs) silence transposons in an

123 mall interfering RNAs) and Piwi proteins and Piwi-interacting RNAs (piRNAs) suggest novel functions f

124 ughters show a markedly different content of Piwi-interacting RNAs (piRNAs) targeting each element, d

125 RNAs) and siRNAs, whereas the latter targets piwi-interacting RNAs (piRNAs) that are 2'-O-methylated

126 vered a class of noncoding small RNAs called PIWI-interacting RNAs (piRNAs) that are abundantly expre

127 n Piwi proteins, MIWI and MILI, partner with Piwi-interacting RNAs (piRNAs) that are depleted of repe

128 Piwi proteins bind to Piwi-interacting RNAs (piRNAs) that are generally 26 to

129 ound approximately 23- to 30-nucleotide (nt) PIWI-interacting RNAs (piRNAs) that are processed from s

130 amily proteins, carry approximately 24-30-nt Piwi-interacting RNAs (piRNAs) that mediate gonadal defe

131 PIWI-interacting RNAs (piRNAs), 23-36 nt small silencing

132 y 29 to 30 nucleotides in length, are called Piwi-interacting RNAs (piRNAs), 94% of which map to 100

133 Recently it was discovered that PIWI-interacting RNAs (piRNAs), a class of small RNA mol

134 Piwi Argonaute protein PRG-1 and associated Piwi-interacting RNAs (piRNAs), as well as by proteins t

135 A third class of small RNAs, Piwi-interacting RNAs (piRNAs), defends the genome from

136 ous small interfering RNAs (endo-siRNAs) and Piwi-interacting RNAs (piRNAs), have been shown to play

137 on the role of small RNAs, and in particular piwi-interacting RNAs (piRNAs), in the epigenetic regula

138 Piwi-interacting RNAs (piRNAs), long thought to be restr

139 ous small interfering RNAs (endo-siRNAs) and Piwi-interacting RNAs (piRNAs), play essential roles in

140 iRNAs, other bilaterian small RNAs, known as Piwi-interacting RNAs (piRNAs), protect the genome from

141 Animal germ cells produce PIWI-interacting RNAs (piRNAs), small silencing RNAs tha

142 UTE/PIWI protein family member that binds to Piwi-interacting RNAs (piRNAs), strongly and specificall

143 TEs) in flies and vertebrates is mediated by Piwi-interacting RNAs (piRNAs), which are approximately

144 e numerous long noncoding RNAs (lncRNAs) and Piwi-interacting RNAs (piRNAs), yet the functions of the

145 th a specific class of small noncoding RNAs, piwi-interacting RNAs (piRNAs).

146 his inhibition is thought to occur via small Piwi-interacting RNAs (piRNAs).

147 small RNAs in the mouse male germline termed piwi-interacting RNAs (piRNAs).

148 We have therefore named these Piwi-interacting RNAs (piRNAs).

149 us small-interfering RNAs (endo-siRNAs), and piwi-interacting RNAs (piRNAs).

150 in concert with their small RNA guides, the Piwi-interacting RNAs (piRNAs).

151 nd silencing recently exemplified by piRNAs (piwi-interacting RNAs), position effect variegation, X-c

152 The production of mature piwi-interacting RNAs requires a critical step of trimmi

153 The discovery of millions of PIWI-interacting RNAs revealed a fascinating and unantic

154 Piwi-piRNA (Piwi-interacting RNA) ribonucleoproteins (piRNPs) enforc

155 the mechanism of biogenesis for tRNA-derived Piwi-interacting RNAs (td-piRNAs) expressed in Bombyx Bm

156 Pnldc1 mutation in mice inhibits piwi-interacting RNA trimming and causes accumulation of

157 e family deadenylase PNLDC1 is implicated in piwi-interacting RNA trimming in silkworms.

158 re matched by small regulatory RNAs, such as piwi-interacting RNAs, which play a potent role in both