ライフサイエンスコーパス: Polycomb

1 ge priming, in a process that exploits novel polycomb activities.

2 s, potentially accounting for enhancement of Polycomb activity, and suggesting that AEBP2 normally pl

3 ranscriptional modulator, which impacts both Polycomb and active gene transcription in mammalian cell

4 nd suggest a functional intersection between Polycomb and AR signaling in CRPC.

5 eukemias revealed that KDM2B cooperates with polycomb and trithorax complexes to regulate differentia

6 tic modifying genes, most prominently in the polycomb and trithorax families.

7 es) and variants in transcription, repressed Polycomb, and enhancer regions, as well as identify five

8 s, which target the 3' UTR of EZH2 and other Polycomb-associated transcripts.

9 ation, and the added repressive influence of polycomb at a subset of CG-dense cis-regulatory sequence

10 Here, we identified an additional Polycomb-binding lncRNA, COLDWRAP.

11 munication between PRC1 and PRC2, repressive Polycomb chromatin domains can erode, rendering target g

12 expression and function of the non-canonical polycomb complex 1 (PRC1) subunit RYBP.

13 Bayesian network analysis connects RBFox2 to Polycomb complex 2 (PRC2) and H3K27me3, and biochemical

14 X disrupts SWI/SNF complex inhibition of the polycomb complex 2 (PRC2) methyltransferase Enhancer of

15 amming and found that reducing levels of the polycomb complex gene Bmi1 significantly enhanced induct

16 In Arabidopsis AtVRN2 is a key member of a Polycomb complex involved in stable repression of Arabid

17 One of the proteins of the Polycomb complex is the Ring finger protein 1 (RING1).

18 The Polycomb complex often binds to lncRNAs in eukaryotes, a

19 Though the polycomb complex proteins are thought to primarily regul

20 We find that the polycomb complex proteins BMI1 and RING1A regulate the u

21 The polycomb complex proto-oncogene BMI1 [B lymphoma Mo-MLV

22 , which codes for a catalytic subunit of the polycomb complex.

23 Polycomb complexes are central to this memory, but many

24 is epigenetically silenced by the repressive Polycomb complexes in growing cells but is activated in

25 -directed chromatin recruitment of mammalian Polycomb complexes is a fundamental component of epigene

26 Gene silencing by Polycomb complexes is central to eukaryotic development.

27 e repression, notably through recruitment of Polycomb complexes, and has long been considered essenti

28 s, suggesting cooperativity between Brg1 and Polycomb complexes.

29 for further analyses of the role of distinct Polycomb components in the control of gene expression pr

30 es, which involve specialization of distinct Polycomb components to deliver first metastable then lon

31 ed into three functionally distinct modules: Polycomb, Core, and Myc.

32 roliferation in the developing epidermis via Polycomb-dependent and -independent SUMO E3 ligase activ

33 rosophila and co-occupies PREs to antagonize Polycomb-dependent silencing.

34 lleles, as defined by differential levels of Polycomb-dependent trimethylation of histone H3 Lys27 (f

35 LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) binds Polycomb-deposited H3K27me3 and is required for repressi

36 study identifies a novel mechanism by which Polycomb directs the developmental process by activating

37 blish precedence for H2AK119u1 in initiating Polycomb domain formation in a physiological context.

38 ions is critical for the formation of stable Polycomb domains at target gene loci.

39 mpeting forces, such as the self-assembly of polycomb domains within the nucleus.

40 links PRC1 and PRC2 in the establishment of Polycomb domains.

41 roles via altering nucleosome stability, at polycomb-enriched bivalent genes the same remodellers ac

42 mity assay, we find that BAF directly evicts Polycomb factors within minutes of its occupancy, thereb

43 stable epigenetic silencing through separate Polycomb factors, which spread across the locus after co

44 ite instability, IDH1 mutation, 19p gain and polycomb features, and backbone demethylation with chrom

45 ex combs (Asx), a regulator of trithorax and polycomb function in Drosophila.

46 phenotype, normally linked to antagonism of Polycomb function.

47 estion of how noncoding RNAs are involved in Polycomb group (PcG) and Trithorax group (TrxG) regulati

48 upports a model in which CpG islands recruit Polycomb group (PcG) complexes; however, which subset of

49 ed by epigenetic regulators belonging to the Polycomb Group (PcG) protein family.

50 ere found most often in association with the polycomb group (PcG) protein Polycomb (Pc), a subunit of

51 Polycomb Group (PcG) proteins are epigenetic repressors

52 Polycomb group (PcG) proteins are responsible for mainta

53 Polycomb Group (PcG) proteins assemble a chromatin state

54 sheds light on how nuclear organization and Polycomb group (PcG) proteins contribute to epigenetical

55 Polycomb group (PcG) proteins function as chromatin-base

56 The Polycomb group (PcG) proteins modulate nucleosomes to ma

57 Regulatory decisions in Drosophila require Polycomb group (PcG) proteins to maintain the silent sta

58 regulation is the balanced activities of the Polycomb group (PcG) proteins within the PRC1 and PRC2 c

59 h INK4A and MIR31HG genomic regions and with Polycomb group (PcG) proteins, and that MIR31HG is requi

60 that regulate genome architecture, including Polycomb group (PcG) proteins, form subnuclear structure

61 s regulated gene silencing is carried out by Polycomb group (PcG) proteins, which must be correctly r

62 d Pol II and enriched with promoter-proximal Polycomb Group (PcG) proteins, yet lacking the classical

63 l modulator that maintains downregulation of Polycomb Group (PcG) target genes in lhp1 mutants, while

64 latory genes require stable silencing by the polycomb group (PcG) to prevent misexpression during dif

65 this screen, CAT7, regulates expression and polycomb group binding at the MNX1 locus during early ne

66 Here we report that Piwi interacts with Polycomb group complexes PRC1 and PRC2 in niche and germ

67 m chromatin and found candidates that impact polycomb group protein (PcG)-regulated gene expression i

68 ever, constitutive repression of CCN3 by the Polycomb group protein EZH2 disrupted this negative feed

69 ogenesis is to suppress transcription of the Polycomb group protein, EZH2, thereby de-repressing gene

70 Polycomb group proteins (PcG) are transcriptional repres

71 Polycomb group proteins and associated histone marks are

72 The Polycomb group proteins and the associated H3K27me3 hist

73 The Polycomb group proteins are transcriptional repressors t

74 miR-16 levels down-regulated BMI1 and other polycomb group proteins like RING1A, RING1B, EZH2 and al

75 Polycomb Group regulation in Arabidopsis (Arabidopsis th

76 Here, we show that the noncanonical Polycomb group RING finger 3/5 (PCGF3/5)-PRC1 complex in

77 Here, we show that the PRC1 component polycomb group ring finger 6 (Pcgf6) is required to main

78 using on promoter CpG sites that localize to Polycomb group target genes that are unmethylated in 11

79 effects on gene expression, particularly of polycomb group target genes.

80 The Polycomb group transcriptional repressor Bmi-1 often ove

81 mutations affect BAP1 interactions with the Polycomb group-like protein, ASXL2, using combinations o

82 alysis of Polycomblike revealed that loss of Polycomb group-mediated repression of the Hox gene Abdom

83 ansitions between trithorax-group (TrxG) and polycomb-group (PcG) chromatin states are vital for the

84 Polycomb-group (PcG) proteins function to ensure correct

85 -binding of histone deacetylases (HDACs) and Polycomb-group (PcG) proteins.

86 Polycomb-group proteins control many fundamental biologi

87 eversible chromatin interactions mediated by Polycomb-group proteins play an important role in these

88 tioning in Arabidopsis thaliana We show that Polycomb-group proteins repress nucellus degeneration be

89 ppression as an alternative to regulation by Polycomb-group proteins, which coordinate embryonic germ

90 rast, regions associated with the repressive Polycomb-Group showed low turnover in ESCs.

91 silenced in the T-cell lineage, and that the polycomb H3K27me3-repressive mark is focally diminished

92 nescence is epigenetically controlled by the polycomb histone methyltransferase enhancer of zeste hom

93 gene repression, highlighting a key role for Polycomb in Xist-dependent chromosome silencing.

94 Here we define the Xist RNA Polycomb Interaction Domain (XR-PID), a 600 nt sequence

95 Polycomb-like (PCL) proteins, such as PHF1, MTF2 and PHF

96 We find that intragenic levels of the polycomb mark H3K27me3 anti-correlate with changes in tr

97 chromatin changes include initial repressive polycomb marking of genes, later manifesting abnormal DN

98 to find that actively transcribed genes with Polycomb marks have greater cell-to-cell variation in ex

99 enovirus E1A, modulate cellular responses to polycomb-mediated epigenetic methylations in human papil

100 NG 6 (REF6, also known as JMJ12) counteracts Polycomb-mediated gene silencing by removing methyl grou

101 hanism of an H3K27 demethylase to counteract Polycomb-mediated gene silencing that regulates plant de

102 ghlights that H3K9me3 and, most importantly, polycomb-mediated H3K27me3 chromatin pathways can secure

103 These data extend the knowledge of polycomb-mediated regulation of gene expression to endot

104 MADS box transcription factor relieves this Polycomb-mediated repression and therefore allows nucell

105 spread enhancer activation and opposition of Polycomb-mediated repression at bivalent promoters.

106 In conclusion, MDM2 supports the Polycomb-mediated repression of lineage-specific genes,

107 Brg1 is also required to maintain Polycomb-mediated repression of non-mesodermal developme

108 on through pharmacological inhibition of the polycomb-mediated repression system.

109 hed by increased CG dinucleotide density and polycomb-mediated repression, manifested by the addition

110 ation was not dependent upon the presence of polycomb-mediated repression.

111 tone H3 at lysine 27 (H3K27ac), which blocks Polycomb-mediated trimethylation of H3K27 (H3K27me3).

112 The Polycomb module represses developmental genes, while the

113 zes at chromatin with members of the Myc and Polycomb module.

114 To identify novel factors involved in the Polycomb pathway in plants, we performed a forward genet

115 epigenomic pathway in which reversal of the Polycomb pathway of repressive histone methylation is re

116 iation with the polycomb group (PcG) protein Polycomb (Pc), a subunit of polycomb repressive complex

117 development is subject to regulation by the Polycomb (Pc), Trithorax (Trx), and Compass chromatin mo

118 The Polycomb PRC1 plays essential roles in development and d

119 ically, VEC exerts this effect by inhibiting polycomb protein activity on the specific gene promoters

120 Disruption of gene silencing by Polycomb protein complexes leads to homeotic transformat

121 rate that a specific interaction between the polycomb protein EZH2 and RNA made from B2 SINE retrotra

122 this issue, Zovoilis et al. report that the polycomb protein EZH2, upon heat shock, facilitates tran

123 Polycomb proteins are critical chromatin modifiers that

124 Polycomb proteins are involved in specific transcription

125 e ribosomal serine/threonine kinase S6K1 and Polycomb proteins at genomic regulatory regions to repre

126 Polycomb proteins interact with each other to form chrom

127 , we identified expression of BMI1 and other Polycomb proteins not previously identified in olfactory

128 n, in this study, we discover that these two polycomb proteins regulate the transcription of active g

129 remodeling and carcinogenesis, together with Polycomb proteins.

130 tion according to which, in the naive state, polycomb recessive complex 2 repressed the IRAK-M promot

131 27 (H3K27) methyltransferase and part of the polycomb recessive complex 2, enhancer of Zeste 2, resul

132 Our findings overturn existing models for Polycomb recruitment by Xist RNA and establish precedenc

133 Our findings define a key pathway for Polycomb recruitment by Xist RNA, providing important in

134 Polycomb recruitment is initiated by the PCGF3/5-PRC1 co

135 Deletion of XR-PID abolishes Xist-dependent Polycomb recruitment, in turn abrogating Xist-mediated g

136 king XR-PID is sufficient for Xist-dependent Polycomb recruitment.

137 , inducing both repression and activation of polycomb-regulated loci.

138 h as super-enhancers, bivalent promoters and Polycomb repressed regions, and identify additional patt

139 ucleosome-Secured Regions (NSRs) occupied by polycomb-repressed chromatin played a role in repressing

140 ptionally active and inactive chromatin, the Polycomb-repressed domains are characterized by a high d

141 Polycomb-repressed domains show the densest packing and

142 Moreover, compared to inactive domains, Polycomb-repressed domains spatially exclude neighbourin

143 rs in the dorsal ectoderm is associated with Polycomb-repressed H3K27me3 chromatin.

144 Polycomb-repressed Hox domains are shown by the same app

145 s into transcriptionally active, inactive or Polycomb-repressed states, and observed distinct chromat

146 uction of de novo superenhancers antagonizes Polycomb repression and superimposes aberrant stem-epith

147 Our findings identify reversal of polycomb repression as a key step in gene activation aft

148 Enhancer of Zeste [E(z)], a component of the Polycomb repression complex 2 (PRC2), is required to mai

149 rikingly insensitive to OGA RNAi at sites of polycomb repression such as the Hox and NK homeobox gene

150 ylation convergently impacted Wnt signaling, Polycomb repression, innate immune cell interactions and

151 Polycomb Repressive Complex (PRC) 2 catalyzes the H3K27m

152 The dependency on the polycomb repressive complex (PRC2) and EZH2 represents o

153 BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and emerging data s

154 In multicellular organisms, Polycomb Repressive Complex 1 (PRC1) and PRC2 repress ta

155 egration site 1 (BMI1) is a component of the polycomb repressive complex 1 (PRC1) complex that is ove

156 e of these sites are binding sites for other Polycomb repressive complex 1 (PRC1) components, others

157 The essential functions of polycomb repressive complex 1 (PRC1) in development and

158 The polycomb repressive complex 1 (PRC1) is a multi-subunit

159 tone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex 1 (PRC1) is defined by the c

160 The polycomb repressive complex 1 (PRC1), containing the cor

161 CBX2, a component of the mammalian Polycomb repressive complex 1 (PRC1), contains a compact

162 We identified UbE2E1 as a novel component of Polycomb repressive complex 1 (PRC1), the E3 ligase comp

163 Subunits of polycomb repressive complex 1 (PRC1), the major histone

164 BMI1 is a component of the Polycomb Repressive Complex 1 (PRC1), which plays a key

165 fferent CBX proteins associate with the core Polycomb repressive complex 1 (PRC1).

166 up (PcG) protein Polycomb (Pc), a subunit of polycomb repressive complex 1 (PRC1).

167 corresponded to locations bound by canonical polycomb repressive complex 1 (PRC1).

168 that Cbx4/2, Rybp, and Ring1B [components of polycomb repressive complex 1 (PRC1)] are predominantly

169 K27 methylation leads to a redistribution of polycomb repressive complex 1 and de-repression of its t

170 ation is linked to the silencing of Scml2, a Polycomb Repressive Complex 1 protein that drives loss o

171 that recognizes CpG islands and recruits the polycomb repressive complex 1.

172 ation blocks nucleation of plant homeodomain-Polycomb repressive complex 2 (PHD-PRC2) and indicates a

173 In hepatocytes, EpCAM is silenced by polycomb repressive complex 2 (PRC2) and ZNF198/LSD1/Co-

174 ermethylated phenotype, mainly occupying the polycomb repressive complex 2 (PRC2) binding sites in hu

175 Polycomb repressive complex 2 (PRC2) catalyzes histone H

176 Polycomb Repressive Complex 2 (PRC2) catalyzes the trime

177 ds to the transient recruitment of EZH2, the polycomb repressive complex 2 (PRC2) component responsib

178 referential dependency on genes encoding the polycomb repressive complex 2 (PRC2) components EZH2, EE

179 Polycomb repressive complex 2 (PRC2) controls maintenanc

180 Polycomb repressive complex 2 (PRC2) has been shown to p

181 Polycomb repressive complex 2 (PRC2) is a histone methyl

182 Polycomb repressive complex 2 (PRC2) is a key chromatin

183 Polycomb repressive complex 2 (PRC2) is an essential reg

184 Polycomb repressive complex 2 (PRC2) is responsible for

185 The Polycomb repressive complex 2 (PRC2) mainly mediates tra

186 Polycomb repressive complex 2 (PRC2) mediates gene silen

187 Polycomb repressive complex 2 (PRC2) methylates lysine 2

188 Polycomb repressive complex 2 (PRC2) modifies chromatin

189 Polycomb repressive complex 2 (PRC2) participates in tra

190 lycomb response elements (PREs), that direct Polycomb repressive complex 2 (PRC2) placement at develo

191 lly considered to promote transcription, and Polycomb Repressive Complex 2 (PRC2) places K27me3, whic

192 repressive complex 2 in cell fate decisions.Polycomb repressive complex 2 (PRC2) plays an essential

193 The polycomb repressive complex 2 (PRC2) regulates different

194 Polycomb repressive complex 2 (PRC2) silences gene expre

195 , but there is a clear lack of the essential Polycomb Repressive Complex 2 (PRC2) subunit EED in the

196 enzymes that catalyze H3K27me3, namely, the polycomb repressive complex 2 (PRC2) subunits enhancer o

197 omologue 2 or 1) is the catalytic subunit of polycomb repressive complex 2 (PRC2) that catalyzes meth

198 histone methyltransferase is a member of the polycomb repressive complex 2 (PRC2) that is highly expr

199 represses SMN2 expression by recruiting the Polycomb Repressive Complex 2 (PRC2) to its locus.

200 ctivity-based communication between PRC1 and Polycomb repressive complex 2 (PRC2) which is required f

201 y activating specific genes, silenced by the Polycomb repressive complex 2 (PRC2), and identify the c

202 etermined to have physical interactions with Polycomb repressive complex 2 (PRC2), and systematically

203 homologue 2 (EZH2), the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), contributes to mai

204 MLL1 and H3K4me2, H3K27me3 levels, a mark of Polycomb repressive complex 2 (PRC2), increase at these

205 e 12 homologue (SUZ12), which is a domain of Polycomb repressive complex 2 (PRC2), promoting the meth

206 er of zeste homolog 2 (EZH2), a component of polycomb repressive complex 2 (PRC2), to inhibit c-Met e

207 issociation of EZH2 and SUZ12, components of polycomb repressive complex 2 (PRC2), transcriptional ac

208 Here we show that polycomb repressive complex 2 (PRC2), which supports neu

209 Here, we show that, in mESCs, the Polycomb repressive complex 2 (PRC2)-associated protein

210 ZH2 exerts its oncogenic function is through polycomb repressive complex 2 (PRC2)-mediated gene repre

211 accompanied by a reduction in the levels of polycomb repressive complex 2 (PRC2)-mediated H3K27 trim

212 G1, was previously known for its function in polycomb repressive complex 2 (PRC2)-mediated transcript

213 ML, via transcription repression mediated by Polycomb repressive complex 2 (PRC2).

214 Polycomb repressive complex 2 (PRC2-EZH2) methylates his

215 Polycomb repressive complex 2 and the epigenetic mark th

216 Polycomb repressive complex 2 deficiency impaired clonal

217 Here, we show that a subset of Polycomb repressive complex 2 factors nucleate silencing

218 suggested that in the crystal structure of a polycomb repressive complex 2 from Chaetomium thermophil

219 the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophil

220 Here we report that knockout of polycomb repressive complex 2 genes in human embryonic s

221 age- and pluripotent state-specific roles of polycomb repressive complex 2 in cell fate decisions.Pol

222 opmental transcription factor genes bound by Polycomb repressive complex 2 in human embryonic stem ce

223 the roles of the distinct components of the Polycomb repressive complex 2 in the control of skin dev

224 In contrast, polycomb repressive complex 2 is dispensable for pluripo

225 androgen receptor signaling and induction of Polycomb Repressive Complex 2 signaling.

226 atalytic activity of the enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), forming re

227 the conditional ablations of three essential Polycomb repressive complex 2 subunits (EED, Suz12, or E

228 e homolog 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 that mediates histone H3 l

229 KSHV genome and contributed to tethering of polycomb repressive complex 2 through physical interacti

230 of H3K27 methyltransferases or of the PRC2 (Polycomb Repressive Complex 2) by pharmaceutical inhibit

231 of zeste homolog 2, the catalytic subunit of polycomb repressive complex 2, and MEF2C-dependent gene

232 lncOL1 interacts with Suz12, a component of polycomb repressive complex 2, to promote oligodendrocyt

233 d Ezh1/2 function largely as subunits of the Polycomb repressive complex 2, which is important in the

234 RC2)-associated protein EPOP (Elongin BC and Polycomb Repressive Complex 2-associated protein; a.k.a.

235 We further show that polycomb repressive complex 2-deficient mouse embryonic

236 These results demonstrate a dual role for polycomb repressive complex 2-mediated epigenetic silenc

237 without invoking the increased enrichment of Polycomb Repressive Complex 2.

238 including homeobox genes and targets of the Polycomb repressive complex 2.

239 Interestingly, targets of polycomb repressive complex in stem cells were mostly af

240 It is likely that the role of Polycomb repressive complex is to dampen expression of t

241 EZH2 is a component of the multi-subunit polycomb repressive complex PRC2, and the down-regulatio

242 and beta-catenin, which contribute to PRC2 (polycomb repressive complex-2) binding to promoter regio

243 SMN expression by recruiting the epigenetic Polycomb repressive complex-2.

244 We find that Polycomb repressive complex-active genes have greater ce

245 to S-nitrosylate RING1A, a key member of the polycomb repressive complex.

246 with LIKE HETEROCHROMATIN PROTEIN1 (LHP1), a Polycomb Repressive Complex1 (PRC1) subunit.

247 We studied POLYCOMB REPRESSIVE COMPLEX2 (PRC2) in Brassicaceae.

248 zeste 12 homolog (SUZ12), a core subunit of Polycomb repressive complex2 (PRC2), undergoes proteasom

249 Polycomb repressive complexes (PRC) are frequently impli

250 The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF)

251 Polycomb repressive complexes (PRCs) are important histo

252 Polycomb repressive complexes (PRCs) are key to normal d

253 mplexes, are known to oppose the activity of Polycomb repressive complexes (PRCs).

254 m chromatin-associated repressive complexes (Polycomb repressive complexes 1 and 2) leading to chroma

255 r regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is

256 The Polycomb repressive complexes PRC1 and PRC2 are key medi

257 Recruitment of the Polycomb repressive complexes PRC1 and PRC2 by Xist RNA

258 The Polycomb repressive complexes PRC1 and PRC2 play a centr

259 This is followed by dissociation of the polycomb repressive complexes, including the H3K27 methy

260 iated, at least in part, by cooperation with Polycomb repressive complexes.

261 ysine 119 (H2AK119Ub1) as a component of the Polycomb repressive deubiquitination (PR-DUB) complex.

262 Here we show that Polycomb-repressive complex 1 (PRC1) directs timely acti

263 mplex (referred to as the DOT1L complex) and polycomb-repressive complex 1 (PRC1).

264 x (CBX)-containing proteins CBX4 and CBX6 of polycomb-repressive complex 1 through the removal of K48

265 rotease 26 in cellular reprogramming through polycomb-repressive complex 1.The ubiquitin-proteasome s

266 Cdkn2a locus and directly interacts with the Polycomb-repressive complex 2 (PRC2) to enable H3K27me3-

267 omolog 2 (EZH2), an enzymatic subunit of the polycomb-repressive complex 2 and the main writer of chr

268 The Polycomb-repressive complexes PRC1 and PRC2 play a key r

269 ation and gene silencing, as a member of the polycomb repressor 2 (PRC2) complex.

270 es also responded to the inactivation of the Polycomb Repressor Complex 2 (PRC2) and its catalytic co

271 Polycomb repressor complex 2 (PRC2) places the histone m

272 Jarid2 is a component of the Polycomb Repressor complex 2 (PRC2), which is responsibl

273 pressed H3K27Me3 and effectively reactivated polycomb repressor complex 2 (PRC2)-silenced tumor suppr

274 ctly interacts with the catalytic subunit of polycomb repressor complex 2 (PRC2).

275 ZIC2 interacts with and maintains polycomb repressor complex 2 at the K-Rta promoter.

276 2, a histone methyl transferase subunit of a Polycomb repressor complex, is recurrently mutated in se

277 Here we show that the polycomb repressor protein Bmi1 marks a population of ca

278 Polycomb response elements (PREs) are specific DNA seque

279 we define short genomic fragments, known as Polycomb response elements (PREs), that direct Polycomb

280 b is required for targeting PRC complexes to Polycomb Response Elements (PREs).

281 ted to DNA via cis-acting elements known as "Polycomb response elements" (PREs).

282 TBP-bound promoters along with promoters of polycomb-silenced genes apparently lacking TBP.

283 ver, the mechanisms underlying opposition to Polycomb silencing are poorly understood.

284 Polycomb silencing at FLC thus has mechanistically disti

285 rminants that specify the genomic targets of Polycomb silencing complexes are still unclear.

286 results indicate that vernalization-mediated Polycomb silencing is coordinated by lncRNAs in a cooper

287 Polycomb silencing of Arabidopsis FLOWERING LOCUS C (FLC

288 Here we demonstrate that ENL overcomes polycomb silencing through recruitment of PAF1 via the c

289 unity to study initiation and maintenance of Polycomb silencing.

290 In this issue, Mardaryev et al. show that Polycomb subunit Cbx4 acts downstream of transcriptional

291 identify important methylated genes (such as polycomb target genes and genes involved in transcriptio

292 27me3 and is required for repression of many Polycomb target genes in Arabidopsis Here we show that L

293 RNA binding of PRC2, and their enrichment at Polycomb target genes provides a means for RNA-mediated

294 's developmental trajectory or identity as a polycomb target.

295 pathway, and key driver analyses showed that Polycomb targets contribute significantly to the non-gen

296 ng astrocytes identifies changes at multiple polycomb targets, including the promoter of Foxo3 In pat

297 se regions and alleviates repression of some polycomb telomeric genes.

298 tes, and an lncRNA, COLDAIR, associates with Polycomb to mediate silencing of the floral repressor FL

299 These observations link polycomb with dynamic changes in transcription and stall

300 complex recruitment is sufficient to oppose Polycomb within minutes, leading to activation of bivale