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2 s, potentially accounting for enhancement of Polycomb activity, and suggesting that AEBP2 normally pl
3 ranscriptional modulator, which impacts both Polycomb and active gene transcription in mammalian cell
5 eukemias revealed that KDM2B cooperates with polycomb and trithorax complexes to regulate differentia
7 es) and variants in transcription, repressed Polycomb, and enhancer regions, as well as identify five
9 ation, and the added repressive influence of polycomb at a subset of CG-dense cis-regulatory sequence
11 munication between PRC1 and PRC2, repressive Polycomb chromatin domains can erode, rendering target g
13 Bayesian network analysis connects RBFox2 to Polycomb complex 2 (PRC2) and H3K27me3, and biochemical
14 X disrupts SWI/SNF complex inhibition of the polycomb complex 2 (PRC2) methyltransferase Enhancer of
15 amming and found that reducing levels of the polycomb complex gene Bmi1 significantly enhanced induct
16 In Arabidopsis AtVRN2 is a key member of a Polycomb complex involved in stable repression of Arabid
24 is epigenetically silenced by the repressive Polycomb complexes in growing cells but is activated in
25 -directed chromatin recruitment of mammalian Polycomb complexes is a fundamental component of epigene
27 e repression, notably through recruitment of Polycomb complexes, and has long been considered essenti
29 for further analyses of the role of distinct Polycomb components in the control of gene expression pr
30 es, which involve specialization of distinct Polycomb components to deliver first metastable then lon
32 roliferation in the developing epidermis via Polycomb-dependent and -independent SUMO E3 ligase activ
34 lleles, as defined by differential levels of Polycomb-dependent trimethylation of histone H3 Lys27 (f
35 LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) binds Polycomb-deposited H3K27me3 and is required for repressi
36 study identifies a novel mechanism by which Polycomb directs the developmental process by activating
37 blish precedence for H2AK119u1 in initiating Polycomb domain formation in a physiological context.
41 roles via altering nucleosome stability, at polycomb-enriched bivalent genes the same remodellers ac
42 mity assay, we find that BAF directly evicts Polycomb factors within minutes of its occupancy, thereb
43 stable epigenetic silencing through separate Polycomb factors, which spread across the locus after co
44 ite instability, IDH1 mutation, 19p gain and polycomb features, and backbone demethylation with chrom
47 estion of how noncoding RNAs are involved in Polycomb group (PcG) and Trithorax group (TrxG) regulati
48 upports a model in which CpG islands recruit Polycomb group (PcG) complexes; however, which subset of
50 ere found most often in association with the polycomb group (PcG) protein Polycomb (Pc), a subunit of
54 sheds light on how nuclear organization and Polycomb group (PcG) proteins contribute to epigenetical
57 Regulatory decisions in Drosophila require Polycomb group (PcG) proteins to maintain the silent sta
58 regulation is the balanced activities of the Polycomb group (PcG) proteins within the PRC1 and PRC2 c
59 h INK4A and MIR31HG genomic regions and with Polycomb group (PcG) proteins, and that MIR31HG is requi
60 that regulate genome architecture, including Polycomb group (PcG) proteins, form subnuclear structure
61 s regulated gene silencing is carried out by Polycomb group (PcG) proteins, which must be correctly r
62 d Pol II and enriched with promoter-proximal Polycomb Group (PcG) proteins, yet lacking the classical
63 l modulator that maintains downregulation of Polycomb Group (PcG) target genes in lhp1 mutants, while
64 latory genes require stable silencing by the polycomb group (PcG) to prevent misexpression during dif
65 this screen, CAT7, regulates expression and polycomb group binding at the MNX1 locus during early ne
67 m chromatin and found candidates that impact polycomb group protein (PcG)-regulated gene expression i
68 ever, constitutive repression of CCN3 by the Polycomb group protein EZH2 disrupted this negative feed
69 ogenesis is to suppress transcription of the Polycomb group protein, EZH2, thereby de-repressing gene
74 miR-16 levels down-regulated BMI1 and other polycomb group proteins like RING1A, RING1B, EZH2 and al
78 using on promoter CpG sites that localize to Polycomb group target genes that are unmethylated in 11
81 mutations affect BAP1 interactions with the Polycomb group-like protein, ASXL2, using combinations o
82 alysis of Polycomblike revealed that loss of Polycomb group-mediated repression of the Hox gene Abdom
83 ansitions between trithorax-group (TrxG) and polycomb-group (PcG) chromatin states are vital for the
87 eversible chromatin interactions mediated by Polycomb-group proteins play an important role in these
88 tioning in Arabidopsis thaliana We show that Polycomb-group proteins repress nucellus degeneration be
89 ppression as an alternative to regulation by Polycomb-group proteins, which coordinate embryonic germ
91 silenced in the T-cell lineage, and that the polycomb H3K27me3-repressive mark is focally diminished
92 nescence is epigenetically controlled by the polycomb histone methyltransferase enhancer of zeste hom
97 chromatin changes include initial repressive polycomb marking of genes, later manifesting abnormal DN
98 to find that actively transcribed genes with Polycomb marks have greater cell-to-cell variation in ex
99 enovirus E1A, modulate cellular responses to polycomb-mediated epigenetic methylations in human papil
100 NG 6 (REF6, also known as JMJ12) counteracts Polycomb-mediated gene silencing by removing methyl grou
101 hanism of an H3K27 demethylase to counteract Polycomb-mediated gene silencing that regulates plant de
102 ghlights that H3K9me3 and, most importantly, polycomb-mediated H3K27me3 chromatin pathways can secure
104 MADS box transcription factor relieves this Polycomb-mediated repression and therefore allows nucell
105 spread enhancer activation and opposition of Polycomb-mediated repression at bivalent promoters.
109 hed by increased CG dinucleotide density and polycomb-mediated repression, manifested by the addition
111 tone H3 at lysine 27 (H3K27ac), which blocks Polycomb-mediated trimethylation of H3K27 (H3K27me3).
114 To identify novel factors involved in the Polycomb pathway in plants, we performed a forward genet
115 epigenomic pathway in which reversal of the Polycomb pathway of repressive histone methylation is re
116 iation with the polycomb group (PcG) protein Polycomb (Pc), a subunit of polycomb repressive complex
117 development is subject to regulation by the Polycomb (Pc), Trithorax (Trx), and Compass chromatin mo
119 ically, VEC exerts this effect by inhibiting polycomb protein activity on the specific gene promoters
121 rate that a specific interaction between the polycomb protein EZH2 and RNA made from B2 SINE retrotra
122 this issue, Zovoilis et al. report that the polycomb protein EZH2, upon heat shock, facilitates tran
125 e ribosomal serine/threonine kinase S6K1 and Polycomb proteins at genomic regulatory regions to repre
127 , we identified expression of BMI1 and other Polycomb proteins not previously identified in olfactory
128 n, in this study, we discover that these two polycomb proteins regulate the transcription of active g
130 tion according to which, in the naive state, polycomb recessive complex 2 repressed the IRAK-M promot
131 27 (H3K27) methyltransferase and part of the polycomb recessive complex 2, enhancer of Zeste 2, resul
132 Our findings overturn existing models for Polycomb recruitment by Xist RNA and establish precedenc
135 Deletion of XR-PID abolishes Xist-dependent Polycomb recruitment, in turn abrogating Xist-mediated g
138 h as super-enhancers, bivalent promoters and Polycomb repressed regions, and identify additional patt
139 ucleosome-Secured Regions (NSRs) occupied by polycomb-repressed chromatin played a role in repressing
140 ptionally active and inactive chromatin, the Polycomb-repressed domains are characterized by a high d
142 Moreover, compared to inactive domains, Polycomb-repressed domains spatially exclude neighbourin
145 s into transcriptionally active, inactive or Polycomb-repressed states, and observed distinct chromat
146 uction of de novo superenhancers antagonizes Polycomb repression and superimposes aberrant stem-epith
148 Enhancer of Zeste [E(z)], a component of the Polycomb repression complex 2 (PRC2), is required to mai
149 rikingly insensitive to OGA RNAi at sites of polycomb repression such as the Hox and NK homeobox gene
150 ylation convergently impacted Wnt signaling, Polycomb repression, innate immune cell interactions and
155 egration site 1 (BMI1) is a component of the polycomb repressive complex 1 (PRC1) complex that is ove
156 e of these sites are binding sites for other Polycomb repressive complex 1 (PRC1) components, others
159 tone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex 1 (PRC1) is defined by the c
162 We identified UbE2E1 as a novel component of Polycomb repressive complex 1 (PRC1), the E3 ligase comp
168 that Cbx4/2, Rybp, and Ring1B [components of polycomb repressive complex 1 (PRC1)] are predominantly
169 K27 methylation leads to a redistribution of polycomb repressive complex 1 and de-repression of its t
170 ation is linked to the silencing of Scml2, a Polycomb Repressive Complex 1 protein that drives loss o
172 ation blocks nucleation of plant homeodomain-Polycomb repressive complex 2 (PHD-PRC2) and indicates a
174 ermethylated phenotype, mainly occupying the polycomb repressive complex 2 (PRC2) binding sites in hu
177 ds to the transient recruitment of EZH2, the polycomb repressive complex 2 (PRC2) component responsib
178 referential dependency on genes encoding the polycomb repressive complex 2 (PRC2) components EZH2, EE
190 lycomb response elements (PREs), that direct Polycomb repressive complex 2 (PRC2) placement at develo
191 lly considered to promote transcription, and Polycomb Repressive Complex 2 (PRC2) places K27me3, whic
192 repressive complex 2 in cell fate decisions.Polycomb repressive complex 2 (PRC2) plays an essential
195 , but there is a clear lack of the essential Polycomb Repressive Complex 2 (PRC2) subunit EED in the
196 enzymes that catalyze H3K27me3, namely, the polycomb repressive complex 2 (PRC2) subunits enhancer o
197 omologue 2 or 1) is the catalytic subunit of polycomb repressive complex 2 (PRC2) that catalyzes meth
198 histone methyltransferase is a member of the polycomb repressive complex 2 (PRC2) that is highly expr
200 ctivity-based communication between PRC1 and Polycomb repressive complex 2 (PRC2) which is required f
201 y activating specific genes, silenced by the Polycomb repressive complex 2 (PRC2), and identify the c
202 etermined to have physical interactions with Polycomb repressive complex 2 (PRC2), and systematically
203 homologue 2 (EZH2), the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), contributes to mai
204 MLL1 and H3K4me2, H3K27me3 levels, a mark of Polycomb repressive complex 2 (PRC2), increase at these
205 e 12 homologue (SUZ12), which is a domain of Polycomb repressive complex 2 (PRC2), promoting the meth
206 er of zeste homolog 2 (EZH2), a component of polycomb repressive complex 2 (PRC2), to inhibit c-Met e
207 issociation of EZH2 and SUZ12, components of polycomb repressive complex 2 (PRC2), transcriptional ac
210 ZH2 exerts its oncogenic function is through polycomb repressive complex 2 (PRC2)-mediated gene repre
211 accompanied by a reduction in the levels of polycomb repressive complex 2 (PRC2)-mediated H3K27 trim
212 G1, was previously known for its function in polycomb repressive complex 2 (PRC2)-mediated transcript
218 suggested that in the crystal structure of a polycomb repressive complex 2 from Chaetomium thermophil
219 the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophil
221 age- and pluripotent state-specific roles of polycomb repressive complex 2 in cell fate decisions.Pol
222 opmental transcription factor genes bound by Polycomb repressive complex 2 in human embryonic stem ce
223 the roles of the distinct components of the Polycomb repressive complex 2 in the control of skin dev
226 atalytic activity of the enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), forming re
227 the conditional ablations of three essential Polycomb repressive complex 2 subunits (EED, Suz12, or E
228 e homolog 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 that mediates histone H3 l
229 KSHV genome and contributed to tethering of polycomb repressive complex 2 through physical interacti
230 of H3K27 methyltransferases or of the PRC2 (Polycomb Repressive Complex 2) by pharmaceutical inhibit
231 of zeste homolog 2, the catalytic subunit of polycomb repressive complex 2, and MEF2C-dependent gene
232 lncOL1 interacts with Suz12, a component of polycomb repressive complex 2, to promote oligodendrocyt
233 d Ezh1/2 function largely as subunits of the Polycomb repressive complex 2, which is important in the
234 RC2)-associated protein EPOP (Elongin BC and Polycomb Repressive Complex 2-associated protein; a.k.a.
236 These results demonstrate a dual role for polycomb repressive complex 2-mediated epigenetic silenc
241 EZH2 is a component of the multi-subunit polycomb repressive complex PRC2, and the down-regulatio
242 and beta-catenin, which contribute to PRC2 (polycomb repressive complex-2) binding to promoter regio
248 zeste 12 homolog (SUZ12), a core subunit of Polycomb repressive complex2 (PRC2), undergoes proteasom
254 m chromatin-associated repressive complexes (Polycomb repressive complexes 1 and 2) leading to chroma
255 r regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is
259 This is followed by dissociation of the polycomb repressive complexes, including the H3K27 methy
261 ysine 119 (H2AK119Ub1) as a component of the Polycomb repressive deubiquitination (PR-DUB) complex.
264 x (CBX)-containing proteins CBX4 and CBX6 of polycomb-repressive complex 1 through the removal of K48
265 rotease 26 in cellular reprogramming through polycomb-repressive complex 1.The ubiquitin-proteasome s
266 Cdkn2a locus and directly interacts with the Polycomb-repressive complex 2 (PRC2) to enable H3K27me3-
267 omolog 2 (EZH2), an enzymatic subunit of the polycomb-repressive complex 2 and the main writer of chr
270 es also responded to the inactivation of the Polycomb Repressor Complex 2 (PRC2) and its catalytic co
273 pressed H3K27Me3 and effectively reactivated polycomb repressor complex 2 (PRC2)-silenced tumor suppr
276 2, a histone methyl transferase subunit of a Polycomb repressor complex, is recurrently mutated in se
279 we define short genomic fragments, known as Polycomb response elements (PREs), that direct Polycomb
286 results indicate that vernalization-mediated Polycomb silencing is coordinated by lncRNAs in a cooper
290 In this issue, Mardaryev et al. show that Polycomb subunit Cbx4 acts downstream of transcriptional
291 identify important methylated genes (such as polycomb target genes and genes involved in transcriptio
292 27me3 and is required for repression of many Polycomb target genes in Arabidopsis Here we show that L
293 RNA binding of PRC2, and their enrichment at Polycomb target genes provides a means for RNA-mediated
295 pathway, and key driver analyses showed that Polycomb targets contribute significantly to the non-gen
296 ng astrocytes identifies changes at multiple polycomb targets, including the promoter of Foxo3 In pat
298 tes, and an lncRNA, COLDAIR, associates with Polycomb to mediate silencing of the floral repressor FL
300 complex recruitment is sufficient to oppose Polycomb within minutes, leading to activation of bivale
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