ライフサイエンスコーパス: Polycomb group

1 as a trithorax group factor that counteracts Polycomb group action in Arabidopsis (Arabidopsis thalia

2 this screen, CAT7, regulates expression and polycomb group binding at the MNX1 locus during early ne

3 The polycomb group complex regulates downstream factors, e.g

4 Previously, we showed that a Polycomb group complex, PRC1, remains continuously assoc

5 One Polycomb group complex, the PRC2 complex, is composed of

6 rabidopsis thaliana) is under control of the polycomb group complex, which includes Fertilization Ind

7 Suz12 is a component of the Polycomb group complexes 2, 3, and 4 (PRC 2/3/4).

8 , we find that subunits of the PRC1 and PRC2 polycomb group complexes are similarly required for DSB-

9 Deregulation of polycomb group complexes polycomb repressive complex 1 (

10 d repressive histone modifications) bound by Polycomb group complexes PRC1 (Polycomb-repressive compl

11 Here we report that Piwi interacts with Polycomb group complexes PRC1 and PRC2 in niche and germ

12 components of the Trithorax/COMPASS-like and Polycomb group complexes together with histone arginine

13 E2F6 is a component of polycomb group complexes, which bind to silenced chromat

14 Polycomb-group complexes repress the locus in lung tumor

15 e genes, characterized by recruitment of the polycomb group enhancer of zeste homolog 2 methyltransfe

16 The Polycomb group family member Bmi1 is overexpressed in nu

17 Bmi-1 is a member of the Polycomb group family of proteins that function in the e

18 The polycomb group family protein BMI-1 is overexpressed by

19 enic self-renewal capacity that requires the Polycomb group family transcription repressor Bmi-1.

20 ndings underscore the importance of Asxl1 in Polycomb group function, development, and hematopoiesis.

21 Deregulation of the polycomb group gene BMI-1 is implicated in the pathogene

22 The Polycomb Group gene Eed is required to establish this di

23 two maize homologs of the single Arabidopsis Polycomb Group gene FIE.

24 1 gene on chromosome 7p15 to 3' exons of the Polycomb group gene JJAZ1/SUZ12 on chromosome 17q11 and

25 Mouse embryos lacking the polycomb group gene member Yin-Yang1 (YY1) die during th

26 mouse modelling data demonstrating that the polycomb group gene SUZ12 functions as tumour suppressor

27 CLF is a Polycomb Group gene, and the clf-59 mutant protein conta

28 Polycomb group genes (PcGs) have been implicated in canc

29 re, we extend the connection between OGT and Polycomb group genes from flies to mammals, showing Poly

30 la polyhomeotic (ph) is one of the important polycomb group genes that is linked to human cancer.

31 e FERTILIZATION-INDEPENDENT SEED (FIS) class Polycomb group genes, the endosperm fails to cellularize

32 xpression in response to the derepression of Polycomb group genes.

33 mors and caused a rapid decrease in the Ezh2 Polycomb group histone H3K27 methyltransferase and an in

34 mutations affect BAP1 interactions with the Polycomb group-like protein, ASXL2, using combinations o

35 ific miRNAs are either tightly controlled by polycomb group-mediated H3K27me3 or maintained in a semi

36 tin conformation within IRER is regulated by polycomb group-mediated histone modifications.

37 alysis of Polycomblike revealed that loss of Polycomb group-mediated repression of the Hox gene Abdom

38 s a plant-specific gene that participates in Polycomb group-mediated transcriptional repression of ta

39 over an early developmental function for the Polycomb group member Bmi1 in supporting PrE lineage for

40 We show that polycomb group members are recruited by poly(ADP ribose)

41 BMI1 is a member of the Polycomb group of chromatin-modifier proteins that is es

42 The Polycomb group of epigenetic enzymes represses expressio

43 x 2 (PRC2) comprises specific members of the Polycomb group of epigenetic modulators.

44 The Polycomb group of proteins (PcG) is important for transc

45 Scml2 is a member of the Polycomb group of proteins involved in epigenetic gene s

46 s, including activation of miR-190, miR-214, polycomb group of proteins, as well as DNA methylation.

47 Members of the Polycomb group of repressors and trithorax group of acti

48 insertion region-1 (BMI1) is a member of the polycomb group of transcription repressors, which functi

49 are structural homologues that belong to the Polycomb group of transcriptional regulators and are bel

50 The Trithorax and Polycomb groups of chromatin regulators are critical for

51 Here, we show that Polycomb-group (Pc-G) proteins, which mediate epigenetic

52 Tightly balanced antagonism between the Polycomb group (PcG) and the Trithorax group (TrxG) comp

53 maintenance of these patterns depends on the Polycomb group (PcG) and trithorax group (trxG) complexe

54 Polycomb group (PcG) and trithorax Group (trxG) proteins

55 Polycomb Group (PcG) and Trithorax Group (TrxG) proteins

56 Polycomb group (PcG) and trithorax group (trxG) proteins

57 The highly-conserved Polycomb group (PcG) and trithorax group (trxG) proteins

58 estion of how noncoding RNAs are involved in Polycomb group (PcG) and Trithorax group (TrxG) regulati

59 We identify silencers of the Polycomb group (PcG) as principal contributors to this m

60 The genomic binding sites of Polycomb group (PcG) complexes have been found to cluste

61 activity of EZH2, a component of repressive Polycomb Group (PcG) complexes like PRC2, is increased o

62 Polycomb group (PcG) complexes PRC1 and PRC2 are well kn

63 Polycomb group (PcG) complexes such as PRC1 mediate tran

64 emodeling complexes counteract repression by Polycomb group (PcG) complexes to sustain active express

65 upports a model in which CpG islands recruit Polycomb group (PcG) complexes; however, which subset of

66 erference (RNAi) protein Argonaute-1 (AGO1), Polycomb group (PcG) component EZH2, and tri-methyl hist

67 Here, we show that a Polycomb group (PcG) component, Enhancer of Zeste [E(z)]

68 nt is mediated by the opposing activities of Polycomb group (PcG) factors and trithorax group (trxG)

69 table repression of these domains depends on Polycomb Group (PcG) functions, which include trimethyla

70 Trithorax group (trxG) and Polycomb group (PcG) gene products are part of an evolut

71 The polycomb group (PcG) genes are epigenetic suppressors of

72 Here we show that Polycomb group (PcG) genes are required for maintenance

73 The polycomb group (PcG) genes encode a family of proteins t

74 Here, we uncover a role of Polycomb Group (PcG) genes in the temporally precise rep

75 ing of terminal differentiation genes by the Polycomb group (PcG) machinery is emerging as a key feat

76 pmental gene silencing through the so-called Polycomb Group (PcG) mechanism.

77 The Polycomb Group (PcG) of chromatin modifiers regulates pl

78 s of development and differentiation are the Polycomb group (PcG) of proteins, organized in the nucle

79 g cell senescence; shed light on the role of polycomb group (PcG) protein Bmi-1 in senescence.

80 miR-31 was accompanied by repression of the polycomb group (PcG) protein BMI1 and induction of cellu

81 The Polycomb group (PcG) protein BMI1 is a key factor in reg

82 The Polycomb group (PcG) protein Bmi1 is an essential epigen

83 The Polycomb group (PcG) protein BMI1 is essential for the a

84 histone methyltransferase and component of a Polycomb group (PcG) protein complex, represses Ink4a/Ar

85 nconventional mechanism of repression by the Polycomb group (PcG) protein Enhancer of zeste [E(Z)], w

86 The Polycomb Group (PcG) protein EZH2 is a critical componen

87 F1 was previously shown to interact with the Polycomb group (PcG) protein Ezh2, a histone methyltrans

88 analysis we identified SLIT2 as a target of polycomb group (PcG) protein EZH2.

89 ed by epigenetic regulators belonging to the Polycomb Group (PcG) protein family.

90 mphoma Mo-MLV insertion region 1 (Bmi1) is a Polycomb Group (PcG) protein important in gene silencing

91 ere found most often in association with the polycomb group (PcG) protein Polycomb (Pc), a subunit of

92 er that is remarkably similar to that of the Polycomb group (PcG) protein Suz12.

93 Conditional knock-out (KO) of Polycomb Group (PcG) protein YY1 results in pro-B cell a

94 of this approach is demonstrated by using a Polycomb group (PcG) protein, Enhancer of Zeste (EZH2),

95 chromatin remodeling complex, as well as the Polycomb Group (PcG) protein-like fly tumor suppressor,

96 Methylated H3K27 is an important mark for Polycomb group (PcG) protein-mediated transcriptional ge

97 ion of Ezh2, a histone methyltransferase and Polycomb group (PcG) protein.

98 nscriptional regulator, while EMF2 encodes a Polycomb group (PcG) protein.

99 monstrated that DFO1 interacts with the rice polycomb group (PcG) proteins (OsMSI1 and OsiEZ1).

100 Polycomb group (PcG) proteins are best known for their r

101 Polycomb group (PcG) proteins are chromatin modifiers th

102 Polycomb Group (PcG) proteins are crucial for epigenetic

103 Polycomb Group (PcG) proteins are epigenetic repressors

104 The Polycomb group (PcG) proteins are epigenetic suppressors

105 Polycomb group (PcG) proteins are epigenetic transcripti

106 Polycomb group (PcG) proteins are essential for accurate

107 Polycomb Group (PcG) proteins are essential regulators o

108 Polycomb group (PcG) proteins are important epigenetic r

109 Polycomb group (PcG) proteins are key chromatin regulato

110 The Polycomb group (PcG) proteins are key regulators of deve

111 Polycomb group (PcG) proteins are required for maintaini

112 Polycomb group (PcG) proteins are required for maintaini

113 Polycomb group (PcG) proteins are required for the epige

114 Polycomb group (PcG) proteins are responsible for mainta

115 Polycomb group (PcG) proteins are responsible for mainta

116 As key epigenetic regulators, polycomb group (PcG) proteins are responsible for the co

117 Polycomb group (PcG) proteins are transcriptional repres

118 Polycomb Group (PcG) proteins assemble a chromatin state

119 d developmental genes through cobinding with Polycomb group (PcG) proteins at transcriptional start s

120 In addition, both tumors overexpress the polycomb group (PcG) proteins BMI-1 and EZH2, which cont

121 in concert to directly repress expression of Polycomb group (PcG) proteins CBX7, embryonic ectoderm d

122 sheds light on how nuclear organization and Polycomb group (PcG) proteins contribute to epigenetical

123 Polycomb group (PcG) proteins control the epigenetic inh

124 Polycomb group (PcG) proteins exert essential functions

125 chromatid cohesion and segregation, and the Polycomb group (PcG) proteins for their roles in epigene

126 The Polycomb Group (PcG) proteins form several complexes wit

127 Polycomb group (PcG) proteins function as chromatin-base

128 Polycomb group (PcG) proteins initiate the formation of

129 For example, the Polycomb Group (PcG) proteins maintain developmental gen

130 A prevailing paradigm posits that Polycomb Group (PcG) proteins maintain stem cell identit

131 Polycomb Group (PcG) proteins maintain transcriptional r

132 Polycomb Group (PcG) proteins mediate heritable gene sil

133 The Polycomb group (PcG) proteins modulate nucleosomes to ma

134 Polycomb group (PcG) proteins play an important role in

135 Polycomb group (PcG) proteins play important roles in re

136 The Polycomb group (PcG) proteins regulate stem cell differe

137 i-1, mammalian cells also express four other polycomb group (PcG) proteins that are closely related t

138 Regulatory decisions in Drosophila require Polycomb group (PcG) proteins to maintain the silent sta

139 The chromatin-associated Polycomb Group (PcG) proteins were first identified in g

140 regulation is the balanced activities of the Polycomb group (PcG) proteins within the PRC1 and PRC2 c

141 y, increasing evidence has demonstrated that polycomb group (PcG) proteins, a subset of histone-modif

142 h INK4A and MIR31HG genomic regions and with Polycomb group (PcG) proteins, and that MIR31HG is requi

143 The polycomb group (PcG) proteins, Bmi-1 and Ezh2, are impor

144 that regulate genome architecture, including Polycomb group (PcG) proteins, form subnuclear structure

145 In arsenic-induced transformed cells, polycomb group (PcG) proteins, including BMI1 and SUZ12,

146 A growing body of evidence suggests that Polycomb group (PcG) proteins, key regulators of lineage

147 ental regulators, and bind to the repressive Polycomb group (PcG) proteins, often in the context of b

148 ax (TRX) antagonizes epigenetic silencing by Polycomb group (PcG) proteins, stimulates enhancer-depen

149 s regulated gene silencing is carried out by Polycomb group (PcG) proteins, which must be correctly r

150 d Pol II and enriched with promoter-proximal Polycomb Group (PcG) proteins, yet lacking the classical

151 tion of both histone deacetylases (HDAC) and polycomb group (PcG) proteins.

152 Evidence is presented that Polycomb group (PcG) repressors can influence paused Pol

153 l modulator that maintains downregulation of Polycomb Group (PcG) target genes in lhp1 mutants, while

154 latory genes require stable silencing by the polycomb group (PcG) to prevent misexpression during dif

155 anscriptional target genes are also bound by Polycomb group (PcG) transcriptional repressor proteins

156 The first genes composing the Polycomb group (PcG) were identified 50 years ago in Dro

157 Sex Comb on Midleg (Scm) is a member of the Polycomb group (PcG), a set of transcriptional repressor

158 (SCM) is a transcriptional repressor in the Polycomb group (PcG), but its molecular role in PcG sile

159 Polyhomeotic (Ph), a member of the Polycomb Group (PcG), is a gene silencer critical for pr

160 neral, are also sensitive to activity of the Polycomb Group (PcG), suggesting that PcG attenuation up

161 e recently described group of embryonic cell Polycomb group (PcG)-marked genes that may be predispose

162 Polycomb group (PcG)-mediated gene silencing is a common

163 Polycomb group (PcG)-mediated repression is an evolution

164 We identify removal of Polycomb group (PcG)-mediated repression on stage-specif

165 ansitions between trithorax-group (TrxG) and polycomb-group (PcG) chromatin states are vital for the

166 pe characteristic of males with mutations in Polycomb-group (PcG) genes.

167 Polycomb-group (PcG) proteins are highly conserved epige

168 Polycomb-group (PcG) proteins function to ensure correct

169 -binding of histone deacetylases (HDACs) and Polycomb-group (PcG) proteins.

170 ved a common pattern of up regulation of the polycomb group PRC2 and enrichment for the histone mark

171 ction of methylation-prone genes compared to Polycomb group protein (PcG) marking in embryonic stem c

172 m chromatin and found candidates that impact polycomb group protein (PcG)-regulated gene expression i

173 a link between an Abd-type Hox protein and a Polycomb group protein at the level of direct protein-pr

174 The Polycomb group protein Bmi-1 is an essential regulator o

175 The polycomb group protein BMI1 is an important regulator of

176 Polycomb group protein BMI1 plays an important role in c

177 ruiting not only MLL complexes, but also the polycomb group protein Bmi1.

178 in turn is required for the stability of the Polycomb group protein complex.

179 PRC1-class Polycomb group protein complexes are essential for devel

180 Here we show that the polycomb group protein EED, a core component of PRC2, ph

181 sferase EHMT2 (also known as G9A) or for the Polycomb group protein EED, involved in repressive H3K9m

182 The Polycomb group protein Enhancer of Zeste has been shown

183 Although the polycomb group protein Enhancer of Zeste Homolog 2 (EZH2

184 The Polycomb group protein enhancer of zeste homolog 2 (EZH2

185 ast cancer with heightened expression of the Polycomb group protein Enhancer of Zeste Homolog 2 (EZH2

186 Among these, the polycomb group protein enhancer of Zeste homologue 2 (EZ

187 Molecular analyses establish that the polycomb group protein EZH2 (enhancer of zeste homolog 2

188 Recent work suggests a link between the polycomb group protein EZH2 and mediation of gene silenc

189 en-responsive elements (ARE) and dictated by Polycomb group protein EZH2 and repressive chromatin rem

190 ever, constitutive repression of CCN3 by the Polycomb group protein EZH2 disrupted this negative feed

191 4) in Genes & Development of the role of the polycomb group protein Ezh2 in muscle stem cells, and di

192 We report that the expression of the Polycomb group protein EZH2 increases in histologically

193 Polycomb group protein Ezh2 is a histone H3 Lys-27 histo

194 The polycomb group protein Ezh2 is a histone methyltransfera

195 inase in FLB1 and a differentially localized Polycomb group protein Ezh2, which is mostly nuclear in

196 AR activation recruits the polycomb group protein EZH2, which subsequently catalyze

197 DNA methyltransferase MET1, and/or the core Polycomb group protein FIE.

198 ng protein homologous to Drosophila SFMBT, a Polycomb group protein involved in epigenetic regulation

199 We identify the polycomb group protein Pcgf1 as an epigenetic regulator

200 epress reporter gene expression and bind the Polycomb group protein SUZ12 and the DNA methyltransfera

201 strated that RA-mediated displacement of the polycomb group protein SUZ12 from a RARE was inhibited i

202 s including age-specific hypermethylation in polycomb group protein target genes and the upregulation

203 The specificity of polycomb group protein targeting is incompletely underst

204 First, we show that SCML2, a Polycomb group protein that associates with PRC1.2 (cont

205 Psc encodes a Polycomb group protein that functions as a central compo

206 The CBX7 gene encodes a polycomb group protein that is known to be downregulated

207 was correlated with higher levels of Bmi1, a polycomb group protein that is known to regulate the Ink

208 ransferase, Ezh2 (enhancer of zeste 2), is a Polycomb group protein that plays important roles in man

209 ogenesis is to suppress transcription of the Polycomb group protein, EZH2, thereby de-repressing gene

210 is study investigates the effect of Bmi-1, a polycomb group protein, on radiation-induced senescence

211 s provide a framework for an RNAi-dependent, Polycomb group protein-mediated heterochromatin formatio

212 ver faster at sites for trithorax-group than polycomb-group protein binding, suggesting that nucleoso

213 ng of DAB2IP is a key mechanism by which the polycomb-group protein histone-lysine N-methyltransferas

214 g activity depends on a binding site for the Polycomb-group protein Pleiohomeotic (Pho) and on pho ge

215 is a mammalian homolog of Drosophila SCM, a Polycomb-group protein that associates with PRC1.

216 trimethylation (H3K27me3) has been linked to polycomb-group-protein-mediated suppression of Hox genes

217 ue of Molecular Cell) have demonstrated that Polycomb group proteins (PcG) and the Kcnq1ot1 regulator

218 Polycomb group proteins (PcG) are required for proper de

219 Polycomb group proteins (PcG) are transcriptional repres

220 Polycomb group proteins (PcG) function as transcriptiona

221 Hox genes are also repressed by polycomb group proteins (PcG), though how these proteins

222 Polycomb group proteins (PCGs) are involved in repressio

223 The Polycomb group proteins (PcGs) play a vital role through

224 complex 1 (PRC1) comprise a core assembly of Polycomb group proteins and additional factors that incl

225 Polycomb group proteins and associated histone marks are

226 t that, contrary to the prevailing view, the Polycomb group proteins and methyltransferase complexes

227 se genes are subjected to repression by both Polycomb group proteins and SetDB1, and loss of either r

228 The Polycomb group proteins and the associated H3K27me3 hist

229 Polycomb group proteins are critical to maintaining gene

230 Polycomb group proteins are essential for early developm

231 Trithorax and polycomb group proteins are generally thought to antagon

232 Polycomb group proteins are required for long-term repre

233 Polycomb group proteins are transcriptional repressors r

234 The Polycomb group proteins are transcriptional repressors t

235 Polycomb group proteins are transcriptional repressors t

236 acetylglucosamine transferase (OGT), and the polycomb group proteins ASXL1 and ASXL2 in vivo.

237 Polycomb group proteins Bmi-1 and Ring1B are core subuni

238 suggest, more generally, that Trithorax and Polycomb group proteins can cooperate with one another t

239 Polycomb group proteins control a hierarchy of gene expr

240 The Polycomb group proteins foster gene repression profiles

241 Recently, the role of Polycomb group proteins has been studied in the specific

242 Polycomb group proteins have an essential role in the ep

243 silent set of miRNA genes is co-occupied by Polycomb group proteins in ES cells and shows tissue-spe

244 the importance of histone methylation by the polycomb group proteins in the mouse circadian clock mec

245 miR-16 levels down-regulated BMI1 and other polycomb group proteins like RING1A, RING1B, EZH2 and al

246 Polycomb group proteins mediate heritable transcriptiona

247 Polycomb group proteins represent a conserved family of

248 How polycomb group proteins repress gene expression in vivo

249 Rather, Polycomb group proteins that are expressed from the mate

250 Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes requ

251 me3 modifications catalyzed by Trithorax and Polycomb group proteins, respectively.

252 results indicate that combined modulation of polycomb group proteins, such as EZH2, along with TrxG p

253 on the mechanism of histone modification via Polycomb Group Proteins, which evolved in tandem with th

254 he mark trimethyl H3K27, we examined whether Polycomb group proteins, which methylate H3K27, were pre

255 glycosylases and repressive targeting by the Polycomb group proteins.

256 lation of histone H3 on lysine 27 (H3K27) by Polycomb group proteins.

257 paternal and maternal genomes as well as by Polycomb group proteins.

258 H3 at lysine 27 (H3K27me) as directed by the Polycomb group proteins.

259 core ES transcriptional circuitry, including Polycomb group proteins.

260 tions, expanding the regulatory diversity of polycomb group proteins.

261 genes previously epigenetically silenced by Polycomb group proteins.

262 of chromatin-remodeling complexes, including Polycomb group proteins.

263 ransferases and repressing proteins, such as Polycomb group proteins; upon differentiation, DNMT acti

264 Polycomb-group proteins control many fundamental biologi

265 eversible chromatin interactions mediated by Polycomb-group proteins play an important role in these

266 tioning in Arabidopsis thaliana We show that Polycomb-group proteins repress nucellus degeneration be

267 Polycomb-group proteins silence gene expression through

268 ypermethylation, recruitment, and binding of polycomb-group proteins, and histone heterochromatin mod

269 ensitive silencing are related properties of Polycomb-group proteins, whereas their activities are ge

270 ppression as an alternative to regulation by Polycomb-group proteins, which coordinate embryonic germ

271 e been identified that mediate the action of Polycomb-group proteins.

272 ber of transcriptional repressors, including Polycomb-group proteins.

273 Polycomb Group regulation in Arabidopsis (Arabidopsis th

274 other findings suggest that KIS antagonizes Polycomb group repression by facilitating ASH1-dependent

275 Recent studies linking polycomb group repression complexes (PRC1 and PRC2) to t

276 tes transcription elongation and counteracts Polycomb group repression via distinct mechanisms.

277 Such genes are also often targets of the polycomb group repressive complexes in embryonic cells.

278 ionally suppressed E-cadherin expression via polycomb group-repressive complexes.

279 p16(INK4a) expression was regulated by the Polycomb group repressor Bmi-1, which we show is a direc

280 G proteins are bound to DNA fragments called Polycomb group response elements (PREs).

281 ounteract silencing mediated by an engrailed Polycomb-group response element.

282 In Drosophila, DNA fragments called Polycomb-group response elements (PREs) have been identi

283 la, PcG proteins are recruited to the DNA by Polycomb-group response elements (PREs), regulatory sequ

284 n or closely linked to the promoter proximal Polycomb-group response elements.

285 Here, we show that the noncanonical Polycomb group RING finger 3/5 (PCGF3/5)-PRC1 complex in

286 id analysis revealed that p47 interacts with polycomb group ring finger 5 (PCGF5) protein, Src protei

287 ear-containing ARF binding protein 1 (GGA1), polycomb group ring finger 5 (PCGF5), actin gamma 1 (ACT

288 Here, we show that the PRC1 component polycomb group ring finger 6 (Pcgf6) is required to main

289 ecruitment of the TRP120-interacting protein polycomb group ring finger protein 5 (PCGF5) to the incl

290 rast, regions associated with the repressive Polycomb-Group showed low turnover in ESCs.

291 Epigenetic events and the upregulation of polycomb group silencing proteins including Bmi1 have be

292 nment and that hypermethylation of stem cell polycomb group target genes is an epigenetic hallmark of

293 using on promoter CpG sites that localize to Polycomb group target genes that are unmethylated in 11

294 profile among 13 CpG loci, characterized by polycomb group target genes, mammalian interspersed repe

295 effects on gene expression, particularly of polycomb group target genes.

296 average methylation among CpG loci found in polycomb group target genes; developmentally related tra

297 We report that stem cell Polycomb group targets are up to 12-fold more likely to

298 Here, we compare these with known polycomb group targets to show that approximately 47% of

299 The Polycomb group transcriptional repressor Bmi-1 often ove

300 the human homolog of the Drosophila L(3)MBT polycomb group tumor suppressor gene, is located on chro