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1 o DNA hypermethylation of genes regulated by Polycomb Repressive Complex 2.
2 including homeobox genes and targets of the Polycomb repressive complex 2.
3 without invoking the increased enrichment of Polycomb Repressive Complex 2.
4 SMN expression by recruiting the epigenetic Polycomb repressive complex-2.
6 gene expression by competitive binding with polycomb repressive complex 2 and initiation of mRNA deg
10 omolog 2 (EZH2), an enzymatic subunit of the polycomb-repressive complex 2 and the main writer of chr
12 of zeste homolog 2, the catalytic subunit of polycomb repressive complex 2, and MEF2C-dependent gene
13 ied EZH2, a histone methyltransferase in the Polycomb repressive complex 2, as a regulator of these g
14 RC2)-associated protein EPOP (Elongin BC and Polycomb Repressive Complex 2-associated protein; a.k.a.
15 and beta-catenin, which contribute to PRC2 (polycomb repressive complex-2) binding to promoter regio
16 ine 27 methyltransferase activity and of the Polycomb Repressive Complex 2 but corresponds instead to
17 of H3K27 methyltransferases or of the PRC2 (Polycomb Repressive Complex 2) by pharmaceutical inhibit
22 suggested that in the crystal structure of a polycomb repressive complex 2 from Chaetomium thermophil
23 the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophil
25 ses revealed that SWI/SNF likely antagonizes Polycomb repressive complex 2, implicating this as one p
26 age- and pluripotent state-specific roles of polycomb repressive complex 2 in cell fate decisions.Pol
27 opmental transcription factor genes bound by Polycomb repressive complex 2 in human embryonic stem ce
28 the roles of the distinct components of the Polycomb repressive complex 2 in the control of skin dev
29 mains largely coincide with domains bound by Polycomb repressive complex 2 in undifferentiated human
31 b group genes from flies to mammals, showing Polycomb repressive complex 2 is necessary to maintain n
33 (miR-125a) expression through inhibition of polycomb repressive complex 2-mediated (PRC2-mediated) m
34 These results demonstrate a dual role for polycomb repressive complex 2-mediated epigenetic silenc
36 og 2 (EZH2), the lysine methyltransferase of Polycomb repressive complex 2, mediates transcriptional
37 ation blocks nucleation of plant homeodomain-Polycomb repressive complex 2 (PHD-PRC2) and indicates a
38 of chromatin structure and the placement of Polycomb repressive complex 2 (PRC2) across the genome.
39 equired for Xist-mediated recruitment of the polycomb repressive complex 2 (PRC2) across the X chromo
40 3K27me3, an epigenetic mark deposited by the Polycomb Repressive Complex 2 (PRC2) and associated with
41 Here, we examine allele-specific binding of Polycomb repressive complex 2 (PRC2) and chromatin compo
44 oding RNA (lincRNA) that associates with the Polycomb Repressive Complex 2 (PRC2) and overexpression
47 lated genes, was found to be associated with Polycomb Repressive Complex 2 (PRC2) as well as PRC2-int
48 ) protein, HEB, directly associates with the Polycomb repressive complex 2 (PRC2) at a subset of deve
49 ermethylated phenotype, mainly occupying the polycomb repressive complex 2 (PRC2) binding sites in hu
50 essible during differentiation by preventing Polycomb repressive complex 2 (PRC2) binding to transcri
51 2 (EZH2) works as a catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) by methylating lysi
55 ncluding Hox family genes and members of the Polycomb repressive complex 2 (PRC2) chromatin-remodelin
56 hich were transcriptionally regulated by the polycomb repressive complex 2 (PRC2) complex and silence
57 ds to the transient recruitment of EZH2, the polycomb repressive complex 2 (PRC2) component responsib
58 loss-of-function somatic alterations of the Polycomb repressive complex 2 (PRC2) components (EED or
60 referential dependency on genes encoding the polycomb repressive complex 2 (PRC2) components EZH2, EE
61 mmed events include global downregulation of Polycomb repressive complex 2 (PRC2) components, recruit
65 Barr virus (EBV) triggers the recruitment of polycomb repressive complex 2 (PRC2) core subunits and t
72 imethylation on H3K27 (H3K27me3) mediated by Polycomb repressive complex 2 (PRC2) has been linked to
75 cetylation by NuRD specifies recruitment for Polycomb Repressive Complex 2 (PRC2) in embryonic stem (
76 loid leukemia, which revealed a role for the Polycomb repressive complex 2 (PRC2) in maintenance of t
77 ly blocking its trimethylation (H3K27me3) by Polycomb repressive complex 2 (PRC2) in Polycomb target
78 Recent studies point to a pivotal role of Polycomb repressive complex 2 (PRC2) in stem cell functi
79 rrier by alleviating the requirement for the Polycomb Repressive Complex 2 (PRC2) in the endosperm.
86 f histone H3 on Lys27 (H3K27me3) mediated by polycomb repressive complex 2 (PRC2) is also important i
89 hylation of histone H3 on Lys27 (H3K27me) by Polycomb repressive complex 2 (PRC2) is conserved, but i
90 identify a localization domain and show that polycomb repressive complex 2 (PRC2) is displaced togeth
92 lation of histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2 (PRC2) is essential for tr
93 ional activation versus repression, and that polycomb repressive complex 2 (PRC2) is involved in epig
94 pmental Cell, Iovino et al. demonstrate that Polycomb repressive complex 2 (PRC2) is required for mai
96 During X chromosome inactivation (XCI), the Polycomb Repressive Complex 2 (PRC2) is thought to parti
97 ransferase EZH2, which in the context of the polycomb repressive complex 2 (PRC2) is well known to tr
98 n and show that its overexpression resembles polycomb repressive complex 2 (PRC2) loss-of-function ph
107 f the repressive histone marker H3K27me3 and polycomb repressive complex 2 (PRC2) near the Fgf8 RARE.
109 lycomb response elements (PREs), that direct Polycomb repressive complex 2 (PRC2) placement at develo
110 lly considered to promote transcription, and Polycomb Repressive Complex 2 (PRC2) places K27me3, whic
112 repressive complex 2 in cell fate decisions.Polycomb repressive complex 2 (PRC2) plays an essential
119 lation on histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2 (PRC2) regulates the balan
122 Knockdown of EZH2, a key component of the Polycomb repressive complex 2 (PRC2) silencing machinery
123 , but there is a clear lack of the essential Polycomb Repressive Complex 2 (PRC2) subunit EED in the
125 enzymes that catalyze H3K27me3, namely, the polycomb repressive complex 2 (PRC2) subunits enhancer o
127 a viral SET domain protein) is an attractive polycomb repressive complex 2 (PRC2) surrogate to study
129 omologue 2 or 1) is the catalytic subunit of polycomb repressive complex 2 (PRC2) that catalyzes meth
130 of Eed, which is an essential subunit of the polycomb repressive complex 2 (PRC2) that catalyzes meth
131 histone methyltransferase is a member of the polycomb repressive complex 2 (PRC2) that is highly expr
132 of three lysine methyltransferase complexes, polycomb repressive complex 2 (PRC2) that methylates his
133 c cofactors from the H3K27 methyltransferase polycomb repressive complex 2 (PRC2) to an H3K27me3 deme
134 er cells induced genome-wide re-targeting of Polycomb repressive complex 2 (PRC2) to an occupancy pat
137 ture inactive X chromosome (Xi) and recruits Polycomb repressive complex 2 (PRC2) to the X-inactivati
139 ctivity-based communication between PRC1 and Polycomb repressive complex 2 (PRC2) which is required f
141 tic programs, the developmental roles of the polycomb repressive complex 2 (PRC2), a chromatin remode
142 y plastic and accompanied by gain or loss of polycomb repressive complex 2 (PRC2), a complex that mod
144 EZH2 encodes the catalytic subunit of the polycomb repressive complex 2 (PRC2), a highly conserved
145 y activating specific genes, silenced by the Polycomb repressive complex 2 (PRC2), and identify the c
146 etermined to have physical interactions with Polycomb repressive complex 2 (PRC2), and systematically
147 mutations of EZH2, a catalytic component of polycomb repressive complex 2 (PRC2), are observed in ~\
148 homologue 2 (EZH2), the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), contributes to mai
149 A well-studied example is the recruitment of polycomb repressive complex 2 (PRC2), for which there is
150 enes, which encode crucial components of the Polycomb repressive complex 2 (PRC2), in 25% of T-ALLs.
151 MLL1 and H3K4me2, H3K27me3 levels, a mark of Polycomb repressive complex 2 (PRC2), increase at these
152 e show that EZH2, a catalytic subunit of the polycomb repressive complex 2 (PRC2), is essential in al
153 e histone methyltransferase component of the polycomb repressive complex 2 (PRC2), is overexpressed w
155 e 12 homologue (SUZ12), which is a domain of Polycomb repressive complex 2 (PRC2), promoting the meth
156 ncer of zeste homolog 2 (EZH2), a subunit of Polycomb repressive complex 2 (PRC2), silences gene expr
157 The 600-kDa E(Z)/ESC complex, also known as Polycomb repressive complex 2 (PRC2), specifically methy
158 ential intersection with epigenetic silencer polycomb repressive complex 2 (PRC2), suggested by share
159 terozygous mutations in two core subunits of Polycomb Repressive Complex 2 (PRC2), the histone H3 lys
160 the histone H3K27 methyltransferase complex Polycomb repressive complex 2 (PRC2), to form a distinct
161 er of zeste homolog 2 (EZH2), a component of polycomb repressive complex 2 (PRC2), to inhibit c-Met e
162 issociation of EZH2 and SUZ12, components of polycomb repressive complex 2 (PRC2), transcriptional ac
163 d as an important component of the mammalian Polycomb repressive complex 2 (PRC2), where it has a maj
165 -G proteins as part of a multimeric complex, Polycomb Repressive Complex 2 (PRC2), which functions as
167 quires histone methyltransferase activity of Polycomb repressive complex 2 (PRC2), which methylates l
169 og 2) is a critical enzymatic subunit of the polycomb repressive complex 2 (PRC2), which trimethylate
170 erase, a subunit of the epigenetic repressor Polycomb Repressive Complex 2 (PRC2), while simultaneous
171 ound that three components of the Neurospora Polycomb repressive complex 2 (PRC2)--[Su-(var)3-9; E(z)
173 c VHL-HIF target genes, we show that loss of Polycomb repressive complex 2 (PRC2)-dependent histone H
174 establishes specific enzymatic inhibition of polycomb repressive complex 2 (PRC2)-EZH2 and PRC2-EZH1
175 ZH2 exerts its oncogenic function is through polycomb repressive complex 2 (PRC2)-mediated gene repre
176 accompanied by a reduction in the levels of polycomb repressive complex 2 (PRC2)-mediated H3K27 trim
177 ntify that ASXL1 mutations result in loss of polycomb repressive complex 2 (PRC2)-mediated histone H3
178 oral repressor flowering locus C (FLC) via a Polycomb Repressive Complex 2 (PRC2)-mediated increase i
179 G1, was previously known for its function in polycomb repressive complex 2 (PRC2)-mediated transcript
180 f Caf1 is associated with a reduction in the Polycomb Repressive Complex 2 (PRC2)-specific histone me
203 dulthood, and comprise the components of the Polycomb-Repressive Complex 2 (PRC2) including the histo
206 ase inhibitor 1C (CDKN1C; p57KIP2), and many polycomb-repressive complex 2 (PRC2) target genes (e.g.,
207 1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential
208 Cdkn2a locus and directly interacts with the Polycomb-repressive complex 2 (PRC2) to enable H3K27me3-
209 at Bvht interacts with SUZ12, a component of polycomb-repressive complex 2 (PRC2), during cardiomyocy
210 strong association with embryonic targets of polycomb-repressive complex 2 (PRC2), indicating that Pa
211 port that EZH2, the enzymatic subunit of the Polycomb-repressive complex 2 (PRC2), is expressed in bo
212 in-containing protein, as a component of the Polycomb-repressive complex 2 (PRC2), which is involved
213 olog 2 (EZH2) is a critical component of the polycomb-repressive complex 2 (PRC2), which is involved
216 itro and in vivo to EZH2, a component of the Polycomb repressive complex 2, required to repress CLU.
217 first, PRDM14 represses Rnf12 by recruiting polycomb repressive complex 2; second, Tsix enables PRDM
219 27 (H3K27me3), elevated enhancer of zeste 2 polycomb repressive complex 2 subunit (Ezh2) expression,
220 atalytic activity of the enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), forming re
221 HMTis directed at EZH1 (enhancer of zeste 2 Polycomb repressive complex 2 subunit 1)/EZH2 are now in
222 the conditional ablations of three essential Polycomb repressive complex 2 subunits (EED, Suz12, or E
223 e homolog 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 that mediates histone H3 l
224 3K27M inhibits the enzymatic activity of the Polycomb repressive complex 2 through interaction with t
225 KSHV genome and contributed to tethering of polycomb repressive complex 2 through physical interacti
226 omeodomain finger proteins act together with Polycomb Repressive Complex 2 to increase repressive his
227 lncOL1 interacts with Suz12, a component of polycomb repressive complex 2, to promote oligodendrocyt
228 hed for genes known to be inactivated by the polycomb repressive complex 2, whereas the group of hypo
229 tion converges exclusively on targets of the Polycomb repressive complex 2 which represses expression
230 d Ezh1/2 function largely as subunits of the Polycomb repressive complex 2, which is important in the
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