ライフサイエンスコーパス: Pro

1 Pro accumulation in plants is a well-documented physiolo

2 Pro- and anti-quorum-sensing molecules can be covalently

3 Pro-119 in the Cys-loop, Pro-198 and Pro-203 in the M1 h

4 Pro-angiogenic conditions therefore drive the proliferat

5 Pro-apoptotic and anti-apoptotic Bcl-2 family proteins r

6 Pro-apoptotic Bax induces mitochondrial outer membrane p

7 Pro-apoptotic BAX is a cell fate regulator playing an im

8 Pro-apoptotic Bcl-2-associated X protein (BAX) is an exe

9 Pro-B cell proliferation and small pre-B cell differenti

10 Pro-caspase-1 consists of three domains, CARD, p20, and

11 Pro-cognitive effects of DMXB-A may result from transien

12 Pro-epileptic effects of IGF-1 were mediated by Akt-mTOR

13 Pro-FD cleavage in serum or plasma was quantified by a n

14 Pro-fibrogenic gene expressions (COL1, TIMP-1, TGF-beta1

15 Pro-fibrotic mesenchymal cells are known to be the key e

16 Pro-inflammatory cytokines and growth factors as well as

17 Pro-inflammatory cytokines are important mediators of is

18 Pro-inflammatory cytokines contribute to pancreatic beta

19 Pro-inflammatory cytokines contribute to the decline in

20 Pro-inflammatory cytokines produced in the tumor microen

21 Pro-inflammatory cytokines secreted by adipose tissue ma

22 Pro-inflammatory cytokines upregulated SOX5 and RANKL ex

23 Pro-inflammatory stimuli lead to endothelial inflammatio

24 Pro-inflammatory stimuli led to increased endothelial CD

25 Pro-inflammatory targets were induced by hypertonicity i

26 Pro-miRNA is an efficient substrate for Microprocessor a

27 Pro-opiomelanocortin (ARC(POMC)) neurons are viewed as t

28 Pro-oxidant components of PM2.5 are capable of directly

29 Pro-oxidants are considered as major constituents of veh

30 Pro-platelet basic protein (PPBP) is a potent neutrophil

31 Pro-resolution mediators, such as lipoxin A4 (LXA4), are

32 Pro-social priming can have a pervasive effect on abnorm

33 Pro-survival Bcl-2 proteins control Bax by constant retr

34 Pro-T cells exhibit a pattern intermediate between pro-B

35 Pro-TH2 cytokines prevent oral tolerance.

36 Pro-tumorigenic M2 macrophage activation was diminished

37 achykinin-related peptide (CabTRP Ia, Ala(1)-Pro(2)-Ser(3)-Gly(4)-Phe(5)-Leu(6)-Gly(7)-Met(8)-Arg(9)-

38 gion of human neuropeptide Y (NPY1-9, Tyr(1)-Pro(2)-Ser(3)-Lys(4)-Pro(5)-Asp(6)-Asn(7)-Pro(8)-Gly(9)-

39 ing to the cis-trans isomerization of Xaa(1)-Pro(2) peptide bonds.

40 isomerization of the N-terminal Ser(P)(118)-Pro(119) in the intrinsically disordered AF1 (activation

41 ral data for GLIC, the behaviors of Pro-119, Pro-203, and Pro-299 mutants are consistent with earlier

42 based on a cis- or trans-configured Glu(18)-Pro(19) peptide bond.

43 that PIN1 binds the phosphorylated Thr(187)-Pro motif in p27 and reduces p27's interaction with cycl

44 a canonical thioredoxin-fold with a Cys(19)-Pro(20)-Trp(21)-Cys(22) motif, and an insertion consisti

45 We assayed propidium(2+) (Pro(2+)) influx kinetics during NLRP3 or Pyrin inflammas

46 in bind the PXXP motifs called Site 2 and 3 (Pro-786-Pro-793) at the N-terminal end of the proline-ri

47 We therefore suggest that Val(3)Pro(8)OXT and Pro(8)OXT are functional variants, which m

48 cacious on Gq and beta-arrestin, while Val(3)Pro(8)OXT showed reduced relative efficacy toward beta-a

49 ls, the Cebidae Pro(8)OXT and Saguinus Val(3)Pro(8)OXT taxon-specific variants act as equi-efficaciou

50 oclonal antibody KD-247 targets the Gly(312)-Pro(313)-Gly(314)-Arg(315) arch of the third hypervariab

51 obic contacts between FtsZ residues Ile-374, Pro-375, and Leu-378 with ZapD residues Leu-74, Trp-77,

52 ptide Y (NPY1-9, Tyr(1)-Pro(2)-Ser(3)-Lys(4)-Pro(5)-Asp(6)-Asn(7)-Pro(8)-Gly(9)-NH2) and a tachykinin

53 1)-Pro(2)-Ser(3)-Lys(4)-Pro(5)-Asp(6)-Asn(7)-Pro(8)-Gly(9)-NH2) and a tachykinin-related peptide (Cab

54 the PXXP motifs called Site 2 and 3 (Pro-786-Pro-793) at the N-terminal end of the proline-rich domai

55 as the amphiphysin SH3 binds Site 9 (Pro-833-Pro-836) toward the C-terminal end.

56 The second element (Arg-838-Pro-844) is located about 50 amino acids downstream of S

57 n, whereas the amphiphysin SH3 binds Site 9 (Pro-833-Pro-836) toward the C-terminal end.

58 Nedd4Lo has a unique N-terminus containing a Pro-rich region.

59 the protein backbone at the Calpha atom of a Pro residue to produce 2-hydroxyproline (2-Hyp).

60 gment derived from ZmARGOS8, consisting of a Pro-rich motif flanked by two transmembrane helices that

61 bear either the N-terminal Pro residue or a Pro at position 2, together with adjacent sequence motif

62 toward IR-A, particularly the analogs with a Pro-Gln insertion in the C-domain.

63 ted by varying the psi dihedral angle in Ace-Pro-NMe indicates that the conformation with the N-H...N

64 mpound N-acetyl-L-proline-N-methylamide (Ace-Pro-NMe) with coordinates taken from the experimentally

65 rein we report that the matrikine acetylated Pro-Gly-Pro (PGP) stimulates vascular inflammation throu

66 p5cs1-4 to identify multiple loci affecting Pro accumulation in Arabidopsis (Arabidopsis thaliana).

67 A conserved late domain motif, Pro-Thr-Ala-Pro (PTAP), located in the p6 region of Gag (p6(Gag)), p

68 a cardiac event compared with Pro/Pro + Ala/Pro genotypes in multivariate analysis (odds ratio, 0.09

69 Pro-119 in the Cys-loop, Pro-198 and Pro-203 in the M1 helix, and Pro-299 in the M4 helix wer

70 GLIC, the behaviors of Pro-119, Pro-203, and Pro-299 mutants are consistent with earlier proline muta

71 t position 180, Gly/Arg at position 239, and Pro/Ser at position 280.

72 n of an involvement of Trp-244, Tyr-248, and Pro-252 in proline binding is further supported.

73 he stacking interaction between Phe(364) and Pro(357), which is absolutely conserved in enteroviral p

74 on between ATP binding by the CBS domain and Pro-sigma(K) cleavage by the membrane domain.

75 ising the RV144 vaccine (Env-gp120, Gag, and Pro).

76 op, Pro-198 and Pro-203 in the M1 helix, and Pro-299 in the M4 helix were sensitive to substitution,

77 e therefore suggest that Val(3)Pro(8)OXT and Pro(8)OXT are functional variants, which might have been

78 ients) in the negative regulatory region and Pro-Glu-Ser-Thr-rich domains, the same two hotspots seen

79 Induction of P5CS1 transcription and Pro accumulation during phosphate deficiency was conside

80 ro-NHEt (LHRHa) to Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt (fragment 1) and Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt

81 -NHEt (fragment 1) and Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt (fragment 2).

82 ments from Glp-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt (LHRHa) to Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt (

83 c) and Z02090 ((68)Ga-DOTA-dPEG2-Lys-Lys-Arg-Pro-Hyp-Gly-Cpg-Ser-D-Tic-Cpg) derived from 2 potent B1R

84 abeled P04158 ((68)Ga-DOTA-dPEG2-Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic) and Z02090 ((68)Ga-DOTA-d

85 etectable in the effluent unless Gly-Pro-Arg-Pro (GPRP) was added to block fibrin polymerization.

86 was attenuated by tirofiban and Gly-Pro-Arg-Pro amide, confirming a role for fibrin in amplifying pl

87 dipeptides: Ala-Arg (AR), Arg-Ala (RA), Arg-Pro (RP), Arg-Glu (RE), and Glu-Arg (ER); and two non-ar

88 We show that arrayed Asp-Pro-Phe (DPF) motifs within the early-arriving endocytic

89 their ability to be seeded, with variants at Pro(301) and Ser(320) showing robust aggregation with se

90 Upon interaction with the AVPR1a, Pro(8)OXT and the common Leu(8)OXT yielded similar signa

91 lts reveal a previously unknown link between Pro metabolism and phosphate nutrition and show that Pro

92 with a sequence comprising a central block (Pro-Hyp-Gly) and two positively charged domains (Pro-Arg

93 or improved solubilization from membranes by Pro-sigma(K)(1-126) and for normal interaction with the

94 Pro-His-DPhe-Arg-Trp-Asn-Ala-Phe-DPro] and c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro], and may be further d

95 equence in the AGRP active loop derivative c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro], where Xxx was the nat

96 ed nanomolar agonist potency at the mMC4R, c[Pro-His-DPhe-Arg-Trp-Asn-Ala-Phe-DPro] and c[Pro-His-DPh

97 s of a reported AGRP macrocyclic scaffold (c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro]) were explored with 14

98 The most potent scaffold, c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro], comprised the hexa-pe

99 [(13)C2]Ala and [(13)C2]Pro were the most abundant and rapidly labeled amino aci

100 found in most placental mammals, the Cebidae Pro(8)OXT and Saguinus Val(3)Pro(8)OXT taxon-specific va

101 Common to the series is a central Pro-Xaa sequence, where Pro is either l- or d-proline, w

102 and Concentrator-5, Invitrogen ChargeSwitch-Pro PCR Purification, and Beckman Coulter AMPure XP.

103 in degrading the neutrophil chemoattractant Pro-Gly-Pro (PGP) and rationalized that the failure of c

104 SpoIVFB is an IMMP that cleaves Pro-sigma(K) during Bacillus subtilis endospore formatio

105 ith a 200-residue polypeptide tag comprising Pro, Ala, and Ser (PAS200) and by fusion with an albumin

106 s modifies with high specificity a conserved Pro, shares with the deacetylation reaction the same act

107 d by conserved N-terminal domains containing Pro-Glu (PE) or Pro-Pro-Glu (PPE) motifs, account for a

108 on Pro-rich proteins or proteins containing Pro-rich binding domains involved in cellular signaling.

109 1, the fourth gluconeogenic enzyme, contains Pro at position 2; Gid4 directly or indirectly recognize

110 (P5CS1) gene was previously shown to control Pro biosynthesis in such adverse conditions.

111 ast, an Abc3 mutant in which an inverted Cys-Pro motif had been replaced with Ala residues fails to b

112 vered a four-residue pi-clamp motif (Phe-Cys-Pro-Phe) for regio- and chemoselective arylation of cyst

113 we show a four-amino-acid sequence (Phe-Cys-Pro-Phe), which we call the 'pi-clamp', that tunes the r

114 In particular, the mu-agonist c[beta-Ala-d-Pro-Phe-Trp] 9 was shown to elicit potent antinociceptio

115 nlike traditional beta-turn motifs such as d-Pro-Gly, both the 2-Abz and d-Phe rings may be further f

116 se insights led to the identification of H-d-Pro-Pip-Glu-NH2 as a highly reactive and stereoselective

117 ally occurring mixed kappa/mu-ligand c[Phe-d-Pro-Phe-Trp] 1 (CJ-15,208).

118 Hyp-Gly) and two positively charged domains (Pro-Arg-Gly) at both N- and C-termini.

119 irpin loop from AGRP cyclized through a DPro-Pro motif.

120 position (ligand 5: H-Dmt-d-Ala-Gly-Phe(4-F)-Pro-Leu-Trp-NH-Bn(3',5'-(CF3)2)) exhibits balanced bindi

121 Interchanging Leu-119 for Pro-119 at the tip of the beta4-beta5 loop in the first

122 resolution could be achieved, especially for Pro-containing protein regions in the alpha subunit of H

123 In this work, we introduce Frame-Pro, a profile homology search tool for PacBio reads.

124 1 channels extends seven helical turns, from Pro-405 to Phe-431, and is flanked by unstructured loops

125 We further demonstrate that Gag-Pro is not the main driver of this association, suggesti

126 positioned on a short loop (Asn-Gln-Gly-Glu-Pro) instead of an alpha-helix and forms hydrogen bonds

127 hat variation surrounding the C-terminal Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs as well as the number of

128 e helix conformation and stabilisation (Gly, Pro, Hyp and Hyl), whilst the Lys content was greater fo

129 Binding was attenuated by tirofiban and Gly-Pro-Arg-Pro amide, confirming a role for fibrin in ampli

130 To our knowledge, the peptides Gly-Pro-Ala-Val, Val-Cys, and Phe-Phe have not been previous

131 ading the neutrophil chemoattractant Pro-Gly-Pro (PGP) and rationalized that the failure of conventio

132 report that the matrikine acetylated Pro-Gly-Pro (PGP) stimulates vascular inflammation through activ

133 activates the chemotactic tripeptide Pro-Gly-Pro.

134 gely undetectable in the effluent unless Gly-Pro-Arg-Pro (GPRP) was added to block fibrin polymerizat

135 g domain: (i) a previously reported (Leu --> Pro) stabilizing mutant (FnIII9'10), (ii) an Arg to Ala

136 d conformation on the stereoselectivity of H-Pro-Pro-Xaa-NH2-type peptidic catalysts in conjugate add

137 These reactions build up H2N-Pro-Gly-Ala-CONHL and H2N-Cys-His-Asp-CONHL (where L = o

138 s infected with TriMV expressing WSMV P1, HC-Pro, P3, 6K1, CI, 6K2, NIa-VPg, or NIb cistrons permitte

139 evidenced by a pronounced decrease in P1/HC-Pro mRNA and the appearance of 35S promoter small interf

140 , Arf8-8, had no detectable effects on P1/HC-Pro phenotype in either the F1 or F2 generations.

141 ion mutant showed little effect on the P1/HC-Pro phenotype in the F1 generation, but almost all arf8-

142 two independent arf8 mutations and the P1/HC-Pro potyviral suppressor of silencing.

143 e F1 generation, but almost all arf8-6/P1/HC-Pro progeny had lost the phenotype in the F2 generation.

144 ected transcriptional silencing of the P1/HC-Pro transgene, as evidenced by a pronounced decrease in

145 Progeny of a cross between P1/HC-Pro transgenic Arabidopsis and the arf8-6 T-DNA insertio

146 ion in developmental defects caused by P1/HC-Pro.

147 In addition, HiC-Pro can use phased genotype data to build allele-specifi

148 corporation of specific binding peptide (His Pro Gln: HPQ) gives M13 bacteriophage high selectivity f

149 que pentasaccharide attached to hydroxylated Pro-143 within its C-terminal F-box-binding domain.

150 This includes a Leu-Lys-Ile-Pro sequence (residues 125-128 of AKAP79) that occupies

151 h peptides contain a putative 'SIP' (Ser-Ile-Pro) domain that is important for interactions with micr

152 +) -dependent complex with EB3 via Ser-x-Ile-Pro aminoacid motif and that disruption of STIM2-EB3 int

153 sphate starvation led to gradual increase in Pro content in wild-type Arabidopsis plants as well as t

154 g high PDH1pro:LUC2 expression and increased Pro accumulation at low water potential were found to be

155 id metabolism-related mutants with increased Pro accumulation.

156 ) rapidly and reversibly blocked the induced Pro(2+) influx and markedly delayed pyroptotic lysis wit

157 Interpretation: Pro-inflammatory cytokine production had a dose-dependen

158 Due to its Pro-preference and resistance to low pH, we conclude tha

159 ', second fixation, (optional) Proteinase K (Pro-K) or sonication treatment, antibody staining, clear

160 iring modifications (alpha)N-methyl Gln or l-Pro at key positions within betaHP.

161 The LA-Pro-SrtA 7M conjugate retained full enzymatic activity,

162 Capture and recycling of the LA-Pro-SrtA 7M conjugate was achieved using betaCD-modified

163 ctedly, we found that 346 TSF sequences lack Pro-1, of which 85% are present in the malonate semialde

164 on substantially impaired Anti while leaving Pro essentially intact.

165 First, mutants of Ala-978 (to Leu, Pro, Phe, or Tyr) and Asp-1028 (to Tyr or Trp) with larg

166 Pro-119 in the Cys-loop, Pro-198 and Pro-203 in the M1 helix, and Pro-299 in the

167 cently, the tetrapetide N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) has emerged as a potent antifibrotic agent

168 tabolically stable peptide sequence NLys-Lys-Pro-Tyr-Tle-Leu suitable for PET imaging.

169 andomly assigned clusters (1:1) with MapInfo Pro (version 11.0) to either the control or intervention

170 -Arg-Tyr-Pro and Asp-Glu-Asp-Thr-Gln-Ala-Met-Pro) showed the highest ORAC values.

171 The middle Pro residue within the tripeptides was replaced with ana

172 e show that this structural motif, a minimal Pro(314)-Trp(316) turn, is essential for HCV RNA replica

173 Using misacylated Pro-tRNAPhe and Phe-tRNAPro, we show that the imino acid

174 A conserved late domain motif, Pro-Thr-Ala-Pro (PTAP), located in the p6 region of Gag

175 Peptides carrying multiple Pro and Gly (residues with lowest helical propensity) re

176 The coat protein and NIa-Pro encoded by these two viruses, when expressed from a

177 rate that WSMV- and TriMV-encoded CP and NIa-Pro proteins are effectors of SIE and that these two pro

178 ther revealed that elicitation of SIE by NIa-Pro requires the entire protein while CP requires only a

179 y, vacuolar localization is required for NIa-Pro's ability to enhance aphid reproduction on host plan

180 Additionally, transgenic expression of NIa-Pro in Arabidopsis alters ET responses and suppresses ap

181 nges were due to a single viral protein, NIa-Pro.

182 Here we show that NIa-Pro responds to the presence of the aphid vector during

183 proteins showed that TriMV CP, and TriMV NIa-Pro to a lesser extent, likewise excluded superinfection

184 heat infected with TriMV expressing WSMV NIa-Pro or coat protein (CP) substantially excluded superinf

185 portantly, SIE is due to functional WSMV NIa-Pro or CP rather than their encoding RNAs, as altering t

186 No Pro(2+) uptake in response to NG or TcdB was observed in

187 suppressed NG and TcdB-induced lysis but not Pro(2+) influx.

188 ng factor G3BP1 via the viral proteinase NS6(Pro) This work provides new insights into host-pathogen

189 mediated by the viral 3C-like proteinase NS6(Pro) Using mutational analysis, we identified the FCV-in

190 Finally, we showed that NS6(Pro)-mediated G3BP1 cleavage impairs SG assembly.

191 e structural data for GLIC, the behaviors of Pro-119, Pro-203, and Pro-299 mutants are consistent wit

192 for the interaction but not for cleavage of Pro-sigma(K) Chemical cross-linking and mass spectrometr

193 of folding in collagen peptides composed of Pro-Hyp-Gly triplet repeats, allowing for truncation to

194 The coordination of Pro and redox metabolism also was indicated by the alter

195 tatus is a key factor in the coordination of Pro and VLCFA metabolism.

196 ial; however, the regulation and function of Pro metabolism remain unclear.

197 enyleneiodonium (DPI) induced high levels of Pro accumulation and strongly repressed PDH1pro:LUC2 exp

198 rovide evidence that individual mutations of Pro-102 or Pro-105 to noncyclic aliphatic residues such

199 In the model, the Proregion of Pro-sigma(K) loops into the membrane domain of SpoIVFB,

200 membrane domain of SpoIVFB, and the rest of Pro-sigma(K) interacts extensively with the linker and t

201 s and unique residues, including the role of Pro(301) in inhibiting Tau aggregation.

202 appears to play a role distinct from that of Pro in the known HP1beta CSD-PXVXL complexes.

203 pecially promising for structural studies on Pro-rich proteins or proteins containing Pro-rich bindin

204 ence that individual mutations of Pro-102 or Pro-105 to noncyclic aliphatic residues such as the Gers

205 etary acid load estimated as either dPRAL or Pro:K ratio was not consistently associated with childho

206 -terminal domains containing Pro-Glu (PE) or Pro-Pro-Glu (PPE) motifs, account for a substantial frac

207 In particular, Pro and VLCFA synthesis share dual roles to help buffer

208 mino acid substitutions (including His, Phe, Pro, Trp, and Tyr) support an enhanced viability during

209 ding motifs containing the signature Asp-Phe-Pro (DFP) tripeptide.

210 The d-Phe-Pro beta-turn of the cyclic beta-hairpin antimicrobial d

211 of the decapeptide Gramicidin S cyclo(d-Phe-Pro-Val-Orn-Leu-)2 (GS).

212 Stalling at poly-Pro motifs is alleviated by the elongation factor P (EF-

213 ene, which codes for the inactive proenzyme (Pro-Lox) from which, after extracellular secretion and p

214 ination kits, PathoDx (Remel) (93%), Prolex (Pro-Lab Diagnostics) (38%), and Streptex (Remel) (53%).

215 Proline (Pro) accumulation is one of the most prominent changes i

216 The full extent of proline (Pro) hydroxylation has yet to be established, as it is l

217 Gid4 recognized the N-terminal proline (Pro) residue and the 5-residue-long adjacent sequence m

218 BMDMs were characterized by rapid Pro(2+) influx after initiation of NLRP3 or Pyrin inflam

219 a protein intake to potassium intake ratio (Pro:K) at 1 y of age and in a subgroup at 2 y of age : B

220 on 2; Gid4 directly or indirectly recognized Pro at position 2 of Pck1, contributing to its targeting

221 sp-47 and the catalytic site with the region Pro-49-Arg-56, which includes the highly conserved DPGR

222 that multiple residues within the SF region (Pro(165), Tyr(166), Ser(167), and Asp(168)) of apoA-I ar

223 D comprises the repeated Tyr-Ser-Pro-Thr-Ser-Pro-Ser motif with potential epigenetic modification sit

224 The CTD comprises the repeated Tyr-Ser-Pro-Thr-Ser-Pro-Ser motif with potential epigenetic modi

225 The AMO WhiteStar Signature Pro machine (Abbott Medical Optics) with the Ellips FX h

226 tt Medical Optics' (AMO) WhiteStar Signature Pro with the Ellips FX handpiece.

227 ess resistance, namely the compatible solute Pro and cuticle lipids.

228 s spectrometry of purified, inactive SpoIVFB-Pro-sigma(K) complex indicated residues of the two prote

229 observed mass consistent with a 4:2 SpoIVFB.Pro-sigma(K)(1-126)-His6 complex.

230 The inactive SpoIVFB.Pro-sigma(K)(1-126)-His6 complex was stable during affin

231 ion resulted in suppression of NG-stimulated Pro(2+) influx and pyroptotic lysis.

232 ucleotide polymorphism rs1143678 substitutes Pro(1146) for Ser in the integrin alphaM cytoplasmic tai

233 illus subtilis IP SpoIVFB with its substrate Pro-sigma(K) depends on particular residues in the inter

234 Though Decon2LS and MASH Suite Pro have been available to provide intraspectrum charge

235 on to orient either toward a visual target ("Pro") or away from it, toward its reverse ("Anti").

236 reveals that an FrmR-specific amino-terminal Pro(2) is proximal to Cys(35), and these residues form t

237 f, the peptides diverged; the sCT C-terminal Pro was crucial for receptor binding, whereas the AC413/

238 enic enzymes that bear either the N-terminal Pro residue or a Pro at position 2, together with adjace

239 soluble receptors and NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) levels were important ac

240 II/IV, RVESRI, and log NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) were retained (chi(2), 6

241 We also observed that Pro-154 of Skp1, a subunit of the Skp1/Cullin-1/F-box pr

242 bolism and phosphate nutrition and show that Pro biosynthesis is target of cross talk between ABA sig

243 ort genes in p5cs1-4 These results show that Pro metabolism is both influenced by and influences cell

244 Based on structural modeling suggesting that Pro-205 in green cone opsin could prevent entry and bind

245 Both the Pro(1-20) and sigma(K)(21-126) parts contributed to impr

246 ng additional hydrogen-bonding capacity, the Pro-->2-Hyp conversion alters the active site and enhanc

247 However, the Pro-198 site displays a unique phenotype that gives evid

248 ter (PDH1pro:LUC2) and RNA sequencing of the Pro synthesis mutant p5cs1-4 to identify multiple loci a

249 or IGF-1R due to a synergistic effect of the Pro-Gln insertion and S29N point mutation.

250 ng either the motif between C1 and C2 or the Pro/Ala-rich linker (PAL) between C0 and C1.

251 the GID-based proteolytic system termed the Pro/N-end rule pathway.

252 We applied PRT to the Pro/N-end rule pathway, whose substrates include the sho

253 fferences appear not only in cases where the Pro-Xaa loop-region is altered, but also when seemingly

254 e shortening after 5 years compared with the Pro/Pro genotype (P=0.031).

255 alogs of the urotensin II (UII, 1, H-Glu-Thr-Pro-Asp-c[Cys-Phe-Trp-Lys-Tyr-Cys]-Val-OH) fragment 4-11

256 -portion residues, and hairpin-loop of three Pro and one Ser residues, as well as the absence of an N

257 e performance cost of switching from Anti to Pro tasks.

258 accommodated into the ribosome and bound to Pro-tRNA(Pro), productive synthesis of the peptide bond

259 ant, comprising two disulfides and an Ile-to-Pro mutation of Env from strain BG505.

260 s and inactivates the chemotactic tripeptide Pro-Gly-Pro.

261 ro(CGG)) and tRNA(His(GUG)) for Um, and tRNA(Pro(GGG)) for Am. tRNA(Ser(UGA)), previously observed as

262 A(Leu), the mitochondrial tRNA(Val) and tRNA(Pro)) were strongly associated with the observed race di

263 be present in the peptidyl site, e.g., tRNA(Pro).

264 confirmed as the TrmJ target for Am in tRNA(Pro(GGG)) and Um in tRNA(Gln(UUG)) by mass spectrometric

265 ct catalyzes the m(1)G37 methylation of tRNA(Pro) Furthermore, substitution of three of the four prol

266 fast mechanism during translocation of tRNA(Pro) into the P-site.

267 NA methylation site in S. pombe, C34 of tRNA(Pro).

268 ated into the ribosome and bound to Pro-tRNA(Pro), productive synthesis of the peptide bond occurs.

269 mation, tRNA(Gln(UUG)), tRNA(Pro(UGG)), tRNA(Pro(CGG)) and tRNA(His(GUG)) for Um, and tRNA(Pro(GGG))

270 rates for Cm formation, tRNA(Gln(UUG)), tRNA(Pro(UGG)), tRNA(Pro(CGG)) and tRNA(His(GUG)) for Um, and

271 y two mechanisms, a slow mechanism when tRNA(Pro) is stalled in the P-site next to an empty A-site an

272 uence which comprises the 3' end of the tRNA-Pro gene corresponding to the TPsiC loop.

273 Trp-Pro was shown to have high 2,2'-azino-bis (3-ethylbenzth

274 s isomerization about a highly conserved Trp-Pro imide bond in a region of the TAD that is required f

275 was coexpressed with C-terminally truncated Pro-sigma(K)(1-126) (which can be cleaved by active SpoI

276 eiodonium but could be reverted to wild-type Pro and PDH1pro:LUC2 expression by reactive oxygen speci

277 Tyr-Pro had the highest ACE inhibitory activity (ACE IC50=5.

278 des AEERYP and DEDTQAMP (Ala-Glu-Glu-Arg-Tyr-Pro and Asp-Glu-Asp-Thr-Gln-Ala-Met-Pro) showed the high

279 ese results suggest that the Val-Glu-Leu-Tyr-Pro would be a beneficial ingredient for nutraceuticals

280 We describe here a so far unknown Pro hydroxylation activity which occurs in active sites

281 of the amidase activity were monitored using Pro-Phe-Arg-pNA, independently of alpha2-macroglobulin.

282 Val-Pro had the highest ORAC activity (19.45+/-2.15mumol of

283 The gene variant Pro/Ala (rs1801282) in the PPARgamma2 has been associate

284 he LTQ-Orbitrap mass spectrometer (LTQ-Velos Pro, Thermo Fisher) for resolving complex mixtures of na

285 linear trap quadropole (LTQ)-Orbitrap Velos Pro hybrid mass spectrometry (negative ion) of selected

286 the validation of the Comprehensive In vitro Pro-Arrhythmia Assay (CiPA).

287 series is a central Pro-Xaa sequence, where Pro is either l- or d-proline, which was chosen to favor

288 ti requires prefrontal cortex (PFC), whereas Pro could be mediated by midbrain superior colliculus (S

289 an export-defective HDAg-L mutant, in which Pro(205) was replaced by Ala.

290 ly, the S121P/S121P PGHS-2 variants in which Pro-127 and Ser-541 are replaced by cysteines spontaneou

291 Here we investigate why Pro is a poor substrate and how EF-P catalyzes the react

292 occurrence of a cardiac event compared with Pro/Pro + Ala/Pro genotypes in multivariate analysis (od

293 of the two major HLA-B*51 subpeptidomes with Pro-2 and Ala-2, the former one was significantly reduce

294 p10 and the differential susceptibility of X-Pro and X-Ala bonds to ERAP1 trimming and together resul

295 catalysts have been developed that bear Xaa-Pro amide bonds.

296 Both Xaa-Pro aminopeptidase and mitochondrial processing activiti

297 we found that these enzymes are genuine Xaa-Pro aminopeptidases, which hydrolyze peptides with proli

298 Trans/cis isomerization of Xaa-Pro bonds is key for the structure and function of sever

299 be significantly lower as compared with Xaa-Pro aminopeptidase activity.

300 lectropermeabilization state, verified by Yo-Pro-1 uptake.