ライフサイエンスコーパス: Px

1 Px and control rats then underwent a 40-h fast followed

2 Px animals acutely administered insulin exhibited furthe

3 Px rats after 1 week developed mild to severe hyperglyce

4 Px rats developed different degrees of hyperglycemia; lo

5 Px was not associated with kidney allograft survival (P

6 Px was transcribed in vitro by the sigmaA holoenzyme and

7 ociated in univariate analysis with the B*35 Px alleles (OR, 0.29; 95% CI, 0.08-0.99; P=.037), which

8 AIDS was completely attributable to HLA-B*35-Px alleles, some of which differ from HLA-B*35-PY allele

9 en total CTL activity and HIV RNA among B*35-Px carriers differed significantly from that among B*35-

10 did not differ between patients bearing B*35-Px genotypes and those bearing B*35-PY genotypes.

11 The association with the B*35-Px group was less strong than with HLA-B*53 alone.

12 specificity to some HLA-B*35 subtypes (B*35-Px group).

13 on 9; and the more broadly reactive HLA-B*35-Px group, which also binds epitopes with proline in posi

14 vity and viral load was observed in the B*35-Px group.

15 ent consequences of HLA-B*35-PY and HLA-B*35-Px in terms of disease progression highlight the importa

16 Here, we show that the B*35-Px molecule B*3503 binds with greater affinity to immuno

17 can present identical HIV-1 epitopes as B*35-Px molecules.

18 allelic variants B*3502/3503/3504/5301 (B*35-Px) progress more rapidly to AIDS than do those with B*3

19 A subset of HLA-B*35 alleles, B*35-Px, are strongly associated with accelerated HIV-1 disea

20 als with B*35-PY, but not in those with B*35-Px.

21 -thirds in ZF rats made hyperglycemic by 60% Px.

22 wofold increase in islets of 14-day post-60% Px Sprague-Dawley rats that hyperexpress beta-cell PPARg

23 found that it decreased from 35 microm at a Px of -0.5 MPa to 6 microm at -8 MPa.

24 In addition, islets isolated 3-7 d after Px showed higher IDX-1 protein expression than control i

25 y detected in these ducts 1 and 7 days after Px or sham Px but was easily detected at 2 and 3 days af

26 ut was easily detected at 2 and 3 days after Px.

27 ts but was strong in ducts at 2-3 days after Px.

28 was extracted from rats 4 and 14 weeks after Px or sham Px surgery.

29 in between Px at stomatal closure (Pg12) and Px at 50% loss of conductivity.

30 These were in the HLA-B35-Px epitope and the HLA-B27-KK10 epitope.

31 cavitation was defined as the margin between Px at stomatal closure (Pg12) and Px at 50% loss of cond

32 , we used the empirical relationship between Px and Df to model the freeze-thaw response in conifer s

33 The gene controlled by Px has been called antE.

34 a functioning kidney allograft, the need for Px for symptoms and radiological findings is not rare (3

35 ed with open flap debridement procedures for Px and Bx.

36 The level of GLUT2 mRNA from Px islets was 24 +/- 4% of that of islets from sham-oper

37 25 cm H2O in the three high-pressure groups (Px).

38 ased 60-fold and glutathione peroxidase (GSH Px) approximately 2.7-fold.

39 Their mRNA levels of bcl-2, bax, and GSH-Px essentially were unchanged.

40 8-OHdG and GSH-Px in saliva in both periodontitis groups were significa

41 The addition of exogenous GSH-Px led to restoration of platelet inhibition by NO.

42 Upregulation of GSH-Px and depletion of GSH indicate a reparative process of

43 Moreover, the mRNA levels of GSH-Px were significantly elevated.

44 Glutathione peroxidase (GSH-Px) activity was decreased in the patients' plasmas comp

45 ies of catalase, glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd) in the liver.

46 2, bax, p53, and glutathione peroxidase (GSH-Px) genes.

47 zyme activity of glutathione peroxidase (GSH-Px) were analyzed with enzyme-linked immunosorbent assay

48 (Cu/Zn SOD) and glutathione peroxidase (GSH-Px).

49 thione peroxidase/glutathione reductase (GSH-Px/GSSG-R) functions, protein expression of gamma-glutam

50 Perifused islets isolated from hyperglycemic Px rats showed reduced insulin responses to GLP-1 and GI

51 ange in beta-cell phenotype of hyperglycemic Px rats resulted in a reduced sensitivity to the beta-ce

52 In Px rats, the mechanism is an increase in the beta-cell i

53 In Px, the degree of suppression with fasting was similar,

54 In contrast, in Px the insulin response to GLP-1 tripled in association

55 Hyperglycemia in Px rats also led to activation of nuclear factor-kappaB

56 BCM increased in Px mice from 2 days onwards and was approximately 68% of

57 degree of hyperglycemia and were reversed in Px rats by 2-week treatment with phlorizin (treatment th

58 ast, the increase was less than threefold in Px, reaching an insulin response at 16.7 mM glucose that

59 a showed that the preferred binding motif is Px(P/A)xPR.

60 ern blot analysis of homogenates of isolated Px islets also showed a reduction in GLUT2 protein; dens

61 cies that maintain relatively high gs at low Px, thereby maintaining carbon assimilation, albeit at t

62 43), all of which match the consensus motif (Px[S/T]P) for phosphorylation by mitogen-activated prote

63 uit (kL) declined with increasingly negative Px.

64 significantly between the Px (n = 39) and no-Px groups, except for a higher proportion of females in

65 raft pancreatectomy (Px) and 196 did not (no-Px).

66 GLUT2 immunofluorescence in the beta-cell of Px rats was greatly reduced.

67 Furthermore, beta-cells of Px rats were not vulnerable to apoptosis when further ch

68 tly different for common pancreatic ducts of Px, sham Px, and unoperated rats and did not change with

69 y reverses the changes in gene expression of Px rats at 4 weeks, the changes at 14 weeks were only pa

70 ecreased in islets of 90% pancreatectomized (Px) hyperglycemic rats, with recovery when glucose level

71 on in islets of partially pancreatectomized (Px) rats.

72 eas in rats 4-6 wk after 90% pancreatectomy (Px) and sham-operated controls.

73 After 90% pancreatectomy (Px), the adult pancreas regenerates in a process recapit

74 hese, 50 underwent allograft pancreatectomy (Px) and 196 did not (no-Px).

75 c regeneration after partial pancreatectomy (Px) and (2) define the involvement of the PI3K/Akt pathw

76 4 weeks after 85-95% partial pancreatectomy (Px) when beta-cells have impaired glucose-induced insuli

77 4 weeks after a 90% partial pancreatectomy (Px), a well-characterized model of hyperglycemia.

78 5 days following 60% partial pancreatectomy (Px).

79 c rats 4 weeks after partial pancreatectomy (Px).

80 way in pancreatic regeneration after partial Px was assessed by effects of a pharmacologic PI3K inhib

81 generation and pAkt expression after partial Px were significantly decreased with aging.

82 educed pancreatic regeneration after partial Px.

83 Following partial Px, pancreatic regeneration and activation of the PI3K p

84 ugh a direct point (Pd), a cross-body point (Px), or a familiar symbolic gesture (S).

85 ta-cell clusters/small islets at 2 days post-Px contributed substantially to BCM augmentation, follow

86 ), thereby maintaining high water potential (Px; isohydric), from those species that maintain relativ

87 diameter across a range of xylem pressures (Px) in the conifers Pinus contorta and Juniperus scopulo

88 ment learning model (exceedance probability, Px = .92) and had increased exploratory behavior compare

89 Promoter Px is turned on at the same time as promoter P3 during e

90 The transcript from promoter Px codes for a small protein with partial homology to th

91 A Bacillus subtilis promoter, Px, that functions in a convergent manner with the sigA

92 /-)), normoglycemic 60% pancreatectomy rats (Px), normoglycemic and hyperglycemic Zucker fatty (ZF) r

93 and loss of conductivity at minimum seasonal Px, respectively.

94 in these ducts 1 and 7 days after Px or sham Px but was easily detected at 2 and 3 days after Px.

95 ed from rats 4 and 14 weeks after Px or sham Px surgery.

96 rent for common pancreatic ducts of Px, sham Px, and unoperated rats and did not change with time aft

97 cific messages were reduced, we analyzed the Px islets for the pancreas-duodenum-specific transcripti

98 teristics differed significantly between the Px (n = 39) and no-Px groups, except for a higher propor

99 duced (approximately 80%) in islets from the Px rats.

100 The most common presentation in the Px group was abdominal pain.

101 pt for a higher proportion of females in the Px group.

102 rglycemia; low hyperglycemia was assigned to Px rats with fed blood glucose levels less than 150 mg/d

103 phenotype, in islets from phlorizin-treated Px rats.

104 Treating Px rats with phlorizin normalized hyperglycemia without

105 showing loss of conductivity (embolism) with Px down to -8 MPa were generated with versus without sup

106 frican-American female, patient (proband X, [Px]) reported with a chief complaint of tooth mobility a