ライフサイエンスコーパス: Q fever

1 differently modulated in men and women with Q fever.

2 ver but are lacking in patients with chronic Q fever.

3 a lions may be a risk factor for contracting Q fever.

4 l pathogen responsible for acute and chronic Q fever.

5 ich is associated with a case of human acute Q fever.

6 oonotic bacterial pathogen that causes human Q fever.

7 r bacterium and the causative agent of human Q fever.

8 he design of new generation vaccines against Q fever.

9 d the etiological agent of the human disease Q fever.

10 iella burnetii, the causative agent of human Q fever.

11 the clinical illness seen in human cases of Q fever.

12 he etiological agent of the zoonotic disease Q fever.

13 differential diagnosis of acute and chronic Q fever.

14 lular bacterium and the etiological agent of Q fever.

15 rnetii, the rickettsial organism that causes Q fever.

16 iphospholipid dosages in patients with acute Q fever.

17 sorders have been described in patients with Q fever.

18 4 at the French National Referral Center for Q fever.

19 ith predisposition to development of chronic Q fever.

20 iella burnetii can lead to acute and chronic Q fever.

21 n an increased likelihood to develop chronic Q fever.

22 e bacterium that causes the zoonotic disease Q fever.

23 MYD88 (-938C>A) were associated with chronic Q fever.

24 contribute to the increased risk of chronic Q fever.

25 f developing a peptide mimic vaccine against Q fever.

26 eloping a safe and effective vaccine against Q fever.

27 The phase I form is responsible for Q fever, a febrile illness with flu-like symptoms that o

28 ar Gram-negative bacterium that causes human Q fever, a flu-like disease that can progress to chronic

29 Coxiella burnetii causes human Q fever, a zoonotic disease that presents with acute flu

30 Coxiella burnetii is the causative agent of Q fever, a zoonotic disease that threatens both human an

31 suspected patient-to-patient transmission of Q fever among pregnant women in a high-risk pregnancy un

32 ellular bacterial pathogen that causes human Q fever, an acute debilitating flu-like illness that can

33 lla burnetii is the bacterial agent of human Q fever, an acute, flu-like illness that can present as

34 neumonia (CAP) is the major manifestation of Q fever, an emerging disease in French Guiana.

35 The outcome of Q fever, an infectious disease caused by Coxiella burnet

36 Of the 759 patients with acute Q fever and available echocardiographic results, 9 (1.2%

37 a valuable technique in diagnosis of chronic Q fever and during follow-up, often leading to a change

38 nt aortic vegetation in a patient with acute Q fever and high levels of IgG anticardiolipin antibodie

39 were genotyped in 139 patients with chronic Q fever and in 220 controls with cardiovascular risk-fac

40 ligate intracellular bacterium, causes human Q fever and is considered a potential agent of bioterror

41 s were associated with the activity of acute Q fever and Q fever endocarditis, respectively.

42 First, we describe our experience on Q fever and Tropheryma whipplei infection management bas

43 ntibiotic prophylaxis in patients with acute Q fever and valvulopathy has never been validated in a c

44 important in the pathophysiology of clinical Q fever and/or the induction of protective immunity.

45 ma, were up-regulated in patients with acute Q fever, and the expression levels of the late genes ALO

46 Cases of chronic Q fever are extremely rare and most often manifest as cu

47 to Coxiella burnetii, the causative agent of Q fever, are uncommon in the United States.

48 gnostic value of (18)F-FDG PET/CT in chronic Q fever at diagnosis and during follow-up.

49 The Q fever bacterium Coxiella burnetii replicates inside ho

50 omas are present in patients with resolutive Q fever but are lacking in patients with chronic Q fever

51 Q fever case report forms submitted during 1999-2015 wer

52 Current practice for diagnosis of Q fever, caused by the intracellular pathogen Coxiella b

53 s used as a new diagnostic tool for previous Q fever, circumventing most of these drawbacks.

54 Linking a single dairy-goat farm to a human Q-fever cluster, we show widespread transmission, massiv

55 ntly (P = .01) increased in males with acute Q fever compared with healthy volunteers.

56 Acute Q fever could be associated with an increased prevalence

57 e, we sought to determine how commonly acute Q fever could cause valvular vegetations associated with

58 igate intracellular bacterial agent of human Q fever, Coxiella burnetii, has a remarkable ability to

59 The intracellular bacterial agent of Q fever, Coxiella burnetii, translocates effector protei

60 to 2014 French National Referral Center for Q fever database.

61 -5% of all acute Q fever infections, chronic Q fever develops, mostly manifesting as endocarditis, in

62 Persistent infection (chronic Q fever) develops in 1%-5% of patients.

63 To test if increased IgG aCL at acute Q fever diagnosis is associated with an increased risk o

64 tes of Coxiella burnetii, the cause of human Q fever, display different phenotypes with respect to in

65 reases in fetal death and malformation after Q fever during pregnancy.

66 fevers for 14 months who was diagnosed with Q fever endocarditis based on an extremely high antibody

67 of clinical and epidemiological features of Q fever endocarditis collected through passive surveilla

68 Some cases of apparent Q fever endocarditis could not be classified by CSTE lab

69 ssess the clinical spectrum and magnitude of Q fever endocarditis in the United States.

70 There are few descriptive analyses of Q fever endocarditis in the United States.

71 The prevention of Q fever endocarditis through the use of systematic echoc

72 Q fever endocarditis was defined according to recently u

73 ults, 9 (1.2%) were considered to have acute Q fever endocarditis, none of whom had a previously know

74 iated with the activity of acute Q fever and Q fever endocarditis, respectively.

75 ut did not meet the CSTE case definition for Q fever endocarditis.

76 02) were independently associated with acute Q fever endocarditis.

77 were specifically increased in patients with Q fever endocarditis.

78 onsidered in the management of patients with Q fever, especially those with persistent focalized infe

79 Coxiella burnetii, the causative agent of Q fever, establishes a unique lysosome-derived intracell

80 About 90% of patients with chronic Q fever failed to form granulomas.

81 will develop chronic fatigue, referred to as Q fever fatigue syndrome (QFS).

82 uman cases and occurred in a region that was Q-fever free before 2009, providing a unique quasi-exper

83 d in the French National Referral Center for Q fever from January 2007 to December 2011 were included

84 iella burnetii, the causative agent of human Q fever, has been considered a prototypical obligate int

85 Coxiella burnetii, the etiological agent of Q fever, has two phase variants.

86 During acute Q fever, high IgG aCL prevalence has been reported, but

87 Coxiella burnetii causes acute Q fever in humans and occasional chronic infections that

88 haride (LPS), is highly virulent, and causes Q fever in humans and pathology in experimental animals.

89 rRNA gene of Coxiella burnetii, the agent of Q fever in humans, contains an unusually high number of

90 , the etiological agent of acute and chronic Q fever in humans, is a naturally intracellular pathogen

91 Coxiella burnetii, the etiological agent of Q fever in humans, is an intracellular pathogen that rep

92 tive bacterium that causes acute and chronic Q fever in humans.

93 ular bacterium that causes acute and chronic Q fever in humans.

94 s is considered to be a late complication of Q fever in patients with preexisting valvular heart dise

95 follow-up period for a patient with chronic Q fever in the United States.

96 ection control guidelines are sufficient for Q fever-infected women in similar settings.

97 ignificant disabilities, related to an acute Q fever infection, without other somatic or psychiatric

98 In 1%-5% of all acute Q fever infections, chronic Q fever develops, mostly man

99 a, Coxiella burnetii, the etiologic agent of Q fever, inhabits a spacious acidified intracellular vac

100 syndrome with valvular vegetations in acute Q fever is a new clinical entity.

101 Q fever is a worldwide zoonosis caused by Coxiella burne

102 Q fever is a zoonosis caused by Coxiella burnetii, a uni

103 Acute Q fever is a zoonotic disease caused by the obligate int

104 Q fever is a zoonotic disease of worldwide significance

105 Q fever is an infection caused by Coxiella burnetii.

106 Q fever is caused by Coxiella burnetii, a bacterium that

107 Acute human Q fever is characterized by flu-like symptoms that, in s

108 The prevalence of Q fever is higher in men than in women.

109 Although Q fever is mainly transmitted by aerosol infection, stud

110 Human Q fever is mainly transmitted by aerosol infection.

111 Coxiella burnetii, the etiological agent of Q fever, is a gram-negative obligate intracellular bacte

112 Coxiella burnetii, the causative agent of Q fever, is a human intracellular pathogen that utilizes

113 Coxiella burnetii, the etiological agent of Q fever, is a small, Gram-negative, obligate intracellul

114 Coxiella burnetii, the causative agent of Q fever, is a zoonotic disease with potentially life-thr

115 Coxiella burnetii, the cause of human Q fever, is an aerosol-borne, obligate intracellular bac

116 Coxiella burnetii, the etiological agent of Q fever, is an obligate intracellular bacterium prolifer

117 Coxiella burnetii, the causative agent of Q fever, is an obligate intracellular bacterium.

118 Growth of Coxiella burnetii, the agent of Q fever, is strictly limited to colonization of a viable

119 were comparable to those seen in human acute Q fever, making this an accurate and valuable animal mod

120 Humans with Q fever may experience an acute flu-like illness and pne

121 lla burnetii, the etiological agent of human Q fever, occupies a unique niche inside the host cell, w

122 lar survival are poorly defined and a recent Q fever outbreak in the Netherlands emphasizes the need

123 Successful host cell colonization by the Q fever pathogen, Coxiella burnetii, requires translocat

124 ected biomarkers were assessed in blood from Q fever patients by real-time reverse transcription poly

125 An excess risk of DLBCL and FL was found in Q fever patients compared with the general population (S

126 Q fever patients with persistent focalized infection wer

127 ncept of M1/M2 polarization is applicable to Q fever patients.

128 les a dynamic approach for the evaluation of Q fever patients.

129 ted biomarkers and tested their relevance in Q fever patients.

130 urately identifies patients with low risk of Q fever pneumonia and may help physicians to make more r

131 bjectives were to estimate the prevalence of Q fever pneumonia and to build a prediction rule to iden

132 a prediction rule to identify patients with Q fever pneumonia for empirical antibiotic guidance.

133 -one patients with CAP were included and the Q fever pneumonia prevalence was 24.4% (95% confidence i

134 th a predictive score </=3 had a low risk of Q fever pneumonia with a negative predictive value of 0.

135 >185 mg/L were independently associated with Q fever pneumonia.

136 st prediction rule to identify patients with Q fever pneumonia.

137 onal transmission patterns associated with a Q-fever point source.

138 A meta-analysis of 136 Q fever pregnancies, including 4 new cases and 7 populat

139 ogenesis and genetics and aid development of Q fever preventatives such as an effective subunit vacci

140 Q fever-related mortality rate in patients with and with

141 effective new generation vaccine to prevent Q fever remains an important public health goal.

142 We review all cases of chronic Q fever reported in the United States and discuss import

143 ion by Coxiella burnetii, the cause of human Q fever, requires pathogen-directed biogenesis of a larg

144 A need exists in Q fever research for animal models mimicking both the ty

145 human patients who had recovered from acute Q fever, respectively, revealed both unique SCV/LCV anti

146 llular pathogens that cause diseases such as Q fever, rickettsioses, brucelloses, tularemia, and othe

147 is, with directed serological testing (i.e., Q fever serology, Bartonella serology) in culture-negati

148 Q fever should be considered in patients with prosthetic

149 Although the name "chronic Q fever" suggests otherwise, rapid evolution (<1 month)

150 We observed a lymphoma in a patient with Q fever that prompted us to investigate the association

151 odel for inhalation to determine the risk of Q fever through tap water.

152 The evolution from acute Q fever to endocarditis is associated with age and valvu

153 Rapid progression from acute Q fever to endocarditis is associated with high levels o

154 A screening-level risk assessment of Q fever transmission through drinking water produced fro

155 To understand the pathogenicity of Q fever, we investigated the roles of immune components

156 single-nucleotide polymorphisms and chronic Q fever were assessed by means of univariate logistic re

157 from an endemic area with a risk for chronic Q fever were enrolled.

158 he French National Referral Center for acute Q fever were included in a cohort study.

159 s with possible, probable, or proven chronic Q fever were included.

160 ll adult Dutch patients suspected of chronic Q fever who were diagnosed since 2007 were retrospective

161 Approximately 20% of patients with acute Q fever will develop chronic fatigue, referred to as Q f