ライフサイエンスコーパス: QT interval

1 ard ECG measures (heart rate, PQ-, QRS-, and QT-intervals).

2 myocardial scar is associated with a longer QT interval.

3 ing RING finger protein 207 (RNF207) and the QT interval.

4 s that shorten action potential duration and QT interval.

5 arts with an INaP blocker also shortened the QT interval.

6 hy by voltage and slight prolongation of the QT interval.

7 rtion of patients, most commonly a prolonged QT interval.

8 mia, as measured by the electrocardiographic QT interval.

9 extremely unlikely in the absence of a short QT interval.

10 sted by prolongation of the QRS duration and QT interval.

11 parent risk of prolongation of the corrected QT interval.

12 10 loci explain 5.4-6.5% of the variation in QT interval.

13 ent human genome-wide association studies of QT interval.

14 q21 locus, which is strongly associated with QT interval.

15 the action potential duration and corrected QT interval.

16 zation and repolarization as manifest in the QT interval.

17 in clinical settings, such as prediction of QT interval.

18 tadalafil produced equivalent effects on the QT interval.

19 action potential and by prolongation of the QT interval.

20 articularly when associated with a prolonged QT interval.

21 eatment of erectile dysfunction (ED), on the QT interval.

22 Q1-G589D mutation alone does not prolong the QT interval.

23 e (a proton-pump inhibitor) will prolong the QT interval.

24 achycardia but abolished the prolongation of QT interval.

25 ontrolling action potential duration and the QT interval.

26 layed repolarization and prolongation of the QT interval.

27 for this pediatric patient cohort with short QT interval.

28 iness was prolonged, along with both QRS and QT interval.

29 r exercise duration, and longer PR, QRS, and QT intervals.

30 al treatments for individuals with prolonged QT intervals.

31 enotype is combined with shorter-than-normal QT intervals.

32 of VT under conditions associated with short QT intervals.

33 10% incidence) were nausea (16%), prolonged QT interval (12%), vomiting (11%), and dysgeusia (11%);

34 is associated with an extremely abbreviated QT interval (200 ms) on ECG and paroxysmal atrial fibril

35 s (84% male; age, 26 +/- 15 years; corrected QT interval, 329 +/- 22 ms) were studied, and 62 were fo

36 over, patients with schizophrenia had longer QT-intervals (410.9 versus 393.1 and 401.9 ms; both P<0.

37 l/L, n=5) led to greater abbreviation of the QT interval, a further increase in TDR(max) (from 55.4+/

38 Extremes of the electrocardiographic QT interval, a measure of cardiac repolarization, are as

39 Prolongation of the electrocardiographic QT interval, a measure of cardiac repolarization, is ass

40 ly 24% to 32% of patients had rate-corrected QT intervals above 500 ms.

41 ments predict that, in addition to the short QT interval, absence of inward rectification in the E299

42 Analysis of corrected QT interval among 74 control subjects from our dataset s

43 The QT interval, an electrocardiographic measure reflecting

44 Furthermore, glucose ingestion increased QT interval and aggravated the cardiac repolarization di

45 Adjustment for QT interval and coronary heart disease risk factors atte

46 s, such as palonosetron, does not affect the QT interval and has a half-life of 40 h that should be a

47 f ethanol) per day with heart rate-corrected QT interval and heart rate assessed from electrocardiogr

48 prognostic association between the baseline QT interval and incident cardiovascular events in indivi

49 the normal activation sequence prolongs the QT interval and increases the existing transmural disper

50 hERG1 channels by some drugs can prolong the QT interval and induce arrhythmia.

51 The QT interval and its components were measured at baseline

52 slight abbreviation (300 micromol/L) of the QT interval and no change in transmural dispersion of re

53 Quinidine normalized the QT interval and prevented stimulation-induced ventricula

54 nate (SSG), has been reported to prolong the QT interval and produce life-threatening arrhythmias.

55 erlap known loci associated with the cardiac QT interval and QRS duration.

56 ients with higher sympathetic control of the QT interval and reduced vagal control of heart rate are

57 ies may be effective in shortening corrected QT interval and reducing TdP recurrence risk.

58 ividuals are at increased risk for prolonged QT interval and SCD.

59 ed IKs inhibition necessary to normalize the QT interval and terminate re-entry in SQT2 conditions wa

60 st that the incidence of prolongation of the QT interval and the occurrence of torsades de pointes is

61 ions in NOS1AP were associated with baseline QT interval and the risk of SCD in white US adults.

62 association between NOS1AP variants and the QT interval and to examine the association with SCD in a

63 adverse cardiac events (prolongation of the QT interval and/or development of torsades de pointes).

64 on of p90RSK (p90RSK-Tg) had prolongation of QT intervals and of ventricular myocyte action potential

65 these mice have prolongation of the QRS and QT intervals and spontaneous ventricular arrhythmias, in

66 ity were assessed every 30 min and corrected QT intervals and T-wave morphology every 60 min.

67 omplexes (PVCs) from 40 patients with normal QT intervals and with PVCs in 24 of the 35 LQTS patients

68 rophysiologically (bradycardia and prolonged QT interval) and functionally (hyperdynamic left ventric

69 arrest (normal left ventricular function and QT interval) and selected family members from the Cardia

70 n (PR interval), ventricular repolarization (QT interval), and ventricular conduction (QRS interval).

71 precordial ECG leads, a shorter-than-normal QT interval, and a history of sudden cardiac death.

72 ion-induced syncope since age 10, had normal QT interval, and displayed ventricular ectopy during str

73 rugs delays cardiac repolarization, prolongs QT interval, and is associated with an increased risk of

74 r hypertrophy, prolongation of the corrected QT interval, and repolarization changes (ST/T wave abnor

75 ght ventricular ejection fraction, prolonged QT interval, and total infarct size and resulted in impr

76 an extend action potential duration, prolong QT intervals, and ultimately contribute to life-threaten

77 own whether any of the components within the QT interval are responsible for its association with SCD

78 nificantly enriched for association with the QT interval, as compared to genome-wide markers.

79 Electrocardiographic parameters, including QT intervals, as well as ventricular action potential wa

80 on age, sex, heart rate, frontal T axis, and QT interval assesses the risk for CVD and compares favor

81 epolarisation and electrocardiographic (ECG) QT interval, associated with increased age-dependent ris

82 Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands wi

83 n of common genetic variants contributing to QT interval at baseline, identified through genome-wide

84 diac PI3K signaling in diabetes prolongs the QT interval at least in part by causing an increase in I

85 ns, followed by normalization in mean HR and QT intervals at 26 days post ventricular amputation (dpa

86 ed the biological clock and normalization of QT intervals at 26 dpa, providing the first evidence of

87 in vitro, the patient reported had a normal QT interval before administration of the drug.

88 e majority of LQTS patients have a corrected QT interval below this threshold, and a significant mino

89 of the channel are associated with the long QT (interval between the Q and T waves in electrocardiog

90 romes, representing the very extremes of the QT interval, both seem to have a high prevalence of AF.

91 dictors for TdP commonly rely on a prolonged QT interval but rarely consider abnormal T-U waves.

92 pective analysis of an ECG identified a long QT interval, but sequencing of known LQT genes was uninf

93 on (APD) of individual myocytes and thus the QT interval by altering multiple ion currents, including

94 r action potential (AP) for investigation of QT interval changes and arrhythmia substrates.

95 or 3.9-ms higher age-, sex- and RR-adjusted QT interval compared with GG individuals (P=0.00006).

96 18594 minor homozygotes had a 12.5-ms-longer QT interval compared with major homozygotes (P = 1.5 x 1

97 494366 minor homozygotes had a 9.3-ms-longer QT interval compared with major homozygotes (P = 5.7 x 1

98 e examined the association of the individual QT-interval components (R-wave onset to R-peak, R-peak t

99 When all of the QT-interval components were included in the same model,

100 Forty-three percent of TdP patients had a QT interval corrected by Bazett's formula, for heart rat

101 mine the association between prolongation of QT interval corrected for heart rate (QTc) with incident

102 .002]) independently of patients' individual QT interval corrected for heart rate (QTc).

103 ed low-frequency HRV and prolongation of the QT interval corrected for heart rate (QTc).

104 the QT interval on electrocardiogram, with a QT interval corrected for heart rate ranging from 620 to

105 QT intervals, corrected for heart rate, >500 ms and abno

106 mice, although action potential duration and QT intervals did not reflect this benefit.

107 bjects at the extremes of a population-based QT interval distribution of 3,966 subjects from the KORA

108 posure has been associated with increases in QT interval duration (QT).

109 neither associated with heart rate-corrected QT interval duration (QTc) nor cardiac events in any of

110 associated with MeanNN, heart-rate-corrected QT interval duration (QTc), deceleration capacity, and w

111 The corrected baseline 12-lead ECG QT interval duration (QTcorr) was determined by adjustme

112 Two NOS1AP SNPs are strongly associated with QT interval duration in a predominately diabetic Europea

113 or protein (NOS1AP) gene are associated with QT interval duration in a type 2 diabetes-enriched sampl

114 e KCNH2 locus are associated with continuous QT interval duration in an unselected community-based sa

115 75 genotypes were associated with continuous QT interval duration in men and women (2-df P=0.002), wi

116 No association between the NOS1AP SNPs and QT interval duration was observed in the limited number

117 atures that, along with heart rate-corrected QT interval duration, may risk stratify perinatal manage

118 QT interval duration, reflecting myocardial repolarizati

119 srupted cardiac function including prolonged QT interval duration.

120 NH2 variants for association with continuous QT interval duration.

121 show that cardiac ion-channel expression and QT-interval duration (an index of myocardial repolarizat

122 e a contributor to population variability in QT-interval duration among men.

123 stosterone levels may explain differences in QT-interval duration between men and women and could be

124 multivariate adjusted differences in average QT-interval duration comparing the highest quartiles wit

125 tween physiologic levels of sex hormones and QT-interval duration in humans was evaluated using data

126 Estradiol levels were not associated with QT-interval duration in men, but there was a marginally

127 The mechanism causing a prolongation of the QT interval during epilepsy remains unknown.

128 Changes in the QT interval during exercise were measured, and QT/RR-int

129 omatic but displaying a marginally prolonged QT interval during exercise.

130 A paradoxical increase in the uncorrected QT interval during infusion of low-dose epinephrine appe

131 The median change in QT interval during low-dose epinephrine infusion was -23

132 vided a significant increase in variation in QT interval explained compared with a model with only no

133 ed 27 nonsynonymous variants associated with QT interval (FDR 5%), 22 of which were in TTN.

134 Median corrected QT interval for heart rate was 312 ms (range: 194 to 355

135 trioventricular block, AZD1305 increased the QT interval from 535+/-28 to 747+/-36 ms (+40%, P<0.0001

136 ericans (n=12,097) and regressed on measured QT interval from ECGs.

137 R, and T axes; heart rate; and PR, QRS, and QT intervals from NHANES I.

138 ontaneous beat-to-beat variability of RR and QT intervals from standard 24-h electrocardiogram Holter

139 otal of 1,059 LQTS patients with a corrected QT interval > or =450 ms presenting with syncope as a fi

140 atient in either group exhibited a corrected QT interval >/=500 msec.

141 A corrected QT interval >500 msecs was considered prolonged.

142 Taken together with the mapping of a QT interval GWAS locus near TTN, our observation of rare

143 Risk associated with short QT interval has recently received recognition.

144 es, but were not associated with uncorrected QT interval, HR-corrected QT interval or high-density li

145 In this study, we sought to validate PGS for QT interval in 2 real-world cohorts of European ancestry

146 sought to determine the prevalence of short QT interval in a pediatric population and associated cli

147 genetic disease characterized by a prolonged QT interval in an electrocardiogram (ECG), leading to hi

148 in one; hypertension and prolonged corrected QT interval in another) occurred in patients initially e

149 shortened the action potential duration and QT interval in arterially perfused rabbit ventricular we

150 as longer than neonatal heart rate-corrected QT interval in both group 2 (491.2+/-27.6; P=0.004) and

151 002 mg/kg intravenously), and placebo on the QT interval in healthy men were compared (placebo and ta

152 of CAPON gene variants with extremes of the QT interval in human populations.

153 ant role for propagation variation affecting QT interval in humans, we show that common polymorphisms

154 the strongest SNP previously associated with QT interval in individuals of European ancestry.

155 Heart rate and QT interval in lead II were measured using the Bazett fo

156 to block late sodium current and to shorten QT interval in LQT3 patients.

157 sociation studies (GWAS) of variation in the QT interval in population-based cohorts now report assoc

158 providing a molecular correlate for a longer QT interval in pregnancy.

159 Hydroquinidine (HQ) prolongs the QT interval in SQTS patients, although whether it reduce

160 his analogue also led to prolongation of the QT interval in the dog that was linked to affinity for h

161 her coding variants at these 28 genes affect QT interval in the general population as well.

162 ed cardiomyocytes nor any lengthening of the QT interval in vivo.

163 tric oxide synthase, are associated with the QT interval in white adults.

164 were significantly associated with adjusted QT interval in whites (P<0.0001).

165 channel blockers are largely used to shorten QT intervals in carriers of SCN5A mutations.

166 S1AP gene variants play a role in modulating QT intervals in healthy subjects and severity of present

167 to control levels and equalized the APD and QT intervals in Inh mice to control and WT levels.

168 However, increased miR-133a levels increased QT intervals in surface electrocardiographic recordings

169 vealed an age-dependent heart rate-corrected QT interval increase (1% per additional 10 years) irresp

170 ts investigated altered heart rate-corrected QT interval irrespective of mutation status, as well as

171 Prolongation of the electrocardiographic QT interval is a risk factor for sudden cardiac death (S

172 The ECG QT interval is associated with risk of sudden cardiac de

173 s have demonstrated that prolongation of the QT interval is associated with sudden cardiac death (SCD

174 The risk of SCD with the QT interval is driven by prolongation of the T-wave onse

175 fficient for diagnosis, unless the corrected QT interval is repeatedly >/=500 ms without an acquired

176 The QT interval is the electrocardiographic manifestation of

177 However, the QT interval itself is insufficient for diagnosis, unless

178 nts (20%) experienced a >/=60-ms increase in QT interval, leading to bedaquiline discontinuation in 2

179 rhythmia phenotype, and only 2 had corrected QT interval longer than 500 milliseconds.

180 pressure, heart rate variability, corrected QT interval, low density lipoprotein (LDL) cholesterol,

181 isplaying ST-segment elevation and corrected QT intervals < or = 360 ms had mutations in genes encodi

182 The neonatal heart rate-corrected QT interval (mean+/-SE) of group 1 (664.7+/-24.9) was lo

183 populations, appropriate use of ischemia and QT-interval monitoring among select populations, alarm m

184 t electrocardiogram occurrences of corrected QT interval more than 500 ms (an indicator of potential

185 effect estimates from association tests with QT interval obtained from prior genome-wide association

186 Diffuse T-wave inversion and a prolonged QT interval occurred in most patients.

187 of onset of 10 months, an average corrected QT interval of 676 ms, and a high prevalence of cardiac

188 897 polymorphism is predicted to prolong the QT interval of cardiac myocytes.

189 the SCN5A-D1790G mutation and shortened the QT interval of LQT3 patients.

190 essential in control of the duration of the QT interval of the electrocardiogram.

191 The long QT interval of type 1 diabetic hearts was shortened by i

192 ex was increased (P<0.001) and the corrected QT interval on ECG was prolonged (P<0.001) in HFpEF rats

193 individuals had extreme prolongation of the QT interval on electrocardiogram, with a QT interval cor

194 Prolonged heart rate-corrected QT interval on electrocardiograms (ECGs) is associated w

195 pounds have been identified that prolong the QT interval on the electrocardiogram and cause torsade d

196 ally produce exaggerated prolongation of the QT interval on the electrocardiogram and the morphologic

197 Prolongation of the QT interval on the electrocardiogram is also a risk fact

198 PD) in cardiac myocytes, prolongation of the QT interval on the surface electrocardiogram (ECG), and

199 ondition characterized by abnormally 'short' QT intervals on the ECG and increased susceptibility to

200 ce of increased risks of prolongation of the QT interval or dysglycemia with the 4-month regimen.

201 men is not beneficial for heart function via QT interval or heart rate but could be detrimental.

202 d with uncorrected QT interval, HR-corrected QT interval or high-density lipoprotein-cholesterol.

203 ucleotide polymorphisms in NOS1AP and either QT interval or SCD were observed in blacks.

204 h congenital or acquired prolongation of the QT interval, or long QT syndrome (LQTS), are at risk of

205 of association between genetic ancestry and QT interval (P=0.94).

206 longer QTrr (i.e., age- and gender-adjusted QT interval; p = 0.0004), a more depressed ST-segment in

207 more reactive sympathetic modulation of the QT interval, particularly during daytime when arrhythmia

208 4991 in meta-analysis: increase in corrected QT interval per C allele: 9.1 +/- 3.2 ms, p = 1.7 x 10(-

209 points; 95% CI, -1.97 to -0.13; P = .03) and QT interval prolongation (18.1 ms; 95% CI, 6.1-30.1; P =

210 Here we report a correlation between QT interval prolongation and T-wave notching in LQTS2 pa

211 dentifying hospitalized patients at risk for QT interval prolongation could lead to interventions to

212 in APD and INaP in myocytes translated into QT interval prolongation for both types of diabetic mice

213 polarization is underscored by evidence that QT interval prolongation in diabetes mellitus also may r

214 pport system (CDSS) for reducing the risk of QT interval prolongation in hospitalized patients.

215 QT interval prolongation is a heritable risk factor for

216 QT interval prolongation is common with ATO and can pose

217 QT interval prolongation is common with ATO treatment, b

218 ereby causing delayed repolarization seen as QT interval prolongation on the ECG.

219 QT interval prolongation on the surface ECG is the hallm

220 Drug-induced QT interval prolongation, a risk factor for life-threate

221 base-line intervals may display exaggerated QT interval prolongation, and the potentially fatal poly

222 hat mutations cause action potential and ECG QT interval prolongation, consistent with clinical pheno

223 ents who receive medications associated with QT interval prolongation, including thioridazine, mesori

224 icant associations were seen among corrected QT interval prolongation, repolarization changes, and al

225 KCNH2, which accounts for the side effect of QT interval prolongation.

226 shed the pressor responses, tachycardia, and QT interval prolongation.

227 a newly recognized risk of dosage-dependent QT interval prolongation.

228 manifest on the surface electrocardiogram as QT interval prolongation.

229 oportion of patients who developed corrected QT-interval prolongation (p = 0.16), extrapyramidal symp

230 The degree of QT-interval prolongation and the number of breakthrough

231 790 microg/L) was associated with subsequent QT-interval prolongation in women.

232 nt of surrogate markers of TdP-risk, such as QT-interval prolongation or inhibition of the rapid dela

233 ositive for long-QT syndrome if the absolute QT interval prolonged by >/= 30 ms at 0.10 mug/kg per mi

234 QT interval-prolonging drug-drug interactions (QT-DDIs)

235 tween methadone and other drugs that possess QT interval-prolonging properties or slow the eliminatio

236 ected, in TdP patients, many known corrected QT interval-prolonging risk factors were simultaneously

237 rate, P duration, PR interval, QRS duration, QT interval, QRS axis, Sokolow-Lyon and Cornell voltages

238 All patients developed corrected QT interval (QTc interval) prolongation (median QTc inte

239 correlated significantly with the corrected QT interval (QTc) and clinical diagnostic score ranging

240 the predictive value of heart rate-corrected QT interval (QTc) for incident coronary heart disease (C

241 patients experienced dose-limiting corrected QT interval (QTc) prolongation, pneumonitis, or neuropat

242 The corrected QT interval (QTc) should be assessed as a routine when o

243 cohort study, prolongation of the corrected QT interval (QTc) was associated with an independent inc

244 abeling prolongation of heart rate-corrected QT interval (QTc), an arrhythmia risk marker.

245 ts of AKAP9 variants on heart rate-corrected QT interval (QTc), cardiac events, and disease severity.

246 with exertional syncope and normal corrected QT interval (QTc).

247 ith recurrent syncope and markedly prolonged QT interval (QTc, 530 ms).

248 for TdP included absolute and rate-corrected QT intervals (QTc) on drug therapy, the magnitude of QT

249 The median baseline corrected QT intervals (QTc) were 444 ms (gene negative), 456 ms (

250 electrocardiographically affected (corrected QT interval [QTc] > or = 470 ms), borderline (QTc 440 to

251 ac death during childhood included corrected QT interval [QTc] duration > 500 ms (hazard ratio [HR];

252 ian age 16 years, average referral corrected QT interval [QTc] of 481 ms) referred with a diagnosis o

253 rs (QRS voltage, QRS duration, and corrected QT interval [QTc]) were evaluated by using multivariable

254 AA) and tested their effects on standardized QT interval residuals.

255 diograms (ST-segment elevation and prolonged QT interval, respectively) and increased risk for malign

256 rious coding variants in TTN associated with QT interval show that TTN plays a role in regulation of

257 ), in a pre-defined set of 7 congenital long QT interval syndrome (cLQTS) genes encoding potassium ch

258 riants are associated with drug-induced long QT interval syndrome (diLQTS) and torsades de pointes.

259 Q1, a gene previously implicated in the long QT interval syndrome.

260 arrhythmogenesis and proarrhythmia; the long QT interval syndrome; newer, more selective class 3 anti

261 (acLQTS), which is associated with prolonged QT intervals, tachycardias, and sudden cardiac arrest.

262 eins are more enriched for associations with QT interval than observed for genome-wide comparisons.

263 ified 35 common variant loci associated with QT interval that collectively explain approximately 8-10

264 al criteria to identify loci associated with QT interval that do not meet genome-wide significance an

265 clinical feature of this syndrome is a long QT interval that results in cardiac arrhythmias.

266 lta), associated with shorter repolarization QT intervals (the time interval between the Q and the T

267 tance and coupling and thereby regulates the QT interval through propagation defects.

268 variants previously associated with baseline QT interval to drug-induced QT prolongation and arrhythm

269 sts that shifting the focus from the overall QT interval to its individual components will refine SCD

270 primary mechanism by which drugs prolong the QT interval) to evaluate our top candidate.

271 ving essentially identical resting corrected QT interval values.

272 ficant minority has normal resting corrected QT interval values.

273 s study aimed to determine whether increased QT interval variability is associated with an increased

274 QT interval variation is assumed to arise from variation

275 us are the most common genetic regulators of QT interval variation.

276 enetic variant, which explains up to 1.5% of QT interval variation.

277 collectively explain approximately 8-10% of QT-interval variation and highlight the importance of ca

278 from the corresponding common complex trait, QT-interval variation, to identify candidate genes that

279 egulator, have recently been associated with QT interval variations in a human whole-genome associati

280 Mean corrected QT interval was 403 (standard deviation, 30) ms, and no

281 Short QT interval was a rare finding in this pediatric populat

282 Although prolongation of the QT interval was associated with a 49% increased risk of

283 The QT interval was associated with incident cardiovascular

284 Corrected QT interval was measured by surface ECG.

285 QT interval was measured using a standard 12-lead electr

286 However, a prolonged rate-corrected QT interval was not a consistent feature, indicating tha

287 SNPs, and a genome-wide association study of QT interval was performed in 10 cohorts (n=13,105).

288 Rate adaptation of QT interval was reduced.

289 The average corrected QT interval was significantly shorter in people with alt

290 ominance was identified, although the median QT interval was significantly shorter in women.

291 which was not correlated with rs16847548 or QT interval, was also independently associated with SCD

292 T axis, heart rate, and heart rate-corrected QT interval were the most significant ECG factors in the

293 QT intervals were assessed using four different correcti

294 In the 1270 (63%) with ECGs, corrected QT intervals were not different in variant carriers vs t

295 Baseline QT intervals were similar in the 2 groups (381 +/- 38 ms

296 atients, the ST-segment, the T-wave, and the QT-interval were analyzed using the MUSE (General Electr

297 the proband, including an exceedingly short QT interval with merging of the QRS and the T wave, abse

298 -deficient mice (ST3Gal4(-/-)) had prolonged QT intervals with a concomitant increase in ventricular

299 units were not associated with the corrected QT interval, with beta = 1.04 (95% confidence interval:

300 on of repolarization and prolongation of the QT interval, yet the mechanisms underlying CO-induced ar