ライフサイエンスコーパス: QTc interval

1 QTc interval >/=500 ms increased the risk of cardiac eve

2 QTc interval prolongation was defined as QTc interval >5

3 QTc intervals were analyzed according to age (< 16 or >

4 QTc intervals were measured in 241 patients with heart f

5 QTc intervals were prolonged (>440 ms) in 122 (51%) pati

6 C) runs (sertraline: 13.1%; placebo: 12.9%), QTc interval greater than 450 milliseconds at end point

7 ed the DSEC were more likely to experience a QTc interval increase of at least 30 milliseconds vs pla

8 en) and were 1.4 times more likely to have a QTc interval above 500 ms.

9 erval: 1.52 to 3.54, p < 0.001) for having a QTc interval >/=99th percentile (>/=458 ms).

10 Having a QTc interval lower than the first percentile (</=372 ms)

11 pregnant women) with cardiac parameters, all QTc intervals were within normal limits, with no signifi

12 Although QTc interval prolonged in 100% of patients, T-wave chang

13 , PR intervals (P = 0.014), QRS duration and QTc interval (both P = 0.003), but Normal-VLDL did not.

14 Median PR interval, QRS duration, and QTc interval were 156, 88, and 402 ms, respectively.

15 ts (PR interval, QRS axis, QRS duration, and QTc interval) were evaluated for single-nucleotide polym

16 Tc) on drug therapy, the magnitude of QT and QTc interval prolongation, and the change in T(peak) to

17 n, estimated glomerular filtration rate, and QTc interval.

18 ogram demonstrated slightly prolonged QT and QTc intervals and normal sinus rhythm.

19 ificantly greater symptoms, increased QT and QTc intervals and QTc dispersion, ventricular tachycardi

20 The RR, QT and QTc intervals and the high frequency component of heart

21 Both QT and QTc intervals are longer during sleep.

22 048 segments showed mean (+/- SD) RR, QT and QTc intervals of 830 +/- 100, 407 +/- 23 and 445 +/- 16

23 ith control, AM and SR increased RR, QT, and QTc intervals (P<0.0001 for all).

24 sinus slowing and increased PR, QRS, QT, and QTc intervals, as seen with azithromycin overdose.

25 QTc interval prolongation was defined as QTc interval >500 ms or increase in QTc of >/=60 ms from

26 dy, a J-shaped association was found between QTc interval duration and risk of AF.

27 red with baseline, the heart rate-corrected (QTc) interval was prolonged by 30 to 60 milliseconds in

28 In patients receiving multiple courses, QTc intervals returned to pretreatment levels before the

29 ine levels and a longer electrocardiographic QTc interval than did the sham group.

30 icant shortening of the electrocardiographic QTc interval and reduction of left ventricular systolic

31 athy, including cardiac isoenzyme elevation, QTc interval prolongation, and rapidly reversible cardia

32 ate during exercise, making the end-exercise QTc interval dependent on peak work load achieved.

33 iables predicts patients at highest risk for QTc interval prolongation and may be useful in guiding m

34 ed to a patient at moderate or high risk for QTc interval prolongation, a computer alert appeared on

35 Female gender, QTc interval > or =500 ms, and interim syncopal events d

36 95% upper confidence limit for the mean 24-h QTc interval was 452 ms (men 439 ms, women 461 ms).

37 sh/wk had a 29.2% lower likelihood of having QTc intervals >0.45 s (P=0.03).

38 binary outcome meta-analyses (human height, QTc interval and gallbladder disease); all previous repo

39 In the 50 patients analyzed with IE, QTc interval prolonged in 50 of 50 (100%) patients (from

40 Mean change in QTc interval did not differ significantly from placebo w

41 For mean increase in QTc interval from baseline, a nonsignificant difference

42 refractory period, and 4% to 6% increases in QTc interval.

43 mouse models show similar problems including QTc interval prolongation and hypothermia.

44 c repolarization disturbances with increased QTc intervals in both patients and controls, but with a

45 ing of the heart rate-corrected QT interval (QTc interval) in Kir2.1-transduced animals (n = 4) and a

46 ll patients developed corrected QT interval (QTc interval) prolongation (median QTc interval 504 ms,

47 1A (QRS duration), NOS1AP, KCNH2, and KCNQ1 (QTc interval).

48 They review the evidence linking QTc interval prolongation, potassium channels, and torsa

49 prevalence and factors associated with long QTc interval in a cohort of opioid-dependent HIV-infecte

50 trophy (77% versus 58%; P=0.02) and a longer QTc interval (466+/-36 versus 453+/-41 milliseconds; P=0

51 Compared with men, women exhibit a longer QTc interval and an increased propensity toward torsade

52 Carriers of 2 mutations had longer QTc intervals (527+/-54 versus 489+/-44 ms; P<0.001); al

53 Device patients had longer QTc intervals (p = 0.03) and more symptoms (p < 0.001).

54 ne and lansoprazole had significantly longer QTc intervals (up to 12 ms in white men) and were 1.4 ti

55 The association with respect to longer QTc intervals was stronger for the outcome of lone AF, a

56 consumption of fish is associated with lower QTc interval in free-eating people without any evidence

57 The average maximal QTc interval was 495 +/- 21 ms and the average QTc range

58 uals receiving the DSEC had a longer maximal QTc interval (mean [SD], 419.4 [11.8] vs 396.1 [15.7] mi

59 nt Metabolife 356 increased the mean maximal QTc interval and SBP.

60 The maximal QTc interval over 24 h in normal subjects is longer than

61 The maximal QTc interval was > or = 500 ms in 6 subjects and > or =

62 Mean time to maximal QTc interval prolongation, changes in T-wave polarity, >

63 riability between hourly minimal and maximal QTc intervals reached their circadian peak shortly after

64 The maximum QTc interval provides incremental prognostic information

65 The maximum QTc interval recorded before age 10 was the strongest pr

66 Mean QTc interval was prolonged by 2.4 ms.

67 was 70 mg/day (range 15-250 mg/day) and mean QTc interval was 438 +/- 34 ms.

68 +/- 23 and 445 +/- 16 ms, respectively (mean QTc interval for men 434 +/- 12 ms, 457 +/- 10 ms for wo

69 d relatives, men exhibited the shortest mean QTc interval in chromosome 7q- and 11p-linked blood rela

70 The mean QTc interval in genotype-negative blood relatives (n = 2

71 hadone dose was 397 +/- 283 mg, and the mean QTc interval was 615 +/- 77 msec.

72 The mean QTc intervals were longer at peak exercise in patients (

73 ent with mexiletine was 22 years, and median QTc interval before therapy 509 ms.

74 interval (QTc interval) prolongation (median QTc interval 504 ms, IQR: 477 to 568 ms) within 24 h of

75 In all 74 patients analyzed with MUSE, QTc interval prolonged from 423 +/- 25 ms to 455 +/- 34

76 In nonathletes, QTc interval abnormalities comprised the majority (52%)

77 n the JLNS family described here have normal QTc intervals (0.43 and 0.44 seconds, respectively).

78 QT-prolonging drugs and reduces the risk of QTc interval prolongation in hospitalized patients with

79 The role of QTc interval prolongation in heart failure remains poorl

80 by examining dose dependency, the percent of QTc intervals higher than 500 msec, and the risk of drug

81 SNPs previously identified as modulators of QTc-interval in genome-wide association studies in the g

82 Prolonged QTc interval (>450 ms) was documented in 33 of 91(36.3%)

83 Prolonged QTc interval is a strong, independent predictor of adver

84 Prolonged QTc interval was an independent predictor of posttranspl

85 A prolonged QTc interval and Q wave were related to post-transplant

86 Cirrhotics had a prolonged QTc interval, a Q wave, abnormal QRS axis deviation, ST

87 family members, none of whom had a prolonged QTc interval.

88 On multivariate analysis, prolonged QTc interval was an independent predictor of all-cause d

89 nt cardiac arrest and dramatically prolonged QTc interval who were both born to healthy parents.

90 rent syncopal events and a greatly prolonged QTc interval.

91 score comprising renal impairment, prolonged QTc interval, and age older than 52 was developed for pr

92 wing in recent years, and cases of prolonged QTc interval and torsades de pointes have been described

93 The prevalence of prolonged QTc interval in opioid-dependent HIV-infected patients o

94 (</= 440 ms [n = 469]), LQTS with prolonged QTc interval (> 440 ms [n = 1,392]), and unaffected fami

95 iver transplantation together with prolonged QTc interval.

96 implantation in 3) and excessively prolonged QTc intervals in 8 (6.7%) (dosage reduced or discontinue

97 ly, both these family members have prolonged QTc intervals and would have been classified as Romano-W

98 ificantly lower than in those with prolonged QTc intervals (15%) (p < 0.001) but higher than in unaff

99 r ACA or SCD only in patients with prolonged QTc intervals (female age > 13 years, hazard ratio: 1.90

100 bradycardia; palpitation; changing PR, QRS, QTc intervals in electrocardiogram; heart failure) for t

101 d >/=120 ms (1.75, 1.17-2.62); corrected QT (QTc) interval >/=450 ms in men or >/=460 ms in women (1.

102 The Bazett-corrected QT (QTc) interval during exercise has been used as a marker

103 gender differences in the rate-corrected QT (QTc) interval in the presence of a QT-prolonging gene.

104 stigate whether the heart rate-corrected QT (QTc) interval on the electrocardiogram (ECG) is associat

105 Corrected QT (QTc) interval prolongation (defined as QTc>500 ms or an

106 icant bradycardia or excessive corrected QT (QTc) interval prolongation.

107 Female gender, corrected QT (QTc) interval, LQT2 genotype, and frequency of cardiac e

108 ects on weight, prolactin, and corrected QT (QTc) interval.

109 and variability of the QT and corrected QT (QTc) intervals over 24 h and to assess their pattern and

110 QT syndrome (LQTS) with normal corrected QT (QTc) intervals.

111 hisms (SNPs) that modulate the corrected QT (QTc)-interval and the occurrence of cardiac events in 63

112 ontrols; however, resting heart rates and QT/QTc intervals were similar at baseline.

113 SCD in patients with LQTS with normal-range QTc intervals (4%) was significantly lower than in those

114 ors ACA or SCD in patients with normal-range QTc intervals included mutation characteristics (transme

115 the baseline, the mean, and the most recent QTc interval recorded before age 10, were less significa

116 subjects, the QTc gender difference reflects QTc interval shortening in men during adolescence.

117 the LQT group had a 24% reduction in resting QTc interval (from 617 +/- 92 to 469 +/- 23 ms, P = .004

118 Besides shortening QTc interval, mexiletine caused a major reduction of lif

119 h the mutation was associated with a shorter QTc interval (P<0.05) and a reduced occurrence of cardia

120 rol (4.8+/-0.30 and 4.5+/-0.23), and shorter QTc intervals (167+/-2.6 versus 182+/-6.4).

121 during adolescence included recent syncope, QTc interval, and sex.

122 The QTc interval and QTc variability reach a peak shortly af

123 The QTc interval prolongs in 100% of patients with early tra

124 +/-6 versus 115+/-11 beats/min; P=0.54), the QTc interval had prolonged significantly more in patient

125 To better understand it, we analyzed the QTc interval duration in patients with heart failure wit

126 Both the QTc interval and the variability between hourly minimal

127 and 13 patients with no CAD to correlate the QTc interval respectively.

128 If the QTc interval exceeds 500 ms, consider discontinuing or r

129 COMMENDATION 4 (RISK STRATIFICATION): If the QTc interval is greater than 450 ms but less than 500 ms

130 t, or for clinically relevant changes in the QTc interval.

131 ed a high degree of daily variability in the QTc interval.

132 rocardiogram for all patients to measure the QTc interval and a follow-up electrocardiogram within 30

133 4) and a 16.7% +/- 1.8% prolongation of the QTc interval (n = 3) in Kir2.1AAA-transduced animals 72

134 Risk factors for prolongation of the QTc interval are chronic hepatitis C-induced cirrhosis,

135 p < 0.001) as significant predictors of the QTc interval; and heart rate (p < 0.001), genotype (p <

136 gs that cause torsade de pointes prolong the QTc interval and bind to the potassium rectifier channel

137 opic drugs have been reported to prolong the QTc interval and increase the risk of ventricular dysrhy

138 ic trioxide does not permanently prolong the QTc interval.

139 shows that arsenic trioxide can prolong the QTc interval.

140 Transmural ischemia prolonged the QTc interval (using the Bazett's formula) in 100% of pat

141 Concern regarding the QTc interval in human immunodeficiency virus (HIV)-infec

142 However, recent studies indicate that the QTc interval is nonlinear with respect to heart rate dur

143 ear relationship between GRS(NOS1AP) and the QTc-interval (P=4.2x10(-7)).

144 pectedly large effects of NOS1AP SNPs on the QTc-interval and a trend for effects on risk of cardiac

145 an analysis for quantitative effects on the QTc-interval, 3 independent SNPs at NOS1AP (rs10494366,

146 .6x10(-7)) were strongly associated with the QTc-interval with marked effects (>12 ms/allele).

147 0001) in QRS duration but was not related to QTc interval or Sokolow-Lyon index.

148 Height was not associated with QTc interval or the Sokolow-Lyon index.

149 up and upward, the risk of AF increased with QTc interval duration in a dose-response manner, reachin

150 val: 1.24 to 1.66, p < 0.001) for those with QTc intervals >/=99th percentile (>/=464 ms).