ライフサイエンスコーパス: R. prowazekii

1 ts was dependent upon either selection of an R. prowazekii rpoB chromosomal mutation imparting rifamp

2 nse strategies targeted towards design of an R. prowazekii vaccine, generation of new antibiotics, an

3 nd R. prowazekii and 29 between R. akari and R. prowazekii.

4 se pair differences between R. australis and R. prowazekii and 29 between R. akari and R. prowazekii.

5 ied 24 base pair differences between ELB and R. prowazekii and 25 between R. rickettsii and R. prowaz

6 ar associations of cytoskeletal material and R. prowazekii to be devoid of cytoskeletal interactions.

7 of insertion sites in both R. rickettsii and R. prowazekii indicated that insertions were random.

8 prowazekii and 25 between R. rickettsii and R. prowazekii; there were 30 base pair differences betwe

9 (ii) native OmpBs purified from R. typhi and R. prowazekii strains Breinl, RP22, and Madrid E.

10 Typhus group rickettsiae (R. typhi and R. prowazekii) adhere to and lyse human and sheep erythr

11 ickettsii, and R. akari with the louse-borne R. prowazekii.

12 Three of these epitopes were present on both R. prowazekii and Rickettsia typhi SPAs.

13 d pld in the process of phagosomal escape by R. prowazekii.

14 use high morbidity and mortality, especially R. prowazekii, the causative agent of typhus.

15 tion conditions, total RNA was isolated from R. prowazekii-infected mouse L929 cells with or without

16 ul for immunoprecipitating active RP534 from R. prowazekii lysed cell extracts, thus verifying that t

17 lk sacs, and G3PDH activity was assayable in R. prowazekii lysed-cell extracts.

18 Furthermore, gpsA mRNA was detected in R. prowazekii purified from hen egg yolk sacs, and G3PDH

19 d used it to demonstrate allelic exchange in R. prowazekii.

20 to all five tlc homologues are expressed in R. prowazekii growing in L-929 cells and have shown thei

21 In this paper we describe the expression in R. prowazekii of the Escherichia coli ereB gene.

22 onrickettsial, antibiotic-selectable gene in R. prowazekii.

23 enomes share 775 genes: 23 are found only in R. prowazekii and R. typhi, 15 are found only in R. cono

24 of newly synthesized 16S rRNA precursors in R. prowazekii, as analyzed by ribonuclease protection as

25 One of the components of this pathway is R. prowazekii open reading frame RP442, which is annotat

26 tone phosphate transport systems in isolated R. prowazekii with respect to kinetics, energy coupling,

27 the elucidation of pathogenic mechanisms of R. prowazekii.

28 yphi RT0101 and to monomethyltransferases of R. prowazekii RP789 and of R. typhi RT0776, and (ii) nat

29 were also identified in the Breinl strain of R. prowazekii and in Rickettsia typhi.

30 introduced into the Rifs Madrid E strain of R. prowazekii by electroporation, and in the presence of

31 otted fever group and the Madrid E strain of R. prowazekii, which contain recognizable inactivating m

32 Madrid E is an attenuated strain of R. prowazekii, while Breinl is a virulent strain.

33 w that as an alternative, isolated, purified R. prowazekii organisms transported exogenous uridyl- an

34 rt of this hypothesis, we show that purified R. prowazekii transported and incorporated DHAP into pho

35 two published rickettsial genome sequences: R. prowazekii and R. conorii.

36 n the present study, we have determined that R. prowazekii utilizes a second, independent triose phos

37 mediated transport systems, we reasoned that R. prowazekii transports DHAP to supply substrate for Gp

38 We previously reported that R. prowazekii acquires triose phosphates for phospholipi

39 These results suggest that R. prowazekii regulates transcription of the rrs in resp

40 Together, these data strongly suggested that R. prowazekii encodes and synthesizes a functional GpsA

41 The R. prowazekii pld gene, encoding a protein with phosphol

42 Therefore, by annotation, the R. prowazekii genome encodes a total of five ATP/ADP tra

43 Both the R. prowazekii Breinl and R. typhi Wilmington metK genes

44 AdoMet transport in E. coli containing the R. prowazekii sam gene exhibited kinetics similar to tha

45 Furthermore, the R. prowazekii dihydroxyacetone phosphate transport syste

46 isons also revealed a 12-kb insertion in the R. prowazekii genome, relative to R. typhi and R. conori

47 Interestingly, the R. prowazekii genome encodes four open reading frames th

48 We chose to define the function of the R. prowazekii capD gene (RP 333) product designated as a

49 In addition, heterologous expression of the R. prowazekii gpsA gene functioned to complement an Esch

50 Analysis of the R. prowazekii Madrid E genome sequence revealed the pres

51 nine-to-lysine change at position 546 of the R. prowazekii RNA polymerase beta subunit.

52 a coli clone banks for AdoMet transport, the R. prowazekii gene coding for a transporter, RP076 (sam)

53 from the origin of replication, compared to R. prowazekii and R. conorii.

54 plication terminus, in R. typhi, compared to R. prowazekii and R. conorii.

55 h appears to have occurred after the typhus (R. prowazekii and R. typhi) and spotted fever (R. conori

56 Native OmpBs from highly virulent R. prowazekii strains Breinl and RP22 contain multiple c

57 ion to generate a pld mutant of the virulent R. prowazekii strain Madrid Evir.

58 a capD transcript in yolk sacs infected with R. prowazekii at ten days post-infection.

59 nd synthesizes a functional GpsA enzyme, yet R. prowazekii is unable to synthesize DHAP as a substrat