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1 R and Bioconductor were used for data analysis.
2 R code is available at github.com/james-e-barrett.
3 R loops, which are mainly co-transcriptional, abundant R
4 R neurons recruit both GABA and GABA-A receptors to thei
5 R(2) was 0.85 and 0.83, respectively.
6 (R)-2,3-Di-O-benzylglyceraldehyde and N-tosyl homoallylam
7 (R)-BPO-27 fully blocked CFTR chloride conductance in epi
8 R-loops accumulate in nucleoli during RNA polymerase I (
9 R-loops are known to interfere with replication forks, a
10 R-spondin1 is a secreted regulator of WNT signaling, inv
12 diffusion coefficient (beta = -0.3, P = .02, R(2) = 0.33) than did steatosis (beta = -0.5, P < .001,
13 let cadmium content and both age (p = 0.048, R(2) = 0.09) and female gender (women: 36.88 +/- 4.11 vs
14 r included nine microRNAs, p=3.63 x 10(-08), R(2)=0.358, permutation-based p=0.039, the gene targets
17 ently reported the discovery of AT-076 (1), (R)-7-hydroxy-N-((S)-1-(4-(3-hydroxyphenyl)piperidin-1-yl
19 phores of the chelating inhibitors (S)-10a, (R)-10a, and 10b were binding within the MMP-13 active si
21 by cadmium doping into the [Au23(SR)16](-) (R = cyclohexyl) nanocluster, in which two neighboring su
22 is analysis is undertaken using the ERA-20CM-R river flow reconstruction for the twentieth century.
23 r a median follow-up of 34 months, with 25% (R-CHOP) and 18% (VR-CHOP) of patients having had PFS eve
29 d to have a Deming-regression slope of 0.97 (R(2) = 0.960) when compared to the total bilirubin value
30 tor (SSRCalc) SCX model ( approximately 0.99 R(2) value) exceeds all previously reported predictors f
31 of D(+*)-(3)(A(-*)-R(*)) and D(+*)-(1)(A(-*)-R(*)), and subsequent reduction of R(*) only occurs in D
33 a 3:1 statistical mixture of D(+*)-(3)(A(-*)-R(*)) and D(+*)-(1)(A(-*)-R(*)), and subsequent reductio
34 by spin statistics of the uncorrelated A(-*)-R(*) radical pair, where the initial charge separation y
35 transfer within the triradical forms D(+*)-A-R(-), but its yield is controlled by spin statistics of
42 e predictor of the error variance for acute (R(2) = 0.20; P < 0.0001) and daily (R(2) = 0.23; P < 0.0
43 ic toxicity with similar precision; adjusted R(2) and R(2) values ranged from 0.56 to 0.86 and 0.66-0
44 athophysiology of FXS as the GABABR agonist (R)-baclofen rescued the imbalances between excitatory an
46 age rate of decline was faster in the ALSFRS-R, with less between-patient variability at baseline (p<
51 s increased, and that of topoisomerase 1, an R-loop preventing factor, is decreased at R-loop-enriche
53 The RDI method has been implemented as an R package, and is available for download through Bitbuck
56 ene Network Expression Simulator in R) is an R package that provides an interface to simulate gene ex
57 chet mechanism), the rear foot producing an (R)-stereocenter at its point of attachment to the track.
59 ty with similar precision; adjusted R(2) and R(2) values ranged from 0.56 to 0.86 and 0.66-0.85, resp
60 h had an OH group substituted at the R-6 and R-7 position on the ring A, showed similar antioxidant a
64 rs of the niche factors Wnt2b, Gremlin1, and R-spondin1, and are sufficient to promote maintenance of
66 onyl)-1H-indol-3-yl]methylene}succinate and (R)-2,2,5,5-tetramethyl-1,3-dioxolane-4-carbaldehyde, fac
68 nvolve modulatory regulatory factors such as R-spondin 1 (Rspo1), an extracellular protein that enhan
69 an R-loop preventing factor, is decreased at R-loop-enriched regions of IFNG and TBX21 (TH1 genes) in
70 in learning and memory, such as Creb, GABA B R and Ip3k, indicating extensive involvement of DNA meth
72 hree recently published Bayesian LMMs, Bayes R, BSLMM, and BOLT-LMM, we investigate an existing data
73 31, 2013 to assess the associations between R/S and incident all-cause mortality using proportional
81 rectal swabs directly using the Xpert Carba-R assay is effective for rapid detection and identificat
82 assessed the performance of the Xpert Carba-R test, a rapid real-time quantitative PCR (qPCR) assay
85 rennets were covalently immobilized on CLEA(R) magnetic supports and the immobilization procedure wa
86 less active, with a correlation coefficient (R(2)) of IC50versus log of autoxidation rate of 0.75.
94 nd deltaGamma; (3) demonstration that deltaR/R after only approximately 200 measurements is substanti
95 gical recordings show that Sema-1a-dependent R axon lamination is required for preventing the spread
96 ese helicases is suppressed by destabilizing R-loops while Pif1 and Rrm3 binding to tDNAs is increase
101 ses in CH4 emission in response to drawdown (R(2) = 0.84, p < 0.01), suggesting that eutrophication m
103 Zn(2+) in opposing directions across the S(E)R membrane in cardiomyocytes and that changes in their a
104 d on RNaseH1-mediated suppression of ectopic R-loops, inversely correlates with disease severity scor
106 ctivity led to the finding that enantiomers (R,R)-68 and (S,S)-68 have differential effects on the ra
107 zebrafish model, we show that encapsulated (R)-roscovitine can speed up inflammation resolution in v
110 d CT data of patients with CoreValve, Evolut R, and SAPIEN 3 transcatheter aortic valve replacement e
111 nalytical performances such as, for example, R(2) of the calibration curve of 0.98 and 0.99 for prote
113 me-wide association studies by using FarmCPU R package to identify 17 genetic loci associated with co
117 n the auditory stimulation and the following R peak was significantly shortened in MCS when the audit
120 have been crystallographically verified for R = 2,6-iPr2C6H3 (Dipp) and R = tBu, and the pentasulfid
125 eviewed for demographics, Hanifin & Rajka (H&R) and United Kingdom Working Party (UKWP) criteria.
129 w cytometric analysis of lung tissue from H2 R-deficient animals revealed increased numbers of CD1d(+
132 in most of the variability in GEP at hourly (R(2 ) = 0.77) to interannual (R(2 ) = 0.80) timescales.
133 had no benefit on the primary outcome (HVLT-R-DR; difference in means -0.43 [95% CI -1.73 to 0.87]).
134 s of two active complexes are reported, 1-I (R(1) =OEt, R(2) =H) and 2-I (R(1) =H, R(2) =NMe2 ).
137 , whether CD6 plays any role in intestinal I/R-induced injury and, if so, the underlying mechanisms,
139 amma-GRK2 inhibition initiated 1 week post-I/R provided little to no further protection in mice with
144 n of ATF6 in cardiac myocytes subjected to I/R increased reactive oxygen species and necrotic cell de
147 and S-9-PAHSA, and this approach identified R-9-PAHSA as the predominant stereoisomer that accumulat
148 an samples visualized using the ImageStream((R)) platform (Millipore Sigma, Darmstadt, Germany), and
154 chastic Gene Network Expression Simulator in R) is an R package that provides an interface to simulat
158 tment with the small molecule TNFR inhibitor R-7050 partially protected hyperoxaluric mice from nephr
159 8-H4 epigenetic marks by the ACK1 inhibitor (R)-9bMS-sensitized naive and enzalutamide-resistant pros
160 rimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused
163 nternational Prognostic Scoring System (IPSS-R) and presence of comorbidity graded according to the H
167 activate the antiviral kinase protein kinase R (PKR), which potently inhibits virus replication.
168 of the innate immune effector protein kinase R, which phosphorylates the eukaryotic initiation factor
173 ely 2.5%), accuracy (>/=90%), and linearity (R(2) >/= 0.99) were attained for all the studied compoun
174 tivity and specificity, excellent linearity (R(2)>0.988) low decision limits and detection capabiliti
176 RR, 1.30; 95% CI, 1.20-1.41); or ZDV-3TC-LPV-R (75 of 167 [44.9%]; ARR, 1.21; 95% CI, 1.01-1.45).
177 TDF-FTC and lopinavir-ritonavir (TDF-FTC-LPV-R) (112 of 231 [48.5%]; ARR, 1.31; 95% CI, 1.13-1.52); z
178 ion in reservoirs exceeds carbon fixation (P<R); the global P/R ratio, however, varies significantly,
179 contains the absolutely conserved (679)LWYIK/R(683) sequence, proposed to embody a "cholesterol recog
180 was obtained from 1.0x10(-8) to 4.1x10(-7)M (R(2)=0.9987) with a detection limit of 2.5x10(-9)M.
181 ignificantly associated with PM2.5 in males (R(2) = 11.1%, P < 0.0001) and females (R(2) = 16.8%, P <
184 relapsed and/or refractory multiple myeloma (R/R MM) after a long period in which dexamethasone and m
187 from the surface using n-alkylamines (NH2R', R' = n-butyl, n-hexyl, n-octyl) (</=0.01 carboxylates nm
189 neurodegeneration in MoCD and introduce NMDA-R antagonists as potential therapeutics for this fatal d
190 gnaling effector in the common synaptic NMDA-R-CaMKII-SynGap-Ras-BRaf-MEK-ERK transduction cascade.
198 R-loop accumulation, and the accumulation of R-loops was exacerbated when both proteins were depleted
201 n-vitro tests showed a linear correlation of R(2)=0.998 between sensor values and reference glucose v
202 osed mechanism, DNA-binding-domains (DBD) of R insert in major grooves of O pre-TS, forming most Coul
203 ined that the major virulence determinant of R. equi is the surface bound virulence associated protei
204 countercurrent heat exchanger in the head of R. prolixus, which decreases the temperature of the inge
205 Significantly, increased cellular load of R-loops and DSBs, which are normalized on RNaseH1-mediat
209 erein, we report the development of a set of R-based scripts that allow for pre- and postprocessing o
212 exceeds carbon fixation (P<R); the global P/R ratio, however, varies significantly, from 0.20 to 0.5
217 at baseline before therapy in all patients (R(2) = 0.28, P <0.01) and with CAL change after therapy
220 gestible starch (SDS) correlated positively (R=0.816, p<0.05) with TPC and water absorption correlate
222 e-H-based approach; this reveals predominant R-loop formation near gene promoters with strong G/C ske
224 , is the same as in the previously published R package for Boolean Networks BoolNet, which enhances c
227 etry (LC-MS) method to separate and quantify R- and S-9-PAHSA, and this approach identified R-9-PAHSA
228 n of the permeation rate, J, droplet radius, R, membrane permeance, k, water viscosity, mu, and the w
229 requires the reference standard method (RAMP(R) immunoassay)) or alternatively on the basis of the co
230 ar orbital (HOMO) with a rectification ratio R = 99, but junctions with radical units have a new acce
233 a genome sequence, little is known regarding R. typhi biology in flea vectors that, importantly, do n
249 AM) flanking the target site, and subsequent R-loop formation and strand scission are driven by compl
250 , represents a superior replacement of Taxol(R) that mitigates the side effects associated with Cremo
253 rturbation experiments further indicate that R-loop induction correlates to transcriptional pausing.
258 intermediate will assemble with HOPS and the R, Qa, and Qc SNAREs, and that this assembly undergoes r
259 ich have a hydroxyl group substituted at the R-3 position on the C ring, have outstanding antioxidant
260 ne, which had an OH group substituted at the R-6 and R-7 position on the ring A, showed similar antio
261 and 1-month were significantly lower for the R-E group than for the NR-E group (treatment main effect
264 not differ significantly for patients in the R-CHOP or intensive therapy cohorts when analyzed by rec
266 w WGS variant data format implemented in the R/Bioconductor package 'SeqArray' for storing variant ca
267 bly needs HOPS, lipid membranes to which the R- or Qa-SNARE and Ypt7:GTP are integrally bound, and ea
272 eakage at expanded CAG repeats occurs due to R-loop formation and reveal two mechanisms for CAG repea
275 ersely, among patients who were resistant to R-CHOP, basal DLBCL mutations did not disappear from cfD
277 vely with the content of beta-glucans (up to R=0.77) and arabinoxylans (up to R=0.80) in bran and ref
279 TAGGED 1 (TOE1)-miR172-resistant (35S::TOE1(R) ) and mutant (flowering locus T-10 (ft-10)) lines wer
280 in FL concentration, accumulation of toxic (R)-FL and formation of toxic (S)-NFL leads to much highe
282 ever, whether and to what extent TRAIL/TRAIL-R signaling in cancer cells can affect the immune microe
284 utilized during activated sludge treatment ((R)-FL is 30x more toxic than (S)-FL; (S)-NFL is 10x more
286 to those for animals infected with wild-type R. typhi and develop comparable pathology and bacterial
288 hances IP1 through vasopressin receptor (V1A-R) but not alpha1 adrenergic receptor (alpha1-AR), sugge
293 es produce 4-piperidones in good yields when R = alkyl or aryl, but oxidation of 2H-pyrans also gives
294 ese impressive findings by examining whether R-E training could attenuate smoking-related craving and
297 duced callose after single inoculations with R. irregularis or P. putida, only the cultivar with high
300 adioligand used for the binding assay, with (R,R)-68 potentiating the radioligand and (S,S)-68 displa
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