ライフサイエンスコーパス: RAMP2

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1 with a receptor activity-modifying protein (RAMP2).

2 the receptor associated modifying protein 2 (RAMP2).

3 hanisms that regulate the trafficking of CLR*RAMP2.

4 regulation of AM-induced degradation of CLR*RAMP2.

5 ecifically with RAMP3, but not with RAMP1 or RAMP2.

6 F-1 when CRLR was co-expressed with RAMP1 or RAMP2.

7 We demonstrate that RAMP2 alters both ligand selectivity and G protein prefe

8 To understand the role of RAMP2 and -3 on the activation and conformation of the C

9 enes such as Expi (Wdnm1), Cyp1b1, Gelsolin, Ramp2 and class I MHC genes.

10 Degradation of CLR*RAMP2 and CLRDelta9KR*RAMP2 was not dependent on the dur

11 Therefore, to determine whether RAMP2 and RAMP3 have distinct functions in vivo, we gene

12 Nevertheless, our studies reveal that RAMP2 and RAMP3 have distinct physiological functions th

13 However, mRNA encoding RAMP2 and RAMP3 was also detected in the gastrointestina

14 IMD and CRLR, RAMP1, RAMP2 and RAMP3 were expressed in all cell types.When ce

15 eceptor activity-modifying proteins 2 and 3 (RAMP2 and RAMP3), respectively.

16 otein receptor activity-modifying protein-2 (RAMP2), and the role of individual G protein alpha-subun

17 In addition, mice with reduced expression of RAMP2 (but not RAMP3) display remarkable subfertility.

18 Pre-treatment (4 days) of HAECs with CRLR or RAMP2, but not RAMP1 or RAMP3, siRNAs abolished protecti

19 LR-RAMP3 complex, but not CRLR-RAMP1 or CRLR-RAMP2 complex, altered receptor trafficking to a recycli

20 d the receptor activity-modifying protein 2 (RAMP2) comprise a receptor for adrenomedullin (AM).

21 ellular domain (ECD) and tethered RAMP1- and RAMP2-CTR ECD fusion proteins and antagonist peptides.

22 ut not to HRS knockdown, whereas CLRDelta9KR*RAMP2 degradation was unaffected.

23 Accordingly, mutant RAMP1 W84A- and RAMP2 E101A-CTR ECD retained AC413/rAmy binding.

24 CGRP analog-bound CLR:RAMP1 and AM-bound CLR:RAMP2 extracellular domain heterodimers at 2.5 and 1.8 A

25 ivity for CGRP/AM in part by RAMP1 Trp-84 or RAMP2 Glu-101 contacting the distinct CGRP/AM C-terminal

26 receptor agonists and highlights a role for RAMP2 in regulating its pharmacology.

27 t the glucagon receptor that is abolished by RAMP2 interaction.

28 Strikingly, we found that, although RAMP2 is required for survival, mice that lack RAMP3 app

29 the C terminus of RAMP3, but not in RAMP1 or RAMP2, leads to protein-protein interactions that determ

30 known that AM induces internalization of CLR*RAMP2, little is known about the molecular mechanisms th

31 AM-, calcrl-, or RAMP2-null mice died mid-gestation after development of

32 e, adrenomedullin receptors are comprised of RAMP2 or RAMP3 (AM1R and AM2R, respectively) and calcito

33 ligand, adrenomedullin (AM), is comprised of RAMP2 or RAMP3 and calcitonin receptor-like receptor (CR

34 d mice with targeted deletions of either the RAMP2 or RAMP3 gene.

35 Co-expression of CRLR with RAMP2 or RAMP3 resulted in a response with the pharmacol

36 The interaction of RAMP2 or RAMP3 with CLR induces conformational variation

37 ion of CRLR when co-expressed with RAMP1 and RAMP2 or RAMP3, respectively, intermedin represents a no

38 upted when P321A was coexpressed with RAMP1, RAMP2, or RAMP3.

39 e observed that AM-induced activation of CLR*RAMP2 promoted ubiquitination of CLR.

40 Because RAMP2, RAMP3, and CLR transduce the signaling of the two

41 intact CTR, AMY1 (CTR.RAMP1), and AMY2 (CTR.RAMP2) receptors using purified CTR extracellular domain

42 cells express the putative ADM-receptor CRLR-RAMP2 the production and secretion of ADM with the conse

43 RAMP2-transported receptors are core-glycosylated and ar

44 Degradation of CLR*RAMP2 and CLRDelta9KR*RAMP2 was not dependent on the duration of AM stimulatio

45 Degradation of CLR*RAMP2 was sensitive to overexpression of hepatocyte grow

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