ライフサイエンスコーパス: RBC

1 RBC alloantigens exist at different densities on the RBC

2 RBC membrane was coated onto the nanogel via a membrane

3 RBC transfusion did not affect overall mortality in crit

4 RBC transfusion improves sublingual microcirculation ind

5 RBC transfusion is often required in patients with sepsi

6 RBCs were collected and assayed before (n = 327), 14 day

7 More than 30,000 RBCs can be analyzed for parasitemia quantification in u

8 ry of alloimmunization, having received >/=1 RBC unit.

9 < 5 WBCs/muL and blasts with/without >/= 10 RBCs/muL or >/= 5 WBCs/muL plus blasts, with WBCs >/= 5

10 = 5 WBCs/muL plus blasts with/without >/= 10 RBCs/muL or clinical signs of CNS disease.

11 y of alloimmunization, having received >/=20 RBC units.

12 HBOC-based perfusion fluid and matched to 5 RBC-perfused livers.

13 that inhibition of K(+) transport abolishes RBC electrophysiological rhythms.

14 cation method to enrich red blood cell AChE (RBC AChE) as a biomarker of exposure.

15 m Dark Field imaging device before and after RBC transfusion.

16 fusion, production of alloantibodies against RBC non-ABO Ags can cause hemolytic transfusion reaction

17 Alloimmunization against RBCs can cause life-threatening delayed hemolytic transf

18 We show that all RBCs, both hypoxia-unaffected and hypoxia-affected ones,

19 binding than human blood group O allogeneic RBC in 22% of tested sera.

20 Although RBC transfusion can result in the development of anti-RB

21 folate deficiency when serum (<7 nmol/L) and RBC (<305 nmol/L) folate were considered, whereas a high

22 ade jkRBCs at comparable levels to cRBCs and RBCs.

23 on reactions, not all patients generate anti-RBC alloantibodies.

24 fusion can result in the development of anti-RBC alloantibodies that increase the probability of life

25 As RBC dendrites expand, they form fewer multi-PSD contacts

26 ve transfusion protocols to reduce avoidable RBC transfusions, but evidence of their effectiveness in

27 Second, we apply a mask-based RBC patch-size normalization method to normalize the var

28 rajectories reveal that in the capillary bed RBCs preferentially move in plane.

29 Also indicating better RBC quality, biomarkers of hemolysis, thrombophilia, and

30 se is reinforced by functional links between RBC and capillary diameters [2, 3].

31 Here, we evaluate the relationship between RBC sizes and bone histometry and use microstructural ev

32 receptors that mediate cell adhesion between RBCs, and between RBCs and white blood cells, platelets,

33 iate cell adhesion between RBCs, and between RBCs and white blood cells, platelets, and the endotheli

34 ional deterioration and was superior to both RBC and buffered dextran-albumin solution for extended l

35 -D phase images of individual melittin-bound RBCs enabled in-depth examination of melittin-induced bi

36 arterial>venous; P<0.05) were accompanied by RBC iron nitrosylhemoglobin formation (venous>arterial;

37 Invasion of the red blood cell (RBC) by the Plasmodium parasite defines the start of mal

38 lf causes reduced peripheral red blood cell (RBC) counts without altering relative abundances of eryt

39 these intakes with serum and red blood cell (RBC) folate among 4878 men and nonpregnant, nonlactating

40 ction with the membrane of a red blood cell (RBC) is important to predict the altered morphologies an

41 ture dependence of the human red blood cell (RBC) metabolic network between 4 and 37 degrees C throug

42 dy, by using a two-component red blood cell (RBC) model and systematic parameter variation, we perfor

43 between donor and recipient red blood cell (RBC) survival times.

44 Red blood cell (RBC) transfusion poses significant risks to critically i

45 is a leading indication for red blood cell (RBC) transfusion worldwide, although optimal thresholds

46 Red blood cell (RBC) transfusions are of vital importance in patients wi

47 number of Hb molecules in a red blood cell (RBC), the effect is detectable through motion analysis o

48 The mechanisms underlying red blood cell (RBC)-mediated hypoxic vasodilation remain controversial,

49 e degree of agglutination of red blood cell (RBC).

50 tic blood disorder in which red blood cells (RBC) exhibit heterogeneous morphology changes and decrea

51 g human antibody binding to red blood cells (RBC) isolated from knockout swine and to allogeneic or a

52 pically delivered by packed red blood cells (RBC).

53 e synapses formed between rod bipolar cells (RBCs) and amacrine type-2 (AII) cells in the mouse retin

54 synapses between rods and rod bipolar cells (RBCs).

55 by perfusate: (1) isolated red blood cells (RBCs) (current clinical standard for OCS); (2) whole blo

56 al for redox equilibrium of red blood cells (RBCs) and, when compromised, the RBCs are more susceptib

57 s with discrete tracking of red blood cells (RBCs) are performed in three realistic microvascular net

58 200 billion red blood cells (RBCs) are produced every day, requiring more than 2 x 10

59 olution microscopy of human red blood cells (RBCs) as a case study.

60 Red blood cells (RBCs) demonstrate procoagulant properties in vitro, and

61 ic ratio of 1 platelet to 9 red blood cells (RBCs) did not inhibit the in vitro development or replic

62 Vertebrate red blood cells (RBCs) display a range of sizes, spanning orders of magni

63 and homozygous sickle (SS) red blood cells (RBCs) express a large number of surface receptors that m

64 resh frozen plasma (FFP) to red blood cells (RBCs) has spread to other surgical and medical fields.

65 Red blood cells (RBCs) have historically been considered passive bystande

66 persons who receive stored red blood cells (RBCs) have recently garnered considerable attention.

67 A simple method to convert red blood cells (RBCs) into efficient microreactors is reported.

68 alciparum, invasion of host red blood cells (RBCs) is essential.

69 Red blood cells (RBCs) of SCD patients have diverse shapes that reveal im

70 sion of either platelets or red blood cells (RBCs) on days with bleeding was often not sufficient to

71 dressed whether exposure to red blood cells (RBCs) stored longer than 35 days is associated with harm

72 of metabolic decay in human red blood cells (RBCs) under cold storage conditions.

73 were investigated on human red blood cells (RBCs) using quantitative phase imaging techniques.

74 cles, either latex beads or red blood cells (RBCs), create aggregates that are easily detectable and

75 ncluding those derived from red blood cells (RBCs), platelets, white blood cells, cancer cells, and b

76 erved in isolated mammalian red blood cells (RBCs), which lack nuclei, suggesting the existence of po

77 ssible cholesterol in human red blood cells (RBCs).

78 echanisms to spread between red blood cells (RBCs).

79 sickle hemoglobin (HbS) in red blood cells (RBCs).

80 porters on erythrocytes (or red blood cells, RBCs) membrane.

81 fortification in rice bran breakfast cereal (RBC).

82 ape factor quantification for the classified RBC image data in order to develop a general multiscale

83 As a consequence, RBCs that display a cell surface Ag, membrane-bound hen

84 understanding of the mechanisms that control RBC adhesion to endothelium may lead to novel approaches

85 bsence of conventional transcription cycles, RBCs maintain a circadian rhythm in membrane electrophys

86 nted with anaemia, associated with decreased RBCs volume (MCV) and reticulocytosis; the flow-cytometr

87 antification of the number of G6PD deficient RBCs and presumably higher predictive power of drug indu

88 correlates with the number of G6PD deficient RBCs.

89 Low Ag-density RBC-induced tolerance protects higher Ag-density RBCs fr

90 induced tolerance protects higher Ag-density RBCs from immune-mediated clearance, is Ag specific, and

91 However, exposure to low Ag-density RBCs is not without consequence, because recipients subs

92 method both for oxygenated and deoxygenated RBCs.

93 ation inside the oxygenated and deoxygenated RBCs.

94 During RBC transfusion, production of alloantibodies against RB

95 lature may exacerbate vascular injury during RBC transfusion.

96 ifferent in patients who received a high FFP:RBC ratio compared with those who received a low ratio.

97 gery, the aOR for death favored the high FFP:RBC ratio subgroup (aOR, 0.16; 95% CI, 0.03-0.79; P = .0

98 High FFP:RBC transfusion ratios are applied mostly to patients wi

99 Examination of FFP:RBC transfusion ratios for patients without trauma.

100 The FFP:RBC ratios of survivors and nonsurvivors were nearly ide

101 an potently impact immune outcomes following RBC transfusion and suggest that RBCs with altered Ag le

102 lymorphism have over a 3-fold lower risk for RBC alloimmunization in comparison with patients without

103 network-level trends previously reported for RBCs at 4 degrees C were conserved but accelerated with

104 We demonstrate that for RBCs entering the capillary bed close to the cortical su

105 ared with exclusive exposure to the freshest RBC units after adjusting for demographic variables, dia

106 nd to define which patients can benefit from RBC transfusion during cardiovascular resuscitation.

107 severe hypoxemia are expected outcomes from RBC transfusion that need to be weighted with its benefi

108 AChE was solubilized from frozen RBC by addition of 1% Triton X-100.

109 membrane-coated nanoparticles from the fused RBC membrane and platelet membrane is demonstrated.

110 To address this, we generated RBCs that stably express the same Ag at different levels

111 ith controls, mice with elevated hematocrit (RBC(HIGH)) formed thrombi at a faster rate and had a sho

112 First, we present an automatic hierarchical RBC extraction method to detect the RBC region (ROI) fro

113 herosclerotic risk, had significantly higher RBC cholesterol accessibility.

114 However, RBC transfusion was associated with increased occurrence

115 swine and to allogeneic or autologous human RBC.

116 swine RBC that is as low as autologous human RBC.

117 al and pharmacological approaches that human RBCs display circadian regulation of membrane conductanc

118 ion of the microengineered vessel with human RBCs resulted in abnormal cytoskeletal rearrangement and

119 30% of human samples having less IgG and IgM RBC xenoreactivity than alloreactivity.

120 91 (92%) measured metabolites (p < 0.05) in RBC metabolism using only measurements of these five bio

121 The suitable amount ATE powder added in RBC was 0.5%.

122 evel responses to temperature differences in RBC metabolism is consistent between 4 and 37 degrees C.

123 gulating the expression of genes involved in RBC invasion.

124 uantitative and qualitative abnormalities in RBCs, including altered hematocrit, sickle cell disease,

125 and, by targeting DNMT1, upregulated HbF in RBCs.

126 that de novo introduction of CD22 ligands in RBCs should abolish B cell activation toward its cognate

127 uated P. falciparum pathogenesis in vitro in RBCs from pregnant women during their 2nd and 3rd trimes

128 uating the transit time when each individual RBC squeezes through a microscale constriction (cross-se

129 The individual RBC trajectories reveal that in the capillary bed RBCs p

130 lysis is based on trajectories of individual RBCs and focuses on layer-specific flow phenomena until

131 e, RBCs bearing low Ag levels fail to induce RBC alloantibodies.

132 wise exhibit distinct propensities to induce RBC alloantibody formation.

133 ence of an adjuvant, is sufficient to induce RBC alloimmunization.

134 alloantigen features that may also influence RBC alloimmunization.

135 in parasite egress from, and invasion into, RBCs.

136 ikely accommodated smaller, more mammal-like RBCs.

137 tions were present between prenatal maternal RBC-Hg and %-5mC at any time point.

138 The mean [standard deviation (SD)] maternal RBC lead level was 1.22 (0.63) mug/dL.

139 nal second trimester red blood cell mercury (RBC-Hg) concentrations with global 5-hydroxymethylcytosi

140 To estimate the effect of one or more RBC within 1 day on three major outcomes (mortality, ICU

141 Patients in the liberal group received more RBC units than patients in the restrictive group (1 [0-3

142 we show in this article that C57BL/6J mouse RBCs are essentially devoid of CD22 and Siglec-G ligands

143 telet hybrid membrane-coated nanoparticles ([RBC-P]NPs), are thoroughly characterized, and it is show

144 da, Israel, and the USA and expected to need RBC transfusions.

145 multiple PSDs with one rod; and neighboring RBCs share 13% of their inputs.

146 cy of active ICAM-4 receptors in both normal RBCs and SS-RBCs.

147 ddition, we showed that incubation of normal RBCs and SS-RBCs with epinephrine, a catecholamine that

148 ncluding terminally differentiated nucleated RBCs that we term "jkRBCs." A screen of small-molecule e

149 Variation in accessibility of RBC cholesterol was unrelated to the cholesterol content

150 y and monotonically related to the degree of RBC agglutination.

151 strategy (hemoglobin threshold, < 7 g/dL) of RBC transfusion during ICU stay.

152 We investigated the effect of RBC transfusion on sublingual microcirculation in hemorr

153 The effects of RBC transfusion on microvascular perfusion are not well

154 The frequency of RBC transfusion among patients with severe (hematocrit,

155 llular) spaces, provide useful indicators of RBC size in tetrapods.

156 study the association between the length of RBC storage and mortality in a large population-based co

157 association was found between the length of RBC storage and mortality.

158 n 30 days or 1 year in relation to length of RBC storage were assessed by using 3 independent analyti

159 The same protocol was used for 20 mL of RBC AChE inhibited with a soman model compound.

160 The number of RBC units transfused was lower in the restrictive transf

161 jor questions persist concerning patterns of RBC size evolution and its paleobiological significance.

162 EhRab35 significantly increased the rate of RBC degradation.

163 al infections, may have an increased risk of RBC alloimmunization and may benefit from personalized t

164 cytes are addressed via model simulations of RBC flow through the venous slits of the human spleen.

165 To assess whether a restrictive strategy of RBC transfusion reduces 28-day mortality when compared w

166 Transfusion of RBC significantly decreased the flow heterogeneity index

167 Transfusion of RBC significantly increased microcirculatory flow index

168 After transfusion of one unit of RBC, hemoglobin concentration increased from 8.5 g/dL (7

169 hown to be effective for removal of 99.1% of RBCs spiked with 1% cancer cells while maintaining a pro

170 Rod-RBC synapses develop while 7% of RBCs undergo programmed cell death (PCD).

171 We generate mice in which 53 and 93% of RBCs, respectively, are removed during development.

172 kle cell disease (SCD), abnormal adhesion of RBCs to endothelial cells is mediated by the intercellul

173 ect is detectable through motion analysis of RBCs in a high magnetic field and gradient.

174 rs illustrate why the making and breaking of RBCs is at the heart of iron physiology, providing an id

175 was unrelated to the cholesterol content of RBCs or plasma, but was associated with the phospholipid

176 er interaction, and subsequent distortion of RBCs is challenging as they occur at multispatial scales

177 However, effects of RBCs on thrombosis are difficult to assess because human

178 P3.1 merozoites exhibit enhanced invasion of RBCs in the presence of active complement.

179 to lipids are inserted into the membrane of RBCs.

180 nced by haemoglobin concentration, number of RBCs and number of reticulocytes.

181 blasts, with WBCs >/= 5 times the number of RBCs; CNS3a to 3c, >/= 5 WBCs/muL plus blasts with/witho

182 velopment of a real-time time observation of RBCs agglutination.

183 on Low levels of CNS leukemia, regardless of RBCs, predict inferior outcome and higher rates of CNS r

184 roved length of time for the cold storage of RBCs in additive solution.

185 tion toward its cognate Ag on the surface of RBCs.

186 Pronase treatment of RBCs only modestly altered cholesterol accessibility.

187 fined as the transfusion of at least 10 U of RBCs in the first 24 hours after a patient's admission t

188 than 7 days, exposed to at least one unit of RBCs stored 8-35 days, and exposed to least one unit of

189 8-35 days, and exposed to least one unit of RBCs stored longer than 35 days.

190 Transfusion of one unit of RBCs.

191 g patients who received more than 6 units of RBCs stored for 30 days or longer, the hazard ratio of d

192 Although constraints on RBC size have been tied to the cell's need to attend cap

193 ficant effect of hemodynamic shear stress on RBC-induced microvascular injury.

194 teristics, such as capillary transit time or RBC velocity, also vary significantly over cortical dept

195 gher ratios of fresh frozen plasma-to-packed RBCs and platelets-to-packed RBCs described in trials of

196 Fresh frozen plasma-to-packed RBCs and platelets-to-packed RBCs ratios were not associ

197 lasma-to-packed RBCs and platelets-to-packed RBCs described in trials of trauma patients were not obs

198 A high platelets-to-packed RBCs ratio (> 1:2) was associated with decreased 48-hour

199 lasma-to-packed RBCs and platelets-to-packed RBCs ratios were not associated with 30-day mortality ha

200 Overall, in our cohort of 6,016 patients, RBC transfusion was not associated with death (hazard ra

201 elp explain why the effects of physiological RBC aggregation are not deleterious in terms of in vivo

202 class I KO cells after depletion with WT pig RBCs to remove cell surface reactive antibodies, but lea

203 ] of blood %-5hmC for a doubling in prenatal RBC-Hg concentration was -0.013% (-0.029, 0.002), -0.031

204 f %-5mC to %-5hmC for a doubling in prenatal RBC-Hg concentration was 4.70% (0.04, 9.58), 22.42% (7.7

205 a robust in vitro culture system to produce RBCs that allow the generation of gene knockouts via CRI

206 ther treatments (MISC), whereas 697 received RBC transfusions only.

207 arge differences between donor and recipient RBC survival times.

208 phagocytic cup formation and thereby reduced RBC internalization, suggesting a potential role of the

209 To determine how E2F-2 regulates RBC production, we comprehensively studied erythropoiesi

210 In these mice, dendrites of the remaining RBCs expand in graded fashion independent of light-evoke

211 yed at finely tuned concentrations to render RBCs highly permeable to substrates, while low concentra

212 Fifteen hemorrhagic shock patients requiring RBC transfusion.

213 gher Ag levels induces a robust Ab response, RBCs bearing low Ag levels fail to induce RBC alloantibo

214 Rod-RBC synapses develop while 7% of RBCs undergo programme

215 n Hb concentration was the result of routine RBC storage; clinical implications are discussed.

216 ework can successfully classify sickle shape RBCs in an automated manner with high accuracy, and we a

217 iculocyte counts and concomitantly shortened RBC lifespans.

218 hologies and mechanical properties of sickle RBCs in sickle cell anemia.

219 rphologies and membrane stiffening of sickle RBCs.

220 asets from 8 SCD patients (over 7,000 single RBC images) through a 5-fold cross validation method bot

221 rmalize the variant size of segmented single RBC patches into uniform size.

222 Single RBCs often form multiple PSDs with one rod; and neighbor

223 Small RBCs, such as those of mammals (which lack nuclei) and b

224 of active ICAM-4 receptors on WT-RBC and SS-RBC membranes, as well as the median unbinding force bet

225 showed that incubation of normal RBCs and SS-RBCs with epinephrine, a catecholamine that binds to the

226 quency of ICAM-4 receptors in WT-RBCs and SS-RBCs, confirming that the activation of ICAM-4 is regula

227 ICAM-4 receptors in both normal RBCs and SS-RBCs.

228 not significantly different from that of SS-RBCs.

229 Here, we report the margination of stiffened RBCs in vivo, and reveal the crucial role of the vessel

230 suggest that the current practice of storing RBCs for up to 42 days does not need to be changed.

231 These data suggest RBCs promote arterial thrombosis by enhancing platelet a

232 These observations suggest RBCs contribute to thrombus formation.

233 Xenoantigenicity of swine RBC can be eliminated via gene disruption.

234 e the levels human antibody binding to swine RBC that is as low as autologous human RBC.

235 Finally, we simulate T2DM RBC suspensions under shear and compare the predicted vi

236 biorheological properties of individual T2DM RBCs.

237 nvestigate the membrane fluctuations of T2DM RBCs and explore the effect of cell shape on the fluctua

238 l, rheological, and dynamic behavior of T2DM RBCs in response to morphological change and membrane st

239 rst, we examine the elastic response of T2DM RBCs subject to static tensile forcing and their viscoel

240 at best describes the main hallmarks of T2DM RBCs, which can be used in future simulation studies of

241 Third, we subject the T2DM RBCs to shear flow and probe the effects of cell shape a

242 The resulting particles, termed RBC-platelet hybrid membrane-coated nanoparticles ([RBC-

243 This study demonstrates that RBC transfusion improves cerebral oxygen delivery global

244 Our data indicate that RBC accessible cholesterol is a stable phenotype with si

245 These results indicate that RBC-targeted scFv/TM exerts multifaceted cytoprotective

246 Flow cytometry showed that RBC from 2-gene knockout swine exhibited less human anti

247 yndrome remain elusive, studies suggest that RBC-induced microvascular injury in the distal lung play

248 CTV analysis revealed that RBCs lose, on average, 17% of their Hb after 42 days of

249 s following RBC transfusion and suggest that RBCs with altered Ag levels may provide a unique tool to

250 ng body of mechanistic studies suggests that RBCs can promote thrombus formation and enhance thrombus

251 fected with intracellular MRSA bacteria, the RBC-nanogels significantly inhibited bacterial growth co

252 archical RBC extraction method to detect the RBC region (ROI) from the background, and then separate

253 The sensor relies on differentiating the RBC deformability (a mechanical biomarker) that is highl

254 In intracellular reducing environment, the RBC-nanogels showed an accelerated drug release profile,

255 Indeed, insertion of CD22 ligands into the RBC cell surface strongly inhibited B cell activation, c

256 ted with the phospholipid composition of the RBC membranes and with plasma triglyceride levels.

257 escription of the entropic elasticity of the RBC spectrin cytoskeleton, including domain unfolding/re

258 results indicate the great potential of the RBC-nanogel system as a new and effective antimicrobial

259 on molecule-4 (ICAM-4), which appears on the RBC membrane and binds to the endothelial alphavbeta3 in

260 antigens exist at different densities on the RBC surface and likewise exhibit distinct propensities t

261 although distinct alloantigens reside on the RBC surface at different levels, most alloantigens also

262 Only the RBC and WB groups met clinical standards for transplanta

263 We demonstrated that the RBC-nanogels effectively neutralized MRSA-associated tox

264 Factors both intrinsic and extrinsic to the RBC contribute to variation in its accessibility.

265 lood cells (RBCs) and, when compromised, the RBCs are more susceptible to haemolysis.

266 more, leakage of haemoglobin (Hb) inside the RBCs at high melittin concentration was also investigate

267 acellular, and mechanical alterations of the RBCs were analyzed quantitatively.

268 Further, the [RBC-P]NP platform exhibits long circulation and suitabil

269 Therefore, similar to endogenous TM, RBC-anchored scFv/TM activates several protective pathwa

270 glucosamine, insulin can efficiently bind to RBC membranes.

271 tory stimuli promote alloimmune responses to RBC Ags.

272 92 (6%) patients were exposed exclusively to RBCs with shortest storage, and 18 854 (76%) patients we

273 e, and 18 854 (76%) patients were exposed to RBCs stored 8-35 days.

274 each day in hospital: exclusively exposed to RBCs stored no longer than 7 days, exposed to at least o

275 4480 (18%) patients were exposed to RBCs with longest storage, 1392 (6%) patients were expos

276 hospital death of time-dependent exposure to RBCs stored longer than 35 days compared with exclusive

277 Exposure to RBCs stored longer than 35 days was not associated with

278 35 days compared with exclusive exposure to RBCs stored no longer than 7 days, both in patients of b

279 Although exposure to RBCs with higher Ag levels induces a robust Ab response,

280 ery of high ratios of plasma and platelet to RBCs in the nontrauma setting.

281 m the background, and then separate touching RBCs in the ROI images by applying an improved random wa

282 between the length of storage of transfused RBCs and patient mortality.

283 work is the first demonstration of utilizing RBC membrane to achieve smart insulin delivery with fast

284 s at 24H focused on perfusion with WB versus RBC.

285 The red, but not viscous, RBC AChE solution was loaded on a Hupresin affinity colu

286 loped an automated, high-throughput, ex-vivo RBC shape classification framework that consists of thre

287 The WB perfusate was superior (vs RBC) for maintaining stability of all monitored paramete

288 er, adverse events have been associated with RBC transfusion, raising safety concerns.

289 njectable polymeric nanocarriers coated with RBC membrane and loaded with Glc-Insulin.

290 At the cellular level, if combined with RBC models, the generated HbS fibers could be applied to

291 Patient-level analyses were conducted with RBC transfusion on day of enrollment as the outcome and

292 led to observe any gradients consistent with RBC SNO-Hb consumption and corresponding delivery of pla

293 Human sera were incubated with RBC isolated from various genetically engineered swine o

294 s, we demonstrated that upon incubation with RBCs EhRab35 is recruited to the site of phagocytic cups

295 tracted more oxygen than those perfused with RBCs (O2 extraction ratio 13.75 vs 9.43 % x10 per gram o

296 ng without reduction after depletion with WT RBCs demonstrate reduced binding to SLA class I KO cells

297 e frequency of active ICAM-4 receptors on WT-RBC and SS-RBC membranes, as well as the median unbindin

298 ased the frequency of ICAM-4 receptors in WT-RBCs and SS-RBCs, confirming that the activation of ICAM

299 llective frequency of unbinding events in WT-RBCs is not significantly different from that of SS-RBCs

300 ive reticulocytes and other markers of young RBCs.