ライフサイエンスコーパス: RCMV

1 RCMV gene expression is tightly regulated in cultured ce

2 RCMV infection accelerated the time to graft CR (SB 70-3

3 RCMV infection was assessed by serologic analysis and qu

4 Acute RCMV infection enhances the development of TVS in rat he

5 ne glands also were obtained from rats after RCMV inoculation in vivo and were analyzed for viral inf

6 en incubated for varying time intervals, and RCMV titers and secretory component (SC) levels in media

7 Simultaneous inoculation of KRV and RCMV induced diabetes in 100% of animals.

8 oculation of LEW*1WR1 dams with both KRV and RCMV prior to pregnancy protected weanling progeny from

9 Our study identified the miRNAs expressed by RCMV in vitro and in vivo and demonstrated that expressi

10 In cultured cells, RCMV expresses approximately 95% of the known viral ORFs

11 The effect of rat CMV (RCMV) (5x105 plaque-forming units) on TVS (neointimal in

12 Although rat CMV (RCMV) and murine CMV (MCMV) exhibit extreme species spec

13 Recently, it was demonstrated that rat CMV (RCMV) infection accelerates the development of transplan

14 viral transcriptional profiles in cultured, RCMV-infected endothelial cells, fibroblasts, and aortic

15 The English isolate of rat cytomegalovirus (RCMV) encodes a 20-kDa protein with a C-type lectin-like

16 cytomegalovirus (HCMV), rat cytomegalovirus (RCMV) encodes multiple CC chemokine-analogous proteins,

17 Both KRV and rat cytomegalovirus (RCMV) induced diabetes in up to 60% of LEW*1WR1 rats, wh

18 Rat cytomegalovirus (RCMV) is a beta-herpesvirus with a 230-kbp genome contai

19 ng of the small RNAs in rat cytomegalovirus (RCMV)-infected fibroblasts and persistently infected sal

20 and briefly exposed to rat cytomegalovirus (RCMV).

21 tic, which has important implications during RCMV infection and reactivation and acceleration of TVS.

22 pressed with late viral gene kinetics during RCMV infection and highly expressed in heart and salivar

23 Grafts from RCMV-infected recipients had upregulation of chemokine e

24 hese profiles to those found in tissues from RCMV-infected rat heart transplant recipients.

25 In addition, graft vessels from RCMV-infected grafts demonstrate the increased infiltrat

26 The herpesvirus RCMV invades and replicates in acinar epithelial cells f

27 venous or intraperitoneal viral inoculation; RCMV infects and undergoes a time-, dose-, strain-, and

28 increased the diabetogenicity of KRV but not RCMV and was associated with a moderate rate of diabetes

29 present study, we determined the kinetics of RCMV-accelerated TVS in a rat heart transplant model.

30 analysis of the restriction fragment KpnR of RCMV revealed significant homology to several C-type lec

31 s from rat lacrimal tissue; the magnitude of RCMV replication in acinar epithelial cells in vitro may

32 The sequence of the coat proteins of RCMV strain O were modeled into the capsid structure of

33 The overall structure of RCMV is similar to that of two other comoviruses, Cowpea

34 The X-ray structure of RCMV strain S has been determined and refined to 2.4 A.

35 this increased expression paralleled that of RCMV-accelerated neointimal formation.

36 We have constructed a recombinant RCMV in which the RCMV MIE enhancer has been replaced wi

37 These findings demonstrated that RCMV invades the rat lacrimal gland after intravenous or

38 Together our findings indicate that RCMV r129 is highly chemotactic, which has important imp

39 in infected cultured cells, indicating that RCMV gene expression in vitro does not reflect viral-gen

40 The RCMV miRNAs are distributed across the viral genome on b

41 The RCMV miRNAs have a genomic positional orientation simila

42 By comparing the RCMV structure with that of other comoviruses, a structu

43 Similar to other reported miRNAs, the RCMV miRNAs had considerable variation at their 3' and 5

44 e current study, we examined the role of the RCMV chemokine r129 in promoting cellular migration and

45 s demonstrated that the core promoter of the RCMV lectin-like gene contains a GATA rather than a TATA

46 ined by real-time PCR that expression of the RCMV miRNA miR-r111.1-2 is highly expressed in the saliv

47 constructed a recombinant RCMV in which the RCMV MIE enhancer has been replaced with that of MCMV.

48 In this study, we used RCMV-specific DNA microarrays to investigate the viral t

49 Red clover mottle virus (RCMV) is a member of the comoviruses, a group of picorna

50 rat embryo fibroblast (REF) cell line while RCMV does not grow in murine fibroblasts.

51 tion of rat heart transplant recipients with RCMV containing the r129-DeltaNT mutation prevented CMV-