ライフサイエンスコーパス: RCT

1 RCTs in the past 5 years were more likely to be focused

2 RCTs in which benefits and complications of fornix- vs l

3 RCTs were searched based on standardized searching rules

4 of at least 2 lines (45% vs 21%; P = .003; 1 RCT, 180 participants).

5 r 1 year (0.08 logMAR [95% CI, 0.02-0.15], 1 RCT, 177 participants).

6 g-acting beta-agonists (LABAs) (n = 3174), 1 RCT of LABAs and inhaled corticosteroids (ICS) (n = 1097

7 for children not pretreated with glasses (1 RCT, 177 participants).

8 Inclusion criteria were 1) RCT, 2) subjects aged >/=19 y, 3) consumption of >/=0.5

9 AMT group based on data from 1021 eyes in 10 RCTs.

10 Among 792 unique articles identified, 27 (11 RCTs, 11 systematic reviews or meta-analyses, and 5 revi

11 We included 114 RCTs with data from 20 275 participants.

12 and funnel plot inspection.Findings from 12 RCTs (n = 609 participants) from 2 to 17 wk of duration

13 For RBC storage duration, 13 RCTs included 5515 participants randomly allocated to re

14 Our meta-analyses included 13 RCTs comprising 2970 psychiatric patients.

15 ials selected by literature search: nAMD: 13 RCTs, DME: 9, RVO: 5), the OCEAN patients' mean age was

16 Of 369 records screened, 14 RCTs were selected for the qualitative and quantitative

17 The search identified 1824 studies, with 14 RCTs of 1196 patients eligible for inclusion.

18 Of 26 eligible RCTs identified, 15 RCTs (1711 patients) provided moderate-quality evidence

19 Sixteen eligible articles reporting 15 RCTs involving 6662 patients assigned to 1 of 10 treatme

20 n older people undergoing RET.We included 17 RCTs; the overall mean +/- SD age and body mass index (B

21 For the femoral neck (18 RCTs, n = 1604), isoflavone treatment showed a significa

22 to -0.14 point]) and physical functioning (2 RCTs; MD, 2.50 [CI, 0.90 to 4.10 point]; SMD, 0.25 [CI,

23 eeks for children pretreated with glasses (2 RCTs, 240 participants); more children treated with patc

24 nalyses for fall-related hospitalizations (2 RCTs; 516 participants) showed no significant associatio

25 ies comprising 3 148 259 participants and 23 RCTs of statins vs placebo or no treatment comprising 11

26 A total of 283 RCTs (159910 participants; mean age, 78.1 years; 74% wom

27 gistry of Controlled Trials for phase 2 or 3 RCTs published up until April 29, 2016.

28 Evidence from 35 RCTs at low risk of bias indicated that ginger, vitamin

29 he planning stage of a postmarketing phase 4 RCT dedicated to the evaluation of cardiovascular safety

30 factors reflecting the conduct of a phase 4 RCT for a general medical condition may influence interp

31 effects meta-analyses for outcomes with >/=4 RCTs were performed.Sixteen RCTs and 20 prospective coho

32 short-term improvements in pain intensity (4 RCTs; mean difference [MD], -0.96 point on a numerical r

33 001; 95% CI: 0.02, 0.05) and femoral neck (4 RCTs, n = 524) to 0.03 (P < 0.05; 95% CI: 0.00, 0.06) co

34 Although historically many phase 4 RCTs focused on efficacy (using a superiority design), c

35 On the basis of phase 4 RCTs of NSAIDs to date, it appears that a comparatively

36 a superiority design), contemporary phase 4 RCTs often are focused on safety and use a noninferiorit

37 inhaled corticosteroids (ICS) (n = 1097), 5 RCTs of the long-acting muscarinic antagonist tiotropium

38 nt and Evaluation guidelines.We identified 5 RCTs comprising 912 participants in total.

39 ther significantly increased at the spine (5 RCTs, n = 682) to 0.04 (P < 0.00001; 95% CI: 0.02, 0.05)

40 Network meta-analysis (including 54 RCTs, 41596 participants, 39 interventions plus usual ca

41 Ts with 10 arms were added for a total of 56 RCTs with 110 arms.

42 inic antagonist tiotropium (n = 4592), and 6 RCTs of ICS (n = 3983).

43 r CAG and AMT based on data from 538 eyes (6 RCTs).

44 s, of which 11 met criteria for inclusion (6 RCTs and 5 prospective observational studies).

45 After screening 5874 citations, 7 RCTs with 10 arms were added for a total of 56 RCTs with

46 al hits, 25 studies (12 open-label trials, 9 RCTs and 4 longitudinal studies) including 10 792 patien

47 Over this 20-year period, 92 RCTs were published containing 64 309 patients (median,

48 screening, studies evaluating test accuracy, RCTs of treatment vs inactive controls, and cohort studi

49 Across all RCTs exclusively recruited within the United States that

50 ature search (MEDLINE) was performed for all RCTs published in top ophthalmology journals and ophthal

51 rformed a systematic review, identifying all RCTs published in PubMed, EMBASE, Scopus, Web of Science

52 V infection, sample size requirements for an RCT with HIV incidence as its outcome are prohibitively

53 Los Angeles County public hospitals into an RCT of a survivorship care nurse counseling session coup

54 tric in men treated within the context of an RCT, we aimed to determine whether PSA failure is associ

55 5-02) that met the following prespecified an RCT in patients with NDMM receiving ASCT followed by len

56 Using an RCT as a vaccine probe, influenza vaccination during pre

57 nowledge the first study to report within an RCT a differential change in cortical morphology during

58 e illness and the first to provide within an RCT in vivo evidence for the presence of neuroanatomical

59 ons, informed by the administrative data and RCT, to assess the impact of immutable time on the measu

60 es underline the complementarity of NISs and RCTs.

61 h or n-3 LC-PUFA intake during pregnancy and RCTs with a prenatal intervention to modify maternal n-3

62 as well as identified systematic reviews and RCTs, for RCTs of adults with low back pain treated in a

63 is an urgent need for long-term studies and RCTs assessing the efficacy of treatments for NCP.

64 Any RCT comparing mortality or clinical efficacy of prolonge

65 We discuss the features of available RCTs and provide the rationale for our recommendations.

66 ence suggests that infliximab is beneficial; RCT evidence for other interventions was lower in qualit

67 eatment-resistant schizophrenia, and blinded RCTs-in contrast to unblinded, randomized effectiveness

68 Forty blinded RCTs with 5172 unique participants (71.5% men; mean [SD]

69 ither have not been or cannot be answered by RCTs.

70 Cluster RCT at community- and hospital-based cancer clinics in W

71 Patients and Methods This cluster RCT with 170 patients who had advanced nonhematologic ca

72 cipated in a double-blind placebo-controlled RCT in 2011 and 2012 on the efficacy of trivalent inacti

73 ulticenter, double-blind, placebo-controlled RCT was powered on a 5% difference in lean body mass (LB

74 le interactions than same-sized conventional RCTs.

75 Also in high-income countries, RCTs have demonstrated that regular blood transfusion is

76 ctive and systematic framework for designing RCTs that incorporates these considerations on a case-by

77 MRI both have similar accuracy in diagnosing RCT of any sort and FTT.

78 rum and more variability of patients than do RCTs.

79 Application of this technology during RCT has the potential to reduce persistent infections th

80 The FI of each RCT was calculated and multivariate regression applied t

81 Ten studies, eight RCTs and two prospective studies, were included.

82 Eighteen RCTs (19.6%) were performed in the United States, 68 (73

83 mentation group and the control group.Eleven RCTs that included 543 participants with follow-up perio

84 Eligible RCTs were selected by 2 independent reviewers, and guide

85 In all, 110 eligible RCTs with nonsignificant primary outcomes were appraised

86 Of 26 eligible RCTs identified, 15 RCTs (1711 patients) provided modera

87 Databases were searched for eligible RCTs in 2 phases.

88 e general population have not been examined, RCTs have assessed the role of supplementation in second

89 Macrophage-to-feces RCT, HDL efflux capacity, and HDL proteomic profiling wa

90 nclusion To our knowledge, this is the first RCT of survivorship care plans to show benefits in clini

91 For RCTs involving therapies for cancers with short survival

92 Quality of evidence for RCTs was low to moderate.

93 identified systematic reviews and RCTs, for RCTs of adults with low back pain treated in ambulatory

94 ntal trial, and five secondary analyses from RCTs in the 2012 PCO on providing palliative care servic

95 f our review of the cumulative evidence from RCTs designed to assess the effect of omega-3 polyunsatu

96 dy publications and 5 of 7 publications from RCTs found a protective association between increased pr

97 Further RCTs of these interventions in patients with coexistent

98 Future RCTs should assess changes in patient-reported outcomes

99 Future RCTs tailored for those most likely to benefit from RIPC

100 al or noncommunicable diseases.We identified RCTs that were published in English before May 2017 that

101 ween 2005 and 2015 was performed to identify RCTs of nutritional interventions administered to critic

102 In RCTs with posttreatment follow-up >/=12 months, antivira

103 In RCTs with statistically nonsignificant primary outcomes

104 In RCTs, the RR for venous thromboembolism was 0.85 (0.73-0

105 An application of the FI in RCTs may aid in the interpretation of results and assess

106 Overestimates of delta occur frequently in RCTs of nutritional interventions in the critically ill

107 Important gaps in RCTs of cardiac arrest treatments exist, especially thos

108 esearchers can then test these hypotheses in RCTs.

109 with acute ICH similar to those included in RCTs and without contraindication to acute BP treatment,

110 ude that the quality of outcome reporting in RCTs of squamous cell carcinoma of the anus is inconsist

111 The risk of bias was low for 3 included RCTs.

112 independently abstracted data from included RCTs.

113 es were considered eligible if they included RCTs comparing different pharmacological regimens for tr

114 We included RCTs in which at least 1 intervention was a targeted (BR

115 We included RCTs with a follow-up of >/=3 wk that assessed the effec

116 growing evidence of mindfulness intervention RCTs by reviewing and discussing (a) the effects of mind

117 We limited the scope of our review to large RCTs of supplementation with major clinical cardiovascul

118 These results suggest the need for a larger RCT to replicate and confirm these findings.

119 0.68 to 1.00, p=0.056), especially in larger RCTs.

120 These findings warrant the design of larger RCTs investigating the potential of these approaches in

121 promoting cholesterol efflux and macrophage RCT through the PPARalpha- LXRalpha- ABCA1/G1pathway in

122 determined eligibility for each of 10 major RCTs for primary prevention of CVD.

123 subgroup of patients from a previous 6-month RCT, there was a high correlation between the results fo

124 e same masked examiners as after the 6-month RCT.

125 Multicentre RCTs with standardized protocols conducted outside epide

126 Nine RCTs, one quasiexperimental trial, and five secondary an

127 No RCT reported any serious adverse event.

128 No RCTs compared screening with no screening, and no studie

129 No RCTs compared screening with no screening.

130 The pooled RCT and non-RCT results, however, showed a significantly lower risk

131 Studies were excluded if they were not RCTs, the antibiotics in the two arms were not the same,

132 a first-line investigation for diagnosis of RCT.

133 eports have suggested that interpretation of RCT results in medical journals can be distorted by auth

134 ommon pitfalls that recurred irrespective of RCT context indicate opportunities for specific training

135 Research articles reporting outcomes of RCT/s comparing 2 or more opioid analgesics for the mana

136 In absence of RCTs, 25 cohort studies could be used to perform a meta-

137 a-analyses, as well as secondary analyses of RCTs in the 2012 PCO, published from March 2010 to Janua

138 examined in the selected 9 meta-analyses of RCTs, coffee was associated with a rise in serum lipids,

139 his systematically searched meta-analysis of RCTs support the idea that the consumption of >/=0.5 ser

140 reased risk observed in the meta-analysis of RCTs.

141 reement between USG and MRI for diagnosis of RCTs was statistically excellent; USG showed a sensitivi

142 eatable process for deciding the outcomes of RCTs that explicitly incorporates burden of disease and

143 The paucity of RCTs is a major limitation in the evaluation of preventi

144 tions, is needed to improve the reporting of RCTs examining chemoradiation for treatment of patients

145 A higher emphasis was placed on RCTs and prospective cohort studies with large sample si

146 1 error rates and sample sizes for oncology RCTs.

147 ived stress scores were only reported in one RCT of patients with active disease.

148 However, long-term results of the ongoing RCTs are awaited to assess whether these pathologic resu

149 Only RCTs published in English from January 1, 1995, to June

150 Only RCTs with industry involvement were eligible.

151 We included only RCTs published as original articles, where an anti-VEGF

152 to determine the robustness of ophthalmology RCTs through application of the Fragility Index (FI), a

153 The pooled RCT and non-RCT results, however, showed a significantly

154 ination therapy was consistent with previous RCTs.

155 urthermore, in a clinical trial with primary RCTs, 53 infected teeth were sampled in vivo, and increa

156 t in the NIS OCEAN with those from published RCTs.

157 to the patient characteristics of published RCTs (trials selected by literature search: nAMD: 13 RCT

158 were set in reference to those of published RCTs in the same indications.

159 Only six published RCTs comprising 2877 patients were identified.

160 tabases and extracted data from 24 qualified RCTs.

161 1) randomised controlled trial (RCT), quasi-RCT, before-after cohort study; 2) including RA patients

162 l tumor after neoadjuvant radiochemotherapy (RCT) is associated with an excellent prognosis.

163 Between day 1 and month 24 (RAPID-RCT), the rate of lung density loss in RAPID-OLE patient

164 6, and Oct 13, 2010, 140 patients from RAPID-RCT entered RAPID-OLE: 76 from the early-start group and

165 r placebo (delayed-start group) in the RAPID-RCT trial were included in this 2-year open-label extens

166 he loss of lung density in relation to RAPID-RCT.

167 ency in a randomised controlled trial (RAPID-RCT), which was followed by an open-label extension tria

168 of the mid or lower rectum who had received RCT (45 to 50 Gy with fluorouracil or capecitabine) were

169 analyses of patient-level data from a recent RCT, in which ICU LOS was the primary endpoint, and in a

170 halmology journals and ophthalmology-related RCTs published in high-impact journals in the past 10 ye

171 BASE and the Cochrane databases for relevant RCTs and calculated pooled OR for 3-month mortality (saf

172 Renal RCTs (n = 5) showed that corticosteroid withdrawal/avoid

173 Of the 626 articles reporting RCTs included in this analysis, 532 (85.0%) reported the

174 investigate the charge transfer resistance (RCT ) of metal-modified DNA.

175 Methodologically rigorous RCTs have demonstrated that mindfulness interventions im

176 Seven RCTs and three quasi-randomized trials were included.

177 Seven RCTs involving 864 patients with low back pain were elig

178 In seven RCTs, totalling n=534 randomized youth with ADHD, n-3 PU

179 Seventeen RCTs were eligible for inclusion.

180 lectrochemical impedance spectroscopy showed RCT 3 times higher for JIA positive sample than for a po

181 mine the effect of C. asiatica alone and six RCTs conducted to determine the effect of C. asiatica-co

182 roviding isoflavones as aglycones.Twenty-six RCTs (n = 2652) were included in the meta-analysis.

183 tcomes with >/=4 RCTs were performed.Sixteen RCTs and 20 prospective cohort studies were included in

184 in DME, with VA significantly higher in some RCTs and lower in others.

185 Using a defined search strategy, RCTs with clearly nonsignificant results for the primary

186 Rotator cuff tears (RCTs) represent a significant proportion of shoulder dis

187 Long-term RCTs that compare MBSR versus active treatments are need

188 NISs can deliver insights that RCTs may not, as NISs can include non-typical patients,

189 The RCT study design mitigated ascertainment bias by randomi

190 heir individual sense of equipoise about the RCT treatments and their intentions for communicating eq

191 ents in which these clinicians presented the RCT to trial-eligible patients were audio-recorded (n =

192 The RCTs were all based in secondary-care hospitals (n = 16)

193 of occurrence of equipoise issues across the RCTs suggests that the findings are likely to be reflect

194 h only few differences between OCEAN and the RCTs.

195 Clinicians recruiting to the RCTs were interviewed (n = 23) to understand their indiv

196 These RCTs demonstrated that fresher blood did not improve cli

197 d body mass index (BMI; in kg/m(2)) in these RCTs were 73.4 +/- 8.1 y and 29.7 +/- 5.5, respectively.

198 As a result of these RCTs, National Institutes of Health recommendations now

199 This RCT demonstrated safe and sustained 2-year reduction in

200 Fifty-three RCTs (57.6%) reported global ordinal outcomes, whereas 1

201 Results: Forty-three RCTs provided data on 12731 patients (mean age, 67 years

202 ient-level data and documentation from three RCTs (Cancer and Leukemia Group B 100104, Gruppo Italian

203 ptom scores (g=0.38, p<0.0001); and in three RCTs, totalling n=214 randomized youth with ADHD, n-3 PU

204 Participant flow through RCTs in chronic heart failure has not been uniformly rep

205 Limiting the results to RCTs showed similar results.

206 ation impairs reverse cholesterol transport (RCT) and reduces high-density lipoprotein (HDL) function

207 canal (RC) space following an RC treatment (RCT) can lead to persistent infections, resulting in tre

208 ive effectiveness randomized clinical trial (RCT) evaluating the 3 anti-vascular endothelial growth f

209 A randomized clinical trial (RCT) of 24 weeks of isoniazid in individuals with pulmon

210 ional multicenter randomized clinical trial (RCT), followed up 18 patients with 36 Miller Class I and

211 ary analysis of a randomized clinical trial (RCT), we evaluated the effect of maternal vaccination on

212 sign and implement randomized control trial (RCT) interventions that can promote resilient functionin

213 Ideally, a randomized controlled trial (RCT) among US women would provide data for guidelines fo

214 n a review of a randomized controlled trial (RCT) by the National Cancer Institute Physicians Data Qu

215 A recent randomised controlled trial (RCT) demonstrated that induction of labour at 39 weeks o

216 This randomized controlled trial (RCT) hypothesized that prolonged enteral nutrition (EN)

217 ts of a cluster randomized controlled trial (RCT) of a combined patient-oncologist intervention to im

218 zed, double-blind, placebo-controlled trial (RCT) of antidepressant medication for 10-week's duration

219 he effects of a randomized controlled trial (RCT) of treatment summaries and survivorship care plans

220 lind, pragmatic randomised controlled trial (RCT) was conducted at eight study sites across the Unite

221 iteria were: 1) randomised controlled trial (RCT), quasi-RCT, before-after cohort study; 2) including

222 eting (phase 4) randomized controlled trial (RCT).

223 All randomized controlled trials (RCT) and observational studies comparing corticosteroid

224 he findings of randomised controlled trials (RCT), observational studies, and meta-analyses vary rega

225 meta-analysis of randomized clinical trials (RCTs) according to the Preferred Reporting Items for Sys

226 ere included: 67 randomized clinical trials (RCTs) and 11 nonrandomized studies.

227 Randomized clinical trials (RCTs) and meta-analyses have reported different conclusi

228 e widely used in randomized clinical trials (RCTs) and observational research.

229 Controlled randomized clinical trials (RCTs) and prospective studies with data on comparison be

230 ective cohort of randomized clinical trials (RCTs) based on archived protocols approved by six resear

231 ere searched for randomized clinical trials (RCTs) comparing LRR vs ORR.

232 of head-to-head randomized clinical trials (RCTs) comparing targeted and immunotherapies leaves unce

233 Randomized clinical trials (RCTs) currently apply the same statistical threshold of

234 be effective in randomized clinical trials (RCTs) for hidradenitis suppurativa (HS) in adults?

235 However, randomized clinical trials (RCTs) for statin use have included participants with spe

236 cancer, yet few randomized clinical trials (RCTs) of communication interventions have been reported.

237 Randomized clinical trials (RCTs) of fall-prevention interventions for participants

238 easing number of randomized clinical trials (RCTs) of other antipsychotics have been published.

239 English-language randomized clinical trials (RCTs) or prospective cohort studies that evaluated scree

240 All randomized clinical trials (RCTs) were identified between July 2010 and July 2015 wi

241 e evidence, from randomized clinical trials (RCTs), for conversion from CNI to mTORi-based immunosupp

242 English-language randomized clinical trials (RCTs); studies evaluating accuracy of screening question

243 d search included randomized control trials (RCTs) that reported on first-line pulmonary tuberculosis

244 es and 9,999 from randomized control trials (RCTs) were identified for these analyses.

245 databases for randomized controlled trials (RCTs) and high-quality quasi-experimental and epidemiolo

246 2016 including randomized controlled trials (RCTs) and prospective cohort studies examining 1) the ef

247 While randomized controlled trials (RCTs) are based on strict inclusion/exclusion criteria,

248 ducted on: (1) randomized controlled trials (RCTs) assessing the effects of n-3 PUFAs on clinical sym

249 ta-analysis of randomized controlled trials (RCTs) comparing 2 methods of hiatal closure for large hi

250 includes five randomized controlled trials (RCTs) conducted to determine the effect of C. asiatica a

251 and PubMed for randomized controlled trials (RCTs) evaluating isoflavone therapies for treating BMD l

252 Multiple randomized controlled trials (RCTs) have assessed the effects of supplementation with

253 findings from randomized controlled trials (RCTs) have been inconsistent.We sought to determine the

254 included only randomized controlled trials (RCTs) in which CAG and AMT had been compared for primary

255 ta-analysis of randomized controlled trials (RCTs) indicated a protective effect of masks and respira

256 e searched for randomized controlled trials (RCTs) investigating cellular immunotherapy or vaccines i

257 lysis of seven randomised controlled trials (RCTs) involving 2370 participants showed a significant a

258 y.We evaluated randomized controlled trials (RCTs) of isolated soluble fiber supplementation in overw

259 ic increase in randomized controlled trials (RCTs) of mindfulness interventions over the past two dec

260 lculations for randomized controlled trials (RCTs) of nutritional interventions that used mortality a

261 ion in several randomized controlled trials (RCTs) of patients with newly diagnosed multiple myeloma

262 f endpoints in randomised controlled trials (RCTs) of radical chemoradiation for treatment of squamou

263 e if they were randomised controlled trials (RCTs) or prospective cohort studies involving repeat exp

264 r 3, 2016, for randomized controlled trials (RCTs) or prospective controlled observational studies of

265 Randomised controlled trials (RCTs) recruiting patients with inflammatory bowel diseas

266 es to identify randomized controlled trials (RCTs) reporting the efficacy of PS for lean mass gain, s

267 ta-analyses of randomized controlled trials (RCTs) suggest calcium could have adverse effects on card

268 Evidence from randomized controlled trials (RCTs) suggests the consumption of konjac glucomannan (KJ

269 erpretation of randomized controlled trials (RCTs) that address important clinical questions.

270 , reviews, and randomized controlled trials (RCTs) that assessed the outcomes glycated hemoglobin (Hb

271 Randomized controlled trials (RCTs) that compared MBSR with usual care or an active co

272 idence from 11 randomized controlled trials (RCTs) that enrolled 33 051 patients who received predomi

273 ve analyses of randomized controlled trials (RCTs) that investigate the effects of red meat consumpti

274 ta-analysis of randomised controlled trials (RCTs) to assess whether intensive BP lowering in patient

275 ta-analysis of randomized controlled trials (RCTs) was carried out.

276 ta-analysis of randomized controlled trials (RCTs) was conducted to evaluate long term function, comp

277 lysis (NMA) of randomized-controlled trials (RCTs) which investigated effectiveness of opioids for th

278 21 randomized controlled trials (RCTs) with a total of 6302 patients were selected and id

279 hed reports of randomized controlled trials (RCTs) with statistically nonsignificant results for prim

280 bo controlled (randomised controlled trials (RCTs)) studies of AChEIs in patients with dementia repor

281 tober 2015 and randomized controlled trials (RCTs), cohort studies or case-control studies were inclu

282 ogically sound randomized controlled trials (RCTs), demonstrating superiority to placebo or relevant

283 FO to identify randomized controlled trials (RCTs), meta-analyses, and systematic reviews that addres

284 s shown in two randomised controlled trials (RCTs)-TRAFFIC and TRANSPORT-in patients with cystic fibr

285 several recent randomized controlled trials (RCTs).

286 mplementary to randomized controlled trials (RCTs).

287 igher doses in randomized controlled trials (RCTs).

288 al studies and randomized controlled trials (RCTs).

289 al studies and randomized controlled trials (RCTs).

290 rt studies and randomised controlled trials (RCTs).

291 Twelve RCTs (1381 patients) produced moderate-quality evidence

292 Twenty RCTs with 1866 participants (1947 eyes) were included.

293 Two RCTs found no patient characteristics that were associat

294 Quality of life was assessed in two RCTs of patients with active disease, but was not signif

295 Separate meta-analyses of two RCTs of adjunctive treatment with anti-cytokine therapy

296 detection of rotator cuff tears of any type (RCT) or FTT.

297 The meta-analysis included 14 unique RCTs with 4034 unique patients.

298 Eligible studies were RCTs that compared isolated soluble fiber with placebo t

299 re included only for interventions for which RCTs were not available.

300 We conducted an 8-wk winter RCT in adults aged 45-70 y (n = 55) who were stratified