ライフサイエンスコーパス: RING finger domain

1 i-spanning membrane protein with a cytosolic RING finger domain.

2 -700 on Cbl, and also requires an intact Cbl RING finger domain.

3 adation of cdc34 and its binding to the ICP0 ring finger domain.

4 UbcH6 E2-conjugating enzymes mapping to the ring finger domain.

5 functions as an E3 ligase independent of the RING finger domain.

6 IAP repeat (BIR) domain and a COOH-terminal RING finger domain.

7 tivation of GCKR by TRAF2 required the TRAF2 RING finger domain.

8 perty of Vmw110 and more particularly of its RING finger domain.

9 ding a 7-amino acid insert within the TRAF2A RING finger domain.

10 r nuclear localization as the amino-terminal ring finger domain.

11 ion, which encodes a transcript containing a RING finger domain.

12 s C-terminal cysteine-rich motif is indeed a RING finger domain.

13 components requires BRCA1's BRCT but not the ring finger domain.

14 on of similarity between these proteins is a RING finger domain.

15 lates protein sumoylation independent of the RING finger domain.

16 tin ligase activity harbored within the MDM2 RING finger domain.

17 vely modulated GATA4 transactivation via its RING finger domain.

18 breviated as E3 activity) is mediated by its RING finger domain.

19 his required the PML N terminus and the MDM2 RING-finger domain.

20 ivation of p53 by PIAS1 does not require the RING-finger domain.

21 RAF, DTRAF2, that contains an amino-terminal Ring-finger domain.

22 UMO-interacting motif (SIM) and a C-terminal RING-finger domain.

23 t, in a manner that was dependent upon PML's RING-finger domain.

24 amino acids of Slx8, but not its C-terminal RING-finger domain.

25 e sequence homology between their respective RING finger domains.

26 dent on its variant SRC homology 2 (SH2) and RING finger domains.

27 binding is a generally proposed function of RING finger domains.

28 irus IAP repeats (BIRs) and carboxy-terminal RING finger domains.

29 ally defined by a C4HC3 consensus similar to RING finger domains.

30 es a conserved protein with zinc knuckle and RING finger domains.

31 CDCrel-1, interacts with Parkin through its ring-finger domains.

32 or ubiquitin-like protein containing PHD and RING finger domains 1 (uhrf1) in zebrafish leads to a re

33 Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential regulator

34 Ubiquitin-like, containing PHD and RING finger domains 1 (uhrf1) is regulated at the transc

35 mutations in the ubiquitin-like with PHD and ring finger domains 1 (uhrf1) or DNA methyltransferase 1

36 DNMT1) and ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) proteins.

37 n ligase UHRF1 (Ubiquitin-like, with PHD and RING finger domains 1) directly participates in the inte

38 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) has a well-established role in ep

39 port that UHRF1 (ubiquitin-like with PHD and RING finger domains 1) interacts with TIP60 both in vitr

40 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is a multi-domain protein associa

41 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is required for maintenance methy

42 in UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1), also known as NP95 in mouse and

43 E3 ligase UHRF1 (ubiquitin-like with PHD and RING finger domains 1), which is commonly upregulated in

44 by Uhrf1 (Ubiquitin-like, Containing PHD and RING Finger Domains 1).

45 UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to hemimethylated

46 e identified the ubiquitin-like with PHD and ring finger domains 2 (UHRF2) gene as an important media

47 a protein of 581 amino acids that contains a RING finger domain, a B-box, and two coiled-coil regions

48 TRIM37 contains a RING finger domain, a hallmark of E3 ubiquitin ligases,

49 entral proline-rich region; and a C-terminal RING finger domain, a motif often found in ubiquitin-pro

50 tion occurred even though hRAD18 possesses a RING finger domain, a structure that is generally associ

51 diate these processes, it requires its C3HC4 RING finger domain, a tertiary structural fold that is c

52 , revealed the presence of an amino-terminal RING finger domain, a zinc binding motif found in a vari

53 protein family, which contain a cluster of a RING-finger domain, a B box/coiled-coil domain and a SPR

54 (2+)-chelating ability of its amino-terminal RING finger domain abolished TRAC-1's ligase activity an

55 Further truncations, which delete the RING finger domain, abrogated the negative regulatory ef

56 ons of the zinc coordination residues of the RING finger domain abrogates TGF-beta resistance, but no

57 As a result, the juxtaposition of PA and RING finger domains across a lipid bilayer facilitates t

58 Our studies suggest that both the RING finger domain activity and the specific binding of

59 ults are consistent with the notion that the RING finger domains allosterically activate E2.

60 Deletion of the enzyme's N-terminal RING-finger domain almost completely abolishes fiber for

61 Alleles of SLX8 that express the RING-finger domain alone show almost complete complement

62 In contrast, the RING finger domain (amino acids 116 to 156) and surprisi

63 n, and a divergent SH2 domain) followed by a RING finger domain and a proline-rich C-terminus.

64 rotein designated as TRAF7, which contains a RING finger domain and a zinc finger domain that are mos

65 , as it possesses a conserved amino terminal RING finger domain and an acidic carboxyl domain.

66 Bmi-1 to the rim of the nucleus requires the RING finger domain and correlates with its ability to tr

67 is a unique TRAF protein because it lacks a RING finger domain and is predominantly expressed in act

68 ted) at Lys-446, which is located within the RING finger domain and plays a critical role in Mdm2 sel

69 sis to determine the importance of the MSL-2 RING finger domain and second cysteine-rich motif.

70 rophobic pocket can be regulated through the RING finger domain and that increases in pocket affinity

71 n assay also showed that both the N-terminal RING finger domain and the intact coiled-coil region of

72 The Slx5 and Slx8 proteins contain RING finger domains and coimmunoprecipitate from cell ex

73 hock protein 90 and did not require the MDM2 RING-finger domain and p53 ubiquitination.

74 tyrosine kinase binding domain, a catalytic RING finger domain, and a C-terminal proline-rich domain

75 iquitin ligase activity of the purified RAG1 RING finger domain, and the tertiary structure of the do

76 ctivate JNK, DTRAF1 lacks an amino-terminal 'Ring-finger' domain, and overexpression of a truncated D

77 Although the RING finger domains are necessary for dimerization, they

78 These results establish the RING finger domain as an essential element in Cbl-mediat

79 Mapping of Not4 identified the RING finger domain as essential for H3K4me3, suggesting

80 a 1.9-kb open reading frame that contains a RING finger domain at its N-terminus and an alanine-rich

81 Delta-PRAJA, which has a deleted RING finger domain at the C terminus, abolishes ubiquiti

82 The intact RING finger domain at the Mdm2 COOH terminus (amino acid

83 This activity requires a functioning MDM2 ring finger domain because the MDM2(C464A) mutant was un

84 d GAL4/PML fusion proteins that retained the RING finger domain but lacked the intact coiled-coil reg

85 strong sequence homology to ICP0 within the RING finger domain but limited similarity elsewhere.

86 UbcH7 interacted with the wild-type c-Cbl RING finger domain but not with a RING finger domain tha

87 similar mechanism or pathway involving their RING finger domain but that their intrinsic activities a

88 ncludes the evolutionarily conserved TKB and RING finger domains but lacks the less conserved C-termi

89 We demonstrate that disruption of the ORF61p RING finger domain by amino acid substitution (Cys19Gly)

90 of 49 patients; all of these cases harbored RING finger domain c-Cbl mutations.

91 n vitro studies, which demonstrated that its RING finger domain can autoubiquitylate and monoubiquity

92 known motifs; EF-hand domains (CGR11) and a ring-finger domain (CGR19), suggestive of function.

93 ICP0 contains a RING finger domain characteristic of a class of E3 ubiqu

94 tin-like (UBL) domain, a zinc knuckle, and a RING finger domain characteristic of some ubiquitin liga

95 indicates that checkpoint with forkhead and ring finger domains (CHFR), a recently identified mitoti

96 ese studies provide evidence that C-terminal RING finger domains, contained within both of these prot

97 ked InsP3R ubiquitination, suggesting that a RING finger domain-containing E3 is also involved in thi

98 omain (PHD) of UHRF1 (ubiquitin-like PHD and RING finger domain-containing protein 1) operates as a f

99 Specifically, we identified a RING finger domain-containing protein, RINCK (for RING-f

100 TRIM21 is a RING finger domain-containing ubiquitin E3 ligase whose

101 Mutations in Z that unfolded its RING finger domain eliminated its inhibitory activity, b

102 trate-independent ubiquitination system, the RING finger domain encoded by exon 2 of ICP0 binds cdc34

103 ciated with the really interesting new gene (RING) finger domain encoded by exon 2.

104 Flag-gp78), but not Flag-gp78 mutated in its RING-finger domain (Flag-RINGmut) with deficient ubiquit

105 ximity to their N termini that consists of a RING finger domain, followed by one or two B box domains

106 The Mdm2 ring finger domain has been shown to possess E3 ligase a

107 A protein lacking the SH2 and RING finger domains has no activity, but a chimeric prot

108 The ring finger domain in Chfr is required for the ligase ac

109 polymerase-associated domain in PolH and the RING finger domain in Pirh2.

110 Recent results implicate the RING finger domain in specific ubiquitination events; it

111 nesis of cysteine residues within a putative RING finger domain in the amino acid sequence of HCF-1 a

112 ibosylation factor domain protein 1), with a RING finger domain in the N-terminal region, two predict

113 een suggested to bind zinc(II) in an unusual RING finger domain in which Thr 455 was postulated as a

114 Dominant negative c-Cbl lacking the ring finger domain inhibited PAR(2) ubiquitination and i

115 any RING finger proteins, by virtue of their RING finger domain, interact with E2 ubiquitin-conjugati

116 nd an in vitro binding assay, that the c-Cbl RING finger domain interacts with UbcH7, a ubiquitin-con

117 A TRAF2 mutant lacking its N-terminal RING finger domain is a dominant-negative inhibitor of T

118 nd increased p53 transactivation by the MdmX ring finger domain is discussed.

119 hemical analyses further show that the yBre1 RING finger domain is essential for H2B ubiquitylation b

120 as with the other target proteins, the ICP0 RING finger domain is essential.

121 dition, we demonstrate that an intact ORF61p RING finger domain is necessary for E3 ubiquitin ligase

122 GCK, and the highly related kinase GCKR, the RING finger domain is needed for their activation.

123 riptional suppression whereas the N-terminal RING finger domain is not required.

124 Thus, a correctly folded RAG1 RING finger domain is required for normal V(D)J recombin

125 nfection, (v) ICP0 carrying mutations in the RING finger domain is stable both early and late in infe

126 key function of ICP0 that requires an intact RING finger domain is that of an ubiquitin E3 ligase: IC

127 The RING-finger domain is a novel zinc-binding Cys-His prote

128 s association with microtubules, whereas the RING-finger domain is required for microtubule stabiliza

129 Ubiquitination of lysines in Hrd1's RING-finger domain is required for substrate retrotransl

130 by the BARD1 protein (residues 8-142), whose RING finger domain itself lacked Ub ligase activity in v

131 We show that Lys65 in the RING finger domain, Lys160 in the B1 Box, and Lys490 in

132 In contrast, the C381A Ring finger domain mutant functions like WT c-Cbl.

133 effect induced by expression of a MEKK1 PHD/RING finger domain mutant were consistent with a higher

134 The RING finger domain of c-Cbl has been shown recently to e

135 xpression of Cbl-Grb2/SH2 fusions containing RING finger domain of Cbl restores normal ubiquitylation

136 Furthermore, deletion of the COOH-terminal RING finger domain of HdmX completely reversed the resis

137 ues required for the interaction between the RING finger domain of ICP0 and UBE2D1, and we report tha

138 t (i) consistent with previous findings, the RING finger domain of ICP0 is required for the activatio

139 etion of ICP0 or mutations in the N-terminal RING finger domain of ICP0 results in the absence of ICP

140 The RING finger domain of ICP0 was required for degradation

141 m2 is an E3 ubiquitin ligase for p53 and the RING finger domain of mdm2 is critical for ligase activi

142 oteolytic cleavage removes the COOH-terminal RING finger domain of mdm2, resulting in the loss of RNA

143 quitination-dependent degradation by the PHD/RING finger domain of MEKK1, which exhibited E3 ubiquiti

144 Point mutations disrupting the RING finger domain of p28 completely abolish its E3 liga

145 The RING finger domain of PIAS1 was essential for its E3 lig

146 1-PIASy interaction but do not depend on the RING finger domain of PIASy.

147 yeast system, and deletion of the N-terminal RING finger domain of PML abolished the interaction.

148 t interaction between IE1 and the N-terminal RING finger domain of PML may inhibit oligomerization an

149 In vitro, the RING finger domain of RAG1 acts as a ubiquitin ligase th

150 main (CRD) of frizzled and the intracellular RING finger domain of RNF43.

151 Here, we showed that purified RING finger domain of ROC1, an essential subunit of SKP1

152 We find that the RING finger domain of SLI-1 is partially dispensable.

153 conserved cysteine residue to glycine in the RING finger domain of the 1863 amino acid BRCA1 protein.

154 xperimentally-induced mutations in the C3HC4 RING finger domain of the Bmi-1 oncoprotein block its ab

155 ed a novel protein, BAP1, which binds to the RING finger domain of the Breast/Ovarian Cancer Suscepti

156 n an N-terminal zinc finger and a C-terminal RING finger domain of the C3HC4 subclass, but show no ho

157 t a mutation that specifically disrupted the ring finger domain of the HUL-2 site had no effect on th

158 f MTA1, whereas MTA1 binds to the N-terminal ring finger domain of the MAT1.

159 The RING finger domain of topors is homologous to a similar

160 r motif common to IKKalpha, IKKbeta, and the RING finger domain of TRAF2, and either IKKalpha or IKKb

161 h the amino-terminal portion of TANK and the ring finger domain of TRAF2.

162 We found that a structurally intact RING finger domain of TRAF3 is required for inhibition o

163 The RING finger domain of Vmw110 (but not the C-terminal reg

164 Using mutant Vmw110 viruses we show that the RING finger domain of Vmw110 is essential for the induce

165 The RING finger domain of Yvh1, but not its phosphatase doma

166 Tyrosine kinase binding and RING finger domains of Cbl are essential for Cbl-mediate

167 Intact tyrosine kinase-binding and RING finger domains of Cbl were found to be essential fo

168 effect by targeting cysteine residues in the RING finger domains of histone E3 ubiquitin ligase, ther

169 und that arsenite could bind directly to the RING finger domains of RNF20 and RNF40 in vitro and in c

170 ity, but a chimeric protein with the SH2 and RING finger domains of SLI-1 replaced by the equivalent

171 We raised antibody against Ring-finger domain of BRCA1.

172 The RING-finger domains of RIN2 and RIN3 encode ubiquitin li

173 r a Cys point mutation within the N-terminal RING finger domain or a small deletion (of positions 281

174 nd could physically interact with either the RING finger domain or central acidic region of full-leng

175 s reduced by wild type Cbl; mutations of the RING finger domain or its deletion abrogated this effect

176 Mutations in the Cbl family RING finger domain or linker sequence constitute importa

177 The second, designated HUL-2, maps to the RING finger domain present in ICP0 encoded by exon 2.

178 DM2 defective either in Rb interaction or in RING finger domain, promotes cell cycle S phase entry in

179 ized genes are a cell growth regulatory with ring finger domain protein (CGR19, Hs.59106), an RB-asso

180 heckpoint with Forkhead-associated (FHA) and RING finger domain protein (CHFR), an E3 ubiquitin ligas

181 The ubiquitin-like, containing PHD and RING finger domains protein 1 (UHRF1) is essential for m

182 Because many RING-finger domain proteins appear to function as E3 ubi

183 , and activated MDM2 binding to its internal RING finger domain, providing evidence for a conformatio

184 In addition, a PIAS1 mutant without the RING-finger domain required for sumoylation could still

185 We report here that full-length ARD1 or the RING finger domain (residues 1-110) produced polyubiquit

186 Recent studies have shown, however, that the ring-finger domain (RFD) of MDM2, where the ubiquitin E3

187 Since MdmX also possesses a ring finger domain that allows MdmX to associate with Md

188 endent degradation and that mutations in its RING finger domain that disrupt ubiquitin ligase activit

189 The N-terminus of the BRCA1 protein bears a RING finger domain that functions as an E3 ubiquitin lig

190 The central region of Pirh2 harbors a RING finger domain that is critical for its ubiquitin li

191 ins (except for TRAF1) contain an N-terminal RING finger domain that is essential for their functions

192 domain of p53, and (iii) a C-terminal C2H2C4 RING finger domain that is required for E2 enzyme-bindin

193 type c-Cbl RING finger domain but not with a RING finger domain that lacks the amino acids that are d

194 otein interactions via its TRAF domain and a RING finger domain that possesses non-conventional E3 ub

195 n addition, DIAP2 also requires a functional RING finger domain to block cell death and target drICE

196 ignaling by a form of TRAF2, which lacks the ring finger domain (TRAF2DeltaN), increases activities o

197 ith the heterodimeric complex of BRCA1/BARD1 RING-finger domains uncovers a common architecture for a

198 protein kinase activation, and an intact Cbl RING finger domain was required for this functional effe

199 l half of the protein, including the TKB and RING finger domains, was sufficient to mediate negative

200 Because Chfr contains a RING-finger domain, we tested whether Chfr inhibits chro

201 ed around the first zinc-binding site of the RING finger domain were conserved in a Drosophila virili

202 Both proteins contain an N-terminal zinc RING-finger domain which confers E3 ubiquitin ligase act

203 rved cysteine residues or a histidine in the RING finger domain, which are required for zinc binding,

204 terminal half of Nrdp1 possesses an atypical RING finger domain, which is required for enhancing ErbB

205 ICP0 has a RING finger domain with E3 ubiquitin ligase activity tha

206 dogenous Hdm2, Mdm2:X fusions containing the ring finger domain with or without the zinc finger domai

207 echanism that involves an interaction of the RING finger domain with UbcH7.

208 oteins between Mdm2 and MdmX by swapping the ring finger domains with or without the zinc finger doma