ライフサイエンスコーパス: RNA decay

1 m(7)G cap that promotes rather than inhibits RNA decay.

2 inetic model can account for a triphasic HCV RNA decay.

3 localized in specialized bodies involved in RNA decay.

4 ate protein expression via nonsense-mediated RNA decay.

5 ames that are resistant to nonsense-mediated RNA decay.

6 on termination is followed by TRAMP-mediated RNA decay.

7 and the mechanisms and regulation of nuclear RNA decay.

8 ase activities that might be involved in HBV RNA decay.

9 ) were likely to result in nonsense-mediated RNA decay.

10 ch RNase E may exercise overall control over RNA decay.

11 ut it is now known to have a general role in RNA decay.

12 FH1 RNA half-life and had no effect on HJ3-5 RNA decay.

13 ive sequences may have unexpected effects on RNA decay.

14 suppresses the output of P(R2) by eliciting RNA decay.

15 th for circle formation, likely representing RNA decay.

16 iency due to activation of nonsense mediated RNA decay.

17 ant implications for the role of RNase J1 in RNA decay.

18 to be critical for initiation of trp leader RNA decay.

19 messenger RNA by nonsense-mediated messenger RNA decay.

20 oly(A) tail and preventing the initiation of RNA decay.

21 recedes a kinetically distinct commitment to RNA decay.

22 d interacts with the exosome to regulate frq RNA decay.

23 d sRNA-mRNA annealing and the role of Hfq in RNA decay.

24 spite the absence of the major, Pi-dependent RNA decay activity of PNPase.

25 yed an important role in the analysis of HCV RNA decay after the initiation of antiviral therapy.

26 at Rrp47 and Mpp6 stimulate exosome-mediated RNA decay, albeit with unique dependencies on elements w

27 Genome-wide RNA decay analysis revealed that stable mRNAs are enrich

28 fy human immunodeficiency virus (HIV) type 1 RNA decay and dolutegravir (DTG) concentrations in the s

29 e are in turn associated with alterations in RNA decay and global transcript abundance profiles that

30 This method has great potential in RNA decay and metabolic regulation studies via individua

31 ible mechanism for the dynamic regulation of RNA decay and processing by inhibitory RNase binding pro

32 Arc synthesis, whereas translation-dependent RNA decay and proteasomal degradation strictly limit the

33 that contributes to cytoplasmic and nuclear RNA decay and quality control.

34 and mRNA quality control, including exosomal RNA decay and transcript retention triggered by defectiv

35 The rates of RNA decay and transcription determine the steady-state l

36 ul for elucidating the factors that regulate RNA decay and transcriptional elongation in vivo.

37 ases with essential roles in RNA maturation, RNA decay, and gene silencing.

38 Both transcription and RNA decay are critical for normal gene regulation.

39 Our study reveals m(6)A-dependent RNA decay as a previously unidentified maternally driven

40 ted RNase J1 in the initiation of trp leader RNA decay as well as in the subsequent steps leading to

41 of the Aptima assay in the detection of HIV RNA decayed as background uninfected PBMC counts increas

42 Finally, in vitro RNA decay assay demonstrates that CUGBP2 is functionally

43 In contrast, RNA decay assays demonstrated that there was no signific

44 In vivo RNA decay assays suggest that active forms of this prote

45 In RNA decay assays, ARE(bcl-2) transcripts were protected

46 asmic HuR levels inhibits c-fos ARE-mediated RNA decay but has little effect on rapid decay directed

47 Hfq also plays a key role in bacterial RNA decay by binding tightly to polyadenylate [poly(A)]

48 l transcripts to a monophosphate can trigger RNA decay by exposing the transcript to attack by 5'-mon

49 A-like ER kinase or membrane-bound messenger RNA decay by inositol-requiring enzyme 1.

50 f mammalian cells and triggers intracellular RNA decay by the pseudokinase and endoribonuclease RNase

51 tes is mediated in part through catalysis of RNA decay by the, interferon-regulated 2-5A system.

52 urprisingly, Upf1 recruitment and subsequent RNA decay can be antagonized by retroviral RNA elements

53 been challenged by the recent discovery that RNA decay can be triggered by a prior non-nucleolytic ev

54 The human ARD-1 (activator of RNA decay) cDNA sequence can rescue mutations in the Esc

55 RNA decay characteristics of the B. subtilis pnpA mutant

56 tin remodelling, transcription, splicing and RNA decay control, enhancer function, and epigenetic reg

57 al RNase J1 cleavage site resulted in faster RNA decay, depending on its location.

58 Analysis of HIV-1 RNA decay dynamics during the initiation of highly activ

59 nisms, including nonsense-mediated messenger RNA decay, endoplasmic reticulum-associated protein degr

60 rains lacking the RNA helicase, DBP2, or the RNA decay enzyme, XRN1, we find that the GAL lncRNAs spe

61 Rather, RNA decay experiments showed that SRSF2 is required to m

62 ity was not affected by RA, as determined by RNA decay experiments.

63 ynthetic lethal with deletion of the nuclear RNA decay factor, RRP6, pointing to a global role for Db

64 m responsible for the recruitment of several RNA decay factors.

65 UPF1 ATPase mutants accumulate 3' RNA decay fragments harbouring a ribosome stalled during

66 dings show that PPR10 serves as a barrier to RNA decay from either the 5' or 3' direction and that a

67 w, neuronal role for UPF1, distinct from its RNA decay functions, in regulating transport and/or tran

68 d quantify the effect of RNase E scarcity on RNA decay, gene regulation and cell growth.

69 This process of nonsense-mediated RNA decay has been most comprehensively studied in the y

70 oth of which are required for STAU1-mediated RNA decay, however, did not have differentiation effects

71 l prevalence and features of cotranslational RNA decay in a plant transcriptome.

72 Messenger RNA decay in Bacillus subtilis is accomplished by a comb

73 at the specific ENE structure inhibits rapid RNA decay in cis by engaging in a limited set of base-pa

74 ul approach to single-molecule assessment of RNA decay in living cells by exploiting the ability of f

75 RNA molecules (2-5A) that activate regulated RNA decay in mammalian tissues.

76 Measurement of LmGT2 RNA decay in promastigotes and axenic amastigotes treate

77 bout mechanisms of quality control and small RNA decay in RNA interference (RNAi) pathways.

78 nitude of human immunodeficiency virus (HIV) RNA decay in semen.

79 eir presence is predictive of the pattern of RNA decay in vivo during heat shock.

80 both 5'-->3' and 3'-->5' exoribonucleolytic RNA decay in vivo, to study the degradation pathway of p

81 They also suggest a model of "programmed" RNA decay in which endonucleolytically generated RNA fra

82 and nonadditive effects on the rate of viral RNA decay, indicating that miR-122 protects HCV RNA from

83 at lowering RNase Y concentration may affect RNA decay indirectly via an effect on RNase J1, which is

84 technique was developed and used to analyze RNA decay intermediates.

85 Messenger RNA decay is an essential step in gene expression to set

86 The polyadenylation- and exosome-mediated RNA decay is involved in the degradation of plant RNAs i

87 As, we show that the mechanism of trp leader RNA decay is not dependent on TRAP binding.

88 The role of miR16 in ARE-RNA decay is sequence-specific and requires the ARE bind

89 mutant plants indicates that cotranslational RNA decay is XRN4 dependent.

90 all peptide release during nonsense-mediated RNA decay, is critical for assembly of stalled polysomes

91 tigate the degradosome's proposed role as an RNA decay machine, we used DNA microarrays to globally a

92 f mRNA, we investigated whether the 5' to 3' RNA decay machinery participated in the regulation of th

93 Eukaryotic cells have a powerful RNA decay machinery that plays an important and diverse

94 Viral RNAs must successfully evade this host RNA decay machinery to establish a productive infection.

95 via physical interaction and recruitment of RNA decay machinery to the AU-rich elements within the 3

96 ruses to both engage and escape the cellular RNA decay machinery underscores the influence these path

97 exoribonuclease component of the cytoplasmic RNA decay machinery.

98 omplex, a major component of the cytoplasmic RNA decay machinery.

99 Messenger RNA decay measurements are typically performed on a popu

100 Messenger RNA decay mediated by the c-fos major protein coding-reg

101 overexpression of HuD dramatically inhibits RNA decay mediated by the full-length MYCN 3'-untranslat

102 We combined nonsense-mediated RNA decay microarrays and array-based comparative genomi

103 megakaryocytes, and demonstrate that linear RNAs decay more rapidly than circRNAs in platelet prepar

104 Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA

105 While nonsense-mediated RNA decay (NMD) is an established mechanism to rapidly d

106 e have recently shown that nonsense-mediated RNA decay (NMD) is inhibited by cellular stresses genera

107 Nonsense-mediated messenger RNA decay (NMD) is triggered by premature translation te

108 essential component of the nonsense-mediated RNA decay (NMD) pathway, in 13 of 15 pulmonary IMT sampl

109 UPF3B--is critical for the nonsense-mediated RNA decay (NMD) pathway, while its autosomal counterpart

110 the core component of the nonsense-mediated RNA decay (NMD) pathway.

111 One hypothesis holds that nonsense-mediated RNA decay (NMD) protects the organism by preventing the

112 Nonsense-mediated RNA decay (NMD) rapidly degrades both mutated mRNAs and

113 recently demonstrated that nonsense-mediated RNA decay (NMD), a mechanism that rapidly degrades selec

114 istent DNA damage inhibits nonsense-mediated RNA decay (NMD), an RNA surveillance and gene-regulatory

115 se' RNA messages is termed nonsense-mediated RNA decay (NMD).

116 radation of their mRNAs by nonsense-mediated RNA decay (NMD).

117 ls by inhibiting nonsense-mediated messenger RNA decay (NMD).

118 Moreover, although pulse-labeled RNA decays normally in orn mutant cells under nonpermiss

119 We also tested the involvement in trp leader RNA decay of the more recently discovered endonuclease R

120 low FAS expression due to nonsense-mediated RNA decay or protein instability, resulting in defective

121 e SMG6 endonuclease of the nonsense-mediated RNA decay pathway are key regulators that control which

122 L gene functions in the interferon-inducible RNA decay pathway known as the 2-5A system.

123 ase L functions in the interferon-inducible, RNA decay pathway known as the 2-5A system.

124 nse-mediated mRNA decay (NMD) is a conserved RNA decay pathway that degrades aberrant mRNAs and direc

125 RNase-L is the terminal component of an RNA decay pathway that is an important mediator of IFN-i

126 In this work we report on a Dbr1p-dependent RNA decay pathway that limits the accumulation of splice

127 ked oligoadenylates (2-5As) that initiate an RNA decay pathway to impair viral replication.

128 in sorghum by means of the nonsense-mediated RNA decay pathway.

129 Messenger RNA decay plays a central role in the regulation and sur

130 es may represent a model system for studying RNA decay process in plant tissues.

131 , human, chick, and zebrafish Bmp2 synthetic RNAs decay rapidly in extracts from cells not expressing

132 , and it is not clear whether the bulk HIV-1 RNA decay rate actually represents a composite of the de

133 The HIV-1 RNA decay rate was assessed using nonlinear mixed-effect

134 In SP, the HIV-RNA decay rate with RPV was as fast as with EVGcobi; by

135 s we demonstrate nonsense mediated messenger RNA decay, reduced levels of OPA1 protein, and impairmen

136 stricts RVFV replication, and this increased RNA decay results in the loss of visible RNA granules, i

137 cing, pre-rRNA processing, RNA transport and RNA decay, scanning is facilitated by helicase activity.

138 s and in xrn1(-) yeast defective in decapped RNA decay, showing that increased RNA1 stability was not

139 study establishes 3' oligouridylation as an RNA decay signal for Dis3l2, and identifies the first ph

140 ation of the YTHDF2-mRNA complex to cellular RNA decay sites.

141 Staufen 1 (STAU1)-mediated messenger RNA decay (SMD) involves the degradation of translationa

142 together with recent insights into bacterial RNA decay, suggest a unifying model for the biogenesis o

143 We show that a key nonsense-mediated RNA decay switch exon (NSE) in ATM is repressed by U2AF,

144 Using a cell-free RNA decay system, we demonstrate that the mammalian exos

145 etween yeast and mammalian nonsense-mediated RNA decay, these data suggest that the two pathways use

146 erved surfaces, and the structural basis for RNA decay, we report the X-ray structure determination f

147 However, small RNAs and 5'-3' RNA decay were not essential for recovery of the transcr

148 ion levels that involves splicing coupled to RNA decay, which we refer to as spliceosome-mediated dec

149 and Rrp47 each contribute to Mtr4-dependent RNA decay, with maximal Mtr4-dependent decay observed wi