ライフサイエンスコーパス: RNA degradation

1 Pase in rRNA and mRNA 3'-end maturation, and RNA degradation.

2 script, thereby triggering nonsense-mediated RNA degradation.

3 n of type I IFN, PKR-mediated apoptosis, and RNA degradation.

4 hat in plants, RNase MRP is involved in TBSV RNA degradation.

5 5, which would otherwise recruit DIS3L for Y RNA degradation.

6 hosphorylase (PNPase) primarily functions in RNA degradation.

7 mall interfering RNAs (siRNAs), which direct RNA degradation.

8 ults in a 10-fold enhancement of the rate of RNA degradation.

9 oxidative cleavage of DNA and possibly also RNA degradation.

10 nce between nucleotide excision and template RNA degradation.

11 as possible causative agents of the observed RNA degradation.

12 RNA-induced silencing complex to avoid viral RNA degradation.

13 18 and 2009 pandemic strains, induces global RNA degradation.

14 ither by inhibiting translation or promoting RNA degradation.

15 n, decreased protein synthesis and increased RNA degradation.

16 transcript integrity number (TIN) to measure RNA degradation.

17 nce between nucleotide excision and template RNA degradation.

18 triggering either translation repression or RNA degradation.

19 onserved pathway mediating sequence-specific RNA degradation.

20 03 stabilizes rpl16 mRNA by impeding 5'-->3' RNA degradation.

21 functions that mediate its participation in RNA degradation.

22 cessing, and failure to do so leads to rapid RNA degradation.

23 between the coding sequences and very rapid RNA degradation.

24 of unintended off-target RNase H1 dependent RNA degradation.

25 s corrected by cycloheximide, which inhibits RNA degradation.

26 rally controlled transcription and regulated RNA degradation.

27 mine the effects of specific 3'-sequences on RNA degradation.

28 nts and animals that induces double-stranded RNA degradation.

29 epleted strains, consistent with substantial RNA degradation.

30 as simple mechanisms for polyadenylation and RNA degradation.

31 may be limited by an alternative pathway for RNA degradation.

32 corresponding to the dsRNA through targeted RNA degradation.

33 id not result from indiscriminate protein or RNA degradation.

34 actions by activating RNase L, resulting in RNA degradation.

35 ogous genes by a process involving messenger RNA degradation.

36 ith a 10 nt complementary sequence catalyzed RNA degradation.

37 tive, quantitative, and convenient assay for RNA degradation.

38 of chloroplast RNA metabolism in addition to RNA degradation.

39 dy against RhlB inhibited the ATP-stimulated RNA degradation.

40 processive with respect to DNA synthesis and RNA degradation.

41 hibits TNF production by enhancing messenger RNA degradation.

42 unction for putative RNA helicases in direct RNA degradation.

43 re important in RNA processing and messenger RNA degradation.

44 in 3' processing of petD pre-mRNA and/or in RNA degradation.

45 enhanced lytic replication by impeding KSHV RNA degradation.

46 tes each further increase the rate of target RNA degradation.

47 avoiding the high temperatures that promote RNA degradation.

48 se DNA methylation independently of exosomal RNA degradation.

49 ation (A) site suggesting altered 3'-end pre-RNA degradation.

50 that they are not subject to miRNA-mediated RNA degradation.

51 s to slower growth and a massive increase in RNA degradation.

52 ples requires optimal RNA yields and minimal RNA degradation.

53 that 5' decay is the primary pathway for HCV RNA degradation.

54 at consistent high levels prior to regulated RNA degradation.

55 hat RNase PH could play a role in structured RNA degradation.

56 ailing assumptions about how this RBP drives RNA degradation.

57 uclease RNase L and consequently block viral RNA degradation.

58 e and must be regulated to avoid nonspecific RNA degradation.

59 (and the subsequent dNTP pools) derived from RNA degradation.

60 discovery of RNA-activated sequence-specific RNA degradation, a phenomenon now referred to as RNA sil

61 iveness 99.2%), enhances intracellular viral RNA degradation about 5-fold, and moderately inhibits vi

62 of virulence gene expression by controlling RNA degradation according to nutritional stress.

63 e not the consequence of miR-iab4/8-mediated RNA degradation acting on those sensitive mRNA species;

64 It is required, however, for RNA degradation activity of tegument-derived vhs and wil

65 Nrd1 stimulates the RNA degradation activity of the exosome in vitro.

66 unterintuitive outcome following the loss of RNA degradation activity suggests a major importance of

67 tinct from its RNA-activated single-stranded RNA degradation activity.

68 This RNA-degradation activity specifically targeted both the

69 st-transcriptional gene silencing results in RNA degradation after transcription.

70 plication of steric blocking ASOs to promote RNA degradation allows one to explore more nucleotide mo

71 cleavage and requires host Xrn1 to complete RNA degradation, although the mechanism of targeting and

72 n length that are generated as byproducts of RNA degradation and abortive transcription initiation.

73 tin gene was used as an internal control for RNA degradation and DNA contamination and as a reference

74 g a common hydrolytic cleavage mechanism for RNA degradation and DNA editing, respectively.

75 Differences were observed in the RNA degradation and DNA extension patterns generated by

76 ated by sense transgenes (S-PTGS) results in RNA degradation and DNA methylation of the transcribed r

77 Our findings redefine the role of RNase E in RNA degradation and explain how unpaired 5'-terminal nuc

78 e mechanisms that control the specificity of RNA degradation and how RNA degradation processes intera

79 genes in metazoans by accelerating messenger RNA degradation and inhibiting translation, thereby redu

80 nd modification of transcripts, translation, RNA degradation and its regulation, is the central and m

81 We find that most maternal RNA degradation and most new transcription correlate wit

82 eukaryotic transcriptomes through noncoding RNA degradation and mRNA quality control, including exos

83 N gene expression prevents cellular RNA degradation and partially rescues the dramatic trans

84 and mitochondria, concurrent with cytosolic RNA degradation and pleiotropic cellular effects, includ

85 major enzymes with 3' to 5' single-stranded RNA degradation and processing activities, can interact

86 omplex of 3'-5' exoribonucleases involved in RNA degradation and processing events, degrades nonstop

87 RNase III is a key enzyme in the pathways of RNA degradation and processing in bacteria and has been

88 y of endoribonucleases has a central role in RNA degradation and processing.

89 tes and resulting in effective inhibition of RNA degradation and processing.

90 the host endoribonuclease RNase MRP in viral RNA degradation and recombination.

91 5 to 1625 in the 3'UTR of HSA mRNA, promotes RNA degradation and that this effect is neutralized by a

92 thout qualitatively changing the products of RNA degradation and those that gave rise to novel degrad

93 The SARS-CoV nsp1 protein increases cellular RNA degradation and thus might facilitate SARS-CoV repli

94 NA cleavage is sufficient to trigger nuclear RNA degradation and transcription termination or whether

95 ase pairing is tolerated as a match for both RNA degradation and translation repression.

96 nscriptional regulation by means of targeted RNA degradation and translational arrest.

97 terized the distinctive patterns of maternal RNA degradation and zygotic gene activation, including t

98 lease which plays an essential role in yeast RNA degradation and/or processing in the nucleus.

99 RXR-alpha mRNA (used as a control to assess RNA degradation) and who had adequate follow-up could be

100 A combination of translational repression, RNA degradation, and activation by germ plasm has also b

101 mide (MTT) assay for mitochondrial activity, RNA degradation, and DNA degradation as determined by ag

102 s have been implicated in small RNA-mediated RNA degradation, and in degradation-independent translat

103 RAMP functions as an exosome cofactor during RNA degradation, and it has been speculated that this ro

104 ase 3, and cytochrome C, Annexin V staining, RNA degradation, and oligonucleosomal DNA cleavage).

105 es, including protein synthesis, protein and RNA degradation, and organelle remodeling.

106 A poly(U) extension did not promote rapid RNA degradation, and RNA turnover was slowed by the addi

107 with the exosome during cytoplasmic 3'-to-5' RNA degradation, and that CER7-dependent regulation of w

108 N-gamma include those involved in apoptosis, RNA degradation, and the inflammatory response.

109 ration is associated with a wave of maternal RNA degradation, and the resulting relative changes to t

110 d accumulated ribonucleotides, indicative of RNA degradation, and these processes were increased in B

111 Specific systems of nuclear RNA degradation appear to target and degrade aberrant pr

112 described in models in which termination and RNA degradation are coupled to the phosphorylation state

113 by one of the seasonal strains, and massive RNA degradation as early as 4 h postinfection by the sea

114 uv3p effects group I intron splicing through RNA degradation as part of the degradosome, or has a dir

115 Many do not show characteristics of general RNA degradation, as seen for the accumulation of small f

116 In vitro RNA degradation assays confirmed its exoribonuclease pro

117 cipitation followed by Northern blotting and RNA degradation assays, we confirm that mature miR-221 i

118 N is a reliable and sensitive measure of the RNA degradation at both transcript and sample level.

119 er and endogenous Xwnt-8 RNAs, directs rapid RNA degradation beginning precisely at the early gastrul

120 -nucleotide polymorphisms, repeat sequences, RNA degradation biases and probes targeting genomic regi

121 d on oligo(dT) priming could be sensitive to RNA degradation; broken mRNA strands should give rise to

122 of viral RNA is important not only for viral RNA degradation but for RNA recombination as well, due t

123 ild-type cells were not due to sRNA-targeted RNA degradation but to direct DCL3 cleavage of miRNA and

124 It is interesting that while DNA and RNA degradation by activated Fe.BLM has been studied ext

125 ions to the 3' ends of RNA substrates affect RNA degradation by both of these enzymes.

126 ow that TRAMP does not significantly enhance RNA degradation by purified exosomes lacking Rrp6 in vit

127 However, since RNA degradation by RNase H appears to generate RNA fragm

128 Although extensive RNA degradation by RNase H likely eliminates many potent

129 hat SmpB binding controls the timing of SsrA RNA degradation by RNase R.

130 However, polyphosphate was found to inhibit RNA degradation by the degradosome in vitro.

131 omponent of TRAMP4, which stimulates nuclear RNA degradation by the exosome.

132 reports showed that purified TRAMP enhanced RNA degradation by the nuclear exosome in vitro.

133 (NNS) pathway in a process that is linked to RNA degradation by the nuclear exosome.

134 icating that fluorescence dequenching due to RNA degradation can be measured in vivo as well as in vi

135 hese results demonstrate that siRNA-directed RNA degradation can take place in the nucleus, suggestin

136 hsB and 333d41 failed to induce the cellular RNA degradation characteristic of HSV.

137 the RNase H domain that reduced the rate of RNA degradation conferred high-level resistance to 3'-az

138 (ob/ob or db/db) mice caused massive adipose RNA degradation confirmed by histological analysis to re

139 re wondered whether the capacity to activate RNA degradation could account for its requirement for gr

140 involved in RNA degradation, suggesting that RNA degradation could play a role in viral RNA recombina

141 Our splicing and RNA degradation data demonstrate the advantages of using

142 expression suggests novel signaling linking RNA degradation/decapping and regulation of translation.

143 tate between the rates of polymerization and RNA degradation determines the frequency of reverse tran

144 RNA degradation distorts the RNA-seq read coverage in a

145 termediaries in triggering sequence-specific RNA degradation during posttranscriptional gene silencin

146 e cytosolic ribonucleoprotein, implying that RNA degradation during reverse transcription may activat

147 suggests that Zld may also regulate maternal RNA degradation during the maternal-to-zygotic transitio

148 aluable approach used to neutralize in vitro RNA degradation effect and improve differential gene exp

149 with TIN scores could effectively neutralize RNA degradation effects by reducing false positives and

150 the viral endonuclease SOX and the cellular RNA degradation enzyme Xrn1 during lytic Kaposi's sarcom

151 tion, confirming inhibitory activity of this RNA-degradation enzyme.

152 he absence of an active P19 results in viral RNA degradation followed by recovery from infection.

153 exonucleolytic decay is the major pathway of RNA degradation following deadenylation in HeLa cytoplas

154 We have repeatedly observed extensive RNA degradation following trypsinization, a routine proc

155 ating that cytoplasmic 5'-to-3' and 3'-to-5' RNA degradation generally counteract S-PTGS, likely by r

156 Among these processes, mRNA decay and stable RNA degradation generally have been considered distinct,

157 phosphorylase (PNP) plays a central role in RNA degradation, generating a pool of ribonucleoside dip

158 nt years, our knowledge of the mechanisms of RNA degradation has increased considerably with discover

159 s defective for transcription repression and RNA degradation, hybrid formation requires Rad51p and Ra

160 that use water as a nucleophile to catalyze RNA degradation (hydrolytic RNases) and RNases that use

161 5'-End-dependent RNA degradation impacts virulence, stress responses, and

162 alpha1(I) collagen messenger RNA by blocking RNA degradation in activated HSCs.

163 Such an activity is important for messenger RNA degradation in bacteria, but this is, to our knowled

164 Poly(A) tails stimulate RNA degradation in bacteria, suggesting that this is the

165 RNA degradation in cells triggers PRC2 recruitment to Cp

166 One of the main mechanisms of messenger RNA degradation in eukaryotes occurs by deadenylation-de

167 A major pathway of messenger RNA degradation in eukaryotic cells is initiated by shor

168 is an RNA pyrophosphohydrolase that triggers RNA degradation in H. pylori, whereas the other, HP0507,

169 P19/43 still suppresses RNAi-mediated viral RNA degradation in infected Nicotiana benthamiana, while

170 t the difference is not merely due to random RNA degradation in low pH samples; rather it reflects a

171 ons but that more Vhs is required to mediate RNA degradation in neurons than in other susceptible cel

172 ristetraprolin (TTP) as a major regulator of RNA degradation in one noncanonical strategy.

173 l as accelerated kinetics of endogenous IL-2 RNA degradation in TCR gamma delta cells.

174 We have re-examined the initial events of RNA degradation in that organism by devising an assay to

175 ast, a parallel pathway for 5'-end-dependent RNA degradation in that species appears to involve an al

176 Delta20, Delta20R, and KOS caused comparable RNA degradation in the absence of actinomycin D.

177 NA cleavage events, and 5'-3' exonucleolytic RNA degradation in the mammalian Pol II termination proc

178 in the cytoplasm of human cells and induces RNA degradation in vitro, as does its purified bacterial

179 ot the action, of an exonuclease involved in RNA degradation in vitro.

180 The influence of HpRppH on RNA degradation in vivo was examined by using RNA-seq to

181 eotide microarrays were used to study global RNA degradation in wild-type Escherichia coli MG1655.

182 e rate of DNA polymerization and the rate of RNA degradation influence the frequency of RT template s

183 hese fragments could be classified as stable RNA degradation intermediates (RNA degradants).

184 th this, sequencing of the 5' and 3' ends of RNA degradation intermediates in infected cells confirme

185 hput approaches for profiling the 5' ends of RNA degradation intermediates on a genome-wide scale are

186 ce, we found a predominance of 5' termini of RNA degradation intermediates that were separated by a l

187 ependent RNase (RNase L) to effect selective RNA degradation is a new approach to the control of gene

188 sphate conversion to induce 5' end-dependent RNA degradation is a two-step process in E. coli involvi

189 Messenger RNA degradation is an essential step in gene expression

190 Here we show that the RNA degradation is associated with changes in premRNA pr

191 RNA degradation is crucial for regulating gene expressio

192 y enolase, a glycolytic enzyme whose role in RNA degradation is currently not understood.

193 Maternal RNA degradation is induced by the binding of proteins an

194 RNA immunoprecipitation studies confirm that RNA degradation is inhibited with short imatinib treatme

195 Increased RNA degradation is likely responsible for the repression

196 epletion of mRNA-binding domains involved in RNA degradation is observed.

197 at impairment of either 5'-to-3' or 3'-to-5' RNA degradation is sufficient to provoke the entry of tr

198 RNA degradation is tightly regulated to selectively targ

199 Because RNA degradation is ubiquitous in all cells, it is clear

200 In general, RNA degradation is via exoribonucleases that degrade RNA

201 In plants the role of RNA silencing in viral RNA degradation is well established, but its potential f

202 Whereas a role for Suv3p in RNA degradation is well established, the function of Suv

203 The RNA degradation kinetics of KOSV2 was identical to that

204 te replication and that virus-mediated small RNA degradation likely contributed to 2'OMe evolution.

205 upregulation of mRNA level, miRNAs-mediated RNA degradation, LIN-66-mediated translational inhibitio

206 is hypothesized to control processes such as RNA degradation, localization, and splicing.

207 RNP complexes from cell lysates suffers from RNA degradation, loss of interacting macromolecules and

208 olynucleotide phosphorylase (PNPase) form an RNA degradation machine that is scaffolded by Y RNA.

209 ndria, DNA replication, gene expression, and RNA degradation machineries coexist within a common nond

210 RNPs and stimulates their destruction by the RNA degradation machinery are still not completely eluci

211 ay be fundamental biochemical differences in RNA degradation machinery between E. coli and other bact

212 rated view of how different cofactors of the RNA degradation machinery cooperate to target and elimin

213 n recently studied and characterized; yet no RNA degradation machinery has been identified in the mam

214 We have ablated the cellular RNA degradation machinery in differentiated B cells and

215 7/Dip, which directly binds and inhibits the RNA degradation machinery of its bacterial host.

216 teins to the ARE and the modification of the RNA degradation machinery of the cell induced by the pre

217 ther flaviviruses commandeer the host cell's RNA degradation machinery to generate the small flavivir

218 P), which helps to recruit components of the RNA degradation machinery to the histone mRNA 3' end.

219 the highly conserved major cellular 3' to 5' RNA degradation machinery, as a physical interactor of C

220 posons that are also targeted by the exosome RNA degradation machinery.

221 ferent cofactors associated with the nuclear RNA degradation machinery.

222 bias, local sequence bias, positional bias, RNA degradation, mapping bias or other unknown reasons,

223 y double-stranded RNA is a sequence-specific RNA degradation mechanism highly conserved in eukaryotes

224 A interference (RNAi) is a sequence-specific RNA degradation mechanism that has been shown to play a

225 RNA silencing is a sequence-specific RNA degradation mechanism that is operational in plants

226 gene silencing (PTGS) is a sequence-specific RNA degradation mechanism that is widespread in eukaryot

227 ins by harboring a polyadenylation-dependent RNA degradation mechanism, but whether SUV3 participates

228 igger silencing through a homology-dependent RNA degradation mechanism.

229 RNA and enhances sequence-specific messenger RNA degradation mediated by the RNA-initiated silencing

230 ation and quantification then post autoclave RNA degradation methodology should be employed, which ma

231 omain, and could therefore contribute to the RNA degradation observed in RNAi.

232 sh samples in a previous study suggests that RNA degradation occurred despite storage of the specimen

233 is can serve as viral defense mechanisms and RNA degradation occurs during both processes, we investi

234 , we have examined the siRNA-mediated target RNA degradation of uPAR and MMP-9 in human glioma cell l

235 In Escherichia coli, RNA degradation often begins with conversion of the 5'-t

236 Bacterial RNA degradation often begins with conversion of the 5'-t

237 Bacterial RNA degradation often begins with conversion of the 5'-t

238 sed rat duodenum to determine the effects of RNA degradation on the analysis of gene expression.

239 xpression of off-target cellular proteins by RNA degradation or translation repression.

240 genes by translational repression, messenger RNA degradation, or both.

241 ing samples because of lack of viable tumor, RNA degradation, or insufficient clinical information, 2

242 y the recently described cytosolic messenger RNA degradation pathway for messages lacking termination

243 g the existence and maintenance of a nuclear RNA degradation pathway in metazoans.

244 The polyadenylation-stimulated RNA degradation pathway takes place in plant and algal o

245 ay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating th

246 The 2',5'-oligoadenylate (2-5A) system is an RNA degradation pathway which plays an important role in

247 The 2-5A system is an interferon-regulated RNA degradation pathway with antiviral, growth-inhibitor

248 ediated mRNA decay (NMD), a highly conserved RNA degradation pathway.

249 nonsense-mediated decay (NMD), a cytoplasmic RNA degradation pathway.

250 Here we describe the RNA degradation pathways against which miR-122 provides

251 ence homology with RNA helicases involved in RNA degradation pathways in other organisms.

252 Saccharomyces cerevisiae cells deficient for RNA degradation pathways revealed that about half of the

253 eps in normal RNA biogenesis or function and RNA degradation pathways.

254 A-directed methylation pathway distinct from RNA degradation pathways.

255 nce between nucleotide excision and template RNA degradation plays an important role in nucleoside re

256 Regulation of RNA degradation plays an important role in the control o

257 imeric gene(s) may also be affected by rapid RNA degradation, presumably due to defects in mRNA proce

258 The assay requires less than 10 min so that RNA degradation problems are avoided.

259 nuclear transcriptome, including a ribosomal RNA degradation procedure that minimizes pre-ribosomal R

260 TGS) or by activation of a sequence-specific RNA degradation process (post-transcriptional gene silen

261 etic series supported a post-transcriptional RNA degradation process as the underlying mechanism for

262 gene silencing (PTGS) is a sequence-specific RNA degradation process conserved in fungi, plants and a

263 Further, TNF-alpha initiated a generalized RNA degradation process in which the participation of PK

264 gene silencing (VIGS) is a sequence-specific RNA degradation process that can be used to downregulate

265 S), or RNA silencing, is a sequence-specific RNA degradation process that targets foreign RNA, includ

266 l the specificity of RNA degradation and how RNA degradation processes interact with translation, RNA

267 After E2 RNA degradation, production of 18S rRNA and 36S pre-rRNA

268 on as well, due to the participation of some RNA degradation products in the RNA recombination proces

269 ves the TBSV RNA in vitro, resulting in TBSV RNA degradation products similar in size to those observ

270 nce mechanism based on random association of RNA degradation products with Argonaute triggers siRNA a

271 d resulted in the accumulation of structured RNA degradation products.

272 ge or strand release, determines the overall RNA degradation rate and that the unwinding step size is

273 Titration of poly(A) into RNA degradation reactions has no effect on turnover of p

274 cillator based on in vitro transcription and RNA degradation reactions to drive a variety of "load" p

275 Ubiquitin and RNA degradation-related pathway genes were selectively d

276 eak in vitro activity, indicating that rapid RNA degradation requires activating cofactors.

277 n transcriptional repression, RNA export and RNA degradation show increased hybrid formation and asso

278 xon splicing sites, and SH RNAs, location of RNA degradation signals, identification of alternative s

279 metabolism, protein synthesis and turnover, RNA degradation, snRNA modification, and snoRNP biogenes

280 five suppressor genes are likely involved in RNA degradation, suggesting that RNA degradation could p

281 provides reproducible staining with minimal RNA degradation suitable for tissues with moderate to hi

282 cripts activate the host's sequence-specific RNA degradation system.

283 ased, sequence-specific, posttranscriptional RNA-degradation system that was programmed by the transg

284 accumulate, implying the existence of active RNA degradation systems.

285 In yeast mitochondria, RNA degradation takes place through the coordinated acti

286 increase AZT resistance by reducing template RNA degradation, thereby providing additional time for R

287 A and rRNA 3'-ends, but also participates in RNA degradation through exonucleolytic digestion and pol

288 RNA degradation, together with RNA synthesis, controls t

289 s through a variety of mechanisms, including RNA degradation, translation inhibition, and transcripti

290 pression through sequence-specific messenger RNA degradation, translational repression, or transcript

291 RNA degradation via the ribonuclease H (RNase H) activit

292 The rate of RNA degradation was constant throughout the transcriptio

293 p to 50 mosquitoes without PCR inhibition or RNA degradation was developed.

294 ibonucleases by trypsin reagent proteases to RNA degradation was examined.

295 sures largely fails to remove the effects of RNA degradation when RNA quality associates with the out

296 nce between nucleotide excision and template RNA degradation, which in turn increased AZT resistance.

297 ipts for detection, can tolerate significant RNA degradation, while still yielding high quality expre

298 d complex macromolecular assembly that links RNA degradation with central carbon metabolism.

299 RNA degradation would also explain why only 11 (52%) of

300 isingly, even samples exhibiting significant RNA degradation yielded robust gene expression results,