ライフサイエンスコーパス: RNA editing

1 l properties, but also by their influence on RNA editing.

2 endent manner by a programmed process called RNA editing.

3 s) RNA structures, a process known as A-to-I RNA editing.

4 cytidine deaminase domains are required for RNA editing.

5 sociated with proteins that specify sites of RNA editing.

6 suggest a role for the N-terminal domain in RNA editing.

7 n specificity factors of cytidine to uridine RNA editing.

8 etic variants associated with variability in RNA editing.

9 protein (GP) is dependent on transcriptional RNA editing.

10 ized as guanosine, a process known as A-to-I RNA editing.

11 utions, extensive gene loss and reduction in RNA editing.

12 on RNA (ADAR)-dependent adenosine-to-inosine RNA editing.

13 ant organelle genomes are modified by C-to-U RNA editing.

14 a deamination reaction in the process termed RNA editing.

15 QTLs (edQTLs) associated with differences in RNA editing.

16 ment of Apobec1-mediated cytosine to uridine RNA editing.

17 viruses and retrotransposons, mediates this RNA editing.

18 understanding of the cis-regulatory code of RNA editing.

19 can affect cis-regulatory elements to alter RNA editing.

20 R--a rigorously annotated database of A-to-I RNA editing.

21 imilar regulation has not been described for RNA editing.

22 that drive the selectivity and frequency of RNA editing.

23 riants generated by alternative splicing and RNA editing.

24 of the ORRM family may likewise function in RNA editing.

25 ant organelle genomes are modified by C-to-U RNA editing.

26 dge gaps about the variation and function of RNA editing.

27 within the RNA duplex structure required for RNA editing.

28 y shown to have sexual stage-specific A-to-I RNA editing.

29 p codon mutation by APOBEC3A-mediated C-to-U RNA editing.

30 he functions and regulation of ADAR-mediated RNA editing.

31 ains of ADAR3 are required for repression of RNA editing.

32 in particular is the frequent occurrence of RNA editing [1].

33 RNA editing, a post-transcriptional process, allows the

34 RNA editing, a widespread post-transcriptional mechanism

35 Lastly, systemic differences in RNA editing activity generates interindividual variation

36 Our study demonstrates the cellular RNA editing activity of a member of the APOBEC3 family o

37 In addition to RNA editing, additional functions have been proposed for

38 detailed insights for further elucidation of RNA editing affecting miRNAs, especially in cancer.In th

39 ovel bioinformatic platform, the Trypanosome RNA Editing Alignment Tool (TREAT), to elucidate the rol

40 utlines positions likely to be implicated in RNA editing, allele-specific expression or loss, somatic

41 Site-directed RNA editing allows for the manipulation of RNA and prote

42 haliana leaves resulted in defects in C-to-U RNA editing, altered accumulation of chloroplast transcr

43 ur study reveals widespread cis variation in RNA editing among genetically distinct individuals and s

44 ochondrial mRNAs undergo internal changes by RNA editing and 3' end modifications.

45 We applied mmPCR-seq to RNA editing and allele-specific expression studies.

46 hyl-4-isoxazole-propionate (AMPA) receptors, RNA editing and alternative splicing generate sequence v

47 h by catalyzing adenosine (A) to inosine (I) RNA editing and binding to regulatory elements in target

48 ase for a mechanistic linkage between A-to-I RNA editing and brain pathologies should be revisited.

49 s have investigated the relationship between RNA editing and disease at a genome-wide level.

50 ion could be repressed by ADARs beyond their RNA editing and double-stranded RNA (dsRNA) binding func

51 ADAR1 and ADAR2 through their non-canonical RNA editing and dsRNA binding-independent functions, alb

52 -out, deletions, chromosomal rearrangements, RNA editing and genome-wide screenings.

53 ociated with loss of ADAR1 are the result of RNA editing and MDA5-dependent functions.

54 and Deadend-1, which are involved in C-to-U RNA editing and microRNA-dependent mRNA silencing, respe

55 ermore, key enzymes for histone methylation, RNA editing and miRNA processing also showed methylation

56 ses, which convert cytosine to uracil during RNA editing and retrovirus or retrotransposon restrictio

57 includes assessment of RNA variant-calling, RNA editing and RNA fusion detection techniques.

58 Here, we outline how RNA editing and RNA modification can rapidly affect gene

59 Here, we focus on RNA editing and show that Apolipoprotein B mRNA-editing

60 xpression of surface GP without the need for RNA editing, and also preventing synthesis of sGP.

61 man transcripts undergo adenosine to inosine RNA editing, and editing is required for normal developm

62 ble-stranded RNAs, such as RNA interference, RNA editing, and RNA localization mediated by protein-RN

63 d with miRNA sequence variation (isomiR) and RNA editing, and the origin of those unmapped reads afte

64 hances the frequency of adenosine-to-inosine RNA editing; and (4) dramatically increases the amount o

65 d as essential components of the chloroplast RNA editing apparatus.

66 entifies posttranscriptional modification by RNA editing as a critical regulatory mechanism of vital

67 Taken together, we identified RNA editing as a novel mechanism to regulate homomeric K

68 data underscore the promise of site-directed RNA editing as a therapeutic or experimental tool.

69 These results highlight RNA editing as an exciting theme for investigating cance

70 for binding to GRIA2 transcript, inhibiting RNA editing, as evidenced by the direct binding of ADAR3

71 QTL (edQTL) analysis with an allele-specific RNA editing (ASED) analysis.

72 strocyte and astrocytoma cell lines inhibits RNA editing at the Q/R site of GRIA2 Furthermore, the do

73 affect cell growth, editosome integrity, and RNA editing between BF and PF stages.

74 differences in gene expression, splicing and RNA editing between embryonic and adult cerebral cortex.

75 Each mutation decreased RNA editing both in vitro and using an in vivo mouse mod

76 f adenosine to inosine is a frequent type of RNA editing, but important details about the biology of

77 To determine the specific role of RNA editing by ADAR1, we generated mice with an editing-

78 RNA editing by adenosine deamination alters genetic info

79 he extent, regulation and enzymatic basis of RNA editing by cytidine deamination are incompletely und

80 RNA editing by deamination of specific adenosine bases t

81 Here we show that RNA editing by Drosophila ADAR modulates the expression

82 ng of precursor RNAs via trans-splicing, and RNA editing by substitution and uridine additions both r

83 We recently discovered RNA editing by the single-domain enzyme APOBEC3A in inna

84 We examined the role of A-to-I RNA editing by two ADARs, ADAR1 and ADAR2, in the sensin

85 capable of robust knockdown and demonstrated RNA editing by using catalytically inactive Cas13 (dCas1

86 These transformants demonstrate that plastid RNA editing can be bypassed through the expression of nu

87 e in silico models we employ further suggest RNA editing can moonlight as a splicing-modulator, albei

88 Adenosine-to-inosine (A-to-I) RNA editing, catalysed by ADAR enzymes conserved in meta

89 Adenosine to inosine RNA editing catalyzed by ADAR enzymes is common in human

90 Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by Adenosine DeAminases acting on

91 matic analysis revealed a complex picture of RNA editing change during transformation.

92 The recoding of genetic information through RNA editing contributes to proteomic diversity, but the

93 tion of uridylates that are catalyzed by the RNA editing core complex (RECC) and directed by hundreds

94 Enzymes embedded into the RNA editing core complex (RECC) catalyze the U-insertion

95 cell viability and provide the evidence that RNA editing could selectively affect drug sensitivity.

96 The RNA editing described here is required for proper proces

97 hows the extent to which gene expression and RNA editing differ between flies from different microcli

98 patiotemporal patterns and new regulators of RNA editing, discovered through an extensive profiling o

99 include activity-induced RNA modifications, RNA editing, dynamic changes in the secondary structure

100 (adenosine deaminase, RNA-specific)-mediated RNA editing dynamically contributes to genetic alteratio

101 ive and time-saving technique to examine the RNA editing efficiency at 37 Arabidopsis thaliana chloro

102 We then confirmed that RNA editing efficiency was markedly greater in the dark

103 cture beyond the editing site duplex affects RNA editing efficiency.

104 By linking the catalytic domain of the RNA editing enzyme ADAR to an antisense guide RNA, speci

105 ell, Zipeto et al. (2016) show targeting the RNA editing enzyme ADAR1 restores expression of let-7 an

106 e K562 in response to shRNA knockdown of the RNA editing enzyme ADAR1.

107 In the case of the RNA editing enzyme ADARB1, which contains an Alu exon pe

108 BP to the catalytic domain of the Drosophila RNA-editing enzyme ADAR and expresses the fusion protein

109 The double-stranded RNA-binding protein and RNA-editing enzyme ADAR was found to bind to oriPtLs, li

110 The human RNA-editing enzyme adenosine deaminase acting on RNA (AD

111 We utilize the binding activity of an RNA-editing enzyme to visualize the in vivo production o

112 Mutations in ADAR, which encodes the ADAR1 RNA-editing enzyme, cause Aicardi-Goutieres syndrome (AG

113 RNA editing enzymes catalyze A>I or C>U transcript alter

114 etazoans, from cnidarians to humans, express RNA editing enzymes.

115 RBP targets are marked with novel RNA editing events and identified by sequencing RNA.

116 We identify 1054 RNA editing events associated with cis genetic polymorph

117 RNA editing events can result in missense codon changes

118 putational statistical framework to identify RNA editing events from RNA-Seq data with high specifici

119 ell transcriptomes, cancer-specific recoding RNA editing events have yet to be discovered.

120 eaminase domains and are required for single RNA editing events in chloroplasts.

121 pipeline for calling SNVs including SNPs and RNA editing events in RNA-seq reads, with our rigorous r

122 Deciphering the functional consequences of RNA editing events is challenging, but emerging genome e

123 effects of several cross-tumor nonsynonymous RNA editing events on cell viability and provide the evi

124 Finally, RNA editing events were less common in islets than previ

125 otide polymorphisms (SNPs) in the genome, or RNA editing events within the RNA.

126 In Arabidopsis, 34 C-to-U RNA editing events, affecting transcripts of 18 plastid

127 Its conservation across land plants and RNA editing events, which restore conserved amino acids,

128 ors and matched adjacent tissues to identify RNA editing events.

129 mputationally, form in vivo and can regulate RNA-editing events.

130 tion and proteins of the multiple organellar RNA editing factor (MORF) family as cofactors.

131 ting interacting protein/multiple organellar RNA editing factor (RIP/MORF) boxes, which are required

132 copeptide motifs in the Arabidopsis thaliana RNA editing factor CLB19 to investigate their individual

133 Members of the RNA-editing factor interacting protein (RIP) family and

134 Members of the Arabidopsis RNA-editing factor interacting protein (RIP) family and

135 identification of several different types of RNA editing factors in plant organelles suggests complex

136 RNA editing factors of the pentatricopeptide repeat (PPR

137 of RRM-containing proteins as mitochondrial RNA editing factors.

138 ggesting stronger cis-directed regulation of RNA editing for most sites, although the small set of co

139 This system, referred to as RNA Editing for Programmable A to I Replacement (REPAIR)

140 Our findings demonstrate the novel RNA editing function of APOBEC3G and suggest a role for

141 Here we demonstrate that deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dys

142 on levels alone, as alternative splicing and RNA editing generate a diverse set of mature transcripts

143 gst single cells, supporting the notion that RNA editing generates diversity within cellular populati

144 Uridine insertion and deletion RNA editing generates functional mitochondrial mRNAs in

145 Uridine insertion and deletion RNA editing generates functional mitochondrial mRNAs in

146 RNA editing generates post-transcriptional sequence chan

147 Extensive messenger RNA editing generates transcript and protein diversity i

148 A-to-I RNA editing has also been hypothesized to be a driving f

149 al mammalian development, and disturbance in RNA editing has been implicated in various pathologic di

150 RNA editing has emerged as a widespread mechanism for ge

151 C3G is known to bind RNAs, APOBEC3G-mediated RNA editing has not been observed.

152 Since adenosine-to-inosine RNA editing has recently emerged as a driver of cancer p

153 Previously, we identified an RNA editing helicase 2-associated subcomplex (REH2C) and

154 ents, respectively, of the approximately 40S RNA editing holoenzyme, the editosome.

155 Focusing on the RNA editing hotspot in miR-200b, a key tumor metastasis

156 identified 19 adenosine-to-inosine (A-to-I) RNA editing hotspots.

157 red through an extensive profiling of A-to-I RNA editing in 8,551 human samples (representing 53 body

158 roximately 20S editosomes, and inhibition of RNA editing in BF cells.

159 ic sequencing uncovered 1000 sites of C-to-U RNA editing in both species, plus a small number (< 60)

160 indings reveal global and dynamic aspects of RNA editing in brain, providing new insight into epitran

161 Altered RNA editing in cancer cells may provide a selective adva

162 Epitranscriptomic changes by RNA editing in cancer represent a novel mechanism contri

163 recent work that shows aberrant patterns of RNA editing in cancer.

164 iversity, but the extent and significance of RNA editing in disease is poorly understood.

165 sine deaminase acting on RNA (ADAR)-mediated RNA editing in Drosophila.

166 The degree of differential RNA editing in epileptic mice correlated with frequency

167 Here we surveyed the global landscape of RNA editing in human brain tissues and identified three

168 uable insights into the functional impact of RNA editing in human cells.

169 lation-level, high-resolution view of A-to-I RNA editing in human cerebella and suggest that A-to-I e

170 xic transcripts as well as APOBEC3A-mediated RNA editing in human monocytes.

171 seful resource for the functional effects of RNA editing in long noncoding RNAs (lncRNAs), we systema

172 hundreds of genes undergo site-specific C>U RNA editing in macrophages during M1 polarization and in

173 factors and expands the understanding of C>U RNA editing in mammals.

174 Like bone marrow-derived macrophages, RNA editing in MG leads to overall changes in the abunda

175 ot reduce hypoxia-induced gene expression or RNA editing in monocytes.

176 Nevertheless, RNA editing in non-coding RNA, such as microRNA (miRNA),

177 domain were changed to UG(1831)GUG(1834)G by RNA editing in perithecia.

178 ons of MORF and MEF proteins are involved in RNA editing in plant mitochondria.

179 RNA editing in plants, animals, and humans modifies geno

180 RNA editing in plastids and mitochondria of flowering pl

181 sequences, we discovered cytidine-to-uridine RNA editing in position 32 of two nucleus-encoded serine

182 Our data reveal a global role for RNA editing in regulating gene expression.

183 ion or RNA processing, as well as changes in RNA editing in response to cellular perturbations or sti

184 Cross-species analysis of RNA editing in several tissues revealed that species, ra

185 ecent reports suggesting increased levels of RNA editing in squids thus raise the question of the nat

186 We studied A-to-I RNA editing in stab wound injury (SWI) and SCI models an

187 er, our results suggest a potential role for RNA editing in the epileptic hippocampus in the occurren

188 ulation of gene expression is the process of RNA editing in the mitochondria of trypanosomes.

189 In this study, we investigate the role of RNA editing in the pathogenicity of EBOV using a guinea

190 Adenosine-to-inosine RNA editing in transcripts encoding the voltage-gated po

191 in the context of the extensive U-insertion RNA editing in trypanosome mitochondria, which may have

192 embedded in RNA stems are targeted by ADARs, RNA editing inF.

193 stid editing factor, ORRM6, does not contain RNA editing interacting protein/multiple organellar RNA

194 RNA editing introduces single nucleotide changes to RNA,

195 In these parasites, RNA editing involves extensive uridylate insertions and

196 RNA editing is a cellular process that precisely alters

197 Adenosine to Inosine (A-to-I) RNA editing is a co- or post-transcriptional mechanism t

198 Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional mechanis

199 RNA editing is a finely tuned, dynamic mechanism for pos

200 RNA editing is a mutational mechanism that specifically

201 RNA editing is a process that alters DNA-encoded sequenc

202 Adenosine-to-inosine (A-to-I) RNA editing is a widespread post-transcriptional mechani

203 RNA editing is a widespread post-transcriptional mechani

204 RNA editing is abundant and frequently elevated in cance

205 A-to-I RNA editing is abundant in the brain, and altered editin

206 RNA editing is an essential post-transcriptional process

207 Uridine insertion/deletion RNA editing is an essential process in kinetoplastid par

208 A-to-I RNA editing is an important step in RNA processing in wh

209 RNA editing is converting hundreds of cytosines into uri

210 Our data support a model in which RNA editing is executed via multiple paths that necessit

211 d to the general assumption that recoding by RNA editing is extremely rare.

212 the fine-tuning mechanism provided by A-to-I RNA editing is important, the underlying rules governing

213 RNA editing is increasingly recognized as a molecular me

214 Recoding RNA editing is more widespread in Drosophila than in ver

215 RNA editing is one of the post-transcriptional processes

216 We here show that RNA editing is particularly common in behaviorally sophi

217 rt reads confounded by sequencing errors and RNA editing is still a tricky problem.

218 efficiency, so the role of the DYW motif in RNA editing is unclear.

219 With very accurate measurement of RNA editing levels at 789 sites in 131 Drosophila melano

220 studies reveal increased or decreased global RNA editing levels depending on the tumor type.

221 diting, or by transcriptome scale changes in RNA editing levels that may affect innate immune signali

222 RNA editing ligase 1 (REL1) is essential for the re-liga

223 any of which are diversified by splicing and RNA editing, localize to >20 excitatory and inhibitory n

224 Although RNA editing markedly increases complexity of the cancer

225 rs that contribute to virus fitness and that RNA editing may be an important mechanism employed by EB

226 RNA editing may promote cancer by dynamically recoding o

227 tudy, we investigated the interaction of the RNA editing mechanism with the RNA interference (RNAi) m

228 nd its expression is tightly regulated by an RNA-editing mechanism during virus replication.

229 pts normal cell physiology, and EBOV uses an RNA-editing mechanism to regulate expression of the GP g

230 Post-transcriptional adenosine-to-inosine RNA editing mediated by adenosine deaminase acting on RN

231 , isoform diversity also may be generated by RNA editing mediated by adenosine deaminase acting on RN

232 rpin stem in COMP can lead to a non-genetic, RNA editing-mediated substitution in COMP that may then

233 elucidate the roles of three proteins in the RNA Editing Mediator Complex (REMC).

234 Fine-tuning of Kv1.1 surface expression by RNA editing might contribute to the complexity of neuron

235 These findings indicate that RNA editing modification may play an important role in t

236 Post-transcriptional C-to-U RNA editing occurs in plant plastid and mitochondrial tr

237 Overall, our results showed that A-to-I RNA editing occurs specifically during sexual reproducti

238 Here, we show that APOBEC1-mediated RNA editing occurs within MG and is key to maintaining t

239 n be tailored to any organism and gene where RNA editing occurs.

240 as well as for adenosine to inosine (A to I) RNA editing of Ctn RNA in muscle cells.

241 Therefore, our data suggest that I400V RNA editing of Kv1.1 leads to a reduced current size by

242 Coregulation and RNA editing of PRUNE2 and PCA3 were confirmed in human p

243 OTEIN6 (ORRM6) result in the near absence of RNA editing of psbF-C77 and the reduction in accD-C794 e

244 We verified protein-recoding RNA editing of selected genes including several that are

245 An analysis of RNA splicing and RNA editing of selected RNA species demonstrated that TA

246 These results indicate that RNA editing on chlB mRNA is important to maintain approp

247 It was thought that in yeast, RNA editing only occurs in tRNAs.

248 A possible role in C-to-U RNA editing or in antiviral defense has been discussed f

249 1CF), the RNA-binding cofactor of APOBEC1 in RNA editing, or Argonaute 2 (AGO2), a key factor in the

250 The dysregulation of the RNA editing pathway was further investigated in an indep

251 , endocannabinoids signaling pathway and the RNA editing pathway were found to be dysregulated in EC.

252 is- and trans-regulatory mechanisms of these RNA editing patterns, respectively.

253 and revealed a striking diversity of altered RNA-editing patterns in tumors relative to normal tissue

254 REPAIR presents a promising RNA-editing platform with broad applicability for resear

255 GP expression through a mechanism of GP gene RNA editing plays an important role in the high pathogen

256 d or tested as an effective tool for SNP and RNA editing prediction.

257 The prevailing concept is that the RNA editing process itself is dysregulated by brain path

258 Finally, analyses of codon usage bias and RNA-editing processes of the conotoxin transcripts demon

259 studies have reported significant changes in RNA editing profiles in disease and development.

260 We characterized the global A-to-I RNA editing profiles of 6,236 patient samples of 17 canc

261 an lymphoblastoid cell lines by combining an RNA editing QTL (edQTL) analysis with an allele-specific

262 d identified three unique patterns of A-to-I RNA editing rates during cortical development: stable hi

263 The term "RNA editing" refers to a variety of mechanistically unre

264 fication of the effect of ORRM2 and ORRM3 on RNA editing reveals a previously undescribed role of RRM

265 Site-directed RNA editing (SDRE) is a strategy to precisely alter gene

266 They both contain an RNA editing site in the glycoprotein gene that controls

267 These DVRs encompassed known SNPs and RNA editing sites as well as novel SNVs, with the majori

268 We show that RNA editing sites can be called with high confidence usi

269 curately detected more than 2 million A-to-I RNA editing sites from next-generation sequencing (NGS).

270 as single-nucleotide polymorphisms (SNPs) or RNA editing sites from RNA-Seq reads is important, yet c

271 The identification of A-to-I RNA editing sites has been dramatically accelerated in t

272 However, the vast majority of these RNA editing sites have unknown functions and are in nonc

273 ncludes a comprehensive collection of A-to-I RNA editing sites identified in humans (Homo sapiens), m

274 mportant resource for exploring functions of RNA editing sites in lncRNAs.

275 25 transcripts harboring conserved recoding RNA editing sites in mammals and several hundred recodin

276 the majority of DVRs corresponding to known RNA editing sites repressed after ADAR1 knockdown.

277 d fly, and observed an appreciable number of RNA editing sites which can significantly impact the sec

278 ive alleles of SNPs and in identification of RNA editing sites.

279 sive because of the unknown function of most RNA editing sites.

280 is and are regulated by post-transcriptional RNA editing, splice variation, post-translational modifi

281 Therefore, RNA editing studies should complement genome sequence da

282 -polypeptide tripartite assembly, termed the RNA editing substrate binding complex (RESC), also funct

283 The RNA editing suggests that the pre-mRNA forms a stable se

284 NA transcripts, altering previous views that RNA editing systems are difficult to maintain in genomes

285 inases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine

286 quid Doryteuthis pealeii recodes proteins by RNA editing to an unprecedented extent.

287 erms, two codons of chlB mRNA are changed by RNA editing to codons encoding evolutionarily conserved

288 This successful use of site-directed RNA editing to repair an endogenous mRNA and restore pro

289 Here, we apply the approach of site-directed RNA editing to repair, at the mRNA level, a disease-caus

290 This adds a unique type of RNA editing to the modifications occurring in nuclear ge

291 The founding member of TUTase family, RNA editing TUTase 1 (RET1), functions as a subunit of t

292 polymorphisms, polymorphisms associated with RNA editing variation are located closer spatially to th

293 cleavage is a likely point of regulation for RNA editing, we elucidated endonuclease specificity in v

294 the influence of genetic variation on A-to-I RNA editing, we integrate genomic and transcriptomic dat

295 To determine if APOBEC3G is capable of RNA editing, we transiently expressed APOBEC3G in the HE

296 ression changes of 150 genes associated with RNA editing were found in tumors, with 3 of the 4 most s

297 ion" and "seizures." Genes with differential RNA editing were preferentially enriched for genes with

298 virus (EBOV) is dependent on transcriptional RNA editing, whereas direct expression of the GP gene re

299 R) orthologs and are believed to lack A-to-I RNA editing, which is the most prevalent editing of mRNA

300 d widespread messenger RNA modifications and RNA editing, with dramatic effects on mammalian transcri