ライフサイエンスコーパス: RNA helicase

1 rbour a targetable requirement for the eIF4A RNA helicase.

2 t on sigB and cshA, which encodes a DEAD box RNA helicase.

3 a cold-inducible DEAD (Asp-Glu-Ala-Asp) box RNA helicase.

4 p68 RNA helicase is a prototypical RNA helicase.

5 in supv3l1, a gene encoding a mitochondrial RNA helicase.

6 factors, including Mpp6, Rrp47, and the Mtr4 RNA helicase.

7 A helicase, whereas ISE2 encodes a DEVH-type RNA helicase.

8 rt stringent control over this very abundant RNA helicase.

9 enolase, phosphofructokinase, and a DEAD box RNA helicase.

10 n observed for many double-stranded DEAD-box RNA helicases.

11 anism is clearly different to those of other RNA helicases.

12 A is strongly homologous to that in DEAD-box RNA helicases.

13 that regulates DHX9 and, potentially, other RNA helicases.

14 steps, driven by eight conserved DEXD/H-box RNA helicases.

15 ely and negatively by multiple host DEAD-box RNA helicases.

16 signature motifs specific to this family of RNA helicases.

17 xpressed RIG-I-like receptor (RLR) family of RNA helicases.

18 ent and a binding partner of GLH-1 (Germline RNA Helicase-1), a constitutive, germline-specific, P-gr

19 ve identified the DEAD (Asp-Glu-Ala-Asp) box RNA helicase 24 (DDX24) as a novel regulator of the p300

20 pectrometry analysis identified the DEAD-box RNA helicase 6 (DDX6) that interacts with the VEGF mRNA

21 l proteins and ribonucleoproteins, including RNA helicase A (DHX9), Y-box binding protein (YBX1), DDX

22 es DHX29, a member of the superfamily 2 DEAH/RNA helicase A (RHA) helicase family that binds to 40S s

23 RNA helicase A (RHA) is a DExH-box RNA helicase that pla

24 In the present study, we show that RNA helicase A (RHA) is an important mediator for EGFR-i

25 of the molecular interplay between Lin28 and RNA helicase A (RHA) known to play an important role in

26 n interactions, including helicases DDX5 and RNA helicase A (RHA) that alters RNA-splicing ratios.

27 e elucidated a unique unwinding mechanism of RNA helicase A (RHA) that entails discrete substeps cons

28 olecular basis for the incorporation of DHX9/RNA helicase A (RHA) to virions remains unclear.

29 ranslational control protein 80 (TCP80), and RNA helicase A (RHA), which positively regulate p53 IRES

30 Interestingly, RNA helicase A and La autoantigen relocated from a nucle

31 oth Chtop and Alyref activate the ATPase and RNA helicase activities of Uap56 and that Uap56 function

32 Purified CshA exhibits typical RNA helicase activities, as exemplified by RNA-dependent

33 coactivate its targets depends on intrinsic RNA helicase activity and binding of a conserved nuclear

34 ling activity in addition to their canonical RNA helicase activity and might therefore participate in

35 s with complex 5'UTRs require enhanced eIF4A RNA helicase activity for translation.

36 Ezrin inhibited the RNA helicase activity of DDX3 but increased its ATPase a

37 resent the first report demonstrating NTPase/RNA helicase activity of the helicase domain of HEV ORF1

38 Our results support a model in which MOV10L1 RNA helicase activity promotes unwinding and funneling o

39 that RNase R contains an unusual, intrinsic RNA helicase activity that facilitates degradation of du

40 enzyme possesses an intrinsic, ATP-dependent RNA helicase activity that is essential in vitro for eff

41 is emerges because modern ribosome possesses RNA helicase activity that likely dates back to the RNA

42 r cells was also inhibited by blocking eIF4A RNA helicase activity with silvestrol and CR-1-31-B.

43 The addition of compounds that altered RNA helicase activity, induced oxidative stress, or stim

44 It contains the characteristic RNA helicase activity.

45 ctive conformation of eIF4A required for its RNA helicase activity.

46 As target eIF4A, specifically inhibiting its RNA helicase activity.

47 HDC2 is an RNA-induced ATPase with a 3'-->5' RNA helicase activity.

48 tudies indicate that GRTH, a multifunctional RNA helicase, acts as a negative regulator of miRNA-469

49 Mtr4 is a conserved Ski2-like RNA helicase and a subunit of the TRAMP complex that act

50 inding protein 4E-Transporter, the Xp54/DDX6 RNA helicase and additional RNA-binding proteins.

51 of human up-frameshift protein 1 (hUPF1), an RNA helicase and master regulator of NMD, in these disor

52 Recently, our group established the DEAD-box RNA helicase and microRNA (miRNA) microprocessor accesso

53 rations in Hippo, mTOR, histone methylation, RNA helicase and p53 signaling pathways in MPMs.

54 nally increased the stability of p68 and p72 RNA helicase and stimulated their ability to coactivate

55 roteins (DBPs) make up the largest family of RNA helicases and are found across all phyla.

56 nes known to modulate TE expression, such as RNA helicases and autophagy genes.

57 n be partially reversed by overexpression of RNA helicases and can be fully overcome upon UV stress,

58 DEAD-box proteins are nonprocessive RNA helicases and can function as RNA chaperones, but th

59 n unexpected interdependence between the two RNA helicases and eIF4G, and suggest that Ded1p is an in

60 uv3p is a member of the DEXH/D box family of RNA helicases and is a critical component of the mitocho

61 he DDX5-RORgammat complex reveals a role for RNA helicases and lncRNAs in tissue-specific transcripti

62 xplanation for the ATP-gated behavior of SF2 RNA helicases and receptor proteins.

63 ionary history of two types of viral sensor, RNA helicases and Toll-like receptors.

64 NS3 has NS2B-dependent protease, RNA helicase, and 5'-RNA triphosphatase activities.

65 Trf4/5 are poly(A) polymerases, Mtr4 is an RNA helicase, and Air1/2 are putative RNA-binding protei

66 protein 4 (PDCD4), an inhibitor of the eIF4A RNA helicase, and contributes to the induction of MUC1-C

67 lices, oligomerizes to function as efficient RNA helicase, and does not unwind DNA duplexes.

68 four major components: RNase E, PNPase, RhlB RNA helicase, and enolase.

69 3Kshort right arrowAKT pathway and the eIF4A RNA helicase, and that this response promotes EGFR signa

70 ded phosphorylation of ATP synthase, DNA and RNA helicases, and proteins important for cell division

71 Here, we identify the conserved RNA helicase Aquarius/EMB-4 as a direct and essential li

72 al mouse challenge, we demonstrate here that RNA helicases are critical for IFN production by immune

73 RNA helicases are essential for virtually all cellular p

74 RNA helicases are involved in almost every aspect of RNA

75 The activities of eight RNA helicases are required for pre-mRNA splicing.

76 Here, we show that several DEAD-box RNA helicases are sensitive to AMP, which is not produce

77 Superfamily 1 and superfamily 2 RNA helicases are ubiquitous messenger-RNA-protein compl

78 DEAD-box RNA helicases are vital for the regulation of various as

79 oup phenotypes in RNA viruses and identifies RNA helicase as an attenuation and fitness determinant i

80 d identified DDX5, an ATP-dependent DEAD-box RNA helicase, as a component of the MAML1 protein comple

81 The DEAH (Asp-Glu-Ala-His) box RNA helicase associated with AU-rich element (RHAU) (als

82 RNA helicase associated with AU-rich element (RHAU) is a

83 RNA helicase associated with AU-rich element (RHAU), a m

84 nscript and the phosphorylation of UPF-1, an RNA helicase associated with nonsense-mediated mRNA deca

85 The DHX36 RNA helicase associated with the Aven complex and was re

86 irus 10, homolog (MOV10) is an IFN-inducible RNA helicase, associated with small RNA-induced silencin

87 ches, we have determined the relation of the RNA helicase, ATP binding, and nuclease activities of RN

88 genetic factors, telomeric proteins, and the RNA helicase, ATRX.

89 activity of specialized helicases including RNA helicase AU (associated with AU rich elements) (RHAU

90 Dhh1 was identified initially as a putative RNA helicase based solely on the presence of conserved h

91 gnaling in Drosophila we have identified the RNA helicase Belle, a recently described component of th

92 Brr2 is an RNA helicase belonging to the Ski2-like subfamily and an

93 In response to viral infection, RIG-I-like RNA helicases bind to viral RNA and activate the mitocho

94 ties of human DDX3X are typical for DEAD-box RNA helicases, but diverge quantitatively from its highl

95 ors are sites of dissociation mediated by an RNA helicase called Rho.

96 polyadenylation by TRAMP and reveal that an RNA helicase can control the activity of another enzyme

97 MOV10, a putative RNA helicase, can be packaged into HIV-1 virions by bind

98 ortantly, we identify the conserved DEAD-box RNA helicase, CGH-1/DDX6, as a key CK2 substrate within

99 luding cohesins, condensins, topoisomerases, RNA helicases, chromatin remodelers, and modifiers-that

100 elix is particularly extensive for Ski2-like RNA helicases compared to related helicases.

101 RhlB, the RNA helicase component of the degradosome, also contribu

102 ily requires the activity of a superfamily 2 RNA helicase contained in the C-terminal domain of nonst

103 Members of the DEAD-box family of RNA helicases contribute to virtually every aspect of RN

104 ntified among multiple proteins the DEAD box RNA helicase CshA (NWMN_1985 or SA1885) by mass spectros

105 The RNA helicase database (www.rnahelicase.org) integrates t

106 ur laboratory demonstrated that the DEAD-box RNA helicase Dbp2 in Saccharomyces cerevisiae is require

107 The evolutionarily conserved RNA helicase Dbp2 regulates formation of these R-loops a

108 In yeast strains lacking the RNA helicase, DBP2, or the RNA decay enzyme, XRN1, we fi

109 DEAD-box RNA helicase Dbp4 is required for 18S rRNA synthesis: ce

110 ect RNA chaperones, including three DEAD box RNA helicases (DBRHs) (CsdA, SrmB, RhlB) and the cold sh

111 DEAD-box RNA helicases (DBRHs) modulate RNA secondary structure,

112 ntification of a viral sensor, consisting of RNA helicases DDX1, DDX21, and DHX36, and the adaptor mo

113 f target genes of this complex including the RNA helicase DDX18.

114 Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status

115 ion in pre-40S complexes is regulated by the RNA helicase DDX21.

116 ese genes ribosomal protein RPL35A, putative RNA helicase DDX24, and coatomer complex I (COPI) subuni

117 RNA helicase DDX3 has oncogenic activity in breast and l

118 The RNA helicase DDX3 is a component of neuronal granules, a

119 ted direct interaction between ezrin and the RNA helicase DDX3, and NSC305787 blocked this interactio

120 Here, we identified the RNA helicase DDX39B as a potent activator of this exon a

121 subtypes of this disease, and nominates the RNA helicase DDX3X as a component of pathogenic beta-cat

122 The DEAD-box RNA helicase DDX3X is frequently mutated in pediatric me

123 The ubiquitous ATP-dependent RNA helicase DDX3X is involved in many cellular function

124 Five host RNA helicases (DDX3X, DDX5, DHX9, DHX37, DDX52) were inh

125 carcinoma cells, we identified the DEAD-box RNA helicase DDX41 as a novel regulator of p21 expressio

126 ts interaction with nucleophosmin (NPM/B23), RNA helicase DDX5 and RNA polymerase I transcription ter

127 The RNA helicase DDX5, and E3 ligase Mex3b, are important ce

128 RF limited the nucleolar localization of the RNA helicase DDX5, which promotes the synthesis and matu

129 We found that mouse PER complexes included RNA helicases DDX5 and DHX9, active RNA polymerase II la

130 own and rescue studies demonstrated that the RNA helicase DDX6 acts enzymatically to facilitate capsi

131 ns, including AGO2 and the ribonucleic acid (RNA) helicase DDX6.

132 Here, we show that the DEAD box RNA helicase, DDX6 is necessary for maintaining adult pr

133 the effects of mutation of the ATP-dependent RNA helicase DeaD were medium independent.

134 ele hi1727, which disrupts the gene encoding RNA helicase dead-box 18 (Ddx18).

135 Here we identify the RNA helicase DEAD-box protein 5 (DDX5) as a RORgammat pa

136 se G or by mutation of the gene encoding the RNA helicase DeaD.

137 Herein, we identified the RNA helicase, DEAD box protein 5 (DDX5), as a regulator

138 We show that two DEAD-box RNA helicases, DeaD and SrmB, activate csrB/C expression

139 Here we report an eIF4A RNA helicase-dependent mechanism of translational contro

140 hat activate decapping, such as the DEAD-box RNA helicase Dhh1, have been postulated to function by l

141 Previously, we showed that the DEAH/RHA RNA helicase Dhr1 dislodges U3 from the pre-rRNA.

142 y with the box C/D snoRNA U3-associated DEAH RNA helicase Dhr1 supposedly involved in central pseudok

143 Nlrp6 bound viral RNA via the RNA helicase Dhx15 and interacted with mitochondrial ant

144 Here, we identified the RNA helicase DHX15 as a novel AR co-activator using a ye

145 analysis, shows that it encodes the DEAH-box RNA helicase Dhx16, shown in other systems to act in RNA

146 ed as anti-viral, while three other cellular RNA helicases (DHX29, DHX35, RIG-I) were identified as p

147 n 3 protein (PTCD3), and a putative DEAD-box RNA helicase, DHX30.

148 y, Mitoma et al. (2013) demonstrate that the RNA helicase DHX33 binds to cytosolic dsRNAs to trigger

149 The RNA helicase DHX33 has been shown to be a critical regul

150 and increases the stability of the DEAH-box RNA helicase DHX33, which is critically involved in ribo

151 that a recently characterized DEAD/DEAH box RNA helicase, DHX33, promotes mRNA translation initiatio

152 In recent times, the RNA helicase DHX34 was found to promote mRNP remodelling

153 acts together are recognized by the DEXH box RNA helicase DHX36.

154 we show that PRRSV N interacts with cellular RNA helicase DHX9 and redistributes the protein into the

155 IGF2 mRNA, enhancing the association of the RNA helicase DHX9 to the IGF2 transcript and promoting I

156 Our data show that, via RNA helicase Dhx9, Nlrp9b recognizes short double-strand

157 The Brr2 RNA helicase disrupts the U4/U6 di-small nuclear RNA-pro

158 ction in RNA metabolism (Topoisomerase 1 and RNA helicases), DNA repair/replication processes (PARP1,

159 First, coexpression of the CH domain and the RNA helicase domain in trans can reconstitute Upf1 funct

160 e-attenuated phenotype were localized to the RNA helicase domain of the NS3 protein by reverse geneti

161 eine- and histidine-rich (CH) domain and the RNA helicase domain of yeast Upf1 can engage in two new

162 inserted in between the RecA modules of the RNA helicase domain.

163 and functionally interacts with the DEAH-box RNA helicase Ecm16 (also known as Dhr1).

164 translation by interacting tightly with the RNA helicase eIF4A via its tandem MA-3 domains.

165 DEAD-box RNA helicases eIF4A and Ded1 are believed to promote tra

166 n initiation involves two conserved DEAD-box RNA helicases, eIF4A and Ded1p.

167 We define the RNA helicase eIF4A2 as the key factor of eIF4F through w

168 The putative RNA helicase encoded by the Arabidopsis gene At1g32490 i

169 Also, acetylation of p72, but not of p68 RNA helicase, enhanced p53-dependent activation of the M

170 RNA helicase enzymes catalyze the in vivo folding and co

171 t aspects of RNA metabolism involve DEAD-box RNA helicases, enzymes that bind and remodel RNA and RNA

172 is of single fluorescent Dbp5 molecules, the RNA helicase essential for mRNA export, revealed that Db

173 is-specific member of the DEAD-box family of RNA helicases essential for spermatogenesis, is present

174 DEAD-box RNA helicases eukaryotic translation initiation factor 4

175 tigated the potential function of DExD/H-box RNA helicase family members (previously shown to sense c

176 The recently discovered RNA helicase family of RIG-I-like receptors (RLRs) is a

177 onarily conserved member of the SF2 DEAD-box RNA helicase family that contributes to the regulation o

178 even nucleus-encoded members of the DEAD box RNA helicase family.

179 RQC-trigger (RQT) subcomplex composed of the RNA helicase-family protein Slh1/Rqt2, the ubiquitin-bin

180 Caenorhabditis elegans protein LAF-1, a DDX3 RNA helicase found in P granules, phase separates into P

181 Vasa is a conserved RNA-helicase found in the germ lines of all metazoans te

182 in kinase 1a (CK1a), and the FRQ-interacting RNA Helicase (FRH) rhythmically represses gene expressio

183 f the frequency (frq), frequency-interacting RNA helicase (frh), white collar-1 (wc-1), and white col

184 FRQ in turn binds to FREQUENCY-Interacting RNA Helicase (FRH), whose clock function has been assume

185 As to take advantage of the side products of RNA helicase function.

186 may be general mechanisms for regulation of RNA helicase functions.

187 remodeling is achieved is largely limited to RNA helicase functions.

188 tified recurrent mutations in the DEAD/H-box RNA helicase gene DDX41 in familial and acquired cases o

189 We identified an RNA helicase gene, DDX3 (DDX3X), which is overexpressed

190 omatic mutations were newly identified in an RNA helicase gene, DDX3X, often concurrent with CTNNB1 m

191 Loss of CGH-1/Ddx6 RNA helicase generates solid granules that are sensitive

192 DDX41 is exemplary of other RNA helicase genes also affected by somatic mutations, s

193 Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) is a testis-specific gonadotro

194 Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25), a testis-specific member of t

195 mber of the ATP-dependent DEX(H/D) family of RNA helicases, has been established as a major cellular

196 Maternal RNA helicases have long been known to be involved in the

197 RNA helicases impact RNA structure and metabolism from t

198 We reported earlier that LAF-1, a DEAD box RNA helicase in C. elegans, dynamically interacts with R

199 and ATP-dependent roles of the Has1 DEAD-box RNA helicase in consecutive pre-rRNA processing and matu

200 mode of regulation of snoRNP function by an RNA helicase in human cells.

201 and provide evidence implicating a mammalian RNA helicase in RNA modification and Pol II elongation c

202 DHX33 is a pivotal DEAH-box RNA helicase in the multistep process of RNA polymerase

203 ngly, we also show that Dbp2 is an efficient RNA helicase in vitro and that Yra1 decreases the effici

204 es the wealth of accumulating information on RNA helicases in a readily accessible format.

205 Our work implicates distinct RNA helicases in specific steps along the nuclear piRNA

206 anism of NMD with an emphasis on the role of RNA helicases in the transition from NMD complexes that

207 brary screen targeting the 58 human DEAD-box RNA helicases in two permissive human cancer cells (HeLa

208 g sarcoma clinical trials and development of RNA helicase inhibition as a novel anti-neoplastic strat

209 ctor-stimulated MCF-10A cells with the eIF4A RNA helicase inhibitors, silvestrol and CR-1-31-B, block

210 This study reports the first RNA helicase interacting with a stem-loop structure at t

211 vasa is a highly conserved RNA helicase involved in animal germ cell development.

212 DDX3X is a conserved DEAD-box RNA helicase involved in translation initiation and othe

213 Brr2p is one of eight RNA helicases involved in pre-mRNA splicing.

214 erately lower in mosquitoes, indicating that RNA helicase is a major fitness determinant of WNV and t

215 dings also indicate that targeting the eIF4A RNA helicase is a novel approach for blocking MUC1-C ove

216 p68 RNA helicase is a prototypical RNA helicase.

217 This DEAD-box RNA helicase is known to be associated with various comp

218 Prp43 and of all other spliceosomal DEAH-box RNA helicases is still elusive.

219 ferentiation-associated protein 5 (MDA5), an RNA helicase, is a key component in activating the expre

220 s the prototypical example of a DEA(D/H)-box RNA helicase, it is highly likely that this unwinding me

221 factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase; its messenger RNA selectivity is proposed

222 folding subunit) and eIF4A (an ATP-dependent RNA helicase) leads to assembly of active eIF4F complex.

223 Unlike a previously reported DEAD box RNA helicase (LOW EXPRESSION OF OSMOTICALLY RESPONSIVE G

224 oll-like receptor (TLR) 3, and the cytosolic RNA helicase MDA-5.

225 The RNA helicase melanoma differentiation-associated gene-5

226 The cytosolic RNA helicases melanoma differentiation-associated gene 5

227 f RBPs, including the binding effects of the RNA helicase MOV10 on mRNA degradation, the potentially

228 physical proximity and coupled activities of RNA helicase Mtr4 (and senataxin) with the noncoding RNA

229 The essential RNA helicase, Mtr4, performs a critical role in RNA proc

230 with polyadenylation and the function of the RNA helicase Mtr4p in modulating poly(A) addition.

231 Trf4p, the Zn-knuckle protein Air2p, and the RNA helicase Mtr4p.

232 Trf4p, the Zn-knuckle protein Air2p, and the RNA helicase Mtr4p.

233 Viral RNA helicases of the NS3/NPH-II group unwind RNA duplexe

234 RNA helicases often require protein cofactors to provide

235 The RNA helicase p68 (DDX5) is an established co-activator o

236 ng: the splicing factor SRSF1 (SF2/ASF), the RNA helicase p68 (DDX5), and the heterogeneous nuclear r

237 ss spectrometry approach and identified DDX5/RNA helicase p68 as an activator of tau exon 10 splicing

238 The RNA helicase p68 is a potent co-activator of p53-depende

239 both types of DM is caused by deficiency of RNA helicase p68.

240 DEAD box RNA helicases play central roles in RNP biogenesis.

241 DEAD/DEAH box RNA helicases play essential roles in numerous RNA metab

242 RNA helicases play fundamental roles in modulating RNA s

243 The DEAD-box class of RNA helicases plays fundamental roles in formation of RN

244 quids or solid lattices, whereas a conserved RNA helicase prevents polymerization into nondynamic sol

245 charomyces cerevisiae mitochondrial DEAD-box RNA helicase protein that is essential for efficient in

246 ion receptors (PRRs) is a group of cytosolic RNA helicase proteins that can identify viral RNA as non

247 y-terminal Sec63-2 domain, with the splicing RNA helicase Prp16p.

248 At1g32490 is a homolog of the yeast splicing RNA helicases Prp2 and Prp22.

249 our results suggest that the cold-inducible RNA helicase RCF1 is essential for pre-mRNA splicing and

250 RNA helicases remove secondary structures that impede ri

251 are 1.6129 and 1.14 nM for DNA helicase and RNA helicase, respectively.

252 We show that the host DDX21 RNA helicase restricts influenza A virus by binding PB1

253 he Kreb's cycle enzyme aconitase, a DEAD-box RNA helicase RhlB and the exoribonuclease polynucleotide

254 processing activities, can interact with the RNA helicase RhlB independently of RNA degradosome forma

255 ination events in bacteria often require the RNA helicase Rho.

256 The cytoplasmic RNA helicase RIG-I mediates innate sensing of RNA viruse

257 a gene, IFNB1, through the activation of the RNA helicase RIG-I, which is encoded by DDX58.

258 ch in turn upregulates the expression of the RNA helicases RIG-I and MDA5.

259 e have shown that LACV infection induced the RNA helicase, RIG-I, and mitochondrial antiviral signali

260 plasmic or endosomal RNA sensors (RIG-I-like RNA helicases [RLR] and Toll-like receptors [TLR]), whic

261 The RNA helicase(s) modulating this stem-loop structure was

262 Here, we show that the DEAD box RNA helicase smut-1 functions redundantly in the mutator

263 ng protein (MAVS), the signaling adaptor for RNA helicases such as RIG-I, resulted in increased death

264 ere it interacts with the MOV10 RISC complex RNA helicase, suggesting a role for IRAV in the processi

265 plicing was unrelated to the activity of the RNA helicase, suggesting that the helicase does indeed p

266 east SUV3 is a nuclear encoded mitochondrial RNA helicase that complexes with an exoribonuclease, DSS

267 h AU-rich element (RHAU) is an ATP-dependent RNA helicase that demonstrates high affinity for quadrup

268 Vasa is a broadly conserved ATP-dependent RNA helicase that functions in the germ line of organism

269 DDX3X is a DEAD-box RNA helicase that has been implicated in multiple aspect

270 e yeast Saccharomyces cerevisiae Sen1, a DNA/RNA helicase that is essential for yeast cell viability

271 ION LIMIT2 (ISE2) is a chloroplast-localized RNA helicase that is indispensable for proper plant deve

272 leukemia virus type 10 protein (MOV10) is an RNA helicase that is induced by type I interferon.

273 is a testis-specific gonadotropin-regulated RNA helicase that is present in Leydig cells (LCs) and g

274 Brr2 is a DExD/H-box RNA helicase that is responsible for U4/U6 unwinding, a

275 UPF1 is an RNA helicase that orchestrates nonsense-mediated decay a

276 arti et al. structurally reveal how UPF1, an RNA helicase that plays a central role in nonsense-media

277 e deficient in MOV10L1, a germ cell-specific RNA helicase that plays a key role in limiting the propa

278 RNA helicase A (RHA) is a DExH-box RNA helicase that plays multiple roles in cellular biolo

279 ealed that ISE2 is a non-canonical Ski2-like RNA helicase that represents a separate sub-clade unique

280 In an effort to understand how RNA helicases that localize to different organelles have

281 BPs) are a widespread class of ATP-dependent RNA helicases that play a key role in unwinding RNA dupl

282 NAs with mRNA evolved as a mechanism used by RNA helicase, the predecessor of ribosomes, to melt RNA

283 th Nsp9 and its RdRp and recruiting cellular RNA helicase to promote the production of longer viral s

284 In addition to the RNA helicase UAP56 and the mRNA export factors ALY2-4 an

285 at interacts directly with the ATP-dependent RNA helicase up-frameshift 1 (UPF1) to reduce the half-l

286 demonstrate that the ATPase activity of the RNA helicase Upf1 allows disassembly of mRNPs undergoing

287 miR-128 represses NMD by targeting the RNA helicase UPF1 and the exon-junction complex core com

288 ntaining mRNAs are controlled by the group I RNA helicase Upf1 and the proteins it interacts with, Up

289 ed miRNAs does not require the ATP-dependent RNA helicase UPF1 in vitro, we report here that cellular

290 A central NMD factor is the ATP-dependent RNA helicase upframeshift 1 (UPF1).

291 Amplifier is nucleated by the DEAD box RNA helicase Vasa and contains the two Piwi proteins par

292 The RNA helicase Vasa is another essential protein in germli

293 ISE1 encodes a mitochondrial DEAD-box RNA helicase, whereas ISE2 encodes a DEVH-type RNA helic

294 d as the result of evolution of a primordial RNA helicase, which has been essential for preventing dy

295 primary driver of the rapid evolution of the RNA helicases, while selective constraint has been a str

296 l component of the NMD machinery is UPF1, an RNA helicase whose ATPase activity is essential for NMD,

297 PRD-1 is an RNA helicase whose orthologs, DDX5 [DEAD (Asp-Glu-Ala-As

298 UPF1 is a DNA/RNA helicase with essential roles in nonsense-mediated m

299 DDX3 is a DEAD box RNA helicase with oncogenic properties.

300 th the H/ACA snoRNP protein yNhp2/hNHP2, the RNA helicase yRok1/hROK1(DDX52), the ribosome biogenesis