ライフサイエンスコーパス: RNA interference

1 is amenable to experimental manipulation by RNA interference.

2 on, energy transfer, functional aptamers and RNA interference.

3 nase activity or blocked its expression with RNA interference.

4 hange their epigenetic status is hampered by RNA interference.

5 and could be selectively inhibited by P2X2R RNA interference.

6 ses, whereas Csx28 enhances, Cas13b-mediated RNA interference.

7 en both EGR1 and EGR4 are knocked down using RNA interference.

8 via adeno-associated virus (AAV) 9-mediated RNA interference.

9 are reversed by ZEB1 knock-down by means of RNA interference.

10 of the major allergen of apple, Mal d 1, by RNA interference.

11 es were manipulated pharmacologically and by RNA interference.

12 uence- and site-specific manner analogous to RNA interference.

13 infection, these genes were knocked down by RNA interference.

14 ated by receptor knockdown experiments using RNA interference.

15 erived from protein and RNA binding studies, RNA-interference, a murine smoking model, and expression

16 A total of 32,164 RNA interference abstracts were identified from 10.5 mil

17 target sequence could abolish the antiviral RNA interference activity.

18 Depleting SRSF10 by RNA interference affected viral splicing and, like 1C8,

19 Targeting the HDACs by using either RNA interference against HDAC1 in CLL or a small molecul

20 kinase C epsilon (PKCepsilon) knockout mice, RNA interference against PKCepsilon, and peptide inhibit

21 Knockdown of Sp TFs by RNA interference also decreased STAT3/pSTAT3 expression.

22 te RIG-I signalling, we performed two global RNA interference analyses to identify both positive and

23 PPARs could activate SULT1C3 transcription, RNA interference analysis indicated the predominance of

24 r simultaneous and conditional repression by RNA interference and artificial microRNA in seedlings le

25 emical-induced protein degradation strategy, RNA interference and CRISPR interference to validate MEL

26 Using RNA interference and CRISPR-Cas9 to generate PAXX(-/-) c

27 RNA interference and ectopic expression assays found tha

28 roxyhexadecanoic acid was affected in tomato RNA interference and ethyl methanesulfonate-cus1 mutants

29 Honey bee antiviral responses include RNA interference and immune pathway activation, but thei

30 RNA interference and immunofluorescence microscopy furth

31 ripts with comparable levels of knockdown as RNA interference and improved specificity.

32 Here, we used RNA interference and RNA-seq to identify splicing events

33 GCK RNA interference and small molecule inhibition induced c

34 result of this viral shift, namely antiviral RNA interference and the interferon system.

35 in the next 1-2 years and virally delivered RNA interference and zinc finger transcriptional repress

36 genic, targeted mutagenesis, gene silencing (RNA interference), and genome editing (CRISPR/Cas9) appr

37 ime PCR, Western blotting, small interfering RNA interference, and kinase inhibitors were used to stu

38 n with ROS of the cells was also verified by RNA interference approach and pharmacological antagoniza

39 e presumed target gene was explored using an RNA interference approach in primary T cells in vitro.

40 To determine the viability of an RNA interference approach to limit FAR expression and re

41 Using genetic and RNA interference approaches, we show that the activity o

42 Antisense oligonucleotides (ASOs) and RNA-interference approaches are emerging as attractive t

43 In this study, we analyzed the potential of RNA interference as a novel crop protection strategy aga

44 RNA interference assays showed that suppression of AP2M1

45 research has been demonstrated by conducting RNA interference assays.

46 f a proteinaceous virus receptor trap and an RNA interference-based component to prevent CVB3-induced

47 RNA interference-based, simultaneous silencing of EcNHX1

48 l assays with CRISPR-Cas-based knockouts and RNA-interference-based knockdowns.

49 For example, RNA interference can efficiently knockdown RNAs, but it

50 A RNA interference construct, designed to a highly conserv

51 on platforms (Tnt1 retrotransposons, hairpin RNA-interference constructs, and CRISPR/Cas9 nucleases)

52 Emerging biotechnologies, such as RNA interference, could provide a new sustainable and en

53 Moreover, besides inhibiting RNA interference, CrPV-1A also inhibits host transcripti

54 ges overexpress Cp and its downregulation by RNA interference decreases markers of glomerular proinfl

55 Pharmacological tools combined with RNA interference demonstrate that secretagogin's loss of

56 ndidate termiticidal modes of action such as RNA interference, digestive inhibition, pathogen enhance

57 d ROCR (regulator of chondrogenesis RNA), by RNA interference disrupted MSC chondrogenesis, concomita

58 Knockdown of NuMA by RNA interference dramatically impaired Astrin recruitmen

59 XIAP inhibition by lentivirus mediated RNA interference enhanced EF24-induced apoptosis, while

60 Depletion of endothelial annexin A2 using RNA interference enhances ICAM-1 membrane mobility and p

61 Using a targeted RNA interference entry screen, we identified glypican 5

62 t mast cell degranulation assay suitable for RNA interference experiments using lentivirus-based shor

63 BEAS-2B knockdown with RNA interference for MUC4 (small interfering RNA [siRNA]

64 RNA interference for receptor-interacting protein kinase

65 onal expression systems, recyclable markers, RNA interference, genome editing, compound screens, infe

66 ibition of mitochondrial transport by Milton RNA interference had no influence on anterograde DCV run

67 eficient in JA biosynthesis or perception by RNA interference had significantly attenuated floral acc

68 Since its discovery, RNA interference has been identified as involved in many

69 mplification, and reducing its expression by RNA interference has been shown to promote growth arrest

70 reducing DHX33 levels through short hairpin RNA interference has the same effect.

71 Other methods such as RNA interference have proven to be effective and are pot

72 HBV core inhibitors, HBV cccDNA transcripts RNA interference, HBV cell apoptosis inducers, HBV RNA,

73 In the present study, host-induced RNA interference (HI-RNAi) approach was used to develop

74 t reducing zfh2 function using a mutation or RNA interference improves survival of flies exposed to e

75 nt of that used by Argonaute proteins during RNA interference in eukaryotes.

76 s not found when S100A12 was knocked down by RNA interference in keratinocytes.

77 Kirrel2 knockdown with RNA interference in MIN6 cells and ablation of Kirrel2 f

78 139) human C2 domain-containing proteins by RNA interference in neuroendocrine cells.

79 ewisii flowers, a phenotype recapitulated by RNA interference in the wild-type background.

80 tly reduced when HaEXPB2 was knocked down by RNA interference in vitro.

81 dentified from study of phenotypes caused by RNA interference in which the wrong tissues are regenera

82 Knockdown of either ADF or cofilin-1 by RNA interference increased the paracellular permeability

83 lls and reduction of DDX24 protein levels by RNA interference induces cell cycle arrest and senescenc

84 mesenchymal cells, and knockdown of DDX3 by RNA interference inhibited oncogenic activity in Ewing s

85 1, in insulin-secreting MIN6 beta-cells with RNA interference inhibits SOCE and ATP-sensitive K(+) (K

86 ion of their receptors via pharmacologic and RNA interference interventions.

87 Methods to introduce RNA interference into adult neurons, in vitro or in vivo

88 pecific silencing of mutant keratins through RNA interference is a promising therapeutic approach for

89 From a clinical perspective, RNA interference is not yet a viable option, and small m

90 RNA interference knockdown of DRD2 in pancreatic tumor c

91 RNA interference knockdown of DRD2 or inhibition with ph

92 verexpression of dominant-negative Rab11 and RNA interference knockdown of endogenous Rab11 inhibited

93 Using a DN approach and RNA interference knockdown, we demonstrated that a gener

94 of a putative tomato ORE1 as target gene for RNA interference knockdown.

95 RNA interference, knockout and rescue experiments demons

96 ondly, conditional gene silencing of PKC1 by RNA interference led to severely reduced growth of the f

97 We used cultured mammalian myoblasts and an RNA interference library targeting 571 kinases to identi

98 The RNA interference lines and the T-DNA insertional mutant

99 nt alleles of nkd1 and nkd2, as well as nkd2-RNA interference lines in which both nkd genes were knoc

100 floral organs into leaves in the most severe RNA interference lines suggest redundant and additive GR

101 how that sfRNA is processed by the antiviral RNA interference machinery in mosquitoes.

102 Silencing Hs-Tyr by RNA interference made the treated nematodes less virulen

103 RNA interference-mediated Akt suppression mimicked the e

104 RNA interference-mediated depletion of KIF23 inhibited l

105 RNA interference-mediated down-regulation of ZmMADS1 res

106 Results demonstrate that vCA1-targeted RNA interference-mediated GLP-1R knockdown increases mot

107 HPS by N1-guanyl-1,7-diaminoheptane (GC7) or RNA interference-mediated inhibition of DHPS or DOHH ind

108 Notably, RNA interference-mediated knockdown of endogenous DDX24

109 asis modulate stem cell behavior in vivo via RNA interference-mediated knockdown of factors involved

110 RNA interference-mediated knockdown of KHARON mRNA resul

111 ngly, the KIT-targeting drug midostaurin and RNA interference-mediated knockdown of KIT reduced expre

112 RNA interference-mediated knockdown of MICAL-L2 or trunc

113 In human hepatocytes, an RNA interference-mediated knockdown of OR10J5 increased

114 newal and survival, whereas its depletion by RNA interference-mediated or antibody-mediated strategie

115 RNA interference-mediated Parkin depletion attenuates CD

116 RNA interference-mediated silencing of pixr, or immunity

117 RNA interference-mediated silencing of SlGGB1 resulted i

118 y because it demonstrates the feasibility of RNA-interference-mediated suppression of an endogenous d

119 ple, mutagenesis, CRISPR-based gene editing, RNA interference, morpholinos or pharmacological inhibit

120 comotion were evaluated using viral-mediated RNA interference (n = 40).

121 own of RNF31 in EBV-transformed IB4 cells by RNA interference negatively regulates the expression of

122 netic techniques, we demonstrate that either RNA interference of hsf-1 or use of an hsf-1(sy441) muta

123 Isoflavonoid biosynthesis was silenced via RNA interference of isoflavone synthase in soybean hairy

124 RNA interference of MLC-4, as well as of its upstream re

125 Inhibition or RNA interference of PGRMC1 abolished the suppressive eff

126 disruption of homologous recombination with RNA-interference of Rad51 Rad51 knockdown increases DNA

127 r different single and multiple knock-downs (RNA interference) of hnf4 and its predicted gene pathway

128 nematode Caenorhabditis elegans, we applied RNA interference on mutants to inactivate two genes, use

129 Insect viruses express suppressors of RNA interference or apoptosis, highlighting the importan

130 The inhibition of FAK and Pyk2 with RNA interference or chemical inhibitors dramatically abo

131 Through RNA interference or pharmacologic inhibition using AT1R

132 al relevance of the candidate molecule using RNA interference or pharmacologic inhibitors in pancreat

133 Disrupting CDK function by RNA interference or pharmacological inhibition restored

134 Inhibition of EZH2 by RNA interference or pharmacological treatment with DZNep

135 Downregulation of p38 MAPK activity via RNA interference or small molecule inhibitor led to cell

136 Suppression of these pathways with RNA interference or specific chemical inhibitors results

137 an be inhibited by targeting HIF-1alpha with RNA interference or the small-molecule inhibitor YC-1.

138 vels and further inhibited PU.1 using either RNA interference or, to our knowledge, first-in-class sm

139 Using RNA interference, Ov-tsp-2 and tsp-3 mRNA expression was

140 clease Dicer is a key component of the human RNA interference pathway and is known for its role in cy

141 Systematic RNA interference perturbation of a Rho GTPase interactom

142 RNA interference reduced keratin synthesis in keratinocy

143 d in calcified human aortic valves, and DRP1 RNA interference reduced primary human valve interstitia

144 d HCMV production and knockdown of IFITMs by RNA interference reduced the virus titer by about 100-fo

145 Reducing TMEM97 through RNA-interference reduces lysosomal lipid storage and res

146 MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but ho

147 down-regulation of P311 levels by lentiviral RNA interference reproduced the deficits seen in P311(-/

148 me points, and in primary neuronal cultures, RNA interference resulted in greater neuronal susceptibi

149 n in either hepatic cells or mouse livers by RNA interference resulted in impaired intrahepatic devel

150 Dmrt1 knockdown in ZZ embryos by RNA interference resulted in male to female sex reversal

151 More important, direct knockdown of GMPS by RNA interference resulted in reduced cell viability and

152 Sustained inhibition of ERAD using RNA interference results in an O. tsutsugamushi growth d

153 PhABCG1 down-regulation by RNA interference results in decreased emission of volati

154 RNA interference revealed that BDNF knockdown can suppre

155 Specific BET protein knockdown by RNA interference revealed that BRD4 was required for myo

156 controlled by double-stranded RNAs, such as RNA interference, RNA editing, and RNA localization medi

157 Enoxacin is a small molecule that stimulates RNA interference (RNAi) and acts as a growth inhibitor s

158 lic sHSPs (class I [CI] and class II [CII]), RNA interference (RNAi) and overexpression lines were cr

159 A function as well as developing the related RNA interference (RNAi) applications.

160 w generation of insect control methods using RNA interference (RNAi) are being developed.

161 MicroRNA (miRNA) biogenesis and miRNA-guided RNA interference (RNAi) are essential for gene expressio

162 Here we identify RNA interference (RNAi) as a major requirement for quies

163 The importance of RNA interference (RNAi) as a mammalian antiviral defense

164 rda Using a viral complementation system and RNA interference (RNAi) assays, we found that ESCRT-I an

165 RNA interference (RNAi) based methods are being develope

166 Suppression of LmCYP4G102 expression by RNA interference (RNAi) does not interfere with moulting

167 RNA interference (RNAi) elicited by long double-stranded

168 RNA interference (RNAi) gene silencing technologies have

169 TGS is mechanistically distinct from the RNA interference (RNAi) gene-silencing pathway.

170 silenced chromatin, and the roles of SIR and RNA interference (RNAi) genes in T. delbrueckii.

171 g the expression of the target genes through RNA interference (RNAi) has significant therapeutic pote

172 , next-generation sequencing, proteomics and RNA interference (RNAi) have led to breakthroughs in our

173 represent potential targets for therapeutic RNA interference (RNAi) in both early and late presentat

174 While the use of RNA interference (RNAi) in molecular biology and functio

175 RNA interference (RNAi) in transgenic maize has recently

176 Efficient gene silencing by RNA interference (RNAi) in vivo requires the recognition

177 RNA interference (RNAi) is a conserved eukaryotic mechan

178 Down-regulation of cyclin D1 using RNA interference (RNAi) is a potential therapeutic appro

179 RNA Interference (RNAi) is a potentially useful tool to

180 Cell-based RNA interference (RNAi) is a powerful approach to screen

181 RNA interference (RNAi) is a promising new technology fo

182 Such feeding RNA interference (RNAi) is best understood in the worm C

183 RNA interference (RNAi) is known for its high catalytic

184 Nuclear RNA interference (RNAi) is mediated by the canonical RNA

185 In arthropods, RNA interference (RNAi) is responsible for antiviral def

186 RNA interference (RNAi) is well known as a mechanism for

187 RNA interference (RNAi) is widely used to analyse gene f

188 sfection with siRNA and outline disparity in RNA interference (RNAi) kinetics at the level of both th

189 ypes of two SUFB mutants, laf6 and hmc1, and RNA interference (RNAi) lines with reduced SUFB expressi

190 nvestigate UPD, and show that defects in the RNA interference (RNAi) machinery or in the YTH domain-c

191 are infected with viruses, and they rely on RNA interference (RNAi) mechanisms to circumvent viral i

192 Using the endogenous RNA interference (RNAi) pathway in Entamoeba, we develop

193 ving nuclease in the Drosophila melanogaster RNA interference (RNAi) pathway that targets viruses and

194 promising therapeutics that make use of the RNA interference (RNAi) pathway, but liabilities arising

195 l noncoding RNAs (sRNAs) associated with the RNA interference (RNAi) pathway.

196 We also found that Perp knockdown by RNA interference (RNAi) rescues detached cells from deat

197 en in nematodes defective in their antiviral RNA interference (RNAi) response, and is neither lethal

198 Inhibition of Smed-teashirt (teashirt) by RNA interference (RNAi) resulted in the regeneration of

199 nts in which mTOR signaling was modulated by RNA interference (RNAi) revealed that B cells were the p

200 An RNA interference (RNAi) screen of the genes that regulat

201 Mining a human genome-wide RNA interference (RNAi) screen revealed a need for multi

202 ated Vg uptake, we performed a comprehensive RNA interference (RNAi) screen targeting GPCRs in the re

203 yavirus replication, we employed genome-wide RNA interference (RNAi) screening and identified 381 gen

204 We adapted pooled RNA interference (RNAi) screening technology for use in

205 Here, using large-scale RNA interference (RNAi) screening, we find that KDM3A, a

206 ransgenic Arabidopsis (Arabidopsis thaliana) RNA interference (RNAi) seeds with lower transcript expr

207 ttranscriptional gene silencing of TOR using RNA interference (RNAi) showed that this gene is involve

208 Plant-mediated RNA interference (RNAi) shows great potential in crop pr

209 Conversely, RNA interference (RNAi) suppression lines of AtORM1 and

210 ver, a physiologically relevant role for the RNA interference (RNAi) suppressor activity of the IAV n

211 RNA interference (RNAi) technology is being developed as

212 Inclisiran (ALN-PCSsc) is a long-acting RNA interference (RNAi) therapeutic agent that inhibits

213 e development of ALN-GO1, an investigational RNA interference (RNAi) therapeutic targeting glycolate

214 the preclinical and clinical development of RNA interference (RNAi) therapeutics using these small R

215 Fitusiran, an investigational RNA interference (RNAi) therapy that targets antithrombi

216 s a powerful delivery strategy for effective RNA interference (RNAi) therapy.

217 In this study we investigate the use of RNA interference (RNAi) to control two dipteran pests, M

218 We used RNA interference (RNAi) to deplete cells of either Nup21

219 Using RNA interference (RNAi) to down regulate whitefly genes

220 The application of RNA interference (RNAi) to mammalian cells has provided

221 dings into preclinical applications using an RNA interference (RNAi)-based approach.

222 Employing RNA interference (RNAi)-based approaches, CHOP was found

223 RNA interference (RNAi)-based gene regulation platforms

224 FLT3 inhibitors, we performed a genome-wide RNA interference (RNAi)-based screen that identified ATM

225 Large-scale RNA interference (RNAi)-based screens have identified ne

226 The RNA interference (RNAi)-based therapeutic ARC-520 for ch

227 cs similar to those of wild-type WNV in both RNA interference (RNAi)-competent and -compromised mosqu

228 The RNA interference (RNAi)-induced transcriptional silencin

229 ies have shown that engineered production of RNA interference (RNAi)-inducing dsRNA in host plants ca

230 e of this rapid transcriptional change using RNA interference (RNAi)-mediated knock-down of genes bel

231 RNA interference (RNAi)-mediated knockdown of CCN1 down-

232 Conversely, RNA interference (RNAi)-mediated knockdown of USP7 in ne

233 However, in contrast to our findings that RNA interference (RNAi)-mediated silencing of BPIFB3 gre

234 Further experiments showed that RNA interference (RNAi)-mediated silencing of either DCT

235 heterochromatin gene silencing together with RNA interference (RNAi).

236 ents an attractive alternative to transgenic RNA interference (RNAi).

237 ls initiates a specific antiviral defense by RNA interference (RNAi).

238 backbones have proven to be useful tools for RNA interference (RNAi).

239 nclude antisense oligonucleotides (ASOs) and RNA interference (RNAi).

240 d silencing complex, the effector complex of RNA interference (RNAi).

241 r functions relevant to PD based on parallel RNA-interference (RNAi) screens in human cell culture an

242 nts repressing either gene (via antisense or RNA interference [RNAi]) were created and exhibited spec

243 this pathway, we conducted a high-throughput RNA interference screen for factors necessary for the bi

244 ion of ARHGEF17, identified in a genome-wide RNA interference screen for human mitosis genes.

245 In this study, we report a genome-wide RNA interference screen in Drosophila S2* cells stimulat

246 W 264.7 macrophages and performed a targeted RNA interference screen of genes encoding chromatin-modi

247 his issue, Mauthe et al. conduct an unbiased RNA interference screen of the ATG proteome to reveal nu

248 In this study, we conducted an RNA interference screen of the Caenorhabditis elegans nu

249 An in vivo RNA interference screen of translational regulators reve

250 Here we performed an RNA interference screen to delineate gene regulatory net

251 Here, we used a streamlined RNA interference screen to silence the expression of 15

252 We used an in vivo RNA interference screen to unveil candidates that altere

253 An RNA interference screen using APP-CTF [99-residue CTF (C

254 Here we used a genome-wide RNA interference screen with E0771 mammary cancer cells

255 Here, using an RNA interference screen, we identify cytohesin 1 (CYTH1)

256 Using a large-scale RNA interference screen, we identify MARCH1 as a negativ

257 Using a whole-genome RNA interference screen, we uncovered 26 novel regulator

258 High-content image analysis coupled to RNA interference screening offers opportunities to explo

259 terogeneity, we performed genome-wide pooled RNA interference screens and identified genes conferring

260 cells, we previously conducted genome-scale RNA interference screens to identify candidate host fact

261 Using computational and pooled in vivo RNA interference screens, we identify the transcription

262 Disruption of XDH by allopurinol or XDH1 by RNA interference significantly affected mosquito surviva

263 f9) and a loss of function analysis by RNAi (RNA interference) silencing of the endogenous APN1 in th

264 Pharmacologic or RNA interference-specific interventions suppressed compl

265 RNA interference studied showed that expression of Vg3 g

266 Results of RNA interference studies demonstrate that basal migratio

267 Biochemical and RNA interference studies demonstrated that both CYPs are

268 RNA interference studies established that Suf (sulfur mo

269 RNA interference suppression of NaSIPP in Nicotiana spp.

270 Conversely, inducible RNA-interference suppression of AFL1 decreased growth an

271 RNA interference target sequencing experiments identifie

272 In particular, RNA interference targeting either both of the CPP syntha

273 egies include antisense oligonucleotides and RNA interference targeting mRNA, and zinc finger transcr

274 rrent study, rats were subjected in utero to RNA interference targeting of the gene Dcdc2 or a scramb

275 By using RNA interference technique, we found that ZxAKT1-silence

276 t, PI3K, or mTOR isoforms and utilization of RNA interference technology have revealed that Akt signa

277 background is achieved by promoter-directed RNA interference that restores wild-type expression.

278 Building on previous evidence using RNA interference, the identified compounds corroborate t

279 s represents a major technological leap over RNA interference, the prior state of the art.

280 Here, we describe an RNA interference therapeutic comprising siRNA targeting

281 Thus, RNA interference through gene and retrotransposon silenc

282 When Alix was silenced by RNA interference, TnBVANK1 was no longer able to cause a

283 dy demonstrated the feasibility of utilizing RNA interference to achieve durable correction of hair s

284 We used RNA interference to examine the effects of AURKA overexp

285 the SEC2 system in plants, we used inducible RNA interference to knock down SCY2 in Arabidopsis.

286 We used virally mediated RNA interference to locally downregulate SERT expression

287 Using targeted RNA interference to modify wing shape far beyond the nat

288 the efficacy of allele-specific silencing by RNA interference to prevent CPVT phenotypic manifestatio

289 rons suggests this can be accomplished using RNA interference to reduce the levels of fidgetin, a mic

290 andidates within all QTL intervals, and used RNA interference to validate effects at four loci.

291 UV-B exposure, similar to levels in ham1ham2 RNA interference transgenic lines with decreased express

292 RNA interference was performed to block BCL11B.

293 d to IRF4 signaling, as knockdown of IRF4 by RNA interference was toxic to ALCL cell lines in vitro a

294 Using conditional RNA interference, we show here that all four neprilysins

295 ressed in adult Drosophila Using conditional RNA interference, we show that all four are specifically

296 e, using loss-of-function screening based on RNA interference, we show that environmental oxygen leve

297 Using RNA interference, we show that overexpression of the tra

298 sh that these CRISPR-Cas systems can achieve RNA interference when heterologously expressed.

299 o disrupt protein function: DNA knockout and RNA interference, which act at the genome and mRNA level

300 ing through publicly available literature on RNA interference with the goal of identifying genes esse