ライフサイエンスコーパス: RNA processing

1 ds (R-loops) formed during transcription and RNA processing.

2 nderstanding of TER evolution and non-coding RNA processing.

3 metabolism, nuclear import, translation, and RNA processing.

4 omoter binding, transcription initiation and RNA processing.

5 gene transcription, signal transduction, and RNA processing.

6 d in histone modification, transcription and RNA processing.

7 lesions caused altered pre-mRNA splicing and RNA processing.

8 RNA-binding protein, plays multiple roles in RNA processing.

9 s the first parvovirus protein implicated in RNA processing.

10 o function of U2AF and U2AF35 in alternative RNA processing.

11 be attributed to stage-regulated alternative RNA processing.

12 related processes, such as transcription and RNA processing.

13 of RNA processing factors and to defects in RNA processing.

14 ESCs, controls a network of genes related to RNA processing.

15 ships, RNA regulation of gene expression and RNA processing.

16 RNAs and proteins are crucial for regulating RNA processing.

17 transcript retention triggered by defective RNA processing.

18 ol steps such as transcription elongation or RNA processing.

19 s transcription, chromatin modification, and RNA processing.

20 at is probably due to a general defect in 3' RNA processing.

21 ganelle organization, chromatin function and RNA processing.

22 gene expression, including transcription and RNA processing.

23 th Cas9-based CRISPR-TFs and Cas6/Csy4-based RNA processing.

24 differentially regulated by Akt isoforms is RNA processing.

25 ranscriptional noise, allelic imbalance, and RNA processing.

26 and RNA-binding protein that is involved in RNA processing.

27 s protein to be implicated directly in viral RNA processing.

28 rodegenerative conditions linked to aberrant RNA processing.

29 o the NE, possibly via a mechanism involving RNA processing.

30 pathways, such as cell cycle progression and RNA processing.

31 -box proteins are involved in all aspects of RNA processing.

32 een transcription, histone modification, and RNA processing.

33 including transcriptional co-activation and RNA processing.

34 assembly and thus possibly to pre-ribosomal RNA processing.

35 is known about its effects on other modes of RNA processing.

36 a mechanism that relates DNA mutagenesis to RNA processing.

37 eq experiments to probe the stochasticity of RNA processing.

38 amage, apoptosis, cell cycle regulation, and RNA processing.

39 nifestation of aberrant transcription and/or RNA processing.

40 -SNF, chromatin modification, DNA repair and RNA processing.

41 ortant new role for E2 in viral and cellular RNA processing.

42 lear foci, leading to abnormal regulation of RNA processing.

43 RRP1B (ribosomal RNA processing 1 homolog B) was first identified as a me

44 lusters, are enriched in factors involved in RNA processing [2], and the association of a subset of a

45 plant innate immunity via inhibition of the RNA-processing 5'-3' exoribonucleases.

46 erize two small molecule modulators of HIV-1 RNA processing, 8-azaguanine and 2-(2-(5-nitro-2-thienyl

47 e group of uncharacterized genes involved in RNA processing, a number of whose products localize to t

48 mediate highly selective pre-CRISPR-derived RNA processing across diverse CRISPR systems.

49 nd, where alternative splicing and messenger RNA processing actively occur.

50 However, the role of RNA exosome and its RNA processing activity on DNA mutagenesis/alteration ev

51 d detection of changes in transcriptional or RNA-processing activity.

52 als older than 60 years, the contribution of RNA processing alterations to human hematopoietic stem a

53 for thousands of bona fide novel elements of RNA processing-alternative splice sites, introns, and cl

54 ed method will fill a void among alternative RNA processing analysis tools for transcriptome studies.

55 This provides a new tool to study RNA processing and a potential lead for small molecules

56 of this continuum highlights dysfunction of RNA processing and aggrephagy as crucial disease-associa

57 Eukaryotic Spt5 couples RNA processing and chromatin modification to transcripti

58 tion initiation, elongation and termination, RNA processing and chromatin modification.

59 Nuclear RNA exosomes catalyze a range of RNA processing and decay activities that are coordinated

60 s endonucleases that play important roles in RNA processing and decay in Escherichia coli and related

61 he nuclear RNA exosome complex that mediates RNA processing and decay, and is mutated in several canc

62 mt-RNA precursors indicative of impaired mt-RNA processing and defective mitochondrial protein synth

63 Here we identify sites involved in RNA processing and degradation as well as transcription

64 Previously, sites of RNA processing and degradation had not been mapped on a

65 entification of the proteins responsible for RNA processing and degradation in this organelle is of g

66 exosome is responsible for a wide variety of RNA processing and degradation reactions.

67 s (RNases) maintain the cellular RNA pool by RNA processing and degradation.

68 conserved multiprotein complex essential for RNA processing and degradation.

69 t isoform-dependent regulatory mechanism for RNA processing and demonstrate its role in lung cancer.

70 Fustin et al. now show that it regulates RNA processing and determines the period and oscillatory

71 roteins with diverse roles in transcription, RNA processing and DNA double-strand break (DSB) repair.

72 rs (RPS15, IKZF3), and collectively identify RNA processing and export, MYC activity, and MAPK signal

73 (Dgcr8)-dependent deficits in primary micro-RNA processing and identified additional changes in gene

74 to transcripts encoding proteins involved in RNA processing and in Wnt and T cell receptor (TCR) sign

75 c aggregates that may sequester FUS, disrupt RNA processing and initiate motor neuron degeneration.

76 sequestration of FUS is predicted to disrupt RNA processing and initiate neurodegeneration.

77 Recent progress revealed the complexity of RNA processing and its association to human disorders.

78 Several steps of mitochondrial RNA processing and maturation, including RNA post-transc

79 was validated by the functional rescue of mt-RNA processing and mitochondrial protein synthesis defec

80 This includes several RNA processing and modification steps required for corre

81 tory processes such as alternative splicing, RNA processing and modification, nuclear export, regulat

82 n were functionally enriched in translation, RNA processing and mRNA metabolic process.

83 s; however, they had little effect on global RNA processing and neuronal survival.

84 Dysfunction in RNA processing and protein homeostasis is an emerging th

85 ility, chromatin regulation, immune evasion, RNA processing and protein homeostasis.

86 m viability because of its role in ribosomal RNA processing and protein synthesis, which is mediated,

87 es highlight the mechanistic intersection of RNA processing and proteostasis in mediating neuroprotec

88 ins (RBPs) and ribonucleoproteins coordinate RNA processing and PTGR.

89 a-retroviruses correlates with defects in 3' RNA processing and reduces viral titers by >10-fold.

90 ction of this family of proteins goes beyond RNA processing and ribosome assembly and includes RNA st

91 as ribonuclear protein complexes involved in RNA processing and ribosome biogenesis.

92 ar bodies believed to be factories of DNA or RNA processing and sites of transcriptional and/or postt

93 monstrates that Akt differentially regulates RNA processing and splicing factors to drive T cell diff

94 of some DIs, particularly in genes encoding RNA processing and splicing factors.

95 t down regulation of genes known to regulate RNA processing and splicing.

96 for protein translation initiation and both RNA processing and stability.

97 onserved enrichment in transcripts mediating RNA processing and stability.

98 Cotranscriptional RNA processing and surveillance factors mediate heteroch

99 eocytoplasmic transport, rRNA biogenesis, or RNA processing and surveillance was disrupted, 2) the bu

100 in GoF salmon, whereas those associated with RNA processing and synthesis, translation, and protein f

101 TDP-43 leads to a dramatic reduction in the RNA processing and the protein levels of IL-6 in serum.

102 erous links exist between co-transcriptional RNA processing and the transcribing RNAPII.

103 how that global changes in transcription and RNA processing and their impact on translation can be an

104 The literature is divided between RNA processing and transcriptional functions for these s

105 RRM proteins are involved in other forms of RNA processing and translation, the primary function of

106 ity module was enriched in genes involved in RNA processing and translation.

107 RNA processing and transport are mediated by cotranscrip

108 THO ribonucleoprotein complex important for RNA processing and transport.

109 Understanding RNA processing and turnover requires knowledge of cleava

110 alleles, and could therefore affect nuclear RNA processing and/or decay.

111 Tdr) proteins are repressed, indicating that RNA-processing and posttranscriptional pathways are impa

112 s changes in cellular processes, cell cycle, RNA-processing and protein turnover as cells acquire neu

113 of the CTD in complex with Rtt103, a 3'-end RNA-processing and transcription termination factor.

114 tion, promoter activation, RNA synthesis and RNA processing, and it is known that SUMOylation, a post

115 pe, productive elongation, cotranscriptional RNA processing, and termination.

116 contribute to the control of transcription, RNA processing, and the cytoplasmic fates of messenger R

117 where it regulates chromatin decondensation, RNA processing, and the phosphorylation state of fundame

118 ications, cell cycle and genome maintenance, RNA processing, and transcription.

119 rs of transcription, chromatin organization, RNA processing, and translation, such that lncRNAs can i

120 e expression at the levels of transcription, RNA processing, and translation.

121 Multiple proteins involved in RNA processing are linked to ALS, including FUS and TDP4

122 ties of, various factors required for normal RNA processing as well as additional cellular functions.

123 indicating that these regions mediate normal RNA processing as well as pathological events.

124 The DWNN is also expressed, via alternative RNA processing, as a small single-domain protein (isofor

125 llele-specific changes in gene expression or RNA processing, as well as changes in RNA editing in res

126 This may be the result of RNA processing at a site 87 bp upstream of vnfDG that wa

127 phila, the RNA-binding protein ELAV inhibits RNA processing at proximal polyadenylation sites, thereb

128 al RNA-binding proteins (RBPs) that regulate RNA processing at several levels, including localization

129 systematic differences in transcription and RNA processing between protein-coding and lincRNA genes

130 E2's role in multiple aspects of chloroplast RNA processing beyond group II intron splicing.

131 higher-order property of super-enhancers in RNA processing beyond transcription.

132 e splicing event results in the formation of RNA processing bodies (PBs), enhanced turnover of angiog

133 tion patterns, and regulation of alternative RNA processing by intronic heterochromatin.

134 )-5 CTD not only to termination, but also to RNA processing by the nuclear exosome.

135 sults implicate Ub signaling in coordinating RNA processing by TLR pathways during an immune response

136 and C9orf72 genes, is that perturbations of RNA processing can be highly adverse in motoneurons.

137 by which genetic markers drive variation in RNA-processing, cataloguing and classifying alleles that

138 and apoptosis, and up-regulation of genes in RNA processing, cellular growth and proliferation.

139 brain development featuring dysregulation of RNA processing, chromatin remodeling and cell-cycle gene

140 ater knowledge of the central role of SMN in RNA processing combined with deep characterization of an

141 ERH interacts with multiple RNA processing complexes, including splicing regulators.

142 However, little is known about how mitotic RNA processing contributes to spindle assembly.

143 Increasing evidence suggests that defective RNA processing contributes to the development of amyotro

144 ay both regulatory and constitutive roles in RNA processing, contributing to the fine-tuning of speci

145 oteostasis; many are hub genes - involved in RNA processing, cytoskeletal metabolism, intracellular t

146 emonstrate that proteins involved in DNA and RNA processing decrease with age and in SSc, whereas tho

147 our understanding of the broad importance of RNA processing deepens.

148 SETD2 to chromatin accessibility changes and RNA processing defects in cancer.

149 somal and U7 small-nuclear RNAs and corrects RNA processing defects induced by SMN deficiency in the

150 ly regulated, induces oncogenesis by causing RNA processing defects, for example, splicing defects.

151 mplex, underscoring its role as a non-coding RNA processing/degradation unit.

152 und that the affected genes were involved in RNA processing, DNA repair, and chromatin remodeling.

153 The minimal RNA-processing domain of SLBP is phosphorylated at an in

154 ing RNA RNase component of the mitochondrial RNA processing endoribonuclease (RMRP) give rise to the

155 Here, we report structures of the U6 RNA processing enzyme Usb1 from yeast and a substrate an

156 ivities and structures of yeast and human U6 RNA processing enzyme Usb1, reconstitute post-transcript

157 itment and activation of a cotranscriptional RNA processing enzyme, Xrn2.

158 (PRORPs) are a recently discovered class of RNA processing enzymes that catalyze maturation of the 5

159 directly analyzing this special alternative RNA processing event.

160 that ubiquinitation of RNAPII is induced by RNA processing events and linked to transcriptional paus

161 essing factors suggesting that CDK12 affects RNA processing events in two distinct ways: Indirectly t

162 ed its application to dissect variability in RNA processing events such as splicing.

163 of the global changes in gene expression and RNA processing events that occur as L. major transforms

164 The identified differential RNA processing events were consistent with RT-qPCR measu

165 isoforms preferentially modified alternative RNA processing events without widespread failure to reco

166 important regulators of post-transcriptional RNA processing events, yet their identities and function

167 and regulatory proteins modulate concurrent RNA-processing events, instruct RNA polymerase where to

168 hanistically, ANG induces cell-type-specific RNA-processing events: tRNA-derived stress-induced small

169 ntified the transcriptome-wide targets of 13 RNA processing, export, and turnover factors in budding

170 t the pentatricopeptide repeat (PPR) protein RNA PROCESSING FACTOR 4 (RPF4) supports the generation o

171 a conserved lncRNA that interacts with a key RNA processing factor and regulates neurogenesis from em

172 The RNA processing factor hnRNP L is required for T cell dev

173 activates the promoter of the cellular SRSF3 RNA processing factor.

174 Here, we identified the RNA-processing factor Nudt21 as a novel regulator of cel

175 ng through direct physical interactions with RNA processing factors and by regulating their expressio

176 letion also leads to a loss of expression of RNA processing factors and to defects in RNA processing.

177 provides evidence for an emerging model that RNA processing factors can modulate the recruitment of t

178 n modifiers, transcriptional regulators, and RNA processing factors during the transcription cycle.

179 signals raise the possibility that specific RNA processing factors may modulate transcription and he

180 Among the RNA processing factors phosphorylated by Cdk9 was the 5'

181 Here we describe a role for the RNA processing factors THRAP3 and BCLAF1 in the regulati

182 RNA pol II serving as a platform to recruit RNA processing factors to nascent transcripts.

183 These mutant RNAs alter the activities of RNA processing factors, including MBNL proteins, leading

184 at R-loops induced by the absence of diverse RNA processing factors, including the RNA/DNA helicases

185 and found that they associate with numerous RNA processing factors.

186 basal transcriptional machinery members, and RNA processing factors.

187 lease (NYN) - that are present in some other RNA processing factors.

188 g chromatin structure and the recruitment of RNA-processing factors during transcription elongation.

189 ing proteins reveals a strong enrichment for RNA-processing factors suggesting that CDK12 affects RNA

190 the enzyme's promoter escape and binding of RNA-processing factors, such as the m(7)G capping enzyme

191 , suggesting an interaction of monomers with RNA-processing factors.

192 Taken together, our study links noncoding RNA processing following RNA polII pausing with regulati

193 l disease and highlighting the importance of RNA processing for correct mitochondrial function.

194 case Mtr4 (and senataxin) with the noncoding RNA processing function of RNA exosome determine the str

195 (Mtb), the enzymes mediating several central RNA processing functions are still unknown.

196 ighly involved in five biological processes: RNA processing; gene transcription; ribosomal proteins;

197 induced splicing alterations are enriched in RNA processing genes, ribosomal genes, and recurrently m

198 In pediatric T-ALL, we have identified 2 RNA processing genes, that is, HNRNPH1/5q35 and DDX3X/Xp

199 first parvovirus protein to be implicated in RNA processing, governs access to the MVC capsid gene by

200 ld-type mtPAP localized to the mitochondrial RNA-processing granules thereby eliminating mislocalizat

201 e expression of a critical protein family in RNA processing, heterogeneous nuclear ribonucleoprotein

202 lycoprotein modeling, crowd-sourced science, RNA processing, hydrogen bond networks, and amyloid form

203 QTL affecting 3' RNA processing identify new functional motifs leading to

204 ALS is associated with RNA processing impairments involving the RNA-binding pro

205 Altering the balance of viral RNA processing impairs replication of the virus.

206 of chromatin structure, gene expression, and RNA processing in a wide range of biological systems, in

207 HATASE-LIKE1 [CPL1]) plays multiple roles in RNA processing in Arabidopsis thaliana Here, we found th

208 TLS expression and that loss of HuR-mediated RNA processing in astrocytes can alter the molecular and

209 ecific transcriptional responses and altered RNA processing in each cell type, with Tnfr1 required fo

210 ations have led to a better understanding of RNA processing in health and disease.

211 topic expression of HSD10 partially restored RNA processing in HSD10 knock-down cells and fibroblasts

212 ore evidence supporting the role of aberrant RNA processing in motor neuron degeneration.

213 g, and highlight the involvement of aberrant RNA processing in neuromuscular disease pathogenesis.

214 anscriptome, highlighting important roles of RNA processing in virus-host interactions.

215 A-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA

216 rotein that controls gene expression through RNA processing, in particular, regulation of splicing.

217 thermore, MATR3 controls critical aspects of RNA processing including alternative polyadenylation and

218 ar protein (hnRNP) has multiple functions in RNA processing including intracellular trafficking.

219 c variants in mediating post-transcriptional RNA processing, including alternative splicing.

220 ith this disease encode proteins involved in RNA processing, including fused-in-sarcoma/translocated-

221 ty was linked with widespread alterations in RNA processing, including intron retention and aberrant

222 h many factors involved in transcription and RNA processing, including selective groups of hnRNP prot

223 les of RNA structure in almost every step of RNA processing, including transcription, splicing, trans

224 polymerase II (Pol II) along with associated RNA processing intermediates.

225 ffinity and cause defects in small nucleolar RNA processing invivo.

226 spindle assembly and challenge the idea that RNA processing is globally repressed during mitosis.

227 Given that the disruption of RNA processing is increasingly implicated in neurologica

228 Thus, specific RNA processing is likely facilitated by preformed DGCR8-

229 Thus, ERH regulation of RNA processing is needed to ensure faithful DNA replicat

230 vidence that the removal of upstream ORFs by RNA processing is not typically required for the transla

231 ion offers an alternate method for analyzing RNA processing kinetics using standard molecular biology

232 in transcription time, degradation rate, and RNA-processing kinetics.

233 t that co-transcriptional recruitment of the RNA processing machinery to nascent mitotic transcripts

234 The exosome complex is the most important RNA processing machinery within the cell.

235 the WTAP complex is a novel component of the RNA processing machinery, implying an important role in

236 tors, including a U1-specific link to the 3' RNA processing machinery.

237 There, it associates with the RNA-processing machinery and specifically interacts with

238 leeping sickness and is known for its unique RNA processing mechanisms that are common to all the kin

239 al conditions as well as transcriptional and RNA processing mutants.

240 1 plays a critical role in the regulation of RNA processing, mutation of the gene encoding this ubiqu

241 We describe a nuclear RNA-processing network in fission yeast with a core modu

242 Alternate RNA processing of caspase-9 generates the splice variant

243 pliceosomal components differentially affect RNA processing of specific genes; however, whether chang

244 for HD, there is increasing interest in the RNA processing of the HTT gene.

245 lication by altering another avenue of viral RNA processing, offering the potential for the developme

246 s particularly useful to analyze products of RNA processing or turnover, and functional RNAs that are

247 ed through increased assembly of cytoplasmic RNA processing (P) bodies where ARE-mRNA localization wa

248 ation plays a particularly prominent role in RNA processing pathways of kinetoplastid protists typifi

249 Here, we discuss recent insights into how RNA processing pathways participate in DNA damage recogn

250 N is expressed ubiquitously and functions in RNA processing pathways that include trafficking of mRNA

251 g elongation with chromatin modification and RNA-processing pathways.

252 matic reorganization of proteins involved in RNA-processing pathways.

253 a 3' to 5' exoribonuclease, RRP6 (ribosomal RNA processing protein 6), as a CELF1-interacting protei

254 of the B cell genome depends upon localized RNA processing protein complex formation in the nucleus.

255 The RNA-processing protein TDP-43 is central to the pathogen

256 at are caused by mutations in another global RNA-processing protein, hGle1.

257 wing functional enrichment in transcription, RNA processing, protein synthesis, primary metabolic pat

258 lar processes, including cell proliferation, RNA processing, protein translation, autophagy, apoptosi

259 rotein superfamily, as well as proteases and RNA processing proteins.

260 t form toxic RNA foci that sequester various RNA processing proteins.

261 enic mechanisms: (i) functional depletion of RNA-processing proteins resulting in disruption of messe

262 Causative mutations in the global RNA-processing proteins TDP-43 and FUS among others, as

263 abolism regulators, translation factors, and RNA-processing proteins.

264 yered liquids that may facilitate sequential RNA processing reactions in a variety of RNP bodies.

265 ition that small RNAs provide specificity to RNA processing reactions through base pairing in diverse

266 biogenesis with aberrant precursor ribosomal RNA processing, reduced 40S subunit ribosomal RNA and 40

267 ression levels) and post-transcriptional (3' RNA processing) regulation across multiple stages of met

268 IWS1, an RNA processing regulator, is phosphorylated by Akt3 and

269 ation of RPS28 mRNA blocks pre-18S ribosomal RNA processing, resulting in a reduction in the number o

270 ls, hnRNPLL mediates a genome-wide switch of RNA processing, resulting in loss of B-cell lymphoma 6 (

271 iptome have enabled an unprecedented view of RNA processing, revealing many previously unknown non-ca

272 C5 is the protein subunit of the transfer RNA processing ribonucleoprotein enzyme RNase P from Esc

273 cells displayed defects in transcription and RNA processing, S7A cells behaved identically to 26r cel

274 rase II (Pol II) termination is dependent on RNA processing signals as well as specific terminator el

275 e analyses that correlate histone marks with RNA processing signals raise the possibility that specif

276 essed transcripts and mapped the genome-wide RNA processing sites (PSSs) in a methanogenic archaeon.

277 e human proteome and play important roles in RNA processing, splicing, export, stability, packaging,

278 TDP-43 mediates many RNA processing steps within distinct protein complexes.

279 ts, and are enriched in functions related to RNA processing such as SF3B1 spliceosomal factor.

280 ofiles of nascent RNA and co-transcriptional RNA processing that are associated with different CTD ph

281 chanistically, PLXNB2 mediates intracellular RNA processing that contribute to cell growth, survival,

282 s induces changes in gene transcription, IgH RNA processing, the unfolded protein response (UPR), and

283 eases but to exert their effects on cellular RNA processing they must first cross the plasma membrane

284 phosphorylation, CDK12 and CDK13 may affect RNA processing through direct physical interactions with

285 a cells, suggesting developmental control of RNA processing through expression of different sets of v

286 olecular processes, including transcription, RNA processing, tight junction, and metabolism.

287 dies show the processes of RNA synthesis and RNA processing to be spatio-temporally coordinated, indi

288 o other omega or mu C regions, as well as by RNA processing to generate different C isoforms.

289 his syndrome, senataxin (SETX), functions in RNA processing to protect the integrity of the genome.

290 The contribution of RNA processing to tumorigenesis is understudied.

291 tion of RNAs, and describe how by modulating RNA processing, translation, and decay PARPs impact mult

292 lated proteins are predominantly involved in RNA processing, translation, and RNAi.

293 -cell stage identified categories related to RNA processing, translation, and transport, consistent w

294 nthetic and stress-related proteins but also RNA-processing, translation and protein assembly factors

295 nd long noncoding RNA (lncRNA) with roles in RNA processing, transport, and stability.

296 d it to investigate two ncRNAs implicated in RNA processing: U1 small nuclear RNA, a component of the

297 s with functions relating to translation and RNA processing were overrepresented in genes with increa

298 n independent nifH1 promoter, but rather, by RNA processing, which produced a very stable nifH1 trans

299 ations of this mechanism for efficient micro-RNA processing will be discussed.

300 m AD and control brains reveals dysregulated RNA processing with accumulation of unspliced RNA specie